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  1. Research

    Effect of local endometrial injury in proliferative vs. luteal phase on IVF outcomes in unselected subfertile women undergoing in vitro fertilization

    Mechanical endometrial injury prior to IVF has been suggested as a means to increase implantation rates by improving endometrial receptivity. However, the effects of endometrial injury in proliferative vs. lut...

    Wenjie Liu, Reshef Tal, He Chao, Minghui Liu and Ying Liu

    Reproductive Biology and Endocrinology 2017 15:75

    Published on: 22 September 2017

  2. Research

    In vitro progesterone production by luteinized human mural granulosa cells is modulated by activation of AMPK and cause of infertility

    Mural granulosa cells from IVF patients were provided by the West Virginia University Center for Reproductive Medicine in Morgantown, WV. The effect of adenosine monophosphate activated protein kinase (AMPK) a...

    E. C. Bowdridge, M. W. Vernon, J. A. Flores and M. J. Clemmer

    Reproductive Biology and Endocrinology 2017 15:76

    Published on: 22 September 2017

  3. Research

    A new insight into male fertility preservation for patients with completely immotile spermatozoa

    Sperm cryopreservation is the most effective method to preserve male fertility but this is normally used for motile spermatozoa. Thus, only motile spermatozoa are used for cryopreservation in most reproductive...

    Huanhua Chen, Guixue Feng, Bo Zhang, Hong Zhou, Caizhu Wang, Jinhui Shu, Xianyou Gan, Ruoyun Lin, Dongmei Huang and Yingqin Huang

    Reproductive Biology and Endocrinology 2017 15:74

    Published on: 18 September 2017

  4. Research

    Expression of factors involved in apoptosis and cell survival is correlated with enzymes synthesizing lysophosphatidic acid and its receptors in granulosa cells originating from different types of bovine ovarian follicles

    Lysophosphatidic acid (LPA) regulates reproductive processes in the cow. Ovarian granulosa cells play a pivotal role in follicle growth and development. Nevertheless, the role of LPA in the local regulation of...

    Emilia Sinderewicz, Katarzyna Grycmacher, Dorota Boruszewska, Ilona Kowalczyk-Zięba, Joanna Staszkiewicz, Tomasz Ślężak and Izabela Woclawek-Potocka

    Reproductive Biology and Endocrinology 2017 15:72

    Published on: 6 September 2017

  5. Research

    Controlled ovulation of the dominant follicle using progestin in minimal stimulation in poor responders

    The use of progestin (P) during ovarian stimulation is effective in blocking the luteinizing hormone (LH) surge in women with normal ovarian reserve, however, its effects have not been determined in poor respo...

    Qiuju Chen, Yun Wang, Lihua Sun, Shaozhen Zhang, Weiran Chai, Qingqing Hong, Hui Long, Li Wang, Qifeng Lyu and Yanping Kuang

    Reproductive Biology and Endocrinology 2017 15:71

    Published on: 5 September 2017

  6. Research

    Does daily co-administration of letrozole and gonadotropins during ovarian stimulation improve IVF outcome?

    For the last year we have been treating normal responders with gonadotropins and letrozole during the whole stimulation in order to improve response to FSH by increasing the intrafollicular androgen concentrat...

    Jigal Haas, Rawad Bassil, Jim Meriano, Nivin Samara, Eran Barzilay, Noa Gonen and Robert F. Casper

    Reproductive Biology and Endocrinology 2017 15:70

    Published on: 30 August 2017

  7. Research

    Plk1 is essential for proper chromosome segregation during meiosis I/meiosis II transition in pig oocytes

    Polo-like kinase 1 (Plk1), as a characteristic regulator in meiosis, organizes multiple biological events of cell division. Although Plk1 has been implicated in various functions in somatic cell mitotic proces...

    Zixiao Zhang, Changchao Chen, Liying Ma, Qiuchen Yu, Shuai Li, Benazir Abbasi, Jiayi Yang, Rong Rui and Shiqiang Ju

    Reproductive Biology and Endocrinology 2017 15:69

    Published on: 29 August 2017

  8. Research

    The decreased expression of TIPE2 protein in the decidua of patients with missed abortion and possible significance

    Missed abortion is a common occurrence for otherwise healthy women. Immunological factor is one of the most important reasons. Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) is a novel negative immun...

    Yingshuo Sun, Xiaoyan Wang, Yue Li, Han Sun, Lu Wan, Xishuang Wang, Lining Zhang, Zhenghui Fang and Zengtao Wei

    Reproductive Biology and Endocrinology 2017 15:68

    Published on: 29 August 2017

  9. Research

    Determining optimal gestational weight gain in the Korean population: a retrospective cohort study

    The World Health Organization (WHO) international body mass index (BMI) cut-off points defining pre-pregnancy BMI categories in the Institute of Medicine (IOM) guidelines are not directly applicable to Asians....

    Sae Kyung Choi, Guisera Lee, Yeon Hee Kim, In Yang Park, Hyun Sun Ko and Jong Chul Shin

    Reproductive Biology and Endocrinology 2017 15:67

    Published on: 22 August 2017

  10. Research

    NLRP7 contributes to in vitro decidualization of endometrial stromal cells

    Nucleotide-binding oligomerization domain (NACHT), leucine rich repeat (LRR) and pyrin domain (PYD) 7 containing protein, NLRP7, is a member of the NLR family which serves as innate immune sensors. Mutations a...

    Jyun-Yuan Huang, Pei-Hsiu Yu, Yueh-Chun Li and Pao-Lin Kuo

    Reproductive Biology and Endocrinology 2017 15:66

    Published on: 15 August 2017

  11. Review

    The Catsper channel and its roles in male fertility: a systematic review

    The Catsper channel is a sperm-specific, Ca2+-permeable, pH-dependent, and low voltage-dependent channel that is essential for the hyperactivity of sperm flagellum, chemotaxis towards the egg, capacitation and ac...

    Xiang-hong Sun, Ying-ying Zhu, Lin Wang, Hong-ling Liu, Yong Ling, Zong-li Li and Li-bo Sun

    Reproductive Biology and Endocrinology 2017 15:65

    Published on: 15 August 2017

  12. Research

    Age-associated mRNA expression changes in bovine endometrial cells in vitro

    Endometrial cells secrete various cytokines and the dysfunction of endometrial cells may directly lead to infertility. Interferon tau (IFNT) secreted by trophoblast cells, a well-known pregnancy recognition si...

    Nao Tanikawa, Ayaka Ohtsu, Ryouka Kawahara-Miki, Koji Kimura, Shuichi Matsuyama, Hisataka Iwata, Takehito Kuwayama and Koumei Shirasuna

    Reproductive Biology and Endocrinology 2017 15:63

    Published on: 14 August 2017

  13. Research

    Evaluation of the cervix tissue homogeneity by ultrasound elastography in infertile women for the prediction of embryo transfer ease: a diagnostic accuracy study

    Ultrasound elastography is a non-invasive medical imaging technique able to quantitatively characterize the stiffness of a given tissue. It has been shown to predict the risk for cervical insufficiency and pre...

    Antonio Stanziano, Anna Maria Caringella, Clementina Cantatore, Giuseppe Trojano, Ettore Caroppo and Giuseppe D’Amato

    Reproductive Biology and Endocrinology 2017 15:64

    Published on: 14 August 2017

  14. Retraction Note

    Retraction Note: Intracytoplasmic morphologically selected sperm injection versus conventional intracytoplasmic sperm injection: a randomized controlled trial

    Giovanni Battista La Sala, Alessia Nicoli, Eleonora Fornaciari, Angela Falbo, Ilaria Rondini, Daria Morini, Barbara Valli, Maria Teresa Villani and Stefano Palomba

    Reproductive Biology and Endocrinology 2017 15:62

    Published on: 11 August 2017

    The original article was published in Reproductive Biology and Endocrinology 2015 13:97

  15. Research

    A novel method to demonstrate that pregnant women with polycystic ovary syndrome hyper-expose their fetus to androgens as a possible stepping stone for the developmental theory of PCOS. A pilot study

    Polycystic ovary syndrome (PCOS), whose aetiology is unknown, is predominately a familial syndrome but confirmation of candidate genes has proved elusive. The developmental hypothesis for the origin of PCOS su...

    Roy Homburg, Anil Gudi, Amit Shah and Alison M. Layton

    Reproductive Biology and Endocrinology 2017 15:61

    Published on: 8 August 2017

  16. Short communication

    Anti-Mullerian hormone is linked to the type of early pregnancy loss in idiopathic recurrent miscarriage: a retrospective cohort study

    We correlated Anti-Mullerian hormone (AMH) levels and other parameters for ovarian reserve to the gestational age at the time of pregnancy loss in women with idiopathic recurrent miscarriage. In a retrospectiv...

    Sophie Pils, Natalia Stepien, Christine Kurz, Kazem Nouri, Regina Promberger and Johannes Ott

    Reproductive Biology and Endocrinology 2017 15:60

    Published on: 2 August 2017

  17. Research

    Testis specific histone 2B is associated with sperm chromatin dynamics and bull fertility-a pilot study

    Bull fertility is the degree of sperm’s ability to fertilize and activate the egg and support embryo development, and this is critical for herd reproductive performance. We used the bull as a unique model orga...

    Naseer A. Kutchy, Ana Velho, Erika S. B. Menezes, Marie Jacobsen, Giselle Thibaudeau, Robert W. Wills, Arlindo Moura, Abdullah Kaya, Andy Perkins and Erdogan Memili

    Reproductive Biology and Endocrinology 2017 15:59

    Published on: 1 August 2017

  18. Short Communication

    Oleic acid induces down-regulation of the granulosa cell identity marker FOXL2, and up-regulation of the Sertoli cell marker SOX9 in bovine granulosa cells

    During negative energy balance, the concentration of different fatty acids, especially of oleic acid (OA) increases in the follicular fluid of cattle. Previously, we showed that OA induced morphological, physi...

    Vengala Rao Yenuganti and Jens Vanselow

    Reproductive Biology and Endocrinology 2017 15:57

    Published on: 26 July 2017

  19. Research

    Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome

    We and others have observed that young girls predisposed to polycystic ovary syndrome (PCOS) display defective insulin sensitivity, beta-cell function and non-esterified fatty acids (NEFA) suppressibility during ...

    Soren Harnois-Leblanc, Andréanne Trottier, Samuel Leblanc, Marie-Claude Battista, David H. Geller and Jean-Patrice Baillargeon

    Reproductive Biology and Endocrinology 2017 15:56

    Published on: 24 July 2017

  20. Commentary

    Response to comment on “Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation”

    According to the literature review, CO2 insufflation on parasitic myoma implantation is not well studied, and we concur that our study is related to “Morcellation-induced parasitic myomas.” We did not compare ...

    Ben-Shian Huang, Huann-Cheng Horng, Peng-Hui Wang, Muh-Hwa Yang and Yi-Jen Chen

    Reproductive Biology and Endocrinology 2017 15:55

    Published on: 20 July 2017

  21. Commentary

    Comment on "Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation"

    The cause of contamination and dissemination of leiomyoma tissue particles and cells in the peritoneal cavity during myomectomy is a challenging issue for both clinicians and researchers. Therefore, the articl...

    Ospan A. Mynbaev, Antonio Malvasi, Sergei S. Simakov and Andrea Tinelli

    Reproductive Biology and Endocrinology 2017 15:54

    Published on: 20 July 2017

  22. Research

    Arcyriaflavin a, a cyclin D1–cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis

    We previously showed that microRNA-503 (miR-503) transfection into endometriotic cyst stromal cells (ECSCs) induced cell cycle arrest at the G0/G1 phase by suppressing cyclin D1. This finding prompted us to ev...

    Tomoko Hirakawa, Kaei Nasu, Yoko Aoyagi, Kanetoshi Takebayashi and Hisashi Narahara

    Reproductive Biology and Endocrinology 2017 15:53

    Published on: 18 July 2017

  23. Research

    Differentiating mouse embryonic stem cells express markers of human endometrium

    Modeling early endometrial differentiation is a crucial step towards understanding the divergent pathways between normal and ectopic endometrial development as seen in endometriosis.

    P. Parasar, C. R. Sacha, N. Ng, E. R. McGuirk, S. Chinthala, P. Ozcan, J. Lindsey, S. Salas, M. R. Laufer, S. A. Missmer and R. M. Anchan

    Reproductive Biology and Endocrinology 2017 15:52

    Published on: 17 July 2017

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