Articles

The ameliorative effect of ellagic acid on di-(2-ethylhexyl) phthalate-induced testicular structural alterations, oxidative stress, inflammation and sperm damages in adult mice

Phthalates such as di (2-ethylhexyl) phthalate (DEHP) are well known exogenous substances, disrupting reproductive system function and structure. The current research demonstrated the effect of ellagic acid (E...

Authors: Azam Hosseinzadeh, Saeed Mehrzadi, Amir Siahpoosh, Zahra Basir, Nosrat Bahrami and Mehdi Goudarzi

Higher preconceptional maternal body mass index is associated with faster early preimplantation embryonic development: the Rotterdam periconception cohort

Overweight and obesity affect millions of people globally, which has also serious implications for reproduction. For example, treatment outcomes after in vitro fertilisation (IVF) are worse in women with a hig...

Authors: Linette van Duijn, Melek Rousian, Jeffrey Hoek, Sten P. Willemsen, Eva S. van Marion, Joop S. E. Laven, Esther B. Baart and Régine P. M. Steegers-Theunissen

The Spin1 interactor, Spindoc, is dispensable for meiotic division, but essential for haploid spermatid development in mice

In mammals, germline development undergoes dramatic morphological and molecular changes and is epigenetically subject to intricate yet exquisite regulation. Which epigenetic players and how they participate in...

Authors: Xue Jiang, Xiaoli Zhu, Yu Cheng, Muhammad Azhar, Xuemei Xing, Wenqing Li, Yuzhu Cao, Qinghua Shi and Jianqiang Bao

UHPLC-MS-MS analysis of oxylipins metabolomics components of follicular fluid in infertile individuals with diminished ovarian reserve

Diminished ovarian reserve (DOR) refers to a decrease in the number and quality of oocytes in the ovary, which results in a lack of sex hormones and a decline of fertility in women. DOR can potentially progres...

Authors: Chengcheng Liang, Xiaole Zhang, Cong Qi, Hui Hu, Qinhua Zhang, Xiuxian Zhu and Yonglun Fu

Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review

Sequential embryo transfer has been proposed as a way to improve embryo implantation in women for in vitro fertilization (IVF), but the effect on pregnancy outcomes remains ambiguous. This systematic review was c...

Authors: Jianeng Zhang, Chong Wang, Huanhuan Zhang and Yan Zhou

Follistatin supplementation induces changes in CDX2 CpG methylation and improves in vitro development of bovine SCNT preimplantation embryos

Caudal Type Homeobox 2 (CDX2) is a key regulator of trophectoderm formation and maintenance in preimplantation embryos. We previously demonstrated that supplementation of exogenous follistatin, during in vitro...

Authors: Mohamed Ashry, Chunyan Yang, Sandeep K. Rajput, Joseph K. Folger, Jason G. Knott and George W. Smith

Association between abnormal body mass index and pregnancy outcomes in patients following frozen embryo transfer: a systematic review and meta-analysis

There has been increasing interest in the relationship between body mass index(BMI) and pregnancy outcomes, especially in women undergoing frozen embryo transfer(FET). Several observational studies have been p...

Authors: Jiaqi Yang, Yichen He, Yiqing Wu, Dan Zhang and Hefeng Huang

TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids

Granulosa cells (GCs) in cumulus oophorus highly express follicle stimulating hormone receptor (FSHR), which is the most important mediator of both estradiol synthesis and oocyte maturation. Obese women have e...

Authors: Nan Wang, Chenchen Si, Lan Xia, Xian Wu, Sheng Zhao, Huihui Xu, Zhide Ding and Zhihong Niu

Expression and significance of miR-30d-5p and SOCS1 in patients with recurrent implantation failure during implantation window

Poor endometrial receptivity is a major factor that leads to recurrent implantation failure. However, the traditional method cannot accurately evaluate endometrial receptivity. Various studies have indicated t...

Authors: Yuhao Zhao, Dongmei He, Hong Zeng, Jiefeng Luo, Shuang Yang, Jingjing Chen, Raed K. Abdullah and Nenghui Liu

Evaluation of intra-ovarian platelet-rich plasma administration on oocytes-dependent variables in patients with poor ovarian response: A retrospective study according to the POSEIDON criteria

Poor ovarian response (POR) is among the common findings in infertile women with no significant underlying condition. The aim of this study was to investigate the intra-ovarian potential of platelet-rich plasm...

Authors: Marzieh Farimani, Arash Nazari, Shahrzad Mohammadi and Roghayeh Anvari Aliabad

Correction to: OTOGL, a gelforming mucin protein, is nonessential for male germ cell development and spermatogenesis in mice

Authors: Zhiming Li, Yan Zhang, Xinzong Zhang, Congcong Cao, Xiaomin Luo, Yaoting Gui, Yunge Tang and Shuiqiao Yuan

Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway

Infertility is a common complication in obese men. Oxidative stress and testicular apoptosis play critical roles in obesity-induced spermatogenesis dysfunction. It has been reported that irisin, an exercise-in...

Authors: Yang Mu, Huang-Guan Dai, Ling-Bo Luo and Jing Yang

MicroRNA-3935 promotes human trophoblast cell epithelial-mesenchymal transition through tumor necrosis factor receptor-associated factor 6/regulator of G protein signaling 2 axis

Insufficient migration and invasion during trophoblast epithelial-mesenchymal transition (EMT) results in the occurrence and development of preeclampsia (PE), and our previous study has screened 52 miRNAs, who...

Authors: Meiyuan Jin, Shouying Xu, Jiayong Li, Yingyu Yao and Chao Tang

Single-cell transcriptome and cell-specific network analysis reveal the reparative effect of neurotrophin-4 in preantral follicles grown in vitro

In-vitro-grow (IVG) of preantral follicles is essential for female fertility preservation, while practical approach for improvement is far from being explored. Studies have indicated that neurotrophin-4 (NT-4)...

Authors: Yingchun Guo, Peigen Chen, Tingting Li, Lei Jia, Yi Zhou, Jiana Huang, Xiaoyan Liang, Chuanchuan Zhou and Cong Fang

HOX cluster and their cofactors showed an altered expression pattern in eutopic and ectopic endometriosis tissues

Endometriosis is major gynecological disease that affects over 10% of women worldwide and 30%-50% of these women have pelvic pain, abnormal uterine bleeding and infertility. The cause of endometriosis is unkno...

Authors: Fereshteh Esfandiari, Fereshteh Chitsazian, Masoumeh Golestan Jahromi, Raha Favaedi, Masood Bazrgar, Reza Aflatoonian, Parvaneh Afsharian, Abbas Aflatoonian and Maryam Shahhoseini

Immediate versus delayed frozen embryo transfer in women following a failed IVF-ET attempt: a multicenter randomized controlled trial

The optimal time at which to perform a frozen-thawed embryo transfer (FET) following a failed in-vitro fertilization-embryo transfer (IVF-ET) attempt remains elusive to most reproductive experts. Physicians often...

Authors: Jing-Yan Song, Feng-Yi Dong, Li Li, Xing-Xing Zhang, Ai-Juan Wang, Yi Zhang, Dan-Dan Gao, Ji-Mei Xiao and Zhen-Gao Sun

Investigation of optimal gestational weight gain based on the occurrence of adverse pregnancy outcomes for Chinese women: a prospective cohort study

To investigate recommendations for appropriate gestational weight gain (GWG) of Chinese females.

Authors: Yin Sun, Zhongzhou Shen, Yongle Zhan, Yawen Wang, Shuai Ma, Suhan Zhang, Juntao Liu, Sansan Wu, Yahui Feng, Yunli Chen, Shuya Cai, Yingjie Shi, Liangkun Ma and Yu Jiang

Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is the most severe form of male infertility; more than half of the NOA patients are idiopathic. Although many NOA risk genes have been detected, the genetic factors for NOA in...

Authors: Dongdong Tang, Mingrong Lv, Yang Gao, Huiru Cheng, Kuokuo Li, Chuan Xu, Hao Geng, Guanjian Li, Qunshan Shen, Chao Wang, Xiaojin He and Yunxia Cao

Recombinant human IL-37 inhibited endometriosis development in a mouse model through increasing Th1/Th2 ratio by inducing the maturation of dendritic cells

Endometriosis is a serious reproductive and general health consequences. Recombinant human IL-37 (rhIL-37) is an inhibitor of inflammation.

Authors: Lijie Li, Zhouzhou Liao, Mingzhu Ye and Jianfa Jiang

Anticentromere antibody induced by immunization with centromere protein and Freund’s complete adjuvant may interfere with mouse early-stage embryo

Anticentromere antibody (ACA) is a member of the antinuclear antibody spectrum (ANAs) which has been speculated to be associated with subfertility. Thus, the present study aimed to investigate the induction of...

Authors: Hanyan Liu, Yufen Zhang, Haiying Liu, Qing Huang and Ying Ying

Maternal and infant outcomes during the COVID-19 pandemic: a retrospective study in Guangzhou, China

In late December 2019, the COVID-19 pandemic caused a great threat to people’s lives worldwide. As a special category of the population, pregnant women are vulnerable during emergencies. This study was designe...

Authors: Jingyun Wang, Yun Wang, Mei-yao He, Yi-xiao Li, Xin Cheng, Xuesong Yang, Rui-man Li and Guang Wang

What is the impact of granulocyte colony-stimulating factor (G-CSF) in subcutaneous injection or intrauterine infusion and during both the fresh and frozen embryo transfer cycles on recurrent implantation failure: a systematic review and meta-analysis?

Among recurrent implantation failure (RIF) patients, the rate of successful implantation remains relatively low due to the complex etiology of the condition, including maternal, embryo and immune factors. Effe...

Authors: Zhijin Hou, Fangjie Jiang, Jie Yang, Yang Liu, Hao Zha, Xiaoling Yang, Jia Bie and Yushi Meng

Cumulative live birth rates between GnRH-agonist long and GnRH-antagonist protocol in one ART cycle when all embryos transferred: real-word data of 18,853 women from China

A consensus has been reached on the preferred primary outcome of all infertility treatment trials, which is the cumulative live birth rate (CLBR). Some recent randomized controlled trials (RCTs) and retrospect...

Authors: Jingwei Yang, Xiaodong Zhang, Xiaoyan Ding, Yuting Wang, Guoning Huang and Hong Ye

Circular RNA hsa_circ_0081343 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-210-5p/DLX3 axis

Various circular RNAs (circRNAs) are dysregulated in the placenta of fetal growth restriction (FGR) fetuses, but their roles and regulatory mechanisms have not been fully elucidated. Herein, we aimed to elucid...

Authors: Hui Wang, Caiqun Luo, Xiaoxia Wu, Jianming Zhang, Zhiyong Xu, Yang Liu, Bohong Li, Jing Li and Jiansheng Xie

Research progress of endometrial receptivity in patients with polycystic ovary syndrome: a systematic review

Polycystic ovary syndrome (PCOS) is a neuroendocrine heterogeneous disease that frequently occurs in women of reproductive age, causing serious damage to the fertility, quality of life, and physical and mental...

Authors: Xuechun Bai, Lianwen Zheng, Dandan Li and Ying Xu

Should rescue ICSI be re-evaluated considering the deferred transfer of cryopreserved embryos in in-vitro fertilization cycles? A systematic review and meta-analysis

Total fertilization failure represents a particularly frustrating condition for couples undergoing in vitro fertilization. With the aim of reducing the occurrence of total fertilization failure, intracytoplasm...

Authors: Alessio Paffoni, Marco Reschini, Valerio Pisaturo, Cristina Guarneri, Simone Palini and Paola Viganò

Decreased angiotensin receptor 1 expression in ± AT1 Knockout mice testis results in male infertility and GnRH reduction

This study aimed to detect the effect of angiotensin receptor 1 (AT1) knock out (KO) on spermatogenesis and hypothalamic-pituitary–gonadal (HPG) axis hormone expression.

Authors: Fangfang Zhao, Yun Zou, Hui Li, Yaheng Zhang, Xuele Liu, Xuehao Zhao, Xinyi Wu, Wenyi Fei, Ziling Xu and Xuejun Yang

BPA and BPS affect the expression of anti-Mullerian hormone (AMH) and its receptor during bovine oocyte maturation and early embryo development

Exposure to endocrine-disrupting chemicals, such as Bisphenol A (BPA) and Bisphenol S (BPS), is widespread and has negative implications on embryonic development. Preliminary evidence revealed that in women un...

Authors: Angela Christina Saleh, Reem Sabry, Gabriela Fabiana Mastromonaco and Laura Alessandra Favetta

Analysis of pregnancy-associated factors after fertility-sparing therapy in young women with early stage endometrial cancer or atypical endometrial hyperplasia

Fertility-sparing therapy is an alternative conservative treatment for patients with early stage endometrioid cancer or atypical endometrial hyperplasia. In this study, we investigated pregnancy outcomes and p...

Authors: Yuan Fan, Xingchen Li, Jiaqi Wang, Yiqin Wang, Li Tian and Jianliu Wang

Correction to: Status of racial disparities between black and white women undergoing assisted reproductive technology in the US

Authors: David B. Seifer, Burcin Simsek, Ethan Wantman and Alexander M. Kotlyar

More blastocysts are produced from fewer oocytes in ICSI  compared to IVF – results from a sibling oocytes study and definition of a new key performance indicator

Which fertilization method, between ICSI and IVF in split insemination treatments, has the highest clinical efficiency in producing clinically usable blastocyst?

Authors: Sandrine Chamayou, Carmen Ragolia, Carmelita Alecci, Giorgia Storaci, Simona Romano, Roberta Sapienza, Elena Maglia, Annalisa Liprino, Clementina Cardea, Michele Fichera and Antonino Guglielmino

Trophoblast derived extracellular vesicles specifically alter the transcriptome of endometrial cells and may constitute a critical component of embryo-maternal communication

The period of time when the embryo and the endometrium undergo significant morphological alterations to facilitate a successful implantation—known as “window of implantation”—is a critical moment in human repr...

Authors: Kasun Godakumara, James Ord, Freddy Lättekivi, Keerthie Dissanayake, Janeli Viil, Nageswara Rao Boggavarapu, Omid R Faridani, Kersti Jääger, Agne Velthut-Meikas, Ülle Jaakma, Andres Salumets and Alireza Fazeli

Mifepristone inhibited the expression of B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyosis

The immune mechanism was shown to be involved in the development of adenomyosis. The aim of the current study was to evaluate the expression of the immune checkpoints B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyos...

Authors: Xiaoyan Qin, Wenjing Sun, Chong Wang, Mingjiang Li, Xingbo Zhao, Changzhong Li and Hui Zhang

Effects of low intensity pulsed ultrasound on expression of B-cell lymphoma-2 and BCL2-Associated X in premature ovarian failure mice induced by 4-vinylcyclohexene diepoxide

Premature ovarian failure (POF) is a common disease in the field of Gynecology. Low intensity pulsed ultrasound (LIPUS) can promote tissue repair and improve function. This study was performed to determine the...

Authors: Haopeng Xu, Yi Xia, Juan Qin, Jie Xu, Chongyan Li and Yan Wang

Tumor susceptibility gene 101 is required for the maintenance of uterine epithelial cells during embryo implantation

The tumor susceptibility gene 101 (Tsg101), a component of the endosomal sorting complex required for transport (ESCRT) complex I, is involved in multiple biological processes involving endomembranous structur...

Authors: Hyunji Byun, Sojung Kwon, Kay-Uwe Wagner, Hyejin Shin and Hyunjung Jade Lim

Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway

Endometriosis is a benign gynecological disease that shares some characteristics with malignant tumors and affects approximately 10% of women of reproductive age. Endometrioma refers to endometriosis that appe...

Authors: Yang Liu, Junyan Ma, Liqi Zhang, Jun Lin and Xiaohua Liu

Time associations between U.S. birth rates and add-Ons to IVF practice between 2005–2016

Until 2010, the National Assisted Reproductive Technology Surveillance System (NASS) report, published annually by the Center for Disease Control and Prevention (CDC), demonstrated almost constantly improving ...

Authors: Norbert Gleicher, Lyka Mochizuki and David H. Barad

MiR-191-5p is upregulated in culture media of implanted human embryo on day fifth of development

Morphological features are the most common criteria used to select human embryos for transfer to a receptive uterine cavity. However, such characteristics are not valid for embryos in cellular arrest. Even ane...

Authors: Ricardo Josué Acuña-González, Mercedes Olvera-Valencia, Jorge Skiold López-Canales, Jair Lozano-Cuenca, Mauricio Osorio-Caballero and Héctor Flores-Herrera

Construction of lncRNA-related competing endogenous RNA network and identification of hub genes in recurrent implantation failure

The mechanism of recurrent implantation failure (RIF) is unclear at present and poor endometrial receptivity may be one of the leading reasons. This study aims to construct a competing endogenous RNA (ceRNA) n...

Authors: Jialyu Huang, Ning Song, Leizhen Xia, Lifeng Tian, Jun Tan, Qianqian Chen, Jing Zhu and Qiongfang Wu

Characterization of the effects of heat stress on autophagy induction in the pig oocyte

Heat stress (HS) occurs when body heat accumulation exceeds heat dissipation and is associated with swine seasonal infertility. HS contributes to compromised oocyte integrity and reduced embryo development. Au...

Authors: Benjamin J. Hale, Yunsheng Li, Malavika K. Adur, Aileen F. Keating, Lance H. Baumgard and Jason W. Ross

5-aza-2′-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/β-catenin pathway in human uterine leiomyomas

Uterine leiomyoma is a benign tumor with unclear pathogenesis and inaccurate treatment. This tumor exhibits altered DNA methylation related to disease progression. DNMT inhibitors as 5-aza-2′-deoxycytidine (5-...

Authors: María Cristina Carbajo-García, Ana Corachán, Marina Segura-Benitez, Javier Monleón, Julia Escrig, Amparo Faus, Antonio Pellicer, Irene Cervelló and Hortensia Ferrero

High-coverage targeted lipidomics revealed dramatic lipid compositional changes in asthenozoospermic spermatozoa and inverse correlation of ganglioside GM3 with sperm motility

It has been previously demonstrated that cholesterol content and cholesterol/phospholipid ratio were significantly higher in asthenozoospermia and oligoasthenoteratozoospermia. The majority of published studie...

Authors: Shuqiang Chen, Ming Wang, Li Li, Jun Wang, Xuhui Ma, Hengde Zhang, Yang Cai, Bin Kang, Jianlei Huang and Bo Li

Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide

Structural and physiological changes in sperm and semen parameters reduce fertility in diabetic patients. Securigera Securidaca (S. Securidaca) seed is a herbal medicine with hypoglycemic, antioxidant, and anti-h...

Authors: Mohammad Babaei, Shahin Alizadeh-Fanalou, Alireza Nourian, Sahar Yarahmadi, Navid Farahmandian, Mohsen Nabi-Afjadi, Iraj Alipourfard and Elham Bahreini

Luteal phase support for in vitro fertilization/intracytoplasmic sperm injection fresh cycles: a systematic review and network meta-analysis

Various luteal phase supports (LPSs) have been proven to increase the pregnancy rate in fresh cycles of in vitro fertilization or intracytoplasmic sperm injection; however, there is still significant debate re...

Authors: Hanglin Wu, Songying Zhang, Xiaona Lin, Shasha Wang and Ping Zhou

The effects of Vitamin D3 supplementation on Spermatogram and endocrine factors in asthenozoospermia infertile men: a randomized, triple blind, placebo-controlled clinical trial

Evaluate the effects of vitamin D3 (VD3) on sperm parameters and endocrine markers in infertile men with asthenozoospermia.

Authors: Leila Maghsoumi-Norouzabad, Ahmad Zare Javid, Anahita Mansoori, Mohammadreza Dadfar and Amirarsalan Serajian

Abnormally increased DNA methylation in chorionic tissue might play an important role in development of ectopic pregnancy

Human Ectopic Pregnancy (hEP) is the second most common cause of pregnancy-related deaths in the first trimester. Without timely detection, EPs can lead to an increased rate of infertility and an elevated risk...

Authors: Wen Cai, Liu Yang, Ruiqing Zhang, Yixia Yang, Shuangdi Li and Jiarong Zhang

Roles of noncoding RNAs in preeclampsia

Preeclampsia (PE) is an idiopathic disease that occurs during pregnancy. It comprises multiple organ and system damage, and can seriously threaten the safety of the mother and infant throughout the perinatal p...

Authors: Ningxia Sun, Shiting Qin, Lu Zhang and Shiguo Liu

Down-regulation of S100P induces apoptosis in endometrial epithelial cell during GnRH antagonist protocol

The gonadotropin-releasing hormone (GnRH) antagonist protocol for in vitro fertilization (IVF) often leads to lower pregnancy rates compared to the GnRH agonist protocol. Decreased endometrial receptivity is o...

Authors: Dan Zhang, Mi Han, Mingjuan Zhou, Mengyu Liu, Yan Li, Bufang Xu and Aijun Zhang

Comparing prediction of ongoing pregnancy and live birth outcomes in patients with advanced and younger maternal age patients using KIDScore™ day 5: a large-cohort retrospective study with single vitrified-warmed blastocyst transfer

The KIDScore™ Day 5 (KS-D5) model, version 3, is a general morphokinetic prediction model (Vitrolife, Sweden) for fetal heartbeat prediction after embryo transfer that was developed based on a large data set t...

Authors: Keiichi Kato, Satoshi Ueno, Jørgen Berntsen, Motoki Ito, Kiyoe Shimazaki, Kazuo Uchiyama and Tadashi Okimura

Effect and mechanisms of reproductive tract infection on oxidative stress parameters, sperm DNA fragmentation, and semen quality in infertile males

Recent years have seen a rising incidence of male infertility, mostly caused by the decline of sperm quality. The ratio of infertile males to infertile females has escalated from 3:7 in 2013 to current 5:5, wh...

Authors: Kang-Sheng Liu, Xiao-Dong Mao, Feng Pan and Rui Fang An