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  1. Ubiquitin-like modifier 1 ligating enzyme 1 (UFL1), the ligase of the UFMylation system, has recently been reported to be involved in apoptosis and endoplasmic reticulum stress (ER stress) in a variety of dise...

    Authors: Xiangting Tang, Hao Dong, Zhi Fang, Jingyi Li, Qi Yang, Ting Yao and Zezheng Pan
    Citation: Reproductive Biology and Endocrinology 2022 20:84
    Content type: Research Published on:

  2. To ascertain whether physical activity (PA) is associated with better sperm quality in sperm donors.

    Authors: Roberto Matorras, Alfredo Navarro, Dagoberto Ramos, Iker Malaina, Jon Irazusta, Alberto Vendrell, Amaia Fernandez, Marcos Ferrando and Fernando Quintana
    Citation: Reproductive Biology and Endocrinology 2022 20:83
    Content type: Research Published on:

  3. Spontaneous abortions (SA) is amongst the most common complications associated with pregnancy in humans, and the underlying causes cannot be identified in roughly half of SA cases. We found miR-135a-5p to be s...

    Authors: Yebin Lu, Xiaoli Zhang, Xueyu Li, Lingjie Deng, Changqiang Wei, Dongmei Yang, Xuemei Tan, Weicheng Pan and Lihong Pang
    Citation: Reproductive Biology and Endocrinology 2022 20:82
    Content type: Research Published on:

  4. Kisspeptin is the leading upstream regulator of pulsatile and surge Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as the key governor of the hypothalamic-pituitary-ovary axis.

    Authors: Kai-Lun Hu, Zimiao Chen, Xiaoxue Li, Enci Cai, Haiyan Yang, Yi Chen, Congying Wang, Liping Ju, Wenhai Deng and Liangshan Mu
    Citation: Reproductive Biology and Endocrinology 2022 20:81
    Content type: Review Published on:

  5. Male fertility and sperm quality are negatively affected by psychological stress. Chronic restraint stress (CRS) is a common psychological stress that has a negative effect on sperm. Betaine (BET), an active i...

    Authors: Xingqi Meng, Lixuan Peng, Jie Xu, Dongming Guo, Wenyu Cao, Yang Xu and Suyun Li
    Citation: Reproductive Biology and Endocrinology 2022 20:80
    Content type: Research Published on:

  6. Disease situations are more aggressive in patients with childhood-onset systemic lupus erythematosus (cSLE) than in those with adult-onset SLE (aSLE). However, information on pregnant women with cSLE and its a...

    Authors: Zhi-Ju Li, Hao-Yue Hu, Zi-Ling Ding, Zi-Wei Bian, Ying-Hua Xu, Hui-Ting Wen, Ya-Li Qu, Jin-Dong Wang, Xiao-Li Huang, Dong Li, Jing Li and Gui-Fang Hu
    Citation: Reproductive Biology and Endocrinology 2022 20:78
    Content type: Research Published on:

  7. Endometriosis (EMS) remains a major challenge to reproductive health due to multifactorial etiology, disease heterogeneity, and the lack of appropriate diagnostic markers and treatment. Eexosome (Exo) has beco...

    Authors: Xi Wang, Mengmeng Zhang, Liaofei Jiang, Xiaoling Fang and Tingting Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:77
    Content type: Research Published on:

  8. Studies have shown that abnormalities in the decidualization process were closely related to recurrent implantation failure (RIF). Prokineticin 2 (PK2) is a secreted protein with angiogenic and tissue remodeli...

    Authors: Jun Zhai, Linna Ma, Ziyin Chang and Ting Yu
    Citation: Reproductive Biology and Endocrinology 2022 20:76
    Content type: Research Published on:

  10. Authors: Chuan Xu, Dongdong Tang, Zhongmei Shao, Hao Geng, Yang Gao, Kuokuo Li, Qing Tan, Guanxiong Wang, Chao Wang, Huan Wu, Guanjian Li, Mingrong Lv, Xiaojin He and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:74
    Content type: Correction Published on:

    The original article was published in Reproductive Biology and Endocrinology 2022 20:41

  11. Normal motor activity of the fallopian tube is critical for human reproduction, and abnormal tubal activity may lead to ectopic pregnancy (EP) or infertility. Progesterone has an inhibitory effect on tubal con...

    Authors: Duo Zhang, Qian Zhu, Wei Xia, Chenfeng Zhu, Xiaoya Zhao, Yiqin Zhang, Chuqing He, Sifan Ji, Xiaocui Li and Jian Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:73
    Content type: Research Published on:

  12. In children, recombinant human growth hormone (rhGH) therapy for treatment of short stature has raised concerns of the early onset of puberty. Puberty is initiated by the activation of the hypothalamus-pituita...

    Authors: Yang Xu, Chang Yong Han, Mi Jung Park and Myung Chan Gye
    Citation: Reproductive Biology and Endocrinology 2022 20:72
    Content type: Research Published on:

  13. Singleton pregnancy is encouraged to reduce pregnancy complications. In addition to single embryo transfer (SET), selective and spontaneous fetal reduction (SEFR and SPFR) can also achieve singleton pregnancie...

    Authors: Chao Wang, Fei Tang, Bing Song, Guanjian Li, Qiong Xing and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:71
    Content type: Research Published on:

  14. Nicotinamide (NAM) is an important antioxidant, which is closely related to female fertility, but its role has not been clearly elucidated. The purpose of the present study was to investigate the effects of NA...

    Authors: Ziyu Guo, Jihong Yang, Guangping Yang, Ting Feng, Xinyue Zhang, Yao Chen, Ruizhi Feng and Yun Qian
    Citation: Reproductive Biology and Endocrinology 2022 20:70
    Content type: Research Published on:

  15. Authors: Shun Bai, Yuan Li, Yangyang Wan, Tonghang Guo, Qi Jin, Ran Liu, Wenjuan Tang, Meiying Sang, Yuanyuan Tao, Baoguo Xie, Yun Zhao, Wei Li, Xiangdong Xu, Qiuling Yue, Xuechun Hu and Bo Xu
    Citation: Reproductive Biology and Endocrinology 2022 20:69
    Content type: Correction Published on:

    The original article was published in Reproductive Biology and Endocrinology 2021 19:92

  16. Advanced models including time-lapse imaging and artificial intelligence technologies have been used to predict blastocyst formation. However, the conventional morphological evaluation of embryos is still wide...

    Authors: Xiaoming Jiang, Jiali Cai, Lanlan Liu, Zhenfang Liu, Wenjie Wang, Jinhua Chen, Chao Yang, Jie Geng, Caihui Ma and Jianzhi Ren
    Citation: Reproductive Biology and Endocrinology 2022 20:68
    Content type: Research Published on:

  17. Increasing evidence has shown that the mammalian target of rapamycin (mTOR) pathway plays a critical role in oocyte meiosis and embryonic development, however, previous studies reporting the effects of rapamyc...

    Authors: Qiyu Yang, Qingsong Xi, Meng Wang, Rui Long, Juan Hu, Zhou Li, Xinling Ren, Lixia Zhu and Lei Jin
    Citation: Reproductive Biology and Endocrinology 2022 20:67
    Content type: Research Published on:

  18. Authors: Jianguo Chen, Chaoran Huang, Tongtong Zhang, Wuqing Gong, Xiaofeng Deng, Hua Liu, Jinbo Liu and Yuanbiao Guo
    Citation: Reproductive Biology and Endocrinology 2022 20:66
    Content type: Correction Published on:

    The original article was published in Reproductive Biology and Endocrinology 2021 19:189

  19. Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation. As a member of the transforming growth factor β (TGF-β) superfamil...

    Authors: Hsun-Ming Chang, Long Bai, Yi-Min Zhu and Peter C. K. Leung
    Citation: Reproductive Biology and Endocrinology 2022 20:65
    Content type: Research Published on:

  20. Our previous two-dimensional electrophoresis experiment showed that the expression of LASP1 in patients with endometriosis was significantly higher than that of control endometrium. However, the molecular mech...

    Authors: Ziyu Zhang, Yaoqing Wang, Liqin Zeng, Kaihui Yu, Yuanqin Wang, Yong Luo, Faying Liu, Bicheng Yang, Yang Zou, Liqun Wang and Ouping Huang
    Citation: Reproductive Biology and Endocrinology 2022 20:64
    Content type: Research Published on:

  21. Non-obstructive azoospermia (NOA) is the most severe type of male infertility, affecting 1% of men worldwide. Most of its etiologies remain idiopathic. Although genetic studies have identified dozens of NOA ge...

    Authors: Dongdong Tang, Kuokuo Li, Hao Geng, Chuan Xu, Mingrong Lv, Yang Gao, Guanxiong Wang, Hui Yu, Zhongmei Shao, Qunshan Shen, Hui Jiang, Xiansheng Zhang, Xiaojin He and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:63
    Content type: Research Published on:

    A Correction has been published.

  22. This systematic review and meta-analysis aimed to compare the short-term reproductive and long-term obstetric outcomes after endometrial preparations by ovarian stimulation protocols and hormone replacement th...

    Authors: Yingying Zhang, Ling Wu, Tin Chiu Li, Chi Chiu Wang, Tao Zhang and Jacqueline Pui Wah Chung
    Citation: Reproductive Biology and Endocrinology 2022 20:62
    Content type: Review Published on:

  23. Microdissection testicular sperm extraction (micro-TESE) in combination with ICSI can make paternity possible for non-obstructive azoospermia (NOA) patients. Testicular sperm can be successfully retrieved in n...

    Authors: Tianwen Peng, Chen Liao, Xin Ye, Zhicong Chen, Yu Lan, Xin Fu and Geng An
    Citation: Reproductive Biology and Endocrinology 2022 20:61
    Content type: Research Published on:

  24. Density gradient centrifugation (DGC) and swim-up (SU) are the two most widely used sperm preparation methods for in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). However, existing com...

    Authors: Meng Rao, Li Tang, Longda Wang, Mengxiang Chen, Gaofeng Yan and Shuhua Zhao
    Citation: Reproductive Biology and Endocrinology 2022 20:60
    Content type: Research Published on:

  26. Endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects 10% of women of reproductive age. Ovarian endometriosis (OE) is the most common lesion in en...

    Authors: Mayuko Murakami, Satoko Osuka, Ayako Muraoka, Shotaro Hayashi, Bayasula, Yukiyo Kasahara, Reina Sonehara, Yumi Hariyama, Kanako Shinjo, Hideaki Tanaka, Natsuki Miyake, Sayako Yoshita, Natsuki Nakanishi, Tomoko Nakamura, Maki Goto and Hiroaki Kajiyama
    Citation: Reproductive Biology and Endocrinology 2022 20:58
    Content type: Research Published on:

  28. In frozen embryo transfer (FET), there is limited consensus on the best means of endometrial preparation in terms of the reproductive outcomes in women with polycystic ovary syndrome (PCOS). The present study ...

    Authors: Yue Wang, Wen-Hui Hu, Qi Wan, Tian Li, Yue Qian, Ming-Xing Chen, Xiao-Jun Tang, Qian Feng, Xiang-Qian Meng, Enoch Appiah Adu-Gyamfi, Yu-Bin Ding, Li-Hong Geng, Xing-Yu Lv and Zhao-Hui Zhong
    Citation: Reproductive Biology and Endocrinology 2022 20:56
    Content type: Research Published on:

  29. To explore the practicality and effectiveness of a flexible low-dose protocol in the fresh embryo transfer cycle: reducing the total amount of antagonist by increasing the interval between administrations of C...

    Authors: Liping Feng, Ruiqi Fan, Aifang Jiang, Junyi Jiang, Qian Wang, Yujun Sun, Pengyun Qiao, Chune Ren and Tingting Yang
    Citation: Reproductive Biology and Endocrinology 2022 20:55
    Content type: Research Published on:

  30. Both mild and conventional controlled ovarian stimulation are the frequently used protocols for poor ovarian responders. However, there are some debates about which treatment is better. Moreover, little is kno...

    Authors: Xiaoping Liu, Huisi Mai, Panyu Chen, Zhiqiang Zhang, Taibao Wu, Jianhui Chen, Peng Sun, Chuanchuan Zhou, Xiaoyan Liang and Rui Huang
    Citation: Reproductive Biology and Endocrinology 2022 20:54
    Content type: Research Published on:

  31. Despite all research efforts during this era of novel time-lapse morphokinetic parameters, a morphological grading system is still routinely being used for embryo selection at the blastocyst stage. The blastoc...

    Authors: Eva S. van Marion, Effrosyni A. Chavli, Joop S. E. Laven, Régine P. M. Steegers-Theunissen, Maria P. H. Koster and Esther B. Baart
    Citation: Reproductive Biology and Endocrinology 2022 20:53
    Content type: Research Published on:

  32. Embryo transfer is a crucial step in IVF cycle, with increasing trend during the last decade of transferring a single embryo, preferably at the blastocyst stage. Despite increasing evidence supporting Day 5 bl...

    Authors: Raoul Orvieto, Anat Jonish-Grossman, Sharon Avhar Maydan, Meirav Noach-Hirsh, Olga Dratviman-Storobinsky and Adva Aizer
    Citation: Reproductive Biology and Endocrinology 2022 20:52
    Content type: Research Published on:

  33. Demystifying the events around early pregnancy is challenging. A wide network of mediators and signaling cascades orchestrate the processes of implantation and trophoblast proliferation. Dysregulation of these...

    Authors: Elpiniki Chronopoulou, Vasiliki Koika, Konstantinos Tsiveriotis, Konstantinos Stefanidis, Sotirios Kalogeropoulos, Neoklis Georgopoulos, George Adonakis and Apostolos Kaponis
    Citation: Reproductive Biology and Endocrinology 2022 20:51
    Content type: Research Published on:

  34. The glucose-6-phosphatase catalytic subunit (G6PC) is a key enzyme that is involved in gluconeogenesis and glycogen decomposition during glycometabolism. Studies have shown that G6PC is abnormally expressed in...

    Authors: Kun Zhu, Chunling Deng, Pan Du, Taorui Liu, Junjie Piao, Yingshi Piao, Meng Yang and Liyan Chen
    Citation: Reproductive Biology and Endocrinology 2022 20:50
    Content type: Research Published on:

  35. Uterine adenomyosis is a common gynecologic disease in premenopausal women, the pathological mechanism of which remains largely unknown. The aim of this study was to identify metabolic biomarkers significantly...

    Authors: Wei Song, Zhibo Zhang, Ying Jiang, Yang Cao, Bo Zhang, Yujie Wang, Honghui Shi and Lan Zhu
    Citation: Reproductive Biology and Endocrinology 2022 20:49
    Content type: Research Published on:

  37. The purpose of this study was to investigate the effects of polycyclic aromatic hydrocarbons (PAHs) other than bisphenol A (BPA) and BPA substitutes on placental cells.

    Authors: Yun Sung Jo, Hyun Sun Ko, Ah Young Kim, Ha Gyeong Jo, Woo Jung Kim and Sae Kyung Choi
    Citation: Reproductive Biology and Endocrinology 2022 20:47
    Content type: Research Published on:

  38. This study aimed to evaluate the influences of SARS-CoV-2 infection on semen parameters and investigate the impact of the infection on in vitro fertilization (IVF) outcomes.

    Authors: Meng Wang, Juan Hu, Bo Huang, Qiyu Yang, Sibo Liu, Zhou Li, Liu Yang, Qingsong Xi, Lixia Zhu and Lei Jin
    Citation: Reproductive Biology and Endocrinology 2022 20:46
    Content type: Research Published on:

  39. Diabetes mellitus (DM), a high incidence metabolic disease, is related to the impairment of male spermatogenic function. Spermidine (SPM), one of the biogenic amines, was identified from human seminal plasma a...

    Authors: Jin-Yuan Wang, Duo Ma, Min Luo, Yong-Peng Tan, Ou Zhong, Ge Tian, Yong-Ting Lv, Mei-Xiang Li, Xi Chen, Zhi-Han Tang, Lin-Lin Hu and Xiao-Can Lei
    Citation: Reproductive Biology and Endocrinology 2022 20:45
    Content type: Research Published on:

  40. The protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway regulates early follicular activation and follicular pool maintenance in female germline cells. Fragile X mental retardation 1 (FM...

    Authors: Julia Rehnitz, Birgitta Messmer, Ulrike Bender, Xuan Phuoc Nguyen, Ariane Germeyer, Katrin Hinderhofer, Thomas Strowitzki and Edison Capp
    Citation: Reproductive Biology and Endocrinology 2022 20:44
    Content type: Research Published on:

  41. The heavy metal cadmium is proposed to be one of the environmental endocrine disruptors of spermatogenesis. Cadmium-induced inhibition of spermatogenesis is associated with a hormone secretion disorder. Letroz...

    Authors: Yao Yao, Yangyang Wan, Xiaoyun Shi, Lan Guo, Hui Jiang, Xiansheng Zhang, Bo Xu and Juan Hua
    Citation: Reproductive Biology and Endocrinology 2022 20:43
    Content type: Research Published on:

  42. Bone morphogenetic protein 15 (BMP15) is expressed in oocytes and plays a crucial role in the reproduction of mono-ovulating species. In humans, BMP15 gene mutations lead to imperfect protein function and prematu...

    Authors: Fatemeh Afkhami, Shirin Shahbazi, Laya Farzadi and Shahla Danaei
    Citation: Reproductive Biology and Endocrinology 2022 20:42
    Content type: Research Published on:

  43. Multiple morphological abnormalities of the sperm flagella (MMAF) is a subtype of severe asthenoteratozoospermia with poorly understood genetic etiology. SPAG6 is a core axonemal component that plays a critica...

    Authors: Chuan Xu, Dongdong Tang, Zhongmei Shao, Hao Geng, Yang Gao, Kuokuo Li, Qing Tan, Guanxiong Wang, Chao Wang, Huan Wu, Guanjian Li, Mingrong Lv, Xiaojin He and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:41
    Content type: Research Published on:

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2022 20:74

  44. The use of frozen embryo transfer in assisted reproductive technology (ART) has steadily increased since development in the early 1980’s. While there are many benefits to delayed frozen embryo transfer, certai...

    Authors: Jacqueline C. Lee, Martina L. Badell and Jennifer F. Kawwass
    Citation: Reproductive Biology and Endocrinology 2022 20:40
    Content type: Review Published on:

  45. Premature ovarian failure (POF) is a serious problem for young women who receive chemotherapy, and its pathophysiological basis is the dysfunction of granulosa cells. According to previous reports, menstrual-d...

    Authors: Rongli Wang, Wei Wang, Lijun Wang, Linnan Yuan, Feiyan Cheng, Xin Guan, Nini Zheng and Xinyuan Yang
    Citation: Reproductive Biology and Endocrinology 2022 20:39
    Content type: Research Published on:

  46. Preeclampsia (PE), a pregnancy disorder that affects 5–7% of pregnant women, is among the primary causes for maternal and perinatal mortality. PE is believed to be associated with insufficient invasion of vill...

    Authors: Junjie Zang, Min Yan, Yan Zhang, Wei Peng, Jianxin Zuo, Huansheng Zhou, Guoqiang Gao, Min Li, Yijing Chu and Yuanhua Ye
    Citation: Reproductive Biology and Endocrinology 2022 20:38
    Content type: Research Published on:

  47. In vitro fertilization (IVF) is currently one of the most effective methods of infertility treatment. An alternative to commonly used ovarian hyperstimulation can become extracorporeal maturation of oocytes (i...

    Authors: Patrycja Strączyńska, Krzysztof Papis, Emilia Morawiec, Michał Czerwiński, Zdzisław Gajewski, Anita Olejek and Anna Bednarska-Czerwińska
    Citation: Reproductive Biology and Endocrinology 2022 20:37
    Content type: Review Published on:

  48. In early pregnancy, differentiating between a normal intrauterine pregnancy (IUP) and abnormal gestations including early pregnancy loss (EPL) or ectopic pregnancy (EP) is a major clinical challenge when ultra...

    Authors: Lynn A. Beer, Suneeta Senapati, Mary D. Sammel, Kurt T. Barnhart, Courtney A. Schreiber and David W. Speicher
    Citation: Reproductive Biology and Endocrinology 2022 20:36
    Content type: Research Published on:

  49. Ovarian tissue cryopreservation and transplantation (OTCTP) is currently the main option available to preserve fertility in prepubertal patients undergoing aggressive cancer therapy treatments. However, a majo...

    Authors: Carmen Terren, Jules Bindels, Michelle Nisolle, Agnès Noël and Carine Munaut
    Citation: Reproductive Biology and Endocrinology 2022 20:35
    Content type: Short communication Published on:

  50. Growth differentiation factor-11 (GDF-11) belongs to the transforming growth factor-β (TGF-β) superfamily. To date, the expression of GDF-11 in the ovary and its role in regulating ovarian function are complet...

    Authors: Qiongqiong Jia, Boqun Liu, Xuan Dang, Yanjie Guo, Xiaoyu Han, Tinglin Song, Jung-Chien Cheng and Lanlan Fang
    Citation: Reproductive Biology and Endocrinology 2022 20:34
    Content type: Research Published on:
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Reproductive Biology and Endocrinology

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