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  1. Phthalates such as di (2-ethylhexyl) phthalate (DEHP) are well known exogenous substances, disrupting reproductive system function and structure. The current research demonstrated the effect of ellagic acid (E...

    Authors: Azam Hosseinzadeh, Saeed Mehrzadi, Amir Siahpoosh, Zahra Basir, Nosrat Bahrami and Mehdi Goudarzi

    Citation: Reproductive Biology and Endocrinology 2021 19:146

    Content type: Research

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  2. Overweight and obesity affect millions of people globally, which has also serious implications for reproduction. For example, treatment outcomes after in vitro fertilisation (IVF) are worse in women with a hig...

    Authors: Linette van Duijn, Melek Rousian, Jeffrey Hoek, Sten P. Willemsen, Eva S. van Marion, Joop S. E. Laven, Esther B. Baart and Régine P. M. Steegers-Theunissen

    Citation: Reproductive Biology and Endocrinology 2021 19:145

    Content type: Research

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  3. In mammals, germline development undergoes dramatic morphological and molecular changes and is epigenetically subject to intricate yet exquisite regulation. Which epigenetic players and how they participate in...

    Authors: Xue Jiang, Xiaoli Zhu, Yu Cheng, Muhammad Azhar, Xuemei Xing, Wenqing Li, Yuzhu Cao, Qinghua Shi and Jianqiang Bao

    Citation: Reproductive Biology and Endocrinology 2021 19:144

    Content type: Short communication

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  4. Diminished ovarian reserve (DOR) refers to a decrease in the number and quality of oocytes in the ovary, which results in a lack of sex hormones and a decline of fertility in women. DOR can potentially progres...

    Authors: Chengcheng Liang, Xiaole Zhang, Cong Qi, Hui Hu, Qinhua Zhang, Xiuxian Zhu and Yonglun Fu

    Citation: Reproductive Biology and Endocrinology 2021 19:143

    Content type: Research

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  5. Sequential embryo transfer has been proposed as a way to improve embryo implantation in women for in vitro fertilization (IVF), but the effect on pregnancy outcomes remains ambiguous. This systematic review was c...

    Authors: Jianeng Zhang, Chong Wang, Huanhuan Zhang and Yan Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:142

    Content type: Research

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  6. Caudal Type Homeobox 2 (CDX2) is a key regulator of trophectoderm formation and maintenance in preimplantation embryos. We previously demonstrated that supplementation of exogenous follistatin, during in vitro...

    Authors: Mohamed Ashry, Chunyan Yang, Sandeep K. Rajput, Joseph K. Folger, Jason G. Knott and George W. Smith

    Citation: Reproductive Biology and Endocrinology 2021 19:141

    Content type: Short communication

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  7. There has been increasing interest in the relationship between body mass index(BMI) and pregnancy outcomes, especially in women undergoing frozen embryo transfer(FET). Several observational studies have been p...

    Authors: Jiaqi Yang, Yichen He, Yiqing Wu, Dan Zhang and Hefeng Huang

    Citation: Reproductive Biology and Endocrinology 2021 19:140

    Content type: Review

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  8. Granulosa cells (GCs) in cumulus oophorus highly express follicle stimulating hormone receptor (FSHR), which is the most important mediator of both estradiol synthesis and oocyte maturation. Obese women have e...

    Authors: Nan Wang, Chenchen Si, Lan Xia, Xian Wu, Sheng Zhao, Huihui Xu, Zhide Ding and Zhihong Niu

    Citation: Reproductive Biology and Endocrinology 2021 19:139

    Content type: Research

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  9. Poor endometrial receptivity is a major factor that leads to recurrent implantation failure. However, the traditional method cannot accurately evaluate endometrial receptivity. Various studies have indicated t...

    Authors: Yuhao Zhao, Dongmei He, Hong Zeng, Jiefeng Luo, Shuang Yang, Jingjing Chen, Raed K. Abdullah and Nenghui Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:138

    Content type: Research

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  10. Poor ovarian response (POR) is among the common findings in infertile women with no significant underlying condition. The aim of this study was to investigate the intra-ovarian potential of platelet-rich plasm...

    Authors: Marzieh Farimani, Arash Nazari, Shahrzad Mohammadi and Roghayeh Anvari Aliabad

    Citation: Reproductive Biology and Endocrinology 2021 19:137

    Content type: Research

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  11. Infertility is a common complication in obese men. Oxidative stress and testicular apoptosis play critical roles in obesity-induced spermatogenesis dysfunction. It has been reported that irisin, an exercise-in...

    Authors: Yang Mu, Huang-Guan Dai, Ling-Bo Luo and Jing Yang

    Citation: Reproductive Biology and Endocrinology 2021 19:135

    Content type: Research

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  12. Insufficient migration and invasion during trophoblast epithelial-mesenchymal transition (EMT) results in the occurrence and development of preeclampsia (PE), and our previous study has screened 52 miRNAs, who...

    Authors: Meiyuan Jin, Shouying Xu, Jiayong Li, Yingyu Yao and Chao Tang

    Citation: Reproductive Biology and Endocrinology 2021 19:134

    Content type: Research

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  13. In-vitro-grow (IVG) of preantral follicles is essential for female fertility preservation, while practical approach for improvement is far from being explored. Studies have indicated that neurotrophin-4 (NT-4)...

    Authors: Yingchun Guo, Peigen Chen, Tingting Li, Lei Jia, Yi Zhou, Jiana Huang, Xiaoyan Liang, Chuanchuan Zhou and Cong Fang

    Citation: Reproductive Biology and Endocrinology 2021 19:133

    Content type: Research

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  14. Endometriosis is major gynecological disease that affects over 10% of women worldwide and 30%-50% of these women have pelvic pain, abnormal uterine bleeding and infertility. The cause of endometriosis is unkno...

    Authors: Fereshteh Esfandiari, Fereshteh Chitsazian, Masoumeh Golestan Jahromi, Raha Favaedi, Masood Bazrgar, Reza Aflatoonian, Parvaneh Afsharian, Abbas Aflatoonian and Maryam Shahhoseini

    Citation: Reproductive Biology and Endocrinology 2021 19:132

    Content type: Research

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  15. The optimal time at which to perform a frozen-thawed embryo transfer (FET) following a failed in-vitro fertilization-embryo transfer (IVF-ET) attempt remains elusive to most reproductive experts. Physicians often...

    Authors: Jing-Yan Song, Feng-Yi Dong, Li Li, Xing-Xing Zhang, Ai-Juan Wang, Yi Zhang, Dan-Dan Gao, Ji-Mei Xiao and Zhen-Gao Sun

    Citation: Reproductive Biology and Endocrinology 2021 19:131

    Content type: Research

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  16. To investigate recommendations for appropriate gestational weight gain (GWG) of Chinese females.

    Authors: Yin Sun, Zhongzhou Shen, Yongle Zhan, Yawen Wang, Shuai Ma, Suhan Zhang, Juntao Liu, Sansan Wu, Yahui Feng, Yunli Chen, Shuya Cai, Yingjie Shi, Liangkun Ma and Yu Jiang

    Citation: Reproductive Biology and Endocrinology 2021 19:130

    Content type: Research

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  17. Non-obstructive azoospermia (NOA) is the most severe form of male infertility; more than half of the NOA patients are idiopathic. Although many NOA risk genes have been detected, the genetic factors for NOA in...

    Authors: Dongdong Tang, Mingrong Lv, Yang Gao, Huiru Cheng, Kuokuo Li, Chuan Xu, Hao Geng, Guanjian Li, Qunshan Shen, Chao Wang, Xiaojin He and Yunxia Cao

    Citation: Reproductive Biology and Endocrinology 2021 19:129

    Content type: Research

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  18. Anticentromere antibody (ACA) is a member of the antinuclear antibody spectrum (ANAs) which has been speculated to be associated with subfertility. Thus, the present study aimed to investigate the induction of...

    Authors: Hanyan Liu, Yufen Zhang, Haiying Liu, Qing Huang and Ying Ying

    Citation: Reproductive Biology and Endocrinology 2021 19:127

    Content type: Research

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  19. In late December 2019, the COVID-19 pandemic caused a great threat to people’s lives worldwide. As a special category of the population, pregnant women are vulnerable during emergencies. This study was designe...

    Authors: Jingyun Wang, Yun Wang, Mei-yao He, Yi-xiao Li, Xin Cheng, Xuesong Yang, Rui-man Li and Guang Wang

    Citation: Reproductive Biology and Endocrinology 2021 19:126

    Content type: Research

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  20. Among recurrent implantation failure (RIF) patients, the rate of successful implantation remains relatively low due to the complex etiology of the condition, including maternal, embryo and immune factors. Effe...

    Authors: Zhijin Hou, Fangjie Jiang, Jie Yang, Yang Liu, Hao Zha, Xiaoling Yang, Jia Bie and Yushi Meng

    Citation: Reproductive Biology and Endocrinology 2021 19:125

    Content type: Review

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  21. A consensus has been reached on the preferred primary outcome of all infertility treatment trials, which is the cumulative live birth rate (CLBR). Some recent randomized controlled trials (RCTs) and retrospect...

    Authors: Jingwei Yang, Xiaodong Zhang, Xiaoyan Ding, Yuting Wang, Guoning Huang and Hong Ye

    Citation: Reproductive Biology and Endocrinology 2021 19:124

    Content type: Research

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  22. Various circular RNAs (circRNAs) are dysregulated in the placenta of fetal growth restriction (FGR) fetuses, but their roles and regulatory mechanisms have not been fully elucidated. Herein, we aimed to elucid...

    Authors: Hui Wang, Caiqun Luo, Xiaoxia Wu, Jianming Zhang, Zhiyong Xu, Yang Liu, Bohong Li, Jing Li and Jiansheng Xie

    Citation: Reproductive Biology and Endocrinology 2021 19:123

    Content type: Research

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  23. Polycystic ovary syndrome (PCOS) is a neuroendocrine heterogeneous disease that frequently occurs in women of reproductive age, causing serious damage to the fertility, quality of life, and physical and mental...

    Authors: Xuechun Bai, Lianwen Zheng, Dandan Li and Ying Xu

    Citation: Reproductive Biology and Endocrinology 2021 19:122

    Content type: Review

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  24. Total fertilization failure represents a particularly frustrating condition for couples undergoing in vitro fertilization. With the aim of reducing the occurrence of total fertilization failure, intracytoplasm...

    Authors: Alessio Paffoni, Marco Reschini, Valerio Pisaturo, Cristina Guarneri, Simone Palini and Paola Viganò

    Citation: Reproductive Biology and Endocrinology 2021 19:121

    Content type: Review

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  25. This study aimed to detect the effect of angiotensin receptor 1 (AT1) knock out (KO) on spermatogenesis and hypothalamic-pituitary–gonadal (HPG) axis hormone expression.

    Authors: Fangfang Zhao, Yun Zou, Hui Li, Yaheng Zhang, Xuele Liu, Xuehao Zhao, Xinyi Wu, Wenyi Fei, Ziling Xu and Xuejun Yang

    Citation: Reproductive Biology and Endocrinology 2021 19:120

    Content type: Research

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  26. Exposure to endocrine-disrupting chemicals, such as Bisphenol A (BPA) and Bisphenol S (BPS), is widespread and has negative implications on embryonic development. Preliminary evidence revealed that in women un...

    Authors: Angela Christina Saleh, Reem Sabry, Gabriela Fabiana Mastromonaco and Laura Alessandra Favetta

    Citation: Reproductive Biology and Endocrinology 2021 19:119

    Content type: Research

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  27. Fertility-sparing therapy is an alternative conservative treatment for patients with early stage endometrioid cancer or atypical endometrial hyperplasia. In this study, we investigated pregnancy outcomes and p...

    Authors: Yuan Fan, Xingchen Li, Jiaqi Wang, Yiqin Wang, Li Tian and Jianliu Wang

    Citation: Reproductive Biology and Endocrinology 2021 19:118

    Content type: Research

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  28. Which fertilization method, between ICSI and IVF in split insemination treatments, has the highest clinical efficiency in producing clinically usable blastocyst?

    Authors: Sandrine Chamayou, Carmen Ragolia, Carmelita Alecci, Giorgia Storaci, Simona Romano, Roberta Sapienza, Elena Maglia, Annalisa Liprino, Clementina Cardea, Michele Fichera and Antonino Guglielmino

    Citation: Reproductive Biology and Endocrinology 2021 19:116

    Content type: Research

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  29. The period of time when the embryo and the endometrium undergo significant morphological alterations to facilitate a successful implantation—known as “window of implantation”—is a critical moment in human repr...

    Authors: Kasun Godakumara, James Ord, Freddy Lättekivi, Keerthie Dissanayake, Janeli Viil, Nageswara Rao Boggavarapu, Omid R Faridani, Kersti Jääger, Agne Velthut-Meikas, Ülle Jaakma, Andres Salumets and Alireza Fazeli

    Citation: Reproductive Biology and Endocrinology 2021 19:115

    Content type: Research

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  30. The immune mechanism was shown to be involved in the development of adenomyosis. The aim of the current study was to evaluate the expression of the immune checkpoints B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyos...

    Authors: Xiaoyan Qin, Wenjing Sun, Chong Wang, Mingjiang Li, Xingbo Zhao, Changzhong Li and Hui Zhang

    Citation: Reproductive Biology and Endocrinology 2021 19:114

    Content type: Research

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  31. Premature ovarian failure (POF) is a common disease in the field of Gynecology. Low intensity pulsed ultrasound (LIPUS) can promote tissue repair and improve function. This study was performed to determine the...

    Authors: Haopeng Xu, Yi Xia, Juan Qin, Jie Xu, Chongyan Li and Yan Wang

    Citation: Reproductive Biology and Endocrinology 2021 19:113

    Content type: Research

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  32. The tumor susceptibility gene 101 (Tsg101), a component of the endosomal sorting complex required for transport (ESCRT) complex I, is involved in multiple biological processes involving endomembranous structur...

    Authors: Hyunji Byun, Sojung Kwon, Kay-Uwe Wagner, Hyejin Shin and Hyunjung Jade Lim

    Citation: Reproductive Biology and Endocrinology 2021 19:112

    Content type: Research

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  33. Endometriosis is a benign gynecological disease that shares some characteristics with malignant tumors and affects approximately 10% of women of reproductive age. Endometrioma refers to endometriosis that appe...

    Authors: Yang Liu, Junyan Ma, Liqi Zhang, Jun Lin and Xiaohua Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:111

    Content type: Research

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  34. Until 2010, the National Assisted Reproductive Technology Surveillance System (NASS) report, published annually by the Center for Disease Control and Prevention (CDC), demonstrated almost constantly improving ...

    Authors: Norbert Gleicher, Lyka Mochizuki and David H. Barad

    Citation: Reproductive Biology and Endocrinology 2021 19:110

    Content type: Research

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  35. Morphological features are the most common criteria used to select human embryos for transfer to a receptive uterine cavity. However, such characteristics are not valid for embryos in cellular arrest. Even ane...

    Authors: Ricardo Josué Acuña-González, Mercedes Olvera-Valencia, Jorge Skiold López-Canales, Jair Lozano-Cuenca, Mauricio Osorio-Caballero and Héctor Flores-Herrera

    Citation: Reproductive Biology and Endocrinology 2021 19:109

    Content type: Research

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  36. The mechanism of recurrent implantation failure (RIF) is unclear at present and poor endometrial receptivity may be one of the leading reasons. This study aims to construct a competing endogenous RNA (ceRNA) n...

    Authors: Jialyu Huang, Ning Song, Leizhen Xia, Lifeng Tian, Jun Tan, Qianqian Chen, Jing Zhu and Qiongfang Wu

    Citation: Reproductive Biology and Endocrinology 2021 19:108

    Content type: Research

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  37. Heat stress (HS) occurs when body heat accumulation exceeds heat dissipation and is associated with swine seasonal infertility. HS contributes to compromised oocyte integrity and reduced embryo development. Au...

    Authors: Benjamin J. Hale, Yunsheng Li, Malavika K. Adur, Aileen F. Keating, Lance H. Baumgard and Jason W. Ross

    Citation: Reproductive Biology and Endocrinology 2021 19:107

    Content type: Research

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  38. Uterine leiomyoma is a benign tumor with unclear pathogenesis and inaccurate treatment. This tumor exhibits altered DNA methylation related to disease progression. DNMT inhibitors as 5-aza-2′-deoxycytidine (5-...

    Authors: María Cristina Carbajo-García, Ana Corachán, Marina Segura-Benitez, Javier Monleón, Julia Escrig, Amparo Faus, Antonio Pellicer, Irene Cervelló and Hortensia Ferrero

    Citation: Reproductive Biology and Endocrinology 2021 19:106

    Content type: Research

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  39. It has been previously demonstrated that cholesterol content and cholesterol/phospholipid ratio were significantly higher in asthenozoospermia and oligoasthenoteratozoospermia. The majority of published studie...

    Authors: Shuqiang Chen, Ming Wang, Li Li, Jun Wang, Xuhui Ma, Hengde Zhang, Yang Cai, Bin Kang, Jianlei Huang and Bo Li

    Citation: Reproductive Biology and Endocrinology 2021 19:105

    Content type: Research

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  40. Structural and physiological changes in sperm and semen parameters reduce fertility in diabetic patients. Securigera Securidaca (S. Securidaca) seed is a herbal medicine with hypoglycemic, antioxidant, and anti-h...

    Authors: Mohammad Babaei, Shahin Alizadeh-Fanalou, Alireza Nourian, Sahar Yarahmadi, Navid Farahmandian, Mohsen Nabi-Afjadi, Iraj Alipourfard and Elham Bahreini

    Citation: Reproductive Biology and Endocrinology 2021 19:104

    Content type: Research

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  41. Various luteal phase supports (LPSs) have been proven to increase the pregnancy rate in fresh cycles of in vitro fertilization or intracytoplasmic sperm injection; however, there is still significant debate re...

    Authors: Hanglin Wu, Songying Zhang, Xiaona Lin, Shasha Wang and Ping Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:103

    Content type: Review

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  42. Evaluate the effects of vitamin D3 (VD3) on sperm parameters and endocrine markers in infertile men with asthenozoospermia.

    Authors: Leila Maghsoumi-Norouzabad, Ahmad Zare Javid, Anahita Mansoori, Mohammadreza Dadfar and Amirarsalan Serajian

    Citation: Reproductive Biology and Endocrinology 2021 19:102

    Content type: Research

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  43. Human Ectopic Pregnancy (hEP) is the second most common cause of pregnancy-related deaths in the first trimester. Without timely detection, EPs can lead to an increased rate of infertility and an elevated risk...

    Authors: Wen Cai, Liu Yang, Ruiqing Zhang, Yixia Yang, Shuangdi Li and Jiarong Zhang

    Citation: Reproductive Biology and Endocrinology 2021 19:101

    Content type: Research

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  44. Preeclampsia (PE) is an idiopathic disease that occurs during pregnancy. It comprises multiple organ and system damage, and can seriously threaten the safety of the mother and infant throughout the perinatal p...

    Authors: Ningxia Sun, Shiting Qin, Lu Zhang and Shiguo Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:100

    Content type: Review

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  45. The gonadotropin-releasing hormone (GnRH) antagonist protocol for in vitro fertilization (IVF) often leads to lower pregnancy rates compared to the GnRH agonist protocol. Decreased endometrial receptivity is o...

    Authors: Dan Zhang, Mi Han, Mingjuan Zhou, Mengyu Liu, Yan Li, Bufang Xu and Aijun Zhang

    Citation: Reproductive Biology and Endocrinology 2021 19:99

    Content type: Research

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  46. The KIDScore™ Day 5 (KS-D5) model, version 3, is a general morphokinetic prediction model (Vitrolife, Sweden) for fetal heartbeat prediction after embryo transfer that was developed based on a large data set t...

    Authors: Keiichi Kato, Satoshi Ueno, Jørgen Berntsen, Motoki Ito, Kiyoe Shimazaki, Kazuo Uchiyama and Tadashi Okimura

    Citation: Reproductive Biology and Endocrinology 2021 19:98

    Content type: Research

    Published on:

  47. Recent years have seen a rising incidence of male infertility, mostly caused by the decline of sperm quality. The ratio of infertile males to infertile females has escalated from 3:7 in 2013 to current 5:5, wh...

    Authors: Kang-Sheng Liu, Xiao-Dong Mao, Feng Pan and Rui Fang An

    Citation: Reproductive Biology and Endocrinology 2021 19:97

    Content type: Research

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