Articles

Silencing of MEG3 attenuated the role of lipopolysaccharides by modulating the miR-93-5p/PTEN pathway in Leydig cells

Leydig cells reflect the activation of inflammation, decrease of androgen production, inhibition of cell growth and promotion of cell apoptosis under orchitis. Maternally expressed gene 3 (MEG3) exerts a cruci...

Authors: Xu Zhou, Jingliang He, Jinbo Chen, Yu Cui, Zhenyu Ou, Xiongbing Zu and Nenghui Liu

Whole blood RNA sequencing reveals a differential transcriptomic profile associated with cervical insufficiency: a pilot study

The uterine cervix is a mechanical and immunological barrier against ascending infection during pregnancy. Cervical insufficiency (CI), a painless cervical dilation that occurs in the mid-trimester, is an impo...

Authors: Ga-Hyun Son, So Yeon Choi, Yeon-Ji Ju, Keun-Young Lee, Jae Jun Lee, Ji-Eun Song, Youngmi Kim and Sung Taek Park

Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules

To enhance understanding of polycystic ovary syndrome (PCOS) at the molecular level; this investigation intends to examine the genes and pathways associated with PCOS by using an integrated bioinformatics anal...

Authors: Praveenkumar Devarbhavi, Lata Telang, Basavaraj Vastrad, Anandkumar Tengli, Chanabasayya Vastrad and Iranna Kotturshetti

Downregulation of TTF1 in the rat hypothalamic ARC or AVPV nucleus inhibits Kiss1 and GnRH expression, leading to puberty delay

TTF1 is a transcription factor that is expressed in the hypothalamus after birth and plays crucial roles in pubertal development. TTF1 may regulate the expression of the Kiss1 gene, which may drive puberty onset ...

Authors: Shaolian Zang, Xiaoqin Yin and Pin Li

The LINC00477/miR-128 axis promotes the progression of polycystic ovary syndrome by regulating ovarian granulosa cell proliferation and apoptosis

Long noncoding RNAs (lncRNAs) participate in the pathogenesis of various human diseases. This study aims to investigate the roles of lncRNA LINC00477 in polycystic ovary syndrome (PCOS), especially the impacts...

Authors: Haijie Gao, Jinna Jiang, Yingying Shi, Jiying Chen, Lijian Zhao and Chenhong Wang

Psychological experience and coping strategies of patients in the Northeast US delaying care for infertility during the COVID-19 pandemic

On March 17, 2020 an expert ASRM task force recommended the temporary suspension of new, non-urgent fertility treatments during an ongoing world-wide pandemic of Covid-19. We surveyed at the time of resumption...

Authors: David B. Seifer, William D. Petok, Alisha Agrawal, Tanya L. Glenn, Arielle H. Bayer, Barry R. Witt, Blair D. Burgin and Harry J. Lieman

Novel variants in DNAH9 lead to nonsyndromic severe asthenozoospermia

Asthenozoospermia is one of the most common causes of male infertility, and its genetic etiology is poorly understood. DNAH9 is a core component of outer dynein arms in cilia and flagellum. It was reported tha...

Authors: Dongdong Tang, Yanwei Sha, Yang Gao, Jingjing Zhang, Huiru Cheng, Junqiang Zhang, Xiaoqing Ni, Chao Wang, Chuan Xu, Hao Geng, Xiaojin He and Yunxia Cao

Improved clinical outcomes after non-invasive oocyte selection and Day 3 eSET in ICSI patients

Non-invasive oocyte quality scoring, based on cumulus gene expression analysis, in combination with morphology scoring, can increase the clinical pregnancy (CPR) and live birth rates (LBR) in Day 3 eSET (elect...

Authors: Inge Van Vaerenbergh, Tom Adriaenssens, Wim Coucke, Lisbet Van Landuyt, Greta Verheyen, Michaël De Brucker, Michel Camus, Peter Platteau, Michel De Vos, Elien Van Hecke, André Rosenthal and Johan Smitz

Possible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis

Accumulating data indicate that sensory nerve derived neuropeptides such as substance P and calcitonin gene related-protein (CGRP) can accelerate the progression of endometriosis via their respective receptors...

Authors: Xiaofang Xu, Xianjun Cai, Xishi Liu and Sun-Wei Guo

Serum progesterone levels greater than 32.5 ng/ml on the day of embryo transfer are associated with lower live birth rate after artificial endometrial preparation: a prospective study

Previous observational studies have highlighted the negative effects of serum hormone levels at the minimum threshold during frozen embryo transfer (FET) cycles. However, still the questions regarding the maxi...

Authors: Ashraf Alyasin, Marzieh Agha-Hosseini, Motahareh Kabirinasab, Hojatollah Saeidi and Maryam Shabani Nashtaei

Commentary on two recently published formal guidelines on management of “mosaic” embryos after preimplantation genetic testing for aneuploidy (PGT-A)

Two professional societies recently published opinions on the clinical management of “mosaic” results from preimplantation genetic testing for aneuploidy (PGT-A) in human blastocyst-stage embryos in associatio...

Authors: Norbert Gleicher, David H. Barad, Zion Ben-Rafael, Demian Glujovsky, Lyka Mochizuki, Deepak Modi, Maximillian Murtinger, Pasquale Patrizio, Raoul Orvieto, Shizuko Takahashi, Andrea Weghofer and Søren Ziebe

Irisin deletion induces a decrease in growth and fertility in mice

Irisin, which is cleaved from fibronectin type III domain-containing protein 5 (Fndc5), plays an important role in energy homeostasis. The link between energy metabolism and reproduction is well known. However, t...

Authors: Yunyao Luo, Xiaoyong Qiao, Yaxian Ma, Hongxia Deng, Charles C. Xu and Liangzhi Xu

Down‐regulation of the Sp1 transcription factor by an increase of microRNA-4497 in human placenta is associated with early recurrent miscarriage

The pathophysiological mechanism of recurrent miscarriage (RM) is unclear. The goals of this study were to determine the role of microRNA-4497 overexpression in placental villus tissues in early RM; To identif...

Authors: Huaiyun Tang, Linqing Pan, Yun Xiong, Leilei Wang, Yugui Cui, Jiayin Liu and Lisha Tang

Association of ABO blood groups with ovarian reserve, and outcomes after assisted reproductive technology: systematic review and meta-analyses

There has been an interest in the relationship between ABO blood groups and infertility. Many studies have investigated the association of ABO blood groups with diminished ovarian reserve (DOR), ovarian hypers...

Authors: Jing Zhao, Zhongyuan Yao, Jie Hao, Bin Xu, Yonggang Wang and Yanping Li

Effect of edaravone on pregnant mice and their developing fetuses subjected to placental ischemia

Growing evidence indicates that reduced uterine perfusion pressure (RUPP) triggers the cascade of events leading to preeclampsia. Edaravone is a powerful free radical scavenger used for the treatment of ischem...

Authors: Marwa Atallah, Toru Yamashita and Koji Abe

Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure

The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus.

Authors: Li Zhou, Chenggang Li, Xiangshu Liu and Tao Zhang

Pretreatment with melatonin improves ovarian tissue cryopreservation for transplantation

Melatonin has anti-inflammatory and antioxidative actions at the mitochondrial level. This indole-containing molecule may protect ovarian grafts during the process of cryopreservation. Therefore, we aimed to d...

Authors: Marcos Eiji Shiroma, Luciana Lamarão Damous, Fernanda Pereira Cotrim, Cristiane Lima Roa, José Cipolla-Neto, Russel Joseph Reiter, Edmund Chada Baracat and José Maria Soares Jr

The cannabinoid receptor CB1 affects the proliferation and apoptosis of adenomyotic human uterine smooth muscle cells of the junctional zone: a mechanism study

The denomyotic junctional zone (JZ) plays an important role in the pathogenesis of adenomyosis. Proliferating cell nuclear antigen (PCNA) is an important nuclear marker of cell proliferation. This study aimed ...

Authors: Sha Wang, Bohan Li, Xue Shen, Hua Duan, Zhengchen Guo, Xiao Li and Fuqing Sun

A 10-year follow‐up on the practice of luteal phase support using worldwide web‐based surveys

It has been demonstrated that luteal phase support (LPS) is crucial in filling the gap between the disappearance of exogenously administered hCG for ovulation triggering and the initiation of secretion of endo...

Authors: Gon Shoham, Milton Leong and Ariel Weissman

The role of Chito-oligosaccharide in regulating ovarian germ stem cells function and restoring ovarian function in chemotherapy mice

In recent years, the discovery of ovarian germ stem cells (OGSCs) has provided a new research direction for the treatment of female infertility. The ovarian microenvironment affects the proliferation and diffe...

Authors: Yaoqi Huang, Haifeng Ye, Feiyin Zhu, Chuan Hu and Yuehui Zheng

Predictive value of live birth rate based on different intrauterine adhesion evaluation systems following TCRA

The aim of this study was to assess the predictive value of five different intrauterine adhesion (IUA) evaluation systems for live birth rate following transcervical resection of adhesion (TCRA).

Authors: Mingzhu Cao, Yingying Pan, Qingyan Zhang, Danming You, Shuying Feng and Zhi Liu

Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance

Energy balance is closely related to reproductive function, wherein hypothalamic kisspeptin mediates regulation of the energy balance. However, the central mechanism of kisspeptin in the regulation of male rep...

Authors: Bo Chang, Chenglin Song, Haining Gao, Tie Ma, Tao Li, Qianhe Ma, Tingting Yao, Meng Wang, Jing Li, Xuejie Yi, Donghui Tang and Shicheng Cao

Effect of somatometric parameters on the prevalence and severity of varicocele: a systematic review and meta-analysis

Published studies have shown contradictory results regarding the relationship between somatometric parameters and varicoceles. We performed a systematic review and meta-analysis to investigate the possible eff...

Authors: Runqing Li, Junjie Liu, Yushan Li and Quanxian Wang

Non-coding RNAs in polycystic ovary syndrome: a systematic review and meta-analysis

Genetic, environmental and epigenetical factors may play important roles in the pathogenesis of polycystic ovary syndrome (PCOS), however the etiology of PCOS remains unclear. Studies indicated that non-coding...

Authors: Liangshan Mu, Xiaoting Sun, Mixue Tu and Dan Zhang

Influence of age, stigma and social support on male temporary ejaculation failure on IVF oocyte retrieval day

To explore the social and psychological factors associated with male Temporary Ejaculation Failure (TEF) during In Vitro Fertilization (IVF), with the goal of providing a theoretical basis for clinical interventi...

Authors: Jinluan Wang and Mingyue Xue

Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis, GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study

Ovarian hyperstimulation syndrome (OHSS) is a common disease during controlled ovarian hyperstimulation treatment. However, the obstetric and neonatal outcomes of this group of patients are unknown. The aim of...

Authors: Linli Hu, Rui Xie, Mengying Wang and Yingpu Sun

Hypoxia and its possible relationship with endometrial receptivity in adenomyosis: a preliminary study

Adenomyosis (AM) is an important cause of female infertility. However, the underlying mechanism remains unclear. This report describes a preliminary study of hypoxia and its possible association with endometri...

Authors: Song Guo, Di Zhang, Xiaowei Lu, Qian Zhang, Ruihuan Gu, Binghui Sun and Yijuan Sun

Development and validation of a model for individualized prediction of cervical insufficiency risks in patients undergoing IVF/ICSI treatment

Women who conceived with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) are more likely to experience adverse pregnancy outcomes than women who conceived naturally. Cervical insufficie...

Authors: Yaoqiu Wu, Xiaoyan Liang, Meihong Cai, Linzhi Gao, Jie Lan and Xing Yang

Association of three missense mutations in the homocysteine-related MTHFR and MTRR gene with risk of polycystic ovary syndrome in Southern Chinese women

The etiology between homocysteine and polycystic ovary syndrome (PCOS) is unclear. In humans, the level of homocysteine is mainly affected by two enzymes: methylene tetrahydrofolate reductase (MTHFR) and methi...

Authors: Wanqin Feng, Yan Zhang, Yuan Pan, Yi Zhang, Minjuan Liu, Yuxin Huang, Yuanling Xiao, Wenyu Mo, Junjie Jiao, Xiaoyang Wang, Dan Tian, Lixia Yang and Ying Ma

FSH regulates RA signaling to commit spermatogonia into differentiation pathway and meiosis

Spermatogenesis is a complex process that is controlled by interactions between germ cells and somatic cells. The commitment of undifferentiated spermatogonia to differentiating spermatogonia and normal sperma...

Authors: Maryam Khanehzad, Roya Abbaszadeh, Marzieh Holakuyee, Mohammad Hossein Modarressi and Seyed Mehdi Nourashrafeddin

Berberine exerts a protective effect on rats with polycystic ovary syndrome by inhibiting the inflammatory response and cell apoptosis

Polycystic ovary syndrome (PCOS) is a common endocrine disease of the female reproductive system that seriously affects women’s health. Berberine (BBR) has many pharmacological properties and is used as an ins...

Authors: Hao-Ran Shen, Xiao Xu and Xue-Lian Li

Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity

The establishment of uterine receptivity is essential for embryo implantation initiation and involves a significant morphological transformation in the endometrial epithelial cells (EECs). The remodeling of ju...

Authors: Jingjie Liang, Kui Li, Kaiyu Chen, Junyong Liang, Ti Qin, Jiayi He, Shuang Shi, Qiang Tan and Zhengguang Wang

Caloric restriction in female reproduction: is it beneficial or detrimental?

Caloric restriction (CR), an energy-restricted intervention with undernutrition instead of malnutrition, is widely known to prolong lifespan and protect against the age-related deteriorations. Recently it is f...

Authors: Jiayi Sun, Xin Shen, Hui Liu, Siying Lu, Jing Peng and Haibin Kuang

Correction to: Status of racial disparities between black and white women undergoing assisted reproductive technology in the US

An amendment to this paper has been published and can be accessed via the original article.

Authors: David B. Seifer, Burcin Simsek, Ethan Wantman and Alexander M. Kotlyar

Tripeptidyl peptidase I promotes human endometrial epithelial cell adhesive capacity implying a role in receptivity

The endometrium undergoes cyclic remodelling throughout the menstrual cycle in preparation for embryo implantation which occurs in a short window during the mid-secretory phase. It is during this short ‘recept...

Authors: Leilani L. Santos, Cheuk Kwan Ling and Evdokia Dimitriadis

Risk of birth defects in children conceived by artificial oocyte activation and intracytoplasmic sperm injection: a meta-analysis

Whether artificial oocyte activation (ICSI-AOA) will increase the risk of birth defects remains controversial. Thus, we performed this study to evaluate the risk of birth defects and further compare the incide...

Authors: Rui Long, Meng Wang, Qi Yu Yang, Shi Qiao Hu, Li Xia Zhu and Lei Jin

Genipin improves reproductive health problems caused by circadian disruption in male mice

Circadian rhythm disruption impacts a wide range of physiological processes, including fertility. However, the effect of circadian disruption on male spermatogenesis and fertility, and treatments for these eff...

Authors: Yihua Xu, Li Wang, Siyuan Cao, Ruihua Hu, Rui Liu, Ke Hua, Zhigang Guo, Hong-Jie Di and Zhigang Hu

Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome

It is reported that growth hormone (GH) can alleviate oxidative stress (OS) induced apoptosis in some types of cells by activating the PI3K/Akt signaling pathway. This study investigated the role and underlyin...

Authors: Yan Gong, Shan Luo, Ping Fan, Huili Zhu, Yujing Li and Wei Huang

Thyroid autoimmunity and IVF/ICSI outcomes in euthyroid women: a systematic review and meta-analysis

Thyroid autoimmunity (TAI) – the presence of anti-thyroid peroxidase and/or anti-thyroglobulin antibodies – affects 8–14% of reproductively-aged women. It is hotly debated whether TAI adversely affects IVF/ICS...

Authors: Ashley Venables, Wilbert Wong, Mandy Way and Hayden Anthony Homer

Establishment of an immortalized stromal cell line derived from human Endometriotic lesion

Endometriosis is a benign gynecological disease with obviously feature of estrogen-dependence and inflammatory response. The applications of primary endometriotic stromal cells in research of endometriosis are...

Authors: Zhi-Xiong Huang, Rong-Feng Wu, Xiao-Mei Mao, Shao-Min Huang, Tian-Tian Liu, Qiong-Hua Chen and Qing-Xi Chen

The association between anti-Müllerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females

High anti-Müllerian hormone (AMH) levels and 25-hydroxyvitamin D [25(OH)D] deficiency have been associated with polycystic ovarian syndrome (PCOS) in adult women, and implicated in its pathogenesis. Herein we ...

Authors: Samantha Simpson, David B. Seifer, Veronika Shabanova, Anna Y. Lynn, Catherine Howe, Erin Rowe, Sonia Caprio and Alla Vash-Margita

Insulin regulation of solute carrier family 2 member 1 (glucose transporter 1) expression and glucose uptake in decidualizing human endometrial stromal cells: an in vitro study

Solute carrier family 2 member 1 (SLC2A1; previously known as glucose transporter 1), is the most abundant glucose transporter in human endometrium and is up-regulated during decidualization, whereas high insu...

Authors: Ivika Jakson, Dorina Ujvari, Sebastian Brusell Gidlöf and Angelica Lindén Hirschberg

Differential expression of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrium in ovarian endometriomas and their correlations with clinicopathological variables

Endometriosis is an estrogen-dependent inflammatory disease that often causes infertility and chronic pelvic pain. Although endometriosis is known as a benign disease, it has demonstrated characteristics of ma...

Authors: Ceyda Sancakli Usta, Gulay Turan, Cagla Bahar Bulbul, Akin Usta and Ertan Adali

The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trial

Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the ...

Authors: Azadeh Hosseini-Najarkolaei, Ashraf Moini, Ladan Kashani, Maryam Farid Mojtahedi, Elnaz Hosseini-Najarkolaee and Ensieh Salehi

Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis

Etiology of polycystic ovary syndrome (PCOS) is attributed to genetic and environmental factors. One environmental factor is oxidative stress. Paraoxonase 1 (PON1) is an antioxidant high-density lipoprotein-as...

Authors: Anthicha Kunjantarachot, Noel Pabalan, Hamdi Jarjanazi, Denise Maria Christofolini, Erik Montagna, Caio Parente Barbosa and Bianca Bianco

Status of racial disparities between black and white women undergoing assisted reproductive technology in the US

Numerous studies have demonstrated substantial differences in assisted reproductive technology outcomes between black non-Hispanic and white non-Hispanic women. We sought to determine if disparities in assiste...

Authors: David B. Seifer, Burcin Simsek, Ethan Wantman and Alexander M. Kotlyar

Racial disparities and in vitro fertilization (IVF) treatment outcomes: time to close the gap

Authors: Tarun Jain

Retinol-binding protein 4 (RBP4) and high sensitivity C-reactive protein (hs-CRP) levels in patients with diminished ovarian reserve (DOR): a cross-sectional study

Antioxidant/oxidant imbalance has been reported to be related to diminished ovarian reserve (DOR). Vitamin A (retinol), a kind of antioxidant, plays a role in restoring ovarian oxidative damage, while C-reacti...

Authors: Wen Zou, Zehao Wang, Jing Xia and Jing Yang

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Many factors, including postponement of marriage, increased life expectancy, and improved success with assisted reproductive technologies have been contributing to increased paternal age in developed nations. ...

Authors: Iman Halvaei, Julia Litzky and Navid Esfandiari

Experiencing earthquake in the first trimester of the fetal life increases subsequent diabetes risk in the adulthood: a cross-sectional study

To investigate the long-term effect of prenatal exposure to earthquake stress on diabetes risk in the adulthood.

Authors: Na Li, Mei Song, Lan Wang, Xiao-chuan Zhao, Ran Wang, Yuan-yuan Gao, Lu-lu Yu, Cui-xia An and Xue-yi Wang