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  1. Content type: Research

    Dehydroepiandrosterone (DHEA) is now widely used as an adjuvant for in vitro fertilization (IVF) cycles in poor ovarian responders (PORs). Several studies showed that DHEA supplementation could improve IVF out...

    Authors: Chyi-Uei Chern, Kuan-Hao Tsui, Salvatore Giovanni Vitale, San-Nung Chen, Peng-Hui Wang, Antonio Cianci, Hsiao-Wen Tsai, Zhi-Hong Wen and Li-Te Lin

    Citation: Reproductive Biology and Endocrinology 2018 16:90

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  2. Content type: Research

    Letrozole is widely employed as ovulation induction agent in women with PCOS, but its use in mild stimulation (MS) protocols for IVF is limited. Aim of the present study was to evaluate the feasibility of a MS...

    Authors: Giuseppe D’Amato, Anna Maria Caringella, Antonio Stanziano, Clementina Cantatore, Simone Palini and Ettore Caroppo

    Citation: Reproductive Biology and Endocrinology 2018 16:89

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  3. Content type: Review

    Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. The...

    Authors: Mahsa Darbandi, Sara Darbandi, Ashok Agarwal, Pallav Sengupta, Damayanthi Durairajanayagam, Ralf Henkel and Mohammad Reza Sadeghi

    Citation: Reproductive Biology and Endocrinology 2018 16:87

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  4. Content type: Research

    The injection of estradiol valerate in female rats induces polycystic ovary syndrome, which is characterized by polycystic ovaries, anovulation, and hyperandrogenism. These characteristics have been associated...

    Authors: Julieta A. Espinoza, Wendy Alvarado, Berenice Venegas, Roberto Domínguez and Leticia Morales-Ledesma

    Citation: Reproductive Biology and Endocrinology 2018 16:86

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  5. Content type: Research

    Cisplatin (CDDP), a widely used chemotherapeutic agent, can induce excessive granulosa cell apoptosis, follicle loss and even premature ovarian insufficiency (POI). However, the mechanism remains elusive, alth...

    Authors: Yuping Wu, Congshun Ma, Huihui Zhao, Yuxia Zhou, Zhenguo Chen and Liping Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:85

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  6. Content type: Research

    Tyrosine kinase receptor erythropoietin-producing hepatocellular receptor A2 (EphA2) is abundant in the endometrium and plays a role in the establishment of eutopic implantation. A similar molecular mechanism ...

    Authors: Huan Jiang, Xiao-Yi Yang and Wei-Jie Zhu

    Citation: Reproductive Biology and Endocrinology 2018 16:84

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  7. Content type: Research

    A molecule identical to nerve growth factor, with ovulation-inducing properties has been discovered in the seminal plasma of South American camelids (ovulation-inducing factor/nerve growth factor; OIF/NGF). We...

    Authors: Rodrigo A. Carrasco, Jaswant Singh and Gregg P. Adams

    Citation: Reproductive Biology and Endocrinology 2018 16:83

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  8. Content type: Research

    Imprinted genes, which are expressed in a parent of origin-specific manner, are thought to mediate the genetic priorities of each parent in pregnancy. Recently we reported that some fetal imprinted gene varian...

    Authors: Clive J. Petry, Albert Koulman, Liangjian Lu, Benjamin Jenkins, Samuel Furse, Philippa Prentice, Lee Matthews, Ieuan A. Hughes, Carlo L. Acerini, Ken K. Ong and David B. Dunger

    Citation: Reproductive Biology and Endocrinology 2018 16:82

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  9. Content type: Research

    Mounting evidence shows that ROS regulation by various antioxidants is essential for the expression of enzymes involved in steroidogenesis and maintenance of progesterone production by the corpus luteum (CL). ...

    Authors: Hyo-Jin Park, Dong Gil Lee, Jung Bae Seong, Hyun-Shik Lee, Oh-Shin Kwon, Beom Sik Kang, Jeen-woo Park, Sang-Rae Lee and Dong-Seok Lee

    Citation: Reproductive Biology and Endocrinology 2018 16:79

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  10. Content type: Research

    Cryptorchidism is one of the most common causes of non-obstructive azoospermia (NOA) leading to male infertility. Despite various medical approaches been utilised, many patients still suffer from infertility. ...

    Authors: Dongdong Tang, Zhenyu Huang, Xiaojin He, Huan Wu, Dangwei Peng, Li Zhang and Xiansheng Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:78

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  11. Content type: Research

    Storage conditions during transportation of explanted ovaries are a critical step in setting up fertility preservation protocols in both animal and human fields. Here, we evaluated the effects of ovary storage...

    Authors: Anna Rita Piras, Giovanni Pietro Burrai, Federica Ariu, Laura Falchi, Maria Teresa Zedda, Salvatore Pau, Sergio Domenico Gadau, Elisabetta Antuofermo, Daniela Bebbere, Sergio Ledda and Luisa Bogliolo

    Citation: Reproductive Biology and Endocrinology 2018 16:76

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  12. Content type: Research

    Appropriate classification of obesity is vital for risk assessment and complication prevention during pregnancy. We aimed to explore which pre-pregnancy BMI cut-offs of obesity, either BMI ≥ 25 kg/m2 as recommend...

    Authors: Yanxin Wu, Wai-Kit Ming, Dongyu Wang, Haitian Chen, Zhuyu Li and Zilian Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:77

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  13. Content type: Research

    Our aim in this study was to investigate morning blood pressure surge (MBPS) in patients of reproductive age with polycystic ovary syndrome (PCOS) and its relation to insulin resistance (IR).

    Authors: Hasan Kadi, Eyup Avci, Akin Usta and Abdullah Orhan Demirtaş

    Citation: Reproductive Biology and Endocrinology 2018 16:75

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  14. Content type: Research

    Pregnancies following assisted reproductive technology (ART) may have elevated potential risk of pregnancy loss (PL) when compared to natural conception. However, rare studies comprehensively analyzed the IVF/...

    Authors: Lingmin Hu, Jiangbo Du, Hong Lv, Jing Zhao, Mengxi Chen, Yifeng Wang, Fang Wu, Feng Liu, Xiaojiao Chen, Junqiang Zhang, Hongxia Ma, Guangfu Jin, Hongbing Shen, Li Chen, Xiufeng Ling and Zhibin Hu

    Citation: Reproductive Biology and Endocrinology 2018 16:74

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  15. Content type: Research

    Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. An lncRNA, namely, Prader-Willi region nonprotein coding RNA 2 (PWRN2), was up-regulated in the cumulus cells of patients wi...

    Authors: Xin Huang, Jiaping Pan, Bi Wu and Xiaoming Teng

    Citation: Reproductive Biology and Endocrinology 2018 16:73

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  16. Content type: Research

    Recently, we demonstrated the three-dimensional (3D) localization of murine trophoblast giant cells in the pregnant uterus using a modified Clear Unobstructed Brain Imaging Cocktails and Computational analysis...

    Authors: Kyosuke Kagami, Yohei Shinmyo, Masanori Ono, Hiroshi Kawasaki and Hiroshi Fujiwara

    Citation: Reproductive Biology and Endocrinology 2018 16:72

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  17. Content type: Methodology

    In vivo studies involving molecular markers of the follicle wall associated with follicular fluid (FF) milieu are crucial for a better understanding of follicle dynamics. The inability to obtain in vivo sample...

    Authors: G. M. Ishak, S. T. Bashir, G. A. Dutra, G. D. A. Gastal, M. O. Gastal, C. A. Cavinder, J. M. Feugang and E. L. Gastal

    Citation: Reproductive Biology and Endocrinology 2018 16:71

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  18. Content type: Research

    What are the underlying socio-demographic factors that lead healthy women to preserve their fertility through elective egg freezing (EEF)? Many recent reviews suggest that women are intentionally postponing fe...

    Authors: M. C. Inhorn, D. Birenbaum-Carmeli, J. Birger, L. M. Westphal, J. Doyle, N. Gleicher, D. Meirow, M. Dirnfeld, D. Seidman, A. Kahane and P. Patrizio

    Citation: Reproductive Biology and Endocrinology 2018 16:70

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  19. Content type: Research

    In an article published in 2017, we discussed the results of the first part of our study into the morphokinetic development of embryos in relation to follicle diameter and homogeneity of follicular development. O...

    Authors: Semra Kahraman, Caroline Pirkevi Çetinkaya, Murat Çetinkaya, Mehmet Ali Tüfekçi, Cumhur Gökhan Ekmekçi and Markus Montag

    Citation: Reproductive Biology and Endocrinology 2018 16:69

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  20. Content type: Research

    The association of recombinant FSH plus recombinant LH in 2:1 ratio may be used not only to induce ovulation in anovulatory women with hypogonadotropic hypogonadism but also to achieve multiple follicular deve...

    Authors: F. S. Mennini, A. Marcellusi, R. Viti, C. Bini, A. Carosso, A. Revelli and C. Benedetto

    Citation: Reproductive Biology and Endocrinology 2018 16:68

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  21. Content type: Research

    Endometriosis is a common condition associated with growth of endometrial-like tissue beyond the uterine cavity. Previous reports have suggested a role for uNK cells in the pathogenesis of endometriosis postul...

    Authors: Josephine A. Drury, Kirstin L. Parkin, Lucy Coyne, Emma Giuliani, Asgerally T. Fazleabas and Dharani K. Hapangama

    Citation: Reproductive Biology and Endocrinology 2018 16:67

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  22. Content type: Research

    For the first time, thorough morphometrical measurements of primordial ovarian follicles were performed and their age-related changes were investigated in Lithuanian women of the reproductive age.

    Authors: Kristina Lasiene, Donatas Gasiliunas, Nomeda Juodziukyniene and Aleksandras Vitkus

    Citation: Reproductive Biology and Endocrinology 2018 16:66

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  23. Content type: Research

    Fragile-X-Mental-Retardation-1- (FMR1)-gene is supposed to be a key gene for ovarian reserve and folliculogenesis. It contains in its 5’-UTR a triplet-base-repeat (CGG), that varies between 26 and 34 in general p...

    Authors: Julia Rehnitz, Diego D. Alcoba, Ilma S. Brum, Jens E. Dietrich, Berthe Youness, Katrin Hinderhofer, Birgitta Messmer, Alexander Freis, Thomas Strowitzki and Ariane Germeyer

    Citation: Reproductive Biology and Endocrinology 2018 16:65

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  24. Content type: Research

    Unicornuate uterus, a congenital uterine malformation resulting from unilateral maldevelopment of Mullerian duct, is more prevalent in women with infertility. Owing to relative rarity of the condition, the evi...

    Authors: Yanrong Chen, Victoria Nisenblat, Puyu Yang, Xinyu Zhang and Caihong Ma

    Citation: Reproductive Biology and Endocrinology 2018 16:64

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  25. Content type: Research

    To examine the effects of IVF, ICSI and FET, as well as in vitro culture, on the safety of offspring, this study was conducted from the perspective of genetic imprinting to investigate whether assisted reprodu...

    Authors: Menglu Ji, Xingling Wang, Wenbin Wu, Yichun Guan, Jing Liu, Jingyan Wang, Wenxia Liu and Chunyan Shen

    Citation: Reproductive Biology and Endocrinology 2018 16:63

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  26. Content type: Research

    Melatonin is a potential therapeutic agent for endometriosis, but its molecular mechanism is unclear. Here, we investigated the effect of melatonin on the epithelial-mesenchymal transition (EMT) in endometriot...

    Authors: Shasha Qi, Lei Yan, Zhao Liu, Yu-lan Mu, Mingjiang Li, Xingbo Zhao, Zi-Jiang Chen and Hui Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:62

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  27. Content type: Research

    This population-based study was designed to investigate whether consumption of sugar-sweetened beverages (SSB) is associated with lower serum total testosterone concentration in men 20–39 years old.

    Authors: Liang Chen, Yu-Mei Xie, Jian-Hao Pei, Jian Kuang, Hong-Mei Chen, Zhong Chen, Zhong-Wen Li, Xiao-Ying Fu, Long Wang, Shui-Qing Lai, Shu-Ting Zhang, Zhi-Jiang Chen and Jin-xin Lin

    Citation: Reproductive Biology and Endocrinology 2018 16:61

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  28. Content type: Research

    It is postulated that women suffered from recurrent implantation failure (RIF) have different endometrial receptivity compared to those who experienced with idiopathic recurrent miscarriage (RM). In this study...

    Authors: Fangrong Wu, Xiaoyan Chen, Yingyu Liu, Bo Liang, Hui Xu, Tin Chiu Li and Chi Chiu Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:60

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  29. Content type: Research

    Our previous study indicated that emergency contraception, including levonorgestrel and progesterone, could lead to ectopic pregnancy following contraception failure. However, our understanding of the effects ...

    Authors: Cheng Li, Hui-Yu Zhang, Yan Liang, Wei Xia, Qian Zhu, Duo Zhang, Zhen Huang, Gui-Lin Liang, Rui-Hong Xue, Hang Qi, Xiao-Qing He, Jiang-Jing Yuan, Ya-Jing Tan, He-Feng Huang and Jian Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:59

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  30. Content type: Research

    Pregnancy-associated plasma protein-A2 (PAPP-A2) is consistently upregulated in the placentae of pregnancies complicated by preeclampsia and fetal growth restriction. The causes and significance of this upregu...

    Authors: Julian K. Christians, Kendra I. Lennie, Maria F. Huicochea Munoz and Nimrat Binning

    Citation: Reproductive Biology and Endocrinology 2018 16:58

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  31. Content type: Research

    Spermatogenesis in most mammals (including human and rat) occurs at ~ 3 °C lower than body temperature in a scrotum and fails rapidly at 37 °C inside the abdomen. The present study investigates the heat-sensit...

    Authors: Santosh K. Yadav, Aastha Pandey, Lokesh Kumar, Archana Devi, Bhavana Kushwaha, Rahul Vishvkarma, Jagdamba P. Maikhuri, Singh Rajender and Gopal Gupta

    Citation: Reproductive Biology and Endocrinology 2018 16:56

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  32. Content type: Research

    The aim of this study was to examine the effectiveness of Tumor Dissociation Enzyme (TDE) on the viability of follicles after digestion of fresh and cryopreserved ovarian cortex fragments (OCFs).

    Authors: Viola Maria Schmidt, Vladimir Isachenko, Gunter Rappl, Gohar Rahimi, Bettina Hanstein, Bernd Morgenstern, Peter Mallmann and Evgenia Isachenko

    Citation: Reproductive Biology and Endocrinology 2018 16:57

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  33. Content type: Research

    Serum leptin levels are augmented in obese infertile men and in men with azoospermia. They also correlate inversely with sperm concentration, motility and normal forms. The mechanisms underlying the adverse ef...

    Authors: Xiaotong Wang, Xiaoke Zhang, Lian Hu and Honggang Li

    Citation: Reproductive Biology and Endocrinology 2018 16:55

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  34. Content type: Research

    Previous studies have shown that androgens, in addition to serving as precursors for ovarian estrogen synthesis, also have a fundamental role in primate ovarian follicular development by augmentation of FSH re...

    Authors: Jigal Haas, Rawad Bassil, Noa Gonen, Jim Meriano, Andrea Jurisicova and Robert F. Casper

    Citation: Reproductive Biology and Endocrinology 2018 16:54

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  35. Content type: Research

    Oral progestin has recently been used to prevent premature LH surges in ovarian stimulation, and this progestin-primed ovarian stimulation (PPOS) is effective and safe in patients with different ovarian reserv...

    Authors: Hongjuan Ye, Hui Tian, Wen He, Qifeng Lyu, Yanping Kuang, Qiuju Chen and Lihua Sun

    Citation: Reproductive Biology and Endocrinology 2018 16:53

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  36. Content type: Short communication

    Retinoids (retinol and its derivatives) are required for the development and maintenance of normal physiological functions of the ovary. However, the mechanisms underlying the regulation of ovarian retinoid ho...

    Authors: Zhuo Liu, Yongfeng Sun, Yanwen Jiang, Yuqiang Qian, Shuxiong Chen, Shan Gao, Lu Chen, Chunjin Li and Xu Zhou

    Citation: Reproductive Biology and Endocrinology 2018 16:52

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  37. Content type: Research

    Puberty is the period during a female mammal’s life when it enters estrus and ovulates for the first time; this indicates that a mammal is capable of reproduction. The onset of puberty is a complex and tightly...

    Authors: Jing Ye, Zhiqiu Yao, Wenyu Si, Xiaoxiao Gao, Chen Yang, Ya Liu, Jianping Ding, Weiping Huang, Fugui Fang and Jie Zhou

    Citation: Reproductive Biology and Endocrinology 2018 16:51

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  38. Content type: Research

    Polycystic ovary syndrome (PCOS) is a complex genetic disease with multifarious phenotypes. Many researches use dehydroepiandrosterone (DHEA) to induce PCOS in pubertal mouse models. The aim of this study was ...

    Authors: Ya-Li Yang, Li-Feng Sun, Yan Yu, Tian-Xia Xiao, Bao-Bei Wang, Pei-Gen Ren, Hui-Ru Tang and Jian V. Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:50

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  39. Content type: Research

    Male factor infertility is quite common as 30–50% of infertility cases are due to sperm defects. The high sperm DNA fragmentation is one of the causes of male factor infertility. Many factors cause sperm DNA f...

    Authors: Basmah Al Omrani, Nadia Al Eisa, Murid Javed, Maher Al Ghedan, Hamoud Al Matrafi and Hamad Al Sufyan

    Citation: Reproductive Biology and Endocrinology 2018 16:49

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  40. Content type: Research

    Pelvic endometriosis (EM) and adenomyosis (AM) have different effects on the fallopian tube. This study aimed to assess the transport capability of the fallopian tube in women with pelvic EM or AM.

    Authors: Wei Xia, Duo Zhang, Jing Ouyang, Yan Liang, Huiyu Zhang, Zhen Huang, Guiling Liang, Qian Zhu, Xiaoming Guan and Jian Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:48

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  41. Content type: Research

    MicroRNAs (MiR) may promote fibroid development via altered expression of genes involved in cell proliferation and ECM formation, and evidence supports aberrant expression of MicroRNA (MiR) 21a-5p in fibroids....

    Authors: Eden R. Cardozo, Rosemary Foster, Anatte E. Karmon, Amy E. Lee, Leah W. Gatune, Bo R. Rueda and Aaron K. Styer

    Citation: Reproductive Biology and Endocrinology 2018 16:46

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  42. Content type: Research

    Stray dogs are the reservoirs and carriers of rabies and are definitive hosts of echinococcosis. To control the overpopulation of stray dogs, zona pellucida 3 (ZP3), a primary receptor for sperm, is a potentia...

    Authors: Ying Wang, Yijie Li, Beibei Zhang and Fuchun Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:47

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  43. Content type: Review

    Besides being a risk factor for multiple metabolic disorders, obesity could affect female reproduction. While increased adiposity is associated with hormonal changes that could disrupt the function of the hypo...

    Authors: Michelle Goldsammler, Zaher Merhi and Erkan Buyuk

    Citation: Reproductive Biology and Endocrinology 2018 16:45

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  44. Content type: Research

    LepR tyrosine site mutation mice (Y123F) exhibit decreased serum E2 levels, immature reproductive organs, infertility as well as metabolic abnormalities. Although the actions of leptin and lepR in the control ...

    Authors: Xiaoyu Tu, Miao Liu, Jianan Tang, Yu Zhang, Yan Shi, Lin Yu and Zhaogui Sun

    Citation: Reproductive Biology and Endocrinology 2018 16:44

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  45. Content type: Review

    Infertility in mammalian females has been a challenge in reproductive medicine. The causes of female infertility include anovulation, ovulated oocyte defects, abnormal fertilization, and insufficient luteal su...

    Authors: Jean Damascene Niringiyumukiza, Hongcai Cai and Wenpei Xiang

    Citation: Reproductive Biology and Endocrinology 2018 16:43

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  46. Content type: Research

    The sensitivity and specificity of non-invasive diagnostic methods for endometriosis, especially at early stages, are not optimal. The clinical diagnostic indicator cancer antigen 125 (CA125) performs poorly i...

    Authors: Jingjie Li, Lihuan Guan, Huizhen Zhang, Yue Gao, Jiahong Sun, Xiao Gong, Dongshun Li, Pan Chen, Xiaoyan Liang, Min Huang and Huichang Bi

    Citation: Reproductive Biology and Endocrinology 2018 16:42

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  47. Content type: Review

    The ‘omics’ approach for a noninvasive diagnosis of male reproductive system disorders has gained momentum during the last decade, particularly from a screening and prognosis point of view. Due to the rapid de...

    Authors: Luna Samanta, Rajeshwari Parida, Tania R. Dias and Ashok Agarwal

    Citation: Reproductive Biology and Endocrinology 2018 16:41

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