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  1. Poor response patients with PCOS who are not susceptible to gonadotropin stimulation are more likely to have canceled cycles or poor clinical outcomes during IVF treatment. However, some limitations exist in t...

    Authors: Bufang Xu, Mingjuan Zhou, Meiyu Cheng, Dan Zhang, Xian Wu, Chenchen Si, Lan Xia, Huihui Xu, Jian Li, Hsun-Ming Chang, Peter C. K. Leung and Aijun Zhang

    Citation: Reproductive Biology and Endocrinology 2020 18:7

    Content type: Research

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  2. LINE1 retrotransposons are mobile DNA elements that copy and paste themselves into new sites in the genome. To ensure their evolutionary success, heritable new LINE-1 insertions accumulate in cells that can tr...

    Authors: Chao Lou, John L. Goodier and Rong Qiang

    Citation: Reproductive Biology and Endocrinology 2020 18:6

    Content type: Review

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  3. It is still one of the unresolved issues if germinal vesicle stage (GV) oocytes can be successfully cryopreserved for fertility preservation and matured in vitro without damage after warming. Several studies h...

    Authors: Dayong Lee, Hyang Heun Lee, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim and S. Samuel Kim

    Citation: Reproductive Biology and Endocrinology 2020 18:5

    Content type: Research

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  4. Human embryos are usually cultured to blastocyst stage by Day 5 or 6 after insemination. However, some embryos grow slowly and reach blastocyst stage at Day 7. Acceptable live birth rates have been reported af...

    Authors: Xiangli Niu, Cassie T. Wang, Richard Li, Ghassan Haddad and Weihua Wang

    Citation: Reproductive Biology and Endocrinology 2020 18:4

    Content type: Short communication

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  5. Only a few microbial studies have conducted in IVF (in vitro fertilization), showing the high-variety bacterial contamination of IVF culture media to cause damage to or even loss of cultured oocytes and embryo...

    Authors: Jelena Štšepetova, Juliana Baranova, Jaak Simm, Ülle Parm, Tiiu Rööp, Sandra Sokmann, Paul Korrovits, Madis Jaagura, Karin Rosenstein, Andres Salumets and Reet Mändar

    Citation: Reproductive Biology and Endocrinology 2020 18:3

    Content type: Research

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  6. Male fertility is multifaceted and its integrity is as well multifactorial. Normal spermatogenesis is dependent on competent testicular function; namely normal anatomy, histology, physiology and hormonal regul...

    Authors: Nermin I. Rizk, Mohamed S. Rizk, Asmaa S. Mohamed and Yahya M. Naguib

    Citation: Reproductive Biology and Endocrinology 2020 18:2

    Content type: Research

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  7. Controlled ovarian stimulation (COS) has a negative effect on the endometrial receptivity compared with natural menstrual cycle. Whether it’s necessary to postpone the first frozen embryo transfer (FET) follow...

    Authors: Yuxia He, Haiyan Zheng, Hongzi Du, Jianqiao Liu, Lei Li, Haiying Liu, Mingzhu Cao and Shiping Chen

    Citation: Reproductive Biology and Endocrinology 2020 18:1

    Content type: Research

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  8. Gestational diabetes mellitus (GDM) has a high prevalence in the period of pregnancy. However, the lack of gold standards in current screening and diagnostic methods posed the biggest limitation. Regulation of...

    Authors: Enchun Li, Tengfei Luo and Yingjun Wang

    Citation: Reproductive Biology and Endocrinology 2019 17:112

    Content type: Research

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  9. Previous studies of expression profiles of major endometrial effectors of steroid physiology in endometriosis have yielded markedly conflicting conclusions, presumably because the relative effects of type of e...

    Authors: G. Anupa, Jai Bhagwan Sharma, Kallol K. Roy, Jayasree Sengupta and Debabrata Ghosh

    Citation: Reproductive Biology and Endocrinology 2019 17:111

    Content type: Research

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  10. This article describes the research trends in sperm DNA fragmentation (SDF) over the past 20 years (1999–2018) using a scientometric approach.

    Authors: Saradha Baskaran, Ashok Agarwal, Manesh Kumar Panner Selvam, Renata Finelli, Kathy Amy Robert, Concetta Iovine, Peter Natesan Pushparaj, Luna Samanta, Avi Harlev and Ralf Henkel

    Citation: Reproductive Biology and Endocrinology 2019 17:110

    Content type: Research

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  11. Capacitation involves physiological changes that spermatozoa must undergo in the female reproductive tract or in vitro to obtain the ability to bind, penetrate and fertilize the egg. Up to date, several method...

    Authors: Lukas Ded, Pavla Dostalova, Eva Zatecka, Andrej Dorosh, Katerina Komrskova and Jana Peknicova

    Citation: Reproductive Biology and Endocrinology 2019 17:109

    Content type: Methodology

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  12. With the widely implementation of universal two-child policy, the number of pregnant women in advanced maternal age (AMA) will increase gradually. We aimed to assess the association of vitamin D levels and ins...

    Authors: Beibei Dong, Mengmeng Zhi, Manman Han, Hao Lin, Hong Yu and Ling Li

    Citation: Reproductive Biology and Endocrinology 2019 17:108

    Content type: Research

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  13. Infertility is linked to depletion of the primordial follicle pool consisting of individual oocytes arrested at the diplotene stage of meiotic prophase I surrounded by granulosa cells. Primordial germ cells, t...

    Authors: Deion M. Burks, Margaret R. McCoy, Sudipta Dutta, Connie J. Mark-Kappeler, Patricia B. Hoyer and Melissa E. Pepling

    Citation: Reproductive Biology and Endocrinology 2019 17:105

    Content type: Research

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  14. The addition of a GnRH analogue to the luteal phase in in vitro fertilization programs has been seldom proposed due to the presence of GnRH receptors in the endometrium. The aim of the study was to evaluate th...

    Authors: Francesco M. Fusi, Claudio M. Brigante, Laura Zanga, Mario Mignini Renzini, Chiara Bosisio and Rubens Fadini

    Citation: Reproductive Biology and Endocrinology 2019 17:103

    Content type: Research

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  15. Endometrial preparation with hormone replacement therapy (HRT) is the preferred regimen for clinicians due to the opportunity to schedule the day of embryo transfer and for patients due to the requirement of f...

    Authors: Fazilet Kubra Boynukalin, Meral Gultomruk, Emre Turgut, Berfu Demir, Necati Findikli, Munevver Serdarogullari, Onder Coban, Zalihe Yarkiner and Mustafa Bahceci

    Citation: Reproductive Biology and Endocrinology 2019 17:102

    Content type: Research

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  16. As the largest family of E3 ligases, the Skp1-cullin 1-F-box (SCF) E3 ligase complex is comprised of Cullins, Skp1 and F-box proteins. And the SCF E3 ubiquitin ligases play an important role in regulating crit...

    Authors: Jiayan Xie, Yimei Jin and Guang Wang

    Citation: Reproductive Biology and Endocrinology 2019 17:101

    Content type: Review

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  17. Non-obstructive azoospermia (NOA) is a multifactorial disorder whose molecular basis remains largely unknown. Circular RNAs (CircRNAs), a novel class of endogenous RNAs, have been recognized to play important ...

    Authors: Pan Ge, Jian Zhang, Liang Zhou, Mo-qi Lv, Yi-xin Li, Jin Wang and Dang-xia Zhou

    Citation: Reproductive Biology and Endocrinology 2019 17:100

    Content type: Research

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  18. The aim of this study was to explore the impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst.

    Authors: Zhiqin Bu, Xinhong Yang, Lin Song, Beijia Kang and Yingpu Sun

    Citation: Reproductive Biology and Endocrinology 2019 17:99

    Content type: Research

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  19. Ovol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains eni...

    Authors: Jin Zhang, Juan Dong, Weibing Qin, Congcong Cao, Yujiao Wen, Yunge Tang and Shuiqiao Yuan

    Citation: Reproductive Biology and Endocrinology 2019 17:98

    Content type: Short communication

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  20. Bovine endometrial epithelial cells (BEECs) undergo regular regeneration after calving. Elevated cortisol concentrations have been reported in postpartum cattle due to various stresses. However, the effects of...

    Authors: Junsheng Dong, Jun Li, Jianji Li, Luying Cui, Xia Meng, Yang Qu and Heng Wang

    Citation: Reproductive Biology and Endocrinology 2019 17:97

    Content type: Research

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  21. Previous work demonstrated that there are numerous miRNAs in human follicular fluids, some of which are associated with reproductive diseases. In the current study, we sought to determine whether microRNAs (mi...

    Authors: Xiong Li, Wenbi Zhang, Jing Fu, Yan Xu, Ruihuan Gu, Ronggui Qu, Lu Li, Yijuan Sun and Xiaoxi Sun

    Citation: Reproductive Biology and Endocrinology 2019 17:96

    Content type: Research

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  22. Polycystic ovary syndrome is characterized by hyperactivity of the ovarian sympathetic nervous system, increases in the content and release of norepinephrine, as well as decreases in the number of β-adrenorece...

    Authors: Berenice Venegas, Lizzbeth Yureli De León Gordillo, Gabriela Rosas, Julieta A. Espinoza, Carolina Morán, Roberto Domínguez and Leticia Morales-Ledesma

    Citation: Reproductive Biology and Endocrinology 2019 17:95

    Content type: Research

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  23. Although thyroid dysfunction caused by Hashimoto’s thyroiditis (HT) is believed to be related to implantation failure due to the underdevelopment of the receptive uterus, it is unknown whether HT itself, even ...

    Authors: Zhangbi Wu, Yaojun Cai, Qin Xia, Tiantian Liu, Hao Yang, Fen Wang, Nan Wang, Zhen Yu, Chunying Yin, Qunan Wang and Defa Zhu

    Citation: Reproductive Biology and Endocrinology 2019 17:94

    Content type: Research

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  24. The nerve growth factor (NGF), a member of the neurotrophins family, plays an important role not only in the nervous but also in other non-nervous systems such as the reproductive system. The aim of the paper ...

    Authors: Cesare Castellini, Simona Mattioli, Alessandro Dal Bosco, Giulia Collodel, Alessandra Pistilli, Anna Maria Stabile, Lara Macchioni, Francesca Mancuso, Giovanni Luca and Mario Rende

    Citation: Reproductive Biology and Endocrinology 2019 17:93

    Content type: Research

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  25. Amphibian diversity is declining at an alarming rate due to habitat loss, invasive species, climate change and diseases. Captive assurance colonies have been established for some species at risk; however, many...

    Authors: Lucía Arregui, Sergio Diaz-Diaz, Elia Alonso-López and Andrew J. Kouba

    Citation: Reproductive Biology and Endocrinology 2019 17:92

    Content type: Research

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  26. Previous studies have demonstrated that progestin-primed ovarian stimulation (PPOS) protocol was a feasible and efficient method in in vitro fertilization (IVF) cycle. However, its application in women with ad...

    Authors: Qian Peng, Xiang Cao, Jing Wang, Lin Wang, Jun Xu, Xiaowei Ji, Suying Liu, Jin Zhu and Xi Dong

    Citation: Reproductive Biology and Endocrinology 2019 17:91

    Content type: Research

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  27. The objective ofthis study was to assess the association between thyroid hormone (TH) levels in follicular fluid (FF) and serum and to determine whether THs impact assisted reproductive technology (ART) outcomes.

    Authors: Yun Ying Cai, Na Lin, Lan Ping Zhong, Hui Juan Duan, Yun Hua Dong, Ze Wu and Heng Su

    Citation: Reproductive Biology and Endocrinology 2019 17:90

    Content type: Research

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  28. The authors regret that the incorrect identification of “omega-3 arachidonic acid” published in the original manuscript [1].

    Authors: Jingjie Li, Lihuan Guan, Huizhen Zhang, Yue Gao, Jiahong Sun, Xiao Gong, Dongshun Li, Pan Chen, Xiaoyan Liang, Min Huang and Huichang Bi

    Citation: Reproductive Biology and Endocrinology 2019 17:89

    Content type: Correction

    Published on:

    The original article was published in Reproductive Biology and Endocrinology 2018 16:42

  29. The antral follicle count (AFC) in mammalian ovaries positively correlates with female fertility. To clarify the causes of differences in fertility between low and high AFC cows, we investigated follicular gro...

    Authors: Kenichiro Sakaguchi, Yojiro Yanagawa, Koji Yoshioka, Tomoko Suda, Seiji Katagiri and Masashi Nagano

    Citation: Reproductive Biology and Endocrinology 2019 17:88

    Content type: Research

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  30. Morulas with delayed growth sometimes coexist with blastocysts. There is still limited evidence regarding the optimal disposal of surplus morulas. With the advancement of vitrification, the freezing-thawing te...

    Authors: Ni-Chin Tsai, Yu-Ting Su, Yu-Ju Lin, Hsin-Ju Chiang, Fu-Jen Huang, Fu-Tsai Kung and Kuo-Chung Lan

    Citation: Reproductive Biology and Endocrinology 2019 17:87

    Content type: Research

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  31. Autoimmune thyroiditis (AIT) with euthyroid is associated with miscarriage. But the exact mechanism remains unclear. Studies have shown that the programmed cell death-1 (PD-1)/programmed cell death -ligand 1 (...

    Authors: Mengya Chen, Nduwimana Gilbert and Haixia Liu

    Citation: Reproductive Biology and Endocrinology 2019 17:86

    Content type: Research

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  32. Voluntary control of fertility is of paramount importance to the modern society. But since the contraceptive methods available for women have their limitations such as urinary tract infections, allergies, cerv...

    Authors: Neeraj Chandra Pant, Ravinder Singh, Vijaya Gupta, Aditi Chauhan, Ravimohan Mavuduru, Vijay Prabha and Prince Sharma

    Citation: Reproductive Biology and Endocrinology 2019 17:85

    Content type: Research

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  33. In the absence of international guidelines indicating the usage of vitrification rather than slow-freezing, the study aim was to analyze a large cohort of slow-frozen/thawed embryos to produce a rationale supp...

    Authors: Francesco Capodanno, Jessica Daolio, Gaetano De Feo, Angela Falbo, Daria Morini, Alessia Nicoli, Luca Braglia, MariaTeresa Villani, Giovanni B. La Sala, Lodovico Parmegiani and Lorenzo Aguzzoli

    Citation: Reproductive Biology and Endocrinology 2019 17:84

    Content type: Research

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  34. Advanced maternal age, family history of diabetes, pre-gestational obesity, increased level of HbA1c, history of gestational diabetes mellitus (GDM), and poor pregnancy consequences are considered risk factors...

    Authors: Azam Kouhkan, Hamid Reza Baradaran, Roya Hosseini, Arezoo Arabipoor, Ashraf Moini, Reihaneh Pirjani, Alireza Khajavi and Mohammad E. Khamseh

    Citation: Reproductive Biology and Endocrinology 2019 17:83

    Content type: Research

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  35. Obesity is a worldwide crisis impairing human health. In this condition, declines in sperm quality stem from reductions in sperm concentration, motility and increase in sperm deformity. The mechanism underlyin...

    Authors: Yuanhong Peng, Wenzhen Zhao, Fei Qu, Jia Jing, Yanqin Hu, Yue Liu and Zhide Ding

    Citation: Reproductive Biology and Endocrinology 2019 17:82

    Content type: Research

    Published on:

  36. Gestational diabetes mellitus (GDM) is associated with important factors that influence fetal development. Sphingolipids are known to be associated with the development of diabetes. Our objective was to examin...

    Authors: Juan F. Mejia, Kelsey M. Hirschi, Kary Y. F. Tsai, Matthew G. Long, Benton C. Tullis, Eliza E. K. Bitter, Benjamin T. Bikman, Paul R. Reynolds and Juan A. Arroyo

    Citation: Reproductive Biology and Endocrinology 2019 17:81

    Content type: Research

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  37. The direct role of antiphospholipid antibodies (aPL) at maternal-fetal interface has not been fully investigated, especially whether they are involved in physiological and pathological implantation conditions,...

    Authors: Valentina Bruno, Marzia Nuccetelli, Carlo Ticconi, Antonella Bruno, Federica Martelli, Maria Vittoria Capogna, Sergio Bernardini, Emilio Piccione and Adalgisa Pietropolli

    Citation: Reproductive Biology and Endocrinology 2019 17:79

    Content type: Research

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  38. Immune dysregulation is one of the mechanisms to promote endometriosis (EMS). Various T cell subpopulations have been reported to play different roles in the development of EMS. The mucosa-associated invariant...

    Authors: Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Yuping Xu, Peipei Guo, Ya Chen, Ping Zhou, Zhaolian Wei, Huanhuan Jiang and Yunxia Cao

    Citation: Reproductive Biology and Endocrinology 2019 17:78

    Content type: Research

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  39. As the most ordinary metabolic disorder during pregnancy, gestational diabetes mellitus (GDM) has become a severe risk for the health of both pregnant female and fetus. Astragaloside IV (AS-IV) is the dominant...

    Authors: Ruixue Zhang, Xuelei Zhang, Baoheng Xing, Jianyong Zhao, Peipei Zhang, Dandan Shi and Fengzhen Yang

    Citation: Reproductive Biology and Endocrinology 2019 17:77

    Content type: Research

    Published on:

  40. Microarray-based and next generation sequencing (NGS) technologies have revealed that segmental aneuploidy is frequently present in human oocytes, cleavage-stage embryos and blastocysts. However, very little r...

    Authors: María-José Escribà, Xavier Vendrell and Vanessa Peinado

    Citation: Reproductive Biology and Endocrinology 2019 17:76

    Content type: Research

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  41. Although in vitro culture system has been optimized in the past few decades, the problem of few or no high quality embryos has been still not completely solved. Accordingly, fully understanding the regulatory ...

    Authors: Jun Tan, Yang Zou, Zhi-Hui Huang, Zhi-Qin Zhang, Li-Ping Wu, Xing-Wu Wu, Xiao-Ju Wan, Cai-Lin Xin and Qiong-Fang Wu

    Citation: Reproductive Biology and Endocrinology 2019 17:75

    Content type: Research

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  42. There is much value in identifying non-invasive ways of measuring endometrial receptivity, as it has the potential to improve outcomes following in vitro fertilization (IVF). It has been suggested that endomet...

    Authors: Zhaojuan Hou, Qiong Zhang, Jing Zhao, Aizhuang Xu, Aihua He, Xi Huang, Shi Xie, Jing Fu, Lan Xiao and Yanping Li

    Citation: Reproductive Biology and Endocrinology 2019 17:74

    Content type: Research

    Published on:

  43. Mediterranean diet (MediDiet) had been reported to be beneficial to human health. However the relationship between diet pattern and outcomes of in vitro fertilization (IVF) treatment was scarcely researched. T...

    Authors: Hongmei Sun, Yihua Lin, Dongxia Lin, Change Zou, Xiangli Zou, Lan Fu, Fanhua Meng and Weiping Qian

    Citation: Reproductive Biology and Endocrinology 2019 17:73

    Content type: Research

    Published on:

  44. Peripheral and uterine natural killer cells (pNK and uNK cells) are key players in the establishment and maintenance of pregnancy and are disturbed in patients with recurrent miscarriage (RM). Different immuno...

    Authors: B. Toth, K. Vomstein, R. Togawa, B. Böttcher, H. Hudalla, Th. Strowitzki, V. Daniel and R. J. Kuon

    Citation: Reproductive Biology and Endocrinology 2019 17:72

    Content type: Research

    Published on:

  45. Palmitic acid (PA) is a common saturated fatty acid that induces apoptosis in various types of cells, including testicular Leydig cells. There is evidence suggesting that PA is increased in patients with obesi...

    Authors: Zhi Chen, Di Wen, Fen Wang, Chunbo Wang and Lei Yang

    Citation: Reproductive Biology and Endocrinology 2019 17:71

    Content type: Research

    Published on:

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