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  1. Research

    Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome

    We and others have observed that young girls predisposed to polycystic ovary syndrome (PCOS) display defective insulin sensitivity, beta-cell function and non-esterified fatty acids (NEFA) suppressibility during ...

    Soren Harnois-Leblanc, Andréanne Trottier, Samuel Leblanc, Marie-Claude Battista, David H. Geller and Jean-Patrice Baillargeon

    Reproductive Biology and Endocrinology 2017 15:56

    Published on: 24 July 2017

  2. Commentary

    Comment on "Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation"

    The cause of contamination and dissemination of leiomyoma tissue particles and cells in the peritoneal cavity during myomectomy is a challenging issue for both clinicians and researchers. Therefore, the articl...

    Ospan A. Mynbaev, Antonio Malvasi, Sergei S. Simakov and Andrea Tinelli

    Reproductive Biology and Endocrinology 2017 15:54

    Published on: 20 July 2017

  3. Commentary

    Response to comment on “Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation”

    According to the literature review, CO2 insufflation on parasitic myoma implantation is not well studied, and we concur that our study is related to “Morcellation-induced parasitic myomas.” We did not compare ...

    Ben-Shian Huang, Huann-Cheng Horng, Peng-Hui Wang, Muh-Hwa Yang and Yi-Jen Chen

    Reproductive Biology and Endocrinology 2017 15:55

    Published on: 20 July 2017

  4. Research

    Arcyriaflavin a, a cyclin D1–cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis

    We previously showed that microRNA-503 (miR-503) transfection into endometriotic cyst stromal cells (ECSCs) induced cell cycle arrest at the G0/G1 phase by suppressing cyclin D1. This finding prompted us to ev...

    Tomoko Hirakawa, Kaei Nasu, Yoko Aoyagi, Kanetoshi Takebayashi and Hisashi Narahara

    Reproductive Biology and Endocrinology 2017 15:53

    Published on: 18 July 2017

  5. Research

    Differentiating mouse embryonic stem cells express markers of human endometrium

    Modeling early endometrial differentiation is a crucial step towards understanding the divergent pathways between normal and ectopic endometrial development as seen in endometriosis.

    P. Parasar, C. R. Sacha, N. Ng, E. R. McGuirk, S. Chinthala, P. Ozcan, J. Lindsey, S. Salas, M. R. Laufer, S. A. Missmer and R. M. Anchan

    Reproductive Biology and Endocrinology 2017 15:52

    Published on: 17 July 2017

  6. Research

    Polycystic ovary syndrome induced by exposure to testosterone propionate and effects of sympathectomy on the persistence of the syndrome

    Polycystic ovary syndrome is a complex disorder affecting 6 to 10% of women of reproductive age. In recent years, the cause of the syndrome has been associated with increased androgen serum levels, as well as ...

    Leticia Morales-Ledesma, Juan Antonio Díaz Ramos and Angélica Trujillo Hernández

    Reproductive Biology and Endocrinology 2017 15:50

    Published on: 10 July 2017

  7. Research

    Towards a better understanding of preimplantation genetic screening for aneuploidy: insights from a virtual trial for women under the age of 40 when transferring embryos one at a time

    The aim of this theoretical study is to explore the cost-effectiveness of aneuploidy screening in a UK setting for every woman aged under the age of 40 years when fresh and vitrified-warmed embryos are transfe...

    Paul N. Scriven

    Reproductive Biology and Endocrinology 2017 15:49

    Published on: 30 June 2017

  8. Review

    The myths surrounding mild stimulation in vitro fertilization (IVF)

    So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes...

    Raoul Orvieto, Valeria Stella Vanni and Norbert Gleicher

    Reproductive Biology and Endocrinology 2017 15:48

    Published on: 24 June 2017

  9. Research

    Oocyte polarized light microscopy, assay of specific follicular fluid metabolites, and gene expression in cumulus cells as different approaches to predict fertilization efficiency after ICSI

    The complex relationship between oocyte morphology, specific follicular fluid metabolites, gene expression in cumulus granulosa cells, and oocyte competence toward fertilization and embryo development still ne...

    Alberto Revelli, Stefano Canosa, Loredana Bergandi, Oleksii A. Skorokhod, Valentina Biasoni, Andrea Carosso, Angela Bertagna, Milena Maule, Elisabetta Aldieri, Maria Diletta D’Eufemia, Francesca Evangelista, Nicola Colacurci and Chiara Benedetto

    Reproductive Biology and Endocrinology 2017 15:47

    Published on: 23 June 2017

  10. Research

    The potential regulatory mechanisms of the gonadotropin-releasing hormone in gonadotropin transcriptions identified with bioinformatics analyses

    The regulation of gonadotropin synthesis and release by gonadotropin­releasing hormone (GnRH) plays an essential role in the neuroendocrine control of reproduction. However, the mechanisms underlying gonadotro...

    Wei Xiang, Baoyun Zhang, Fenglin Lv, Guangde Feng, Long Chen, Fang Yang, Ke Zhang, Chunyu Cao, Pingqing Wang and Mingxing Chu

    Reproductive Biology and Endocrinology 2017 15:46

    Published on: 17 June 2017

  11. Research

    Differences in utilization of Intracytoplasmic sperm injection (ICSI) within human services (HHS) regions and metropolitan megaregions in the U.S.

    Anecdotal evidence suggests that US practice patterns for ART differ by geographical region. The purpose of this study was to determine whether use of ICSI differs by region and to evaluate whether these rates...

    Pavel Zagadailov, Albert Hsu, David B. Seifer and Judy E. Stern

    Reproductive Biology and Endocrinology 2017 15:45

    Published on: 12 June 2017

  12. Research

    Effect of race and ethnicity on utilization and outcomes of assisted reproductive technology in the USA

    The purpose of this study was to determine the utilization and live birth rates of assisted reproductive technology (ART) modalities among various racial and ethnic groups in recent years.

    Alice J. Shapiro, Sarah K. Darmon, David H. Barad, David F. Albertini, Norbert Gleicher and Vitaly A. Kushnir

    Reproductive Biology and Endocrinology 2017 15:44

    Published on: 8 June 2017

  13. Research

    Activating transcription factor 3 promotes embryo attachment via up-regulation of leukemia inhibitory factor in vitro

    A receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understo...

    Xi Cheng, Jingyu Liu, Huizhi Shan, Lihua Sun, Chenyang Huang, Qiang Yan, Ruiwei Jiang, Lijun Ding, Yue Jiang, Jianjun Zhou, Guijun Yan and Haixiang Sun

    Reproductive Biology and Endocrinology 2017 15:42

    Published on: 2 June 2017

  14. Research

    Expression of genes associated with BMP signaling pathway in porcine oocytes before and after IVM – a microarray approach

    The full maturational capability of mammalian oocytes is accompanied by nuclear and cytoplasmic modifications, which are associated with proliferation and differentiation of surrounding cumulus cells. These ev...

    Joanna Budna, Marta Rybska, Sylwia Ciesiółka, Artur Bryja, Sylwia Borys, Wiesława Kranc, Katarzyna Wojtanowicz-Markiewicz, Michal Jeseta, Ewa Sumelka, Dorota Bukowska, Paweł Antosik, Klaus P. Brüssow, Małgorzata Bruska, Michał Nowicki, Maciej Zabel and Bartosz Kempisty

    Reproductive Biology and Endocrinology 2017 15:43

    Published on: 2 June 2017

  15. Research

    Natriuretic peptides improve the developmental competence of in vitro cultured porcine oocytes

    Natriuretic peptides (NPs), brain and C type NPs (BNP and CNP), were involved in the maintenance of porcine oocyte meiotic arrest. The present study investigated the effects of NPs on developmental competence ...

    Yanhao Zhang, Huarong Wang, Wei Liu, Ye Yang, Xiao Wang, Zhiyuan Zhang, Qirui Guo, Chao Wang and Guoliang Xia

    Reproductive Biology and Endocrinology 2017 15:41

    Published on: 30 May 2017

  16. Research

    p,p’-DDT induces testicular oxidative stress-induced apoptosis in adult rats

    The 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p’-DDT) is a known persistent organic pollutant and male reproductive toxicant. The present study is designed to test the hypothesis that oxidative stress m...

    Neila Marouani, Dorsaf Hallegue, Mohsen Sakly, Moncef Benkhalifa, Khémais Ben Rhouma and Olfa Tebourbi

    Reproductive Biology and Endocrinology 2017 15:40

    Published on: 26 May 2017

  17. Research

    Outcome of in vitro fertilization in women with subclinical hypothyroidism

    Previous studies examining associations between subclinical hypothyroidism (SCH) with in vitro fertilization (IVF) outcome indicate some benefits of levothyroxine (LT4) treatment. But IVF outcomes in treated S...

    YunYing Cai, LanPing Zhong, Jie Guan, RuiJin Guo, Ben Niu, YanPing Ma and Heng Su

    Reproductive Biology and Endocrinology 2017 15:39

    Published on: 25 May 2017

  18. Review

    Role of microRNAs in premature ovarian insufficiency

    Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follic...

    Ying Guo, Junyan Sun and Dongmei Lai

    Reproductive Biology and Endocrinology 2017 15:38

    Published on: 12 May 2017

  19. Research

    Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator

    The aim of this study was to compare pregnancy rates in patients undergoing IVF/ICSI with embryo transfer after 4 and 5 days of culture in a closed incubation system with integrated time-lapse imaging.

    Verena Holschbach, Julia Weigert, Jens Erik Dietrich, Sabine Roesner, Markus Montag, Thomas Strowitzki and Bettina Toth

    Reproductive Biology and Endocrinology 2017 15:37

    Published on: 8 May 2017

  20. Review

    Comparative neonatal outcomes in singleton births from blastocyst transfers or cleavage-stage embryo transfers: a systematic review and meta-analysis

    Comparative neonatal outcomes with respect to singleton births from blastocyst transfers or cleavage-state embryo transfers are controversial with respect to which method is superior. Many studies have yielded...

    Xingling Wang, Mingze Du, Yichun Guan, Bijun Wang, Junwei Zhang and Zihua Liu

    Reproductive Biology and Endocrinology 2017 15:36

    Published on: 4 May 2017

  21. Research

    Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats

    Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory ho...

    Xinghui Han, Yuanyuan He, Gulan Zeng, Yonghong Wang, Wen Sun, Junchao Liu, Yanyan Sun and Jian Yu

    Reproductive Biology and Endocrinology 2017 15:35

    Published on: 2 May 2017

  22. Research

    Association of skewed X-chromosome inactivation with FMR1 CGG repeat length and anti-Mullerian hormone levels: a cohort study

    Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if...

    David H. Barad, Sarah Darmon, Andrea Weghofer, Gary J. Latham, Filipovic-Sadic, Qi Wang, Vitaly A. Kushnir, David F. Albertini and Norbert Gleicher

    Reproductive Biology and Endocrinology 2017 15:34

    Published on: 28 April 2017

  23. Research

    A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use

    It has become increasingly apparent that the trophectoderm (TE) at blastocyst stage is much more mosaic than has been appreciated. Whether preimplantation genetic screening (PGS), utilizing a single TE biopsy ...

    Norbert Gleicher, Jacob Metzger, Gist Croft, Vitaly A. Kushnir, David F. Albertini and David H Barad

    Reproductive Biology and Endocrinology 2017 15:33

    Published on: 27 April 2017

  24. Research

    Effect of different artificial shrinkage methods, when applied before blastocyst vitrification, on perinatal outcomes

    In recent years, single blastocyst transfer combined with vitrification has been applied widely, which can maximize the cumulative pregnancy rate in per oocyte retrieval cycles and minimize the multiple pregna...

    Caizhu Wang, Guixue Feng, Bo Zhang, Hong Zhou, Jinhui Shu, Ruoyun Lin, Huanhua Chen and Zhulian Wu

    Reproductive Biology and Endocrinology 2017 15:32

    Published on: 26 April 2017

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