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  1. Content type: Review

    Hundreds of thousands of young women are diagnosed with cancer each year, and due to recent advances in screening programs, diagnostic methods and treatment options, survival rates have significantly improved....

    Authors: Roberto Marci, Maddalena Mallozzi, Luisa Di Benedetto, Mauro Schimberni, Stefano Mossa, Ilaria Soave, Stefano Palomba and Donatella Caserta

    Citation: Reproductive Biology and Endocrinology 2018 16:112

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  2. Content type: Review

    During recent years, an increasing percentage of male infertility has to be attributed to an array of environmental, health and lifestyle factors. Male infertility is likely to be affected by the intense expos...

    Authors: Kavindra Kumar Kesari, Ashok Agarwal and Ralf Henkel

    Citation: Reproductive Biology and Endocrinology 2018 16:118

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  3. Content type: Review

    The objective of this study was to carry out a systematic review and meta-analysis of embryologic and clinical outcomes following open versus closed vitrification of human oocytes and embryos.

    Authors: Hongcai Cai, Jean Damascene Niringiyumukiza, Yamin Li, Qiaohong Lai, Yinzhao Jia, Ping Su and Wenpei Xiang

    Citation: Reproductive Biology and Endocrinology 2018 16:123

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  4. Content type: Review

    Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age ...

    Authors: Asher Bashiri, Katherine Ida Halper and Raoul Orvieto

    Citation: Reproductive Biology and Endocrinology 2018 16:121

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  5. Content type: Research

    Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ p...

    Authors: Zhengling Liu, Zengyan Wang, Changhong Hao, Yonghui Tian and Jingjing Fu

    Citation: Reproductive Biology and Endocrinology 2018 16:120

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  6. Content type: Review

    There is growing evidence that lifestyle choices account for the overall quality of health and life (QoL) reflecting many potential lifestyle risks widely associated with alterations of the reproductive functi...

    Authors: Stefano Palomba, Jessica Daolio, Sara Romeo, Francesco Antonino Battaglia, Roberto Marci and Giovanni Battista La Sala

    Citation: Reproductive Biology and Endocrinology 2018 16:113

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  7. Content type: Review

    Male infertility is a widespread condition among couples. In about 50% of cases, couple infertility is attributable to the male partner, mainly due to a failure in spermatogenesis. In recent times, the crucial...

    Authors: Alessandro Ilacqua, Giulia Izzo, Gian Pietro Emerenziani, Carlo Baldari and Antonio Aversa

    Citation: Reproductive Biology and Endocrinology 2018 16:115

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  8. Content type: Review

    This article is a review that addresses the following topics, divided by paragraphs. The first paragraph investigates the effects of physical activity on ovarian function, analyzing in particular the changes c...

    Authors: Sandro La Vignera, Rosita A. Condorelli, Rossella Cannarella, Ylenia Duca and Aldo E. Calogero

    Citation: Reproductive Biology and Endocrinology 2018 16:108

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  9. Content type: Research

    There is limited literature investigating the effects of body mass index (BMI) and androgen level on in vitro fertilization (IVF) outcomes with a gonadotropin-releasing hormone (GnRH)-antagonist protocol in po...

    Authors: Wan Yang, Rui Yang, Mingmei Lin, Yan Yang, Xueling Song, Jiajia Zhang, Shuo Yang, Ying Song, Jia Li, Tianshu Pang, Feng Deng, Hua Zhang, Ying Wang, Rong Li and Jie Jiao

    Citation: Reproductive Biology and Endocrinology 2018 16:119

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  10. Content type: Research

    Matrix metalloproteinases (Mmps) and their tissue inhibitors (Timps) are widely recognized as crucial factors for extracellular matrix remodeling in the ovary and are involved in follicular growth, ovulation, ...

    Authors: Gabriel Levin, Tatiane Maldonado Coelho, Nathali Guimarães Nóbrega, Marina Trombetta-Lima, Mari Cleide Sogayar and Ana Claudia Oliveira Carreira

    Citation: Reproductive Biology and Endocrinology 2018 16:116

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  11. Content type: Review

    It is universally accepted that lifestyle interventions are the first step towards a good overall, reproductive and sexual health. Cessation of unhealthy habits, such as tobacco, alcohol and drug use, poor nut...

    Authors: Andrea Sansone, Massimiliano Sansone, Diana Vaamonde, Paolo Sgrò, Ciro Salzano, Francesco Romanelli, Andrea Lenzi and Luigi Di Luigi

    Citation: Reproductive Biology and Endocrinology 2018 16:114

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  12. Content type: Research

    Diabetes induces many complications including reduced fertility and low oocyte quality, but whether it causes increased mtDNA mutations is unknown.

    Authors: Li Li, Chang-Sheng Wu, Guan-Mei Hou, Ming-Zhe Dong, Zhen-Bo Wang, Yi Hou, Heide Schatten, Gui-Rong Zhang and Qing-Yuan Sun

    Citation: Reproductive Biology and Endocrinology 2018 16:110

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  13. Content type: Short communication

    Maternal virilization during pregnancy is a rare phenomenon. Polycystic ovary syndrome (PCOS), luteoma and luteinic cysts are the most frequent and benign etiologies. This article presents two cases of recurre...

    Authors: M. Deknuydt, A. Dumont, A. Bruyneel, D. Dewailly and S. Catteau-Jonard

    Citation: Reproductive Biology and Endocrinology 2018 16:107

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  14. Content type: Research

    Given the seriousness of chemotherapy-induced ovarian injury in female cancer patients, the preservation of fertility, including through the use of cryopreservation technology and pharmaceuticals, requires inv...

    Authors: Ying Qin, Akira Iwase, Tomohiko Murase, Bayasula, Chiharu Ishida, Nao Kato, Tomoko Nakamura, Satoko Osuka, Sachiko Takikawa, Maki Goto, Tomomi Kotani and Fumitaka Kikkawa

    Citation: Reproductive Biology and Endocrinology 2018 16:106

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  15. Content type: Research

    Spermatogenesis is a complex process involving the self-renewal and differentiation of spermatogonia into mature spermatids in the seminiferous tubules. During spermatogenesis, germ cells migrate from the base...

    Authors: Yue Liu, Yanqin Hu, Li Wang and Chen Xu

    Citation: Reproductive Biology and Endocrinology 2018 16:105

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  16. Content type: Research

    The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones o...

    Authors: Liangshan Mu, Jiexue Pan, Lili Yang, Qianqian Chen, Ya Chen, Yili Teng, Peiyu Wang, Rong Tang, Xuefeng Huang, Xia Chen and Haiyan Yang

    Citation: Reproductive Biology and Endocrinology 2018 16:104

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  17. Content type: Research

    Since the first report of a decline in semen quality in 1974, there have been several reports of similar declines across populations. Despite some scattered reports of declining semen quality in the Indian sub...

    Authors: Priyanka Mishra, Mahendra Pal Singh Negi, Mukesh Srivastava, Kiran Singh and Singh Rajender

    Citation: Reproductive Biology and Endocrinology 2018 16:103

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  18. Content type: Research

    FSHR SNPs may influence the ovarian sensitivity to endogenous and exogenous FSH stimulation. Given the paucity of data on the FSHR c.919A > G, c.2039A > G and − 29G > A SNPs in Hispanic population, we here analyz...

    Authors: Gabriela García-Jiménez, Teresa Zariñán, Rocío Rodríguez-Valentín, Nancy R. Mejía-Domínguez, Rubén Gutiérrez-Sagal, Georgina Hernández-Montes, Armando Tovar, Fabián Arechavaleta-Velasco, Patricia Canto, Julio Granados, Hortensia Moreno-Macias, Teresa Tusié-Luna, Antonio Pellicer and Alfredo Ulloa-Aguirre

    Citation: Reproductive Biology and Endocrinology 2018 16:100

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  19. Content type: Research

    Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility and hyperandrogenism. Evidence favors insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps pr...

    Authors: Lei Dou, Yahong Zheng, Lu Li, Xiaowei Gui, Yajuan Chen, Meng Yu and Yi Guo

    Citation: Reproductive Biology and Endocrinology 2018 16:99

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  20. Content type: Research

    Traditional semen parameters have shown little to none predictive value for fertilization and blastocyst viability for a successful pregnancy. Therefore, the purpose of this study was to explore the usefulness...

    Authors: Pamela Tello-Mora, Leticia Hernández-Cadena, Jeimy Pedraza, Esther López-Bayghen and Betzabet Quintanilla-Vega

    Citation: Reproductive Biology and Endocrinology 2018 16:102

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  21. Content type: Review

    Early human placental development strongly resembles carcinogenesis in otherwise healthy tissues. The progenitor cells of the placenta, the cytotrophoblast, rapidly proliferate to produce a sufficient number o...

    Authors: Rachel C. West, Gerrit J. Bouma and Quinton A. Winger

    Citation: Reproductive Biology and Endocrinology 2018 16:101

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  22. Content type: Research

    The Sertoli cell is the only somatic cell within the seminiferous tubules, and is vital for testis development and spermatogenesis. Rosiglitazone (RSG) is a member of the thiazolidinedione family and is a pero...

    Authors: Xie Ge, Peng Pan, Jun Jing, Xuechun Hu, Li Chen, Xuhua Qiu, Rujun Ma, Kadiliya Jueraitetibaike, Xuan Huang and Bing Yao

    Citation: Reproductive Biology and Endocrinology 2018 16:98

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  23. Content type: Research

    Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder in women of reproductive age and is commonly complicated by adverse endometrial outcomes. Long non-coding RNAs (lncRNAs) are a class of no...

    Authors: Xueying Zhang, Ying Xu, Lulu Fu, Dandan Li, Xiaowei Dai, Lianlian Liu, Jingshun Zhang, Lianwen Zheng and Manhua Cui

    Citation: Reproductive Biology and Endocrinology 2018 16:96

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  24. Content type: Research

    Cryptorchidism as a common genitourinary malformation with the serious complication of male infertility draws widespread attention. With several reported miRNAs playing critical roles in spermatogonial stem ce...

    Authors: Zhenyu Huang, Dongdong Tang, Jingjing Gao, Xianming Dou, Peng Cheng, Dangwei Peng, Yao Zhang, Jun Mao, Li Zhang and Xiansheng Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:97

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  25. Content type: Research

    Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarkably decreases the chance of pregnancy, which might be related to its impact on metabolic abnormalities in these patients. It...

    Authors: Majid Dastorani, Esmat Aghadavod, Naghmeh Mirhosseini, Fatemeh Foroozanfard, Shahrzad Zadeh Modarres, Mehrnush Amiri Siavashani and Zatollah Asemi

    Citation: Reproductive Biology and Endocrinology 2018 16:94

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  26. Content type: Research

    Spontaneous abortion is one of the most common complications in early pregnancy. A preventive test to identify women who will experience a miscarriage, even before first symptoms occur, is not established. Act...

    Authors: Alexander Freis, Janina Schlegel, Volker Daniel, Julia Jauckus, Thomas Strowitzki and Ariane Germeyer

    Citation: Reproductive Biology and Endocrinology 2018 16:93

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  27. Content type: Research

    Evidence suggests that subclinical hypothyroidism (SCH) and thyroid autoimmunity (TAI) are associated with adverse pregnancy outcomes. This systematic review and meta-analysis was conducted to determine whethe...

    Authors: Meng Rao, Zhengyan Zeng, Shuhua Zhao and Li Tang

    Citation: Reproductive Biology and Endocrinology 2018 16:92

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  28. Content type: Research

    Elevated plasma gonadotropins were associated with desensitization of Sertoli and Leydig cells in the male testis. Testis spermatogenesis ability would be improved via inhibiting high endogenous gonadotropin i...

    Authors: Xuechun Hu, Zheng Ding, Zhiwei Hong, Zhichuan Zou, Yuming Feng, Ruilou Zhu, Jinzhao Ma, Xie Ge, Chaojun Li and Bing Yao

    Citation: Reproductive Biology and Endocrinology 2018 16:91

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  29. Content type: Research

    Dehydroepiandrosterone (DHEA) is now widely used as an adjuvant for in vitro fertilization (IVF) cycles in poor ovarian responders (PORs). Several studies showed that DHEA supplementation could improve IVF out...

    Authors: Chyi-Uei Chern, Kuan-Hao Tsui, Salvatore Giovanni Vitale, San-Nung Chen, Peng-Hui Wang, Antonio Cianci, Hsiao-Wen Tsai, Zhi-Hong Wen and Li-Te Lin

    Citation: Reproductive Biology and Endocrinology 2018 16:90

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  30. Content type: Research

    Letrozole is widely employed as ovulation induction agent in women with PCOS, but its use in mild stimulation (MS) protocols for IVF is limited. Aim of the present study was to evaluate the feasibility of a MS...

    Authors: Giuseppe D’Amato, Anna Maria Caringella, Antonio Stanziano, Clementina Cantatore, Simone Palini and Ettore Caroppo

    Citation: Reproductive Biology and Endocrinology 2018 16:89

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  31. Content type: Review

    Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. The...

    Authors: Mahsa Darbandi, Sara Darbandi, Ashok Agarwal, Pallav Sengupta, Damayanthi Durairajanayagam, Ralf Henkel and Mohammad Reza Sadeghi

    Citation: Reproductive Biology and Endocrinology 2018 16:87

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  32. Content type: Research

    The injection of estradiol valerate in female rats induces polycystic ovary syndrome, which is characterized by polycystic ovaries, anovulation, and hyperandrogenism. These characteristics have been associated...

    Authors: Julieta A. Espinoza, Wendy Alvarado, Berenice Venegas, Roberto Domínguez and Leticia Morales-Ledesma

    Citation: Reproductive Biology and Endocrinology 2018 16:86

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  33. Content type: Research

    Cisplatin (CDDP), a widely used chemotherapeutic agent, can induce excessive granulosa cell apoptosis, follicle loss and even premature ovarian insufficiency (POI). However, the mechanism remains elusive, alth...

    Authors: Yuping Wu, Congshun Ma, Huihui Zhao, Yuxia Zhou, Zhenguo Chen and Liping Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:85

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  34. Content type: Research

    Tyrosine kinase receptor erythropoietin-producing hepatocellular receptor A2 (EphA2) is abundant in the endometrium and plays a role in the establishment of eutopic implantation. A similar molecular mechanism ...

    Authors: Huan Jiang, Xiao-Yi Yang and Wei-Jie Zhu

    Citation: Reproductive Biology and Endocrinology 2018 16:84

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  35. Content type: Research

    A molecule identical to nerve growth factor, with ovulation-inducing properties has been discovered in the seminal plasma of South American camelids (ovulation-inducing factor/nerve growth factor; OIF/NGF). We...

    Authors: Rodrigo A. Carrasco, Jaswant Singh and Gregg P. Adams

    Citation: Reproductive Biology and Endocrinology 2018 16:83

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  36. Content type: Research

    Imprinted genes, which are expressed in a parent of origin-specific manner, are thought to mediate the genetic priorities of each parent in pregnancy. Recently we reported that some fetal imprinted gene varian...

    Authors: Clive J. Petry, Albert Koulman, Liangjian Lu, Benjamin Jenkins, Samuel Furse, Philippa Prentice, Lee Matthews, Ieuan A. Hughes, Carlo L. Acerini, Ken K. Ong and David B. Dunger

    Citation: Reproductive Biology and Endocrinology 2018 16:82

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  37. Content type: Research

    Mounting evidence shows that ROS regulation by various antioxidants is essential for the expression of enzymes involved in steroidogenesis and maintenance of progesterone production by the corpus luteum (CL). ...

    Authors: Hyo-Jin Park, Dong Gil Lee, Jung Bae Seong, Hyun-Shik Lee, Oh-Shin Kwon, Beom Sik Kang, Jeen-woo Park, Sang-Rae Lee and Dong-Seok Lee

    Citation: Reproductive Biology and Endocrinology 2018 16:79

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  38. Content type: Research

    Cryptorchidism is one of the most common causes of non-obstructive azoospermia (NOA) leading to male infertility. Despite various medical approaches been utilised, many patients still suffer from infertility. ...

    Authors: Dongdong Tang, Zhenyu Huang, Xiaojin He, Huan Wu, Dangwei Peng, Li Zhang and Xiansheng Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:78

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  39. Content type: Research

    Storage conditions during transportation of explanted ovaries are a critical step in setting up fertility preservation protocols in both animal and human fields. Here, we evaluated the effects of ovary storage...

    Authors: Anna Rita Piras, Giovanni Pietro Burrai, Federica Ariu, Laura Falchi, Maria Teresa Zedda, Salvatore Pau, Sergio Domenico Gadau, Elisabetta Antuofermo, Daniela Bebbere, Sergio Ledda and Luisa Bogliolo

    Citation: Reproductive Biology and Endocrinology 2018 16:76

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  40. Content type: Research

    Appropriate classification of obesity is vital for risk assessment and complication prevention during pregnancy. We aimed to explore which pre-pregnancy BMI cut-offs of obesity, either BMI ≥ 25 kg/m2 as recommend...

    Authors: Yanxin Wu, Wai-Kit Ming, Dongyu Wang, Haitian Chen, Zhuyu Li and Zilian Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:77

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  41. Content type: Research

    Our aim in this study was to investigate morning blood pressure surge (MBPS) in patients of reproductive age with polycystic ovary syndrome (PCOS) and its relation to insulin resistance (IR).

    Authors: Hasan Kadi, Eyup Avci, Akin Usta and Abdullah Orhan Demirtaş

    Citation: Reproductive Biology and Endocrinology 2018 16:75

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  42. Content type: Research

    Pregnancies following assisted reproductive technology (ART) may have elevated potential risk of pregnancy loss (PL) when compared to natural conception. However, rare studies comprehensively analyzed the IVF/...

    Authors: Lingmin Hu, Jiangbo Du, Hong Lv, Jing Zhao, Mengxi Chen, Yifeng Wang, Fang Wu, Feng Liu, Xiaojiao Chen, Junqiang Zhang, Hongxia Ma, Guangfu Jin, Hongbing Shen, Li Chen, Xiufeng Ling and Zhibin Hu

    Citation: Reproductive Biology and Endocrinology 2018 16:74

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  43. Content type: Research

    Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. An lncRNA, namely, Prader-Willi region nonprotein coding RNA 2 (PWRN2), was up-regulated in the cumulus cells of patients wi...

    Authors: Xin Huang, Jiaping Pan, Bi Wu and Xiaoming Teng

    Citation: Reproductive Biology and Endocrinology 2018 16:73

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  44. Content type: Research

    Recently, we demonstrated the three-dimensional (3D) localization of murine trophoblast giant cells in the pregnant uterus using a modified Clear Unobstructed Brain Imaging Cocktails and Computational analysis...

    Authors: Kyosuke Kagami, Yohei Shinmyo, Masanori Ono, Hiroshi Kawasaki and Hiroshi Fujiwara

    Citation: Reproductive Biology and Endocrinology 2018 16:72

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