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  1. Luteinizing hormone (LH) is critical in follicle growth and oocyte maturation. However, the value of recombinant LH (r-LH) supplementation to recombinant follicle stimulating hormone (r-FSH) during controlled ...

    Authors: Meng Wang, Rui Huang, Xiaoyan Liang, Yundong Mao, Wenhao Shi and Qian Li
    Citation: Reproductive Biology and Endocrinology 2022 20:114
  2. Three primary monoamines—serotonin, norepinephrine, and dopamine—play major roles in the placenta-fetal brain axis. Analogously to the brain, the placenta has transport mechanisms that actively take up these m...

    Authors: Veronika Vachalova, Rona Karahoda, Martina Ottaviani, Kasin Yadunandam Anandam, Cilia Abad, Christiane Albrecht and Frantisek Staud
    Citation: Reproductive Biology and Endocrinology 2022 20:112
  3. The American Society for Reproductive Medicine estimates that fewer than a quarter of infertile couples have sufficient access to infertility care. Insurers in the United States (US) have long considered infer...

    Authors: Benjamin J. Peipert, Melissa N. Montoya, Bronwyn S. Bedrick, David B. Seifer and Tarun Jain
    Citation: Reproductive Biology and Endocrinology 2022 20:111
  4. Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS). We hypothesized that magnesium supplementation would yield benefici...

    Authors: Mahsima Jaripur, Hatav Ghasemi-Tehrani, Gholamreza Askari, Mahsa Gholizadeh-Moghaddam, Cain C. T. Clark and Mohammad Hossein Rouhani
    Citation: Reproductive Biology and Endocrinology 2022 20:110
  5. Early pregnancy is marked by placentation and embryogenesis, which take place under physiological low oxygen concentrations. This oxygen condition is crucial for many aspects of placentation, trophoblast funct...

    Authors: Rebekka Einenkel, Jens Ehrhardt, Marek Zygmunt and Damián Oscar Muzzio
    Citation: Reproductive Biology and Endocrinology 2022 20:109
  6. Unexplained recurrent spontaneous abortion (URSA) is one of the most common diseases in pregnancy and is mainly caused by immune disorders. The foetus is similar to semiallogeneic maternal tissue, so the balan...

    Authors: Dingchen Pan, Qian Liu, Le Du, Yang Yang and Guojing Jiang
    Citation: Reproductive Biology and Endocrinology 2022 20:108
  7. Advanced maternal age and obesity are associated with impaired female fertility. Moreover, fatty acids (FA) in follicular fluid (FF) play important roles in oocyte maturation and embryo development. However, t...

    Authors: Yujie Liu, Kelly Tilleman, Bruno Vlaeminck, Rachel Gervais, P Yvan Chouinard, Petra De Sutter and Veerle Fievez
    Citation: Reproductive Biology and Endocrinology 2022 20:107
  8. There is a lack of biomarkers for distinguishing non-obstructive azoospermia (NOA) patients with successful sperm retrieval (Sp+) from those with failed sperm retrieval (Sp-). This study aimed to determine the...

    Authors: Xiaoxiao Han, Lin Hao, Zhenduo Shi, Ying Li, Liang Wang, Zhenbei Li, Qiang Zhang, Fangfang Hu, Yijuan Cao, Kun Pang and Zuobin Zhu
    Citation: Reproductive Biology and Endocrinology 2022 20:106
  9. Doxorubicin (DOX) is an effective chemotherapy drug, but its clinical use has adverse effects on male reproduction. However, there are few studies about the specific biological processes related to male reprod...

    Authors: Teng Zi, YaNan Liu, YuSheng Zhang, ZeLin Wang, ZhiXin Wang, Song Zhan, Zhu Peng, Ning Li, XueXia Liu and FuJun Liu
    Citation: Reproductive Biology and Endocrinology 2022 20:105
  10. Human granulosa-lutein cells (hGLCs) amply express sirtuin-1 (SIRT1), a NAD + -dependent deacetylase that is associated with various cellular functions. SIRT1 was shown to elevate cAMP on its own and additivel...

    Authors: Jackson Sapuleni, Magdalena Szymanska and Rina Meidan
    Citation: Reproductive Biology and Endocrinology 2022 20:104
  11. Globozoospermia (OMIM: 102530) is a rare type of teratozoospermia (< 0.1%). The etiology of globozoospermia is complicated and has not been fully revealed. Here, we report an infertile patient with globozoospe...

    Authors: Gelin Huang, Xueguang Zhang, Guanping Yao, Lin Huang, Sixian Wu, Xiaoliang Li, Juncen Guo, Yuting Wen, Yan Wang, Lijun Shang, Na Li and Wenming Xu
    Citation: Reproductive Biology and Endocrinology 2022 20:103
  12. To investigate in a longitudinal cohort study, the best treatment to preserve fertility in cryptorchid subjects. Patients treated with immediate hormonal vs. delayed vs. combined (hormone plus surgery) therapy...

    Authors: Riccardo Bartoletti, Antonio Luigi Pastore, Filippo Menchini Fabris, Tommaso Di Vico, Riccardo Morganti, Andrea Mogorovich, Girolamo Morelli, Diego Peroni, Yazan Al Salhi and Alessandro Zucchi
    Citation: Reproductive Biology and Endocrinology 2022 20:102
  13. Maternal obesity is a global issue that has devastating effects across the reproductive spectrum such as meiotic defects in oocytes, consequently worsening pregnancy outcomes. Different studies have shown that...

    Authors: Yanling Wan, Tahir Muhammad, Tao Huang, Yue Lv, Qianqian Sha, Shuang Yang, Gang Lu, Wai-yee Chan, Jinlong Ma and Hongbin Liu
    Citation: Reproductive Biology and Endocrinology 2022 20:101
  14. Insulin-like growth factor-binding protein-5 (IGFBP-5) has recently been shown to alter the reproductive capacity by regulating insulin-like growth factor (IGF) bioavailability or IGF-independent effects. The ...

    Authors: Zhiqiu Yao, Maosen Lin, Tao Lin, Xinbao Gong, Pin Qin, Hailing Li, Tiezhu Kang, Jing Ye, Yanyun Zhu, Qiwen Hong, Ya Liu, Yunsheng Li, Juhua Wang and Fugui Fang
    Citation: Reproductive Biology and Endocrinology 2022 20:100
  15. Enhancer of zeste homologue 2 (EZH2), the core member of polycomb repressive complex 2 (PRC2), has multiple splicing modes and performs various physiological functions. However, function and mechanism of alte...

    Authors: Shi-meng Guo, Xing-ping Liu, Qing Tian, Cai-feng Fei, Yi-ran Zhang, Zhi-ming Li, Ying Yin, Ximiao He and Li-quan Zhou
    Citation: Reproductive Biology and Endocrinology 2022 20:99
  16. To evaluate in women with functional hypothalamic amenorrhea (FHA), whether there is a difference between patients with and without polycystic ovarian morphology (PCOM) concerning the response to a gonadotropi...

    Authors: Marlene Hager, Johannes Ott, Julian Marschalek, Marie-Louise Marschalek, Clemens Kinsky, Rodrig Marculescu and Didier Dewailly
    Citation: Reproductive Biology and Endocrinology 2022 20:98
  17. Follicle-stimulating hormone signaling is essential for the initiation and early stages of spermatogenesis. Follicle-stimulating hormone receptor is exclusively expressed in Sertoli cells. As the only type of ...

    Authors: Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang and Fu-Qing Tan
    Citation: Reproductive Biology and Endocrinology 2022 20:97
  18. Myostatin (MSTN) is member of the transforming growth factor β (TGF-β) superfamily and was originally identified in the musculoskeletal system as a negative regulator of skeletal muscle growth. The functional ...

    Authors: Sijia Wang, Lanlan Fang, Luping Cong, Jacqueline Pui Wah Chung, Tin Chiu Li and David Yiu Leung Chan
    Citation: Reproductive Biology and Endocrinology 2022 20:96
  19. Ovulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the function of most of the LH-regulated genes. Defective ERK kinase sign...

    Authors: Gurhan Guney, Mine Islimye Taşkın, Nazli Sener, Ezgi Tolu, Yavuz Dodurga, Levent Elmas, Orkun Cetin and Cengiz Sarigul
    Citation: Reproductive Biology and Endocrinology 2022 20:95
  20. Hypertensive disorders of pregnancy (HDP) are an important cause of maternal and fetal mortality, and its potential risk factors are still being explored. Endometrial thickness (EMT), as one of the important m...

    Authors: Meng Zhang, Jing Li, Xiao Fu, Yiting Zhang, Tao Zhang, Bingjie Wu, Xinyue Han and Shanshan Gao
    Citation: Reproductive Biology and Endocrinology 2022 20:93
  21. The impact of maternal pre-pregnancy bodyweight on gestational diabetes mellitus (GDM) following assisted reproductive technology (ART) treatment has been insufficiently investigated. The aim of this study was...

    Authors: Yiquan Xiong, Jing Wang, Yana Qi, Chunrong Liu, Mingxi Li, Guanhua Yao, Wei Sun, Yongyao Qian, Lishan Ye, Hui Liu, Qiushi Xu, Kang Zou, Jing Tan and Xin Sun
    Citation: Reproductive Biology and Endocrinology 2022 20:92
  22. Kisspeptin released from Kiss-1 neurons in the hypothalamus plays an essential role in the control of the hypothalamic–pituitary–gonadal axis by regulating the release of gonadotropin-releasing hormone (GnRH)....

    Authors: Hiroe Okada, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride and Satoru Kyo
    Citation: Reproductive Biology and Endocrinology 2022 20:91
  23. Nonobstructive azoospermia (NOA) is one of the most difficult forms of male infertility to treat, and its pathogenesis is still unclear. miRNAs can regulate autophagy by affecting their target gene expression....

    Authors: Yuan Wang, Cheng-Cheng Tian, Yun-Yun Jiao, Min-Rui Liu, Xue-Shan Ma, Hai-Xia Jin, Ying-Chun Su, Xiang-Yang Zhang, Wen-Bin Niu, Gui-Don Yao and Wen-Yan Song
    Citation: Reproductive Biology and Endocrinology 2022 20:90
  24. Insulin-like growth factor 2 (IGF2) mRNA binding proteins (IMPs) family belongs to a highly conserved family of RNA-binding proteins (RBPs) and is responsible for regulating RNA processing including localizati...

    Authors: Xiao Xu, Hao-Ran Shen, Jia-Rong Zhang and Xue-Lian Li
    Citation: Reproductive Biology and Endocrinology 2022 20:89
  25. According to current definitions of Polycystic Ovary Syndrome (PCOS), hyperandrogenism is considered as a key element in the pathogenesis of this common endocrinopathy. However, until now, studies about ovaria...

    Authors: Alice Bongrani, Ingrid Plotton, Namya Mellouk, Christelle Ramé, Fabrice Guerif, Pascal Froment and Joëlle Dupont
    Citation: Reproductive Biology and Endocrinology 2022 20:88
  26. In absence of contraindication, breast cancer patients of reproductive age can undergo fertility preservation with controlled ovarian stimulation for oocyte/embryo cryopreservation before the administration of...

    Authors: Imane Lalami, Julie Labrosse, Isabelle Cedrin-Durnerin, Marjorie Comtet, Claire Vinolas, Fabien Krief, Christophe Sifer, Maeliss Peigne and Michael Grynberg
    Citation: Reproductive Biology and Endocrinology 2022 20:87
  27. Ubiquitin-like modifier 1 ligating enzyme 1 (UFL1), the ligase of the UFMylation system, has recently been reported to be involved in apoptosis and endoplasmic reticulum stress (ER stress) in a variety of dise...

    Authors: Xiangting Tang, Hao Dong, Zhi Fang, Jingyi Li, Qi Yang, Ting Yao and Zezheng Pan
    Citation: Reproductive Biology and Endocrinology 2022 20:84
  28. To ascertain whether physical activity (PA) is associated with better sperm quality in sperm donors.

    Authors: Roberto Matorras, Alfredo Navarro, Dagoberto Ramos, Iker Malaina, Jon Irazusta, Alberto Vendrell, Amaia Fernandez, Marcos Ferrando and Fernando Quintana
    Citation: Reproductive Biology and Endocrinology 2022 20:83
  29. Spontaneous abortions (SA) is amongst the most common complications associated with pregnancy in humans, and the underlying causes cannot be identified in roughly half of SA cases. We found miR-135a-5p to be s...

    Authors: Yebin Lu, Xiaoli Zhang, Xueyu Li, Lingjie Deng, Changqiang Wei, Dongmei Yang, Xuemei Tan, Weicheng Pan and Lihong Pang
    Citation: Reproductive Biology and Endocrinology 2022 20:82
  30. Kisspeptin is the leading upstream regulator of pulsatile and surge Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as the key governor of the hypothalamic-pituitary-ovary axis.

    Authors: Kai-Lun Hu, Zimiao Chen, Xiaoxue Li, Enci Cai, Haiyan Yang, Yi Chen, Congying Wang, Liping Ju, Wenhai Deng and Liangshan Mu
    Citation: Reproductive Biology and Endocrinology 2022 20:81
  31. Male fertility and sperm quality are negatively affected by psychological stress. Chronic restraint stress (CRS) is a common psychological stress that has a negative effect on sperm. Betaine (BET), an active i...

    Authors: Xingqi Meng, Lixuan Peng, Jie Xu, Dongming Guo, Wenyu Cao, Yang Xu and Suyun Li
    Citation: Reproductive Biology and Endocrinology 2022 20:80
  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dongdong Tang, Kuokuo Li, Hao Geng, Chuan Xu, Mingrong Lv, Yang Gao, Guanxiong Wang, Hui Yu, Zhongmei Shao, Qunshan Shen, Hui Jiang, Xiansheng Zhang, Xiaojin He and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:79

    The original article was published in Reproductive Biology and Endocrinology 2022 20:63

  33. Disease situations are more aggressive in patients with childhood-onset systemic lupus erythematosus (cSLE) than in those with adult-onset SLE (aSLE). However, information on pregnant women with cSLE and its a...

    Authors: Zhi-Ju Li, Hao-Yue Hu, Zi-Ling Ding, Zi-Wei Bian, Ying-Hua Xu, Hui-Ting Wen, Ya-Li Qu, Jin-Dong Wang, Xiao-Li Huang, Dong Li, Jing Li and Gui-Fang Hu
    Citation: Reproductive Biology and Endocrinology 2022 20:78
  34. Endometriosis (EMS) remains a major challenge to reproductive health due to multifactorial etiology, disease heterogeneity, and the lack of appropriate diagnostic markers and treatment. Eexosome (Exo) has beco...

    Authors: Xi Wang, Mengmeng Zhang, Liaofei Jiang, Xiaoling Fang and Tingting Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:77
  35. Studies have shown that abnormalities in the decidualization process were closely related to recurrent implantation failure (RIF). Prokineticin 2 (PK2) is a secreted protein with angiogenic and tissue remodeli...

    Authors: Jun Zhai, Linna Ma, Ziyin Chang and Ting Yu
    Citation: Reproductive Biology and Endocrinology 2022 20:76
  36. Authors: Chuan Xu, Dongdong Tang, Zhongmei Shao, Hao Geng, Yang Gao, Kuokuo Li, Qing Tan, Guanxiong Wang, Chao Wang, Huan Wu, Guanjian Li, Mingrong Lv, Xiaojin He and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:74

    The original article was published in Reproductive Biology and Endocrinology 2022 20:41

  37. Normal motor activity of the fallopian tube is critical for human reproduction, and abnormal tubal activity may lead to ectopic pregnancy (EP) or infertility. Progesterone has an inhibitory effect on tubal con...

    Authors: Duo Zhang, Qian Zhu, Wei Xia, Chenfeng Zhu, Xiaoya Zhao, Yiqin Zhang, Chuqing He, Sifan Ji, Xiaocui Li and Jian Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:73
  38. In children, recombinant human growth hormone (rhGH) therapy for treatment of short stature has raised concerns of the early onset of puberty. Puberty is initiated by the activation of the hypothalamus-pituita...

    Authors: Yang Xu, Chang Yong Han, Mi Jung Park and Myung Chan Gye
    Citation: Reproductive Biology and Endocrinology 2022 20:72
  39. Singleton pregnancy is encouraged to reduce pregnancy complications. In addition to single embryo transfer (SET), selective and spontaneous fetal reduction (SEFR and SPFR) can also achieve singleton pregnancie...

    Authors: Chao Wang, Fei Tang, Bing Song, Guanjian Li, Qiong Xing and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:71
  40. Nicotinamide (NAM) is an important antioxidant, which is closely related to female fertility, but its role has not been clearly elucidated. The purpose of the present study was to investigate the effects of NA...

    Authors: Ziyu Guo, Jihong Yang, Guangping Yang, Ting Feng, Xinyue Zhang, Yao Chen, Ruizhi Feng and Yun Qian
    Citation: Reproductive Biology and Endocrinology 2022 20:70
  41. Authors: Shun Bai, Yuan Li, Yangyang Wan, Tonghang Guo, Qi Jin, Ran Liu, Wenjuan Tang, Meiying Sang, Yuanyuan Tao, Baoguo Xie, Yun Zhao, Wei Li, Xiangdong Xu, Qiuling Yue, Xuechun Hu and Bo Xu
    Citation: Reproductive Biology and Endocrinology 2022 20:69

    The original article was published in Reproductive Biology and Endocrinology 2021 19:92

  42. Advanced models including time-lapse imaging and artificial intelligence technologies have been used to predict blastocyst formation. However, the conventional morphological evaluation of embryos is still wide...

    Authors: Xiaoming Jiang, Jiali Cai, Lanlan Liu, Zhenfang Liu, Wenjie Wang, Jinhua Chen, Chao Yang, Jie Geng, Caihui Ma and Jianzhi Ren
    Citation: Reproductive Biology and Endocrinology 2022 20:68
  43. Increasing evidence has shown that the mammalian target of rapamycin (mTOR) pathway plays a critical role in oocyte meiosis and embryonic development, however, previous studies reporting the effects of rapamyc...

    Authors: Qiyu Yang, Qingsong Xi, Meng Wang, Rui Long, Juan Hu, Zhou Li, Xinling Ren, Lixia Zhu and Lei Jin
    Citation: Reproductive Biology and Endocrinology 2022 20:67
  44. Authors: Jianguo Chen, Chaoran Huang, Tongtong Zhang, Wuqing Gong, Xiaofeng Deng, Hua Liu, Jinbo Liu and Yuanbiao Guo
    Citation: Reproductive Biology and Endocrinology 2022 20:66

    The original article was published in Reproductive Biology and Endocrinology 2021 19:189

  45. Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation. As a member of the transforming growth factor β (TGF-β) superfamil...

    Authors: Hsun-Ming Chang, Long Bai, Yi-Min Zhu and Peter C. K. Leung
    Citation: Reproductive Biology and Endocrinology 2022 20:65

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