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  1. Content type: Research

    Age-associated infertility is a problem worldwide, and management of oxidative stress is known to be essential. Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant...

    Authors: Nana Akino, Osamu Wada-Hiraike, Wataru Isono, Hiromi Terao, Harunori Honjo, Yuichiro Miyamoto, Michihiro Tanikawa, Kenbun Sone, Mana Hirano, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Kaori Koga, Katsutoshi Oda, Tomoyuki Fujii and Yutaka Osuga

    Citation: Reproductive Biology and Endocrinology 2019 17:23

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  2. Content type: Research

    Previous studies, which were primarily based on the fluorescent in-situ hybridisation (FISH) technique, revealed conflicting evidence regarding male foetal microchimerism in endometriosis. FISH is a relatively...

    Authors: Muzaffer A. Bhat, Jai B. Sharma, Kallol K. Roy, Jayasree Sengupta and Debabrata Ghosh

    Citation: Reproductive Biology and Endocrinology 2019 17:22

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  3. Content type: Research

    Endometriosis is thought to affect the effectiveness of ART by an increased risk of miscarriage. We aimed to investigate the impact of endometriosis in women achieving singleton pregnancies through IVF fresh c...

    Authors: Puyu Yang, Yang Wang, Zhangxin Wu, Ningning Pan, Liying Yan and Caihong Ma

    Citation: Reproductive Biology and Endocrinology 2019 17:21

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  4. Content type: Research

    Despite being born with a significant number of primordial cells which representing the ancestor cells of the germ-line, women experience a depletion of ovarian reserve and sub-fertility mid-way into their hea...

    Authors: Haroon Latif Khan, Shahzad Bhatti, Samina Suhail, Rohina Gul, Aisha Awais, Humaira Hamayun, Farah Enver, Sana Abbas, Zahira Hassan, Rameen Nisar, Saba Sardar and Warda Asif

    Citation: Reproductive Biology and Endocrinology 2019 17:20

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  5. Content type: Research

    Steroidogenesis is an indispensable process that is indirectly associated with spermatogenesis in the Leydig cell (LC) to utilize the lipid droplets (LDs) that are critical to maintaining normal testosterone s...

    Authors: Imran Tarique, Waseem Ali Vistro, Xuebing Bai, Ping Yang, Chen Hong, Yufei Huang, Abdul Haseeb, Enxue Liu, Noor Samad Gandahi, Mengdi Xu, Yifei Liu and Qiusheng Chen

    Citation: Reproductive Biology and Endocrinology 2019 17:19

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  6. Content type: Review

    To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation.

    Authors: Alessandro Conforti, Sandro C. Esteves, Francesca Di Rella, Ida Strina, Pasquale De Rosa, Alessia Fiorenza, Fulvio Zullo, Giuseppe De Placido and Carlo Alviggi

    Citation: Reproductive Biology and Endocrinology 2019 17:18

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  7. Content type: Review

    The objective of this systematic review was to examine the literature and to compare the effectiveness of letrozole (LE) versus laparoscopic ovarian drilling (LOD) for the induction of ovulation in women with ...

    Authors: Qiong Yu, Shifu Hu, Yingying Wang, Guiping Cheng, Wei Xia and Changhong Zhu

    Citation: Reproductive Biology and Endocrinology 2019 17:17

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  8. Content type: Research

    Little is known about resident attitudes toward elective egg freezing (EF) or how educational exposure to EF affects residents’ views and ability to counsel patients. This study aimed to evaluate US OB/GYN res...

    Authors: Navid Esfandiari, Julia Litzky, Joshua Sayler, Pavel Zagadailov, Karen George and Leslie DeMars

    Citation: Reproductive Biology and Endocrinology 2019 17:16

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  9. Content type: Research

    Intrauterine insemination (IUI) is the first-line treatment for non-tubal infertility. Injectable gonadotropins are often chosen as adjunctive stimulation to promote the growth of ovarian follicles in IUI cycl...

    Authors: Yiwen Liu, Xiang Y. Ye and Crystal Chan

    Citation: Reproductive Biology and Endocrinology 2019 17:14

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  10. Content type: Research

    To assess the predictive value of each individual morphological parameter: blastocoele expansion degree, inner cell mass (ICM), and trophectoderm (TE) grades on the clinical pregnancy outcome in frozen–warmed ...

    Authors: Jing Zhao, Yi Yan, Xi Huang, Lunquan Sun and Yanping Li

    Citation: Reproductive Biology and Endocrinology 2019 17:15

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  11. Content type: Research

    Excessive gestational weight gain (GWG), which is associated with adverse long-term effects on the health of the offspring, has become a major clinical problem. Accumulating evidence indicates that the ovary k...

    Authors: Zhiyang Zhou, Qi Lin, Xinxin Xu, Gaby Sukma Illahi, Chenle Dong and Xueqing Wu

    Citation: Reproductive Biology and Endocrinology 2019 17:13

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  12. Content type: Review

    Among the factors causing male infertility, one of the most debated is the exposure to environmental contaminants. Recently, the chemical compound Bisphenol A (BPA) has drawn attention from the reproductive sc...

    Authors: Federica Cariati, Nadja D’Uonno, Francesca Borrillo, Stefania Iervolino, Giacomo Galdiero and Rossella Tomaiuolo

    Citation: Reproductive Biology and Endocrinology 2019 17:6

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  13. Content type: Research

    Detrimental exposures during pregnancy have been implicated in programming offspring to develop permanent changes in physiology and metabolism, increasing the risk for developing diseases in adulthood such as ...

    Authors: Amy K. Schutt, Chellakkan S. Blesson, Jean W. Hsu, Cecilia T. Valdes, William E. Gibbons, Farook Jahoor and Chandra Yallampalli

    Citation: Reproductive Biology and Endocrinology 2019 17:12

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  14. Content type: Review

    A mounting body of the literature suggests that environmental chemicals found in food and water could affect female reproduction. Many worldwide daily-used products have been shown to contain chemicals that co...

    Authors: Justin Rashtian, Diana E. Chavkin and Zaher Merhi

    Citation: Reproductive Biology and Endocrinology 2019 17:5

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  15. Content type: Research

    In assisted reproductive technology, prediction of treatment failure remains a great challenge. The development of more sensitive assays for measuring anti-Müllerian hormone (AMH) has allowed for the possibili...

    Authors: A. G. Grynnerup, K. Løssl, F. Pilsgaard, S. A. Lunding, M. Storgaard, J. W. Bogstad, L. Prætorius, A. Zedeler, L. Bungum, A. Nyboe Andersen and A. Pinborg

    Citation: Reproductive Biology and Endocrinology 2019 17:11

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  16. Content type: Research

    A low oxygen supply to the fetus causes intrauterine growth restriction and can affect gonadal development of the offspring, having a potential impact on fertility. We investigated histology and gene expressio...

    Authors: Valentina Pampanini, Kirsi Jahnukainen, Lena Sahlin, Daniela Germani, Antonella Puglianiello, Stefano Cianfarani and Olle Söder

    Citation: Reproductive Biology and Endocrinology 2019 17:10

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  17. Content type: Review

    MicroRNAs (miRNAs) are short, noncoding RNAs that posttranscriptionally regulate gene expression. In the past decade, studies on miRNAs in ovaries have revealed the key roles of miRNAs in ovarian development a...

    Authors: Jinbi Zhang, Yinxue Xu, Honglin Liu and Zengxiang Pan

    Citation: Reproductive Biology and Endocrinology 2019 17:9

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  18. Content type: Review

    Over the past two decades, public health has focused on the identification of environmental chemical factors that are able to adversely affect hormonal function, known as endocrine disruptors (EDs). EDs mimic ...

    Authors: Andrea Di Nisio and Carlo Foresta

    Citation: Reproductive Biology and Endocrinology 2019 17:4

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  19. Content type: Review

    A central dogma of mammalian reproductive biology is that the size of the primordial follicle pool represents reproductive capacity in females. The assembly of the primordial follicle starts after the primordi...

    Authors: Bo Pan and Julang Li

    Citation: Reproductive Biology and Endocrinology 2019 17:8

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  20. Content type: Research

    Diminished ovarian reserve (DOR) remains one of the greatest obstacles affecting the chance of a successful live birth after fertility treatment. The present study was set to investigate whether using a “dual ...

    Authors: Ming-Huei Lin, Frank Shao-Ying Wu, Yuh-Ming Hwu, Robert Kuo-Kuang Lee, Ryh-Sheng Li and Sheng-Hsiang Li

    Citation: Reproductive Biology and Endocrinology 2019 17:7

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  21. Content type: Research

    Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melato...

    Authors: Longfei Xiao, Junjie Hu, Liangli Song, Yong Zhang, Weitao Dong, Yuting Jiang, Quanwei Zhang, Ligang Yuan and Xingxu Zhao

    Citation: Reproductive Biology and Endocrinology 2019 17:1

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  22. Content type: Research

    Fertility preservation (FP) protocols in case of breast cancer (BC) include mature oocyte cryopreservation following letrozole associated controlled ovarian hyperstimulation (Let-COH). To date, the impact of L...

    Authors: Oranite Goldrat, Geraldine Van Den Steen, Eric Gonzalez-Merino, Julie Dechène, Christine Gervy, Anne Delbaere, Fabienne Devreker, Viviane De Maertelaer and Isabelle Demeestere

    Citation: Reproductive Biology and Endocrinology 2019 17:3

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  23. Content type: Research

    Chronic endometritis (CE) is a condition which results in reduced receptivity of embryos by dysregulated lymphocyte subsets, abnormal expression of cytokines, chemokines and other regulatory molecules in the e...

    Authors: Wen-juan Wang, Hong Zhang, Zhong-quan Chen, Wei Zhang, Xue-mei Liu, Jiang-ye Fang, Fu-jun Liu and Joanne Kwak-Kim

    Citation: Reproductive Biology and Endocrinology 2019 17:2

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  24. Content type: Review

    Air pollution is a cause of concern for human health. For instance, it is associated with an increased risk for cancer, cardiovascular and respiratory disorders. In vitro and in vivo studies suggested that air...

    Authors: Alessandro Conforti, Marika Mascia, Giuseppina Cioffi, Cristina De Angelis, Giuseppe Coppola, Pasquale De Rosa, Rosario Pivonello, Carlo Alviggi and Giuseppe De Placido

    Citation: Reproductive Biology and Endocrinology 2018 16:117

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  25. Content type: Research

    Recently, a novel approach with delaying the start of controlled ovarian stimulation along with gonadotropin-releasing hormone (GnRH) antagonist pretreatment for 7 days after estrogen priming for further suppr...

    Authors: Mahnaz Ashrafi, Arezoo Arabipoor, Azar Yahyaei, Zahra Zolfaghari and Firouzah Ghaffari

    Citation: Reproductive Biology and Endocrinology 2018 16:124

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  26. Content type: Review

    Exposure to air pollution has been clearly associated with a range of adverse health effects, including reproductive toxicity. However, a limited amount of research has been conducted to examine the associatio...

    Authors: Joanna Jurewicz, Emila Dziewirska, Michał Radwan and Wojciech Hanke

    Citation: Reproductive Biology and Endocrinology 2018 16:109

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  27. Content type: Review

    Hundreds of thousands of young women are diagnosed with cancer each year, and due to recent advances in screening programs, diagnostic methods and treatment options, survival rates have significantly improved....

    Authors: Roberto Marci, Maddalena Mallozzi, Luisa Di Benedetto, Mauro Schimberni, Stefano Mossa, Ilaria Soave, Stefano Palomba and Donatella Caserta

    Citation: Reproductive Biology and Endocrinology 2018 16:112

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  28. Content type: Review

    During recent years, an increasing percentage of male infertility has to be attributed to an array of environmental, health and lifestyle factors. Male infertility is likely to be affected by the intense expos...

    Authors: Kavindra Kumar Kesari, Ashok Agarwal and Ralf Henkel

    Citation: Reproductive Biology and Endocrinology 2018 16:118

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  29. Content type: Review

    The objective of this study was to carry out a systematic review and meta-analysis of embryologic and clinical outcomes following open versus closed vitrification of human oocytes and embryos.

    Authors: Hongcai Cai, Jean Damascene Niringiyumukiza, Yamin Li, Qiaohong Lai, Yinzhao Jia, Ping Su and Wenpei Xiang

    Citation: Reproductive Biology and Endocrinology 2018 16:123

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  30. Content type: Review

    Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age ...

    Authors: Asher Bashiri, Katherine Ida Halper and Raoul Orvieto

    Citation: Reproductive Biology and Endocrinology 2018 16:121

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  31. Content type: Research

    Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ p...

    Authors: Zhengling Liu, Zengyan Wang, Changhong Hao, Yonghui Tian and Jingjing Fu

    Citation: Reproductive Biology and Endocrinology 2018 16:120

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  32. Content type: Review

    There is growing evidence that lifestyle choices account for the overall quality of health and life (QoL) reflecting many potential lifestyle risks widely associated with alterations of the reproductive functi...

    Authors: Stefano Palomba, Jessica Daolio, Sara Romeo, Francesco Antonino Battaglia, Roberto Marci and Giovanni Battista La Sala

    Citation: Reproductive Biology and Endocrinology 2018 16:113

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  33. Content type: Review

    Male infertility is a widespread condition among couples. In about 50% of cases, couple infertility is attributable to the male partner, mainly due to a failure in spermatogenesis. In recent times, the crucial...

    Authors: Alessandro Ilacqua, Giulia Izzo, Gian Pietro Emerenziani, Carlo Baldari and Antonio Aversa

    Citation: Reproductive Biology and Endocrinology 2018 16:115

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  34. Content type: Review

    This article is a review that addresses the following topics, divided by paragraphs. The first paragraph investigates the effects of physical activity on ovarian function, analyzing in particular the changes c...

    Authors: Sandro La Vignera, Rosita A. Condorelli, Rossella Cannarella, Ylenia Duca and Aldo E. Calogero

    Citation: Reproductive Biology and Endocrinology 2018 16:108

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  35. Content type: Research

    There is limited literature investigating the effects of body mass index (BMI) and androgen level on in vitro fertilization (IVF) outcomes with a gonadotropin-releasing hormone (GnRH)-antagonist protocol in po...

    Authors: Wan Yang, Rui Yang, Mingmei Lin, Yan Yang, Xueling Song, Jiajia Zhang, Shuo Yang, Ying Song, Jia Li, Tianshu Pang, Feng Deng, Hua Zhang, Ying Wang, Rong Li and Jie Jiao

    Citation: Reproductive Biology and Endocrinology 2018 16:119

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  36. Content type: Research

    Matrix metalloproteinases (Mmps) and their tissue inhibitors (Timps) are widely recognized as crucial factors for extracellular matrix remodeling in the ovary and are involved in follicular growth, ovulation, ...

    Authors: Gabriel Levin, Tatiane Maldonado Coelho, Nathali Guimarães Nóbrega, Marina Trombetta-Lima, Mari Cleide Sogayar and Ana Claudia Oliveira Carreira

    Citation: Reproductive Biology and Endocrinology 2018 16:116

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  37. Content type: Review

    It is universally accepted that lifestyle interventions are the first step towards a good overall, reproductive and sexual health. Cessation of unhealthy habits, such as tobacco, alcohol and drug use, poor nut...

    Authors: Andrea Sansone, Massimiliano Sansone, Diana Vaamonde, Paolo Sgrò, Ciro Salzano, Francesco Romanelli, Andrea Lenzi and Luigi Di Luigi

    Citation: Reproductive Biology and Endocrinology 2018 16:114

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  38. Content type: Research

    Diabetes induces many complications including reduced fertility and low oocyte quality, but whether it causes increased mtDNA mutations is unknown.

    Authors: Li Li, Chang-Sheng Wu, Guan-Mei Hou, Ming-Zhe Dong, Zhen-Bo Wang, Yi Hou, Heide Schatten, Gui-Rong Zhang and Qing-Yuan Sun

    Citation: Reproductive Biology and Endocrinology 2018 16:110

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  39. Content type: Short communication

    Maternal virilization during pregnancy is a rare phenomenon. Polycystic ovary syndrome (PCOS), luteoma and luteinic cysts are the most frequent and benign etiologies. This article presents two cases of recurre...

    Authors: M. Deknuydt, A. Dumont, A. Bruyneel, D. Dewailly and S. Catteau-Jonard

    Citation: Reproductive Biology and Endocrinology 2018 16:107

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  40. Content type: Research

    Given the seriousness of chemotherapy-induced ovarian injury in female cancer patients, the preservation of fertility, including through the use of cryopreservation technology and pharmaceuticals, requires inv...

    Authors: Ying Qin, Akira Iwase, Tomohiko Murase, Bayasula, Chiharu Ishida, Nao Kato, Tomoko Nakamura, Satoko Osuka, Sachiko Takikawa, Maki Goto, Tomomi Kotani and Fumitaka Kikkawa

    Citation: Reproductive Biology and Endocrinology 2018 16:106

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  41. Content type: Research

    Spermatogenesis is a complex process involving the self-renewal and differentiation of spermatogonia into mature spermatids in the seminiferous tubules. During spermatogenesis, germ cells migrate from the base...

    Authors: Yue Liu, Yanqin Hu, Li Wang and Chen Xu

    Citation: Reproductive Biology and Endocrinology 2018 16:105

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  42. Content type: Research

    The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones o...

    Authors: Liangshan Mu, Jiexue Pan, Lili Yang, Qianqian Chen, Ya Chen, Yili Teng, Peiyu Wang, Rong Tang, Xuefeng Huang, Xia Chen and Haiyan Yang

    Citation: Reproductive Biology and Endocrinology 2018 16:104

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  43. Content type: Research

    Since the first report of a decline in semen quality in 1974, there have been several reports of similar declines across populations. Despite some scattered reports of declining semen quality in the Indian sub...

    Authors: Priyanka Mishra, Mahendra Pal Singh Negi, Mukesh Srivastava, Kiran Singh and Singh Rajender

    Citation: Reproductive Biology and Endocrinology 2018 16:103

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  44. Content type: Research

    FSHR SNPs may influence the ovarian sensitivity to endogenous and exogenous FSH stimulation. Given the paucity of data on the FSHR c.919A > G, c.2039A > G and − 29G > A SNPs in Hispanic population, we here analyz...

    Authors: Gabriela García-Jiménez, Teresa Zariñán, Rocío Rodríguez-Valentín, Nancy R. Mejía-Domínguez, Rubén Gutiérrez-Sagal, Georgina Hernández-Montes, Armando Tovar, Fabián Arechavaleta-Velasco, Patricia Canto, Julio Granados, Hortensia Moreno-Macias, Teresa Tusié-Luna, Antonio Pellicer and Alfredo Ulloa-Aguirre

    Citation: Reproductive Biology and Endocrinology 2018 16:100

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  45. Content type: Research

    Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility and hyperandrogenism. Evidence favors insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps pr...

    Authors: Lei Dou, Yahong Zheng, Lu Li, Xiaowei Gui, Yajuan Chen, Meng Yu and Yi Guo

    Citation: Reproductive Biology and Endocrinology 2018 16:99

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  46. Content type: Research

    Traditional semen parameters have shown little to none predictive value for fertilization and blastocyst viability for a successful pregnancy. Therefore, the purpose of this study was to explore the usefulness...

    Authors: Pamela Tello-Mora, Leticia Hernández-Cadena, Jeimy Pedraza, Esther López-Bayghen and Betzabet Quintanilla-Vega

    Citation: Reproductive Biology and Endocrinology 2018 16:102

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  47. Content type: Review

    Early human placental development strongly resembles carcinogenesis in otherwise healthy tissues. The progenitor cells of the placenta, the cytotrophoblast, rapidly proliferate to produce a sufficient number o...

    Authors: Rachel C. West, Gerrit J. Bouma and Quinton A. Winger

    Citation: Reproductive Biology and Endocrinology 2018 16:101

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  48. Content type: Research

    The Sertoli cell is the only somatic cell within the seminiferous tubules, and is vital for testis development and spermatogenesis. Rosiglitazone (RSG) is a member of the thiazolidinedione family and is a pero...

    Authors: Xie Ge, Peng Pan, Jun Jing, Xuechun Hu, Li Chen, Xuhua Qiu, Rujun Ma, Kadiliya Jueraitetibaike, Xuan Huang and Bing Yao

    Citation: Reproductive Biology and Endocrinology 2018 16:98

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