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  1. Obesity impacts fertility and is positively correlated with endometrial hyperplasia and endometrial cancer occurrence. Endometrial epithelia often harbor disease driver-mutations, while endometrial stroma are ...

    Authors: Mike R. Wilson, Hilary Skalski, Jake J. Reske, Marc Wegener, Marie Adams, Galen Hostetter, Hanne M. Hoffmann, Jamie J. Bernard, Victoria L. Bae-Jump, Jose M. Teixeira and Ronald L. Chandler
    Citation: Reproductive Biology and Endocrinology 2022 20:163
  2. Previous studies have demonstrated that the supraphysiological E2 level is negatively correlated with birthweight. However, the cut-off value of E2 level that significantly affects birthweight is unknown, and ...

    Authors: Jing Wu, Hengde Zhang and Xiaohong Wang
    Citation: Reproductive Biology and Endocrinology 2022 20:162
  3. Mammalian sperm maturation in the epididymis is mainly modulated by exosomes that are secreted into the epididymal lumen from epididymal epithelial cells (EECs). Exposure to oxidative stress (OS) resulting fro...

    Authors: Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu and Zhide Ding
    Citation: Reproductive Biology and Endocrinology 2022 20:161
  4. MicroRNAs (miRNAs) are considered potential biomarkers for various diseases. This study investigated whether hsa-miR-320a-3p and hsa-miR-483-5p levels in human ovarian granulosa cells derived from follicular flui...

    Authors: Yu Liu, Qiaojuan Mei, Jiahao Yang, Qiuzi Shen, Min Zou, Jiao Li, Huaibiao Li, Ling Zhang and Wenpei Xiang
    Citation: Reproductive Biology and Endocrinology 2022 20:160
  5. The widely accepted explanation of preeclampsia (PE) pathogenesis is insufficient trophoblast invasion and impaired uterine spiral artery remodeling. However, the underlying molecular mechanism remains unclear.

    Authors: Lingyun Liao, Min Liu, Yijie Gao, Xiaohong Wei, Yangxue Yin, Linbo Gao and Rong Zhou
    Citation: Reproductive Biology and Endocrinology 2022 20:159
  6. Steroidogenesis is a complex process of sequential enzymatic reactions affected by climate change. Animals respond to altered day length, the so-called photoperiod, with changes in physiology. The study aimed ...

    Authors: Eman Hassan, Shahinaz Magdy, Amany Attaallah, Eman Gaber, Omnia Mansour, Rehab A. Gomaa, Hala Odessy, Maria Augustyniak, Lamia M. El-Samad and Abeer El Wakil
    Citation: Reproductive Biology and Endocrinology 2022 20:158
  7. Polycystic ovary syndrome (PCOS) is a complex reproductive disorder, that affects approximately 5–10% of women of reproductive age. The disease is complex because its evolution may be impacted by genetic, life...

    Authors: Faying Liu, Lifeng Tian, Jun Tan, Zengming Li, Haiyan Qin, Dingfei Xu, Zhihui Huang, Xingwu Wu, Ge Chen, Qiongfang Wu and Yang Zou
    Citation: Reproductive Biology and Endocrinology 2022 20:157
  8. Reproductive aging is characterized by a decline in oocyte quantity and quality, which is directly associated with a decline in reproductive potential, as well as poorer reproductive success and obstetrical ou...

    Authors: Ecem Esencan, Gabriela Beroukhim and David B. Seifer
    Citation: Reproductive Biology and Endocrinology 2022 20:156
  9. Altered sperm DNA methylation patterns of imprinted genes as well as certain spermatogenesis-related genes has been proposed as a possible mechanism of male subfertility. Some reports suggest that there is an ...

    Authors: Bing Song, Yujie Chen, Chao Wang, Guanjian Li, Zhaolian Wei, Xiaojin He and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:155
  10. The importance of actin and microtubule (MT) cytoskeletons in testis function in rodents is known to some extent, but its role in the etiology of azoospermia in humans remains unexplored. Here, we examined if ...

    Authors: Xiaolong Wu, Damin Yun, Mengmeng Sang, Jianpeng Liu, Liwei Zhou, Jie Shi, Lingling Wang, Tiao Bu, Linxi Li, YingYing Huang, Dengfeng Lin, Fei Sun and C. Yan Cheng
    Citation: Reproductive Biology and Endocrinology 2022 20:154
  11. Women with polycystic ovary syndrome (PCOS) have high circulating anti-Müllerian hormone (AMH) levels which is correlated with antral follicle count and polycystic ovarian morphology and negatively correlated ...

    Authors: Josefin Kataoka, Ingrid Larsson, Eva Lindgren, Li Oskarson Kindstrand, Johanna Schmidt and Elisabet Stener-Victorin
    Citation: Reproductive Biology and Endocrinology 2022 20:153
  12. Extracellular vesicles (EVs) could mediate embryo-maternal communication to affect embryo implantation by delivering biology information, including microRNA (miRNA), protein, lipid. Our previous research shows...

    Authors: Renwu Hua, Qiaorui Liu, Weisi Lian, Ting ting Kang, Dengying Gao, Cheng Huang, Yueying Wang and Minggang Lei
    Citation: Reproductive Biology and Endocrinology 2022 20:152
  13. This study aims to study whether the change of endometrial thickness between the day of human chorionic gonadotrophin (HCG) administration and the day of embryo transfer (ET) has any effect on ectopic pregnanc...

    Authors: Qiuyuan Li, Ahui Liu, Haofei Shen and Xuehong Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:151
  14. Peptidylarginine deiminase enzymes (PADs) convert arginine residues to citrulline in a process called citrullination or deimination. Recently, two PADs, PAD2 and PAD4, have been linked to hormone signaling in ...

    Authors: Kelly L. Sams, Chinatsu Mukai, Brooke A. Marks, Chitvan Mittal, Elena Alina Demeter, Sophie Nelissen, Jennifer K. Grenier, Ann E. Tate, Faraz Ahmed and Scott A. Coonrod
    Citation: Reproductive Biology and Endocrinology 2022 20:150
  15. Previous research has shown that the type and duration of erotic material that men have access to during masturbation can influence semen parameters. To our knowledge, the use of virtual reality (VR) headsets ...

    Authors: Daniel Rosenkjær, Allan Pacey, Robert Montgomerie and Anne-Bine Skytte
    Citation: Reproductive Biology and Endocrinology 2022 20:149
  16. Encapsulation of follicles within a biomatrix is one approach to maintaining 3-D follicle architecture during culture. Hyaluronan is one component of the natural extracellular matrix (ECM) that provides suppor...

    Authors: Nina Desai, Maribeth Spangler, Vaani Nanavaty, Arsela Gishto and Alyssa Brown
    Citation: Reproductive Biology and Endocrinology 2022 20:148
  17. To compare the efficacy and safety of follitropin delta in its individualized fixed-dose regimen with follitropin alfa in a conventional adjustable dosing regimen in Chinese women. 

    Authors: Rui Yang, Yunshan Zhang, Xiaoyan Liang, Xueru Song, Zhaolian Wei, Jianqiao Liu, Yezhou Yang, Jichun Tan, Qingxue Zhang, Yingpu Sun, Wei Wang, Weiping Qian, Lei Jin, Shuyu Wang, Yang Xu, Jing Yang…
    Citation: Reproductive Biology and Endocrinology 2022 20:147
  18. Tamoxifen (TAM) is a frequently-used treatment for breast cancer (BC). But the TAM resistance seriously affects the patient therapeutic effect. Previous research indicated that circular RNAs (circRNAs) might p...

    Authors: Shiyong Yang, Changwu Zou, Yuxin Li, Xianguo Yang, Wei Liu, Guannan Zhang and Nina Lu
    Citation: Reproductive Biology and Endocrinology 2022 20:146
  19. To assess the association between chromosomal polymorphisms (CPM) with congenital anomalies and perinatal complications in a cohort of newborns from couples undergoing intracytoplasmic sperm injection (ICSI), ...

    Authors: Freddy Rodriguez, Maria Cruz and Antonio Requena
    Citation: Reproductive Biology and Endocrinology 2022 20:145
  20. Nowadays, different modes and timing of GnRH-agonist combined with hCG trigger, for final follicular maturation, have been described. While LH + FSH are the naturally occurring final follicular maturation trig...

    Authors: Yuval Yung, Adva Aizer, Sarah Tieb, Sharon Avhar Maydan, Ettie Maman, Lilach Marom Haham, Jigal Haas and Raoul Orvieto
    Citation: Reproductive Biology and Endocrinology 2022 20:144
  21. In this case report, we highlight the practical dilemma, i.e. to perform ovarian tissue cryopreservation surgery in a 45, X Turner Syndrome patient or not, by reporting on the presence of follicles in a 13-yea...

    Authors: MJ Schleedoorn, K Fleischer, DDM Braat, AJM Oerlemans, AAEM van der Velden and R Peek
    Citation: Reproductive Biology and Endocrinology 2022 20:143
  22. Successful implantation is a complex process that is influenced by embryo quality, endometrial receptivity, immune factors, and the specific type of in vitro fertilization protocol used. DNA topoisomerase IIα ...

    Authors: Huijia Fu, Wang Tan, Zhi Chen, Zi Ye, Yuhan Duan, Jiayu Huang, Hongbo Qi and Xiru Liu
    Citation: Reproductive Biology and Endocrinology 2022 20:142
  23. Frozen-thawed embryo transfer (FET) is thought to be associated with obstetric and neonatal complications after in vitro fertilization/intracytoplasmic single sperm injection (IVF/ICSI) treatment. The study ai...

    Authors: Junting Xu, Hong Zhou, Tianfan Zhou, Yi Guo, Shanshan Liang, Yanping Jia, Kunming Li and Xiaoming Teng
    Citation: Reproductive Biology and Endocrinology 2022 20:141
  24. The gonadotropin-releasing hormone agonist (GnRH-a) has been used in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles for a long time. This paper evaluates the efficacy and safety of t...

    Authors: Ying Zhang, Wenxian Zhao, Yifan Han, Xin Chen, Shaoyuan Xu, Yueyue Hu, Honglu Diao and Changjun Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:140
  25. Infertile men with higher sexual dysfunction risk and increased psychological burden, were also associated with more inclined to timed intercourse. Decreased semen quality may have adverse effects on male sexu...

    Authors: Xiaowei Yu, Songling Zhang, Linjiao Chen, Xiao Yuan Zhang and Qun Wang
    Citation: Reproductive Biology and Endocrinology 2022 20:139
  26. Circular RNAs (circRNAs) play a vital role in cancer progression. However, there are still numerous circRNAs that have not been functionally explored. Our study aimed to disclose the role of circ-CSNK1G1 in tr...

    Authors: Xiaochen Zan, Wenfang Li, Geng Wang, Jie Yuan, Yongbiao Ai, Jun Huang and Zhi Li
    Citation: Reproductive Biology and Endocrinology 2022 20:138
  27. We aimed to compare the clinical and perinatal outcomes of patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment with either an ...

    Authors: Di Wang, Ting Chu, Ting Yu and Jun Zhai
    Citation: Reproductive Biology and Endocrinology 2022 20:137
  28. Pre-eclampsia (PE), associated with placental malperfusion, is the primary reason for maternal and perinatal mortality and morbidity that can cause vascular endothelial injury and multi-organ injury. Despite c...

    Authors: Jingqi Qi, Bingbing Wu, Xiuying Chen, Wei Wei and Xudong Yao
    Citation: Reproductive Biology and Endocrinology 2022 20:136
  29. Preterm birth (PTB) is the primary cause of infant morbidity and mortality. Moreover, previous studies have established that PTB is related to premature cervical ripening. However, the underlying mechanism rem...

    Authors: Yan Yan, Zhuorong Gu, Baihe Li, Xirong Guo, Zhongxiao Zhang, Runjie Zhang, Zheng Bian and Jin Qiu
    Citation: Reproductive Biology and Endocrinology 2022 20:135
  30. Fertility-sparing treatment of atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EC) patients has recently emerged important social health topic. This study is designed to explore the ris...

    Authors: Yingqiao Ding, Yuan Fan, Xingchen Li, Yiqin Wang, Jianliu Wang and Li Tian
    Citation: Reproductive Biology and Endocrinology 2022 20:134
  31. The serum TSH level of PCOS patients was higher than that of the general female population. For patients with thyroid dysfunction, the abnormal TSH level is negatively related to the outcomes of assisted repro...

    Authors: Shaoyuan Xu, Ying Zhang, Cancan Qiang and Changjun Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:133
  32. Chemoresistance is one of the major obstacles that lead to poor prognosis in cervical cancer. linc00958 was reported to be an oncogene in cervical cancer. However, its role in mediating chemoresistance remains...

    Authors: Jing Tian, Lei Cheng, Enqi Kong, Wenjin Gu, Yuanyuan Jiang, Quan Hao, Beihua Kong and Li Sun
    Citation: Reproductive Biology and Endocrinology 2022 20:132
  33. For optimal fertility testing, serum anti-Müllerian hormone levels are used in combination with other testing to provide reliable ovarian reserve evaluations. The use of the ADx 100 card is widely commercially...

    Authors: Erin Silliman, Esther H. Chung, Elizabeth Fitzpatrick, Julie A. Jolin, Michelle Brown, James Hotaling, Aaron K. Styer and Anatte E. Karmon
    Citation: Reproductive Biology and Endocrinology 2022 20:131
  34. To generate an effective embryo prediction model and identify a non-invasive evaluation method by analyzing microRNAs (miRNAs) in embryo culture medium.

    Authors: Shintaro Kamijo, Toshio Hamatani, Hiroyuki Sasaki, Hiroki Suzuki, Akane Abe, Osamu Inoue, Maki Iwai, Seiji Ogawa, Kei Odawara, Kanako Tanaka, Mutsumi Mikashima, Masami Suzuki, Kenji Miyado, Ryo Matoba, Yasushi Odawara and Mamoru Tanaka
    Citation: Reproductive Biology and Endocrinology 2022 20:130
  35. Polycystic ovary syndrome (PCOS) is the most common endocrine, metabolic, and multi-causal disorder in the reproductive period with a possible genetic origin. Women with PCOS are characterized by oligo-ovulati...

    Authors: Mojgan Javedani Masroor, Hossein Sheybani, Shiva Sheybani and Nastaran Abolghasem
    Citation: Reproductive Biology and Endocrinology 2022 20:129
  36. To examine the effects and mechanisms of transcutaneous electrical acupoint stimulation (TEAS) on pregnancy outcomes in women undergoing in vitro fertilization (IVF)-embryo transfer (ET).

    Authors: Xiaojun Feng, Na Zhu, Shuo Yang, Li Wang, Wei Sun, Rong Li, Fei Gong, Songping Han, Rong Zhang and Jisheng Han
    Citation: Reproductive Biology and Endocrinology 2022 20:127
  37. The suggested effects of the oocyte secreted GDF9 and BMP15 growth factors on oocyte maturation are currently based on recombinant proteins, and little is known about native GDF9 and BMP15 in humans.

    Authors: Jesús Cadenas, Susanne Elisabeth Pors, Ajay Kumar, Bhanu Kalra, Stine Gry Kristensen, Claus Yding Andersen and Linn Salto Mamsen
    Citation: Reproductive Biology and Endocrinology 2022 20:126
  38. Human umbilical cord mesenchymal stem cells (hUCMSCs, retrospectively registered) have a lot of promise for treating theca interstitial cells(TICs) dysfunction in premature ovarian insufficiency (POI). The mec...

    Authors: Qianqian Luo, Yu Tang, Zhonglin Jiang, Hongchu Bao, Qiang Fu and Hongqin Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:125
  39. Patients with recurrent implantation failure (RIF) may have more uterine contractions. Several observational studies suggested that atosiban administration around embryo transfer resulted in higher pregnancy r...

    Authors: Chuan Ling Tang, Qi Yue Li, Feng Lian Chen, Chen Ting Cai, Yue Yan Dong, Yuan Yuan Wu, Jian Zhi Yang, Mei Zhao, Feng Li Chi, Ling Hong, Ai Ai, Miao Xin Chen, Kun Ming Li, Xiao Ming Teng and Zhi Qin Chen
    Citation: Reproductive Biology and Endocrinology 2022 20:124
  40. The previous model-based cost-effectiveness analyses regarding elective oocyte cryopreservation remained debatable, while the usage rate may influence the cost per live birth. The aim of this study is to discl...

    Authors: Ih-Jane Yang, Ming-Yih Wu, Kuang-Han Chao, Shin-Yi Wei, Yi-Yi Tsai, Ting-Chi Huang, Mei-Jou Chen and Shee-Uan Chen
    Citation: Reproductive Biology and Endocrinology 2022 20:123
  41. In contrast with the preceding stages of the germ cells, spermatozoa are unusually rich in small non-coding RNAs in comparison to the coding RNAs. These small RNAs may have had an essential role in the process...

    Authors: Meghali Joshi, Syed Waseem Andrabi, Ranjeet Kumar Yadav, Satya Narayan Sankhwar, Gopal Gupta and Singh Rajender
    Citation: Reproductive Biology and Endocrinology 2022 20:122
  42. Intrauterine adhesion (IUA) is a clinical disease characterized by the uterine cavity occlusion caused by the damage of the endometrial basal layer. Bone marrow mesenchymal stem cells (BMSCs) transplantation h...

    Authors: Liwei Yuan, Jia Cao, Mingyue Hu, Dabao Xu, Yan Li, Shiyun Zhao, Juanjuan Yuan, Huixing Zhang, Yani Huang, He Jin, Meixia Chen and Dan Liu
    Citation: Reproductive Biology and Endocrinology 2022 20:121
  43. During implantation, a symphony of interaction between the trophoblast originated from the trophectoderm of the implanting blastocyst and the endometrium leads to a successful pregnancy. Defective interaction ...

    Authors: Xintong Li, Suranga P. Kodithuwakku, Rachel W. S. Chan, William S. B. Yeung, Yuanqing Yao, Ernest H. Y. Ng, Philip C. N. Chiu and Cheuk-Lun Lee
    Citation: Reproductive Biology and Endocrinology 2022 20:120
  44. Cytoplasmic and nuclear maturation of oocytes, as well as interaction with the surrounding cumulus cells, are important features relevant to the acquisition of developmental competence.

    Authors: Bailey N. Walker, Jada Nix, Chace Wilson, Mackenzie A. Marrella, Savannah L. Speckhart, Lydia Wooldridge, Con-Ning Yen, Jocelyn S. Bodmer, Laila T. Kirkpatrick, Sarah E. Moorey, David E. Gerrard, Alan D. Ealy and Fernando H. Biase
    Citation: Reproductive Biology and Endocrinology 2022 20:119
  45. Fertility awareness and menses prediction are important for improving fecundability and health management. Previous studies have used physiological parameters, such as basal body temperature (BBT) and heart ra...

    Authors: Jia-Le Yu, Yun-Fei Su, Chen Zhang, Li Jin, Xian-Hua Lin, Lu-Ting Chen, He-Feng Huang and Yan-Ting Wu
    Citation: Reproductive Biology and Endocrinology 2022 20:118
  46. Diabetes mellitus (DM)-related complications are important health problems worldwide. The underlying mechanisms for diabetic male subfertility/infertility are considerably complicated and need to be unveiled f...

    Authors: Ping Wang, Shoubing Zhang, Shuai Lin and Zhengmei Lv
    Citation: Reproductive Biology and Endocrinology 2022 20:117
  47. Inflammatory state within the ovaries can disrupt normal follicular dynamics, leading to reduced oocyte quality and infertility. How the production of inflammatory mediators generated by macrophages with diffe...

    Authors: Thaise S. Martins, Bruno M. Fonseca and Irene Rebelo
    Citation: Reproductive Biology and Endocrinology 2022 20:116
  48. Luteinizing hormone (LH) is critical in follicle growth and oocyte maturation. However, the value of recombinant LH (r-LH) supplementation to recombinant follicle stimulating hormone (r-FSH) during controlled ...

    Authors: Meng Wang, Rui Huang, Xiaoyan Liang, Yundong Mao, Wenhao Shi and Qian Li
    Citation: Reproductive Biology and Endocrinology 2022 20:114

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