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  1. The endometrial luminal epithelium is the first point of attachment of embryos during implantation. Failure of embryos to firmly adhere results in implantation failure and infertility. A receptive endometrial ...

    Authors: Wei Zhou, Leilani Santos and Evdokia Dimitriadis

    Citation: Reproductive Biology and Endocrinology 2020 18:66

    Content type: Research

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  2. Nicotine, a pharmacologically active component of tobacco adversely affects the male reproductive system and fertility whereas icariin (ICA), the main active ingredient in Epimedium herba has been used in the tre...

    Authors: Guochao Ni, Xuhui Zhang, Seth Yaw Afedo and Rong Rui

    Citation: Reproductive Biology and Endocrinology 2020 18:65

    Content type: Research

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  3. Recent developments in organoid technology are revolutionizing our knowledge about the biology, physiology, and function of various organs. Female reproductive biology and medicine also benefit from this techn...

    Authors: Heidar Heidari-Khoei, Fereshteh Esfandiari, Mohammad Amin Hajari, Zeynab Ghorbaninejad, Abbas Piryaei and Hossein Baharvand

    Citation: Reproductive Biology and Endocrinology 2020 18:64

    Content type: Review

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  4. Unexplained recurrent spontaneous abortion (URSA) is defined as two or more consecutive pregnancy losses, generally of unknown cause; it is related to a failure of fetal–maternal immunological tolerance. Regul...

    Authors: Li Luo, Xun Zeng, Zhongying Huang, Shan Luo, Lang Qin and Shangwei Li

    Citation: Reproductive Biology and Endocrinology 2020 18:62

    Content type: Research

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  5. Gestational diabetes mellitus (GDM) is the most common medical complication associated with pregnancy, which may impose risks on both mother and fetus. Micro RNAs (miRNAs) and long noncoding RNAs (lncRNAs) are...

    Authors: Yan Feng, Xin Qu, Yu Chen, Qi Feng, Yinghong Zhang, Jianwei Hu and Xiaoyan Li

    Citation: Reproductive Biology and Endocrinology 2020 18:61

    Content type: Research

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  6. A majority of common metabolic diseases can result in excessive lipolysis, leading to elevated levels of non-esterified fatty acids (NEFAs) in the body fluids. In females, increased NEFA levels in the follicul...

    Authors: Vijay Simha Baddela, Arpna Sharma and Jens Vanselow

    Citation: Reproductive Biology and Endocrinology 2020 18:60

    Content type: Review

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  7. Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disease with unknown pathogenesis. However, the treatment of Diane-35 combined with metformin can improve the endocrine and ovulation of PC...

    Authors: Shun Zhang, Haoyan Tu, Jun Yao, Jianghua Le, Zhengxu Jiang, Qianqian Tang, Rongrong Zhang, Peng Huo and Xiaocan Lei

    Citation: Reproductive Biology and Endocrinology 2020 18:58

    Content type: Research

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  8. A recently published Position Statement (PS) by the Preimplantation Genetics Diagnosis International Society (PGDIS) regarding utilization of preimplantation genetic testing for aneuploidy (PGT-A) in association ...

    Authors: N. Gleicher, D. F. Albertini, D. H. Barad, H. Homer, D. Modi, M. Murtinger, P. Patrizio, R. Orvieto, S. Takahashi, A. Weghofer, S. Ziebe and N. Noyes

    Citation: Reproductive Biology and Endocrinology 2020 18:57

    Content type: Debate

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  9. Bisphenol S (BPS) is increasingly used as a replacement for bisphenol A in the manufacture of products containing polycarbonates and epoxy resins. However, further studies of BPS exposure are needed for the as...

    Authors: Hedvika Řimnáčová, Miriam Štiavnická, Jiří Moravec, Marouane Chemek, Yaroslav Kolinko, Olga García-Álvarez, Peter R. Mouton, Azalia Mariel Carranza Trejo, Tereza Fenclová, Nikola Eretová, Petr Hošek, Pavel Klein, Milena Králíčková, Jaroslav Petr and Jan Nevoral

    Citation: Reproductive Biology and Endocrinology 2020 18:56

    Content type: Research

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  10. The use of recombinant human follicle-stimulating hormone (r-hFSH) in ovarian stimulation protocols for infertility treatment in assisted reproductive technology (ART) clinical practice is well established. Mo...

    Authors: Peter Sydow, Norbert Gmeinwieser, Katrin Pribbernow, Christoph Keck and Inka Wiegratz

    Citation: Reproductive Biology and Endocrinology 2020 18:54

    Content type: Research

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  11. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Elham Ghadhanfar, Aseel Alsalem, Shaimaa Al-Kandari, Jumana Naser, Fawzi Babiker and Maie Al-Bader

    Citation: Reproductive Biology and Endocrinology 2020 18:53

    Content type: Expression of Concern

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    The Research to this article has been published in Reproductive Biology and Endocrinology 2017 15:97

  12. The major difference between a natural cycle and an artificially prepared cycle is the lack of luteinizing hormone (LH) peak in the latter. The LH/hCG receptors were identified to express in human endometrium ...

    Authors: Ling Deng, Xin Chen, Christophe Blockeel, De-Sheng Ye and Shi-Ling Chen

    Citation: Reproductive Biology and Endocrinology 2020 18:52

    Content type: Research

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  13. Gestational diabetes mellitus (GDM) is a common complication in pregnancy that poses a serious threat to the health of both mother and child. While the specific etiology and pathogenesis of this disease are no...

    Authors: Huiyan Wang, Wenbo Zhou, Guangtong She, Bin Yu and Lizhou Sun

    Citation: Reproductive Biology and Endocrinology 2020 18:51

    Content type: Research

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  14. The presence of submucous fibroids strongly impacts on IVF results, therefore, these patients should be considered for surgical or medical treatment. The aim of this study was to assess the role of Ulipristal ...

    Authors: Giuseppe Morgante, Gabriele Centini, Libera Troìa, Raoul Orvieto and Vincenzo De Leo

    Citation: Reproductive Biology and Endocrinology 2020 18:50

    Content type: Research

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  15. Cigarette smokers have a reduced risk of developing preeclampsia, possibly attributed to an increase in carbon monoxide (CO) levels. Carbon monoxide is a gasotransmitter that has been implicated in maintaining...

    Authors: Megan A. Dickson, Nichole Peterson, Karalyn E. McRae, Jessica Pudwell, Chandrakant Tayade and Graeme N. Smith

    Citation: Reproductive Biology and Endocrinology 2020 18:49

    Content type: Short communication

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  16. Decreased endometrial thickness (EMT) has been suggested to be associated with reduced birthweight of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) newborns. Considering the differences in...

    Authors: Jialyu Huang, Jiaying Lin, Xuefeng Lu, Hongyuan Gao, Ning Song, Renfei Cai and Yanping Kuang

    Citation: Reproductive Biology and Endocrinology 2020 18:48

    Content type: Research

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  17. This study investigates the effect of letrozole on hormone profiles, semen parameters, body mass index (BMI), degree of oxidative stress and sperm chromatin integrity in men with idiopathic oligo/astheno/terat...

    Authors: Leila Kooshesh, Soghra Bahmanpour, Shahriar Zeighami and Mohammad Hussain Nasr-Esfahani

    Citation: Reproductive Biology and Endocrinology 2020 18:47

    Content type: Research

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  18. The H19 long noncoding RNA (lncRNA) belongs to a highly conserved, imprinted gene cluster involved in embryonic development and growth control. We previously described a novel mechanism whereby the Anti-muller...

    Authors: Xi Xia, Martina S. Burn, Yong Chen, Cengiz Karakaya and Amanda Kallen

    Citation: Reproductive Biology and Endocrinology 2020 18:46

    Content type: Research

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  19. The prolonged lockdown of health services providing high-complexity fertility treatments –as currently recommended by many reproductive medicine entities– is detrimental for society as a whole, and infertility...

    Authors: Carlo Alviggi, Sandro C. Esteves, Raoul Orvieto, Alessandro Conforti, Antonio La Marca, Robert Fischer, Claus Y. Andersen, Klaus Bühler, Sesh K. Sunkara, Nikolaos P. Polyzos, Ida Strina, Luigi Carbone, Fabiola C. Bento, Daniela Galliano, Hakan Yarali, Lan N. Vuong…

    Citation: Reproductive Biology and Endocrinology 2020 18:45

    Content type: Commentary

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  20. This study was made to figure out, does low and high estradiol levels during in vitro fertilization (IVF) cycles have a different effect on carotid artery distensibility (Cdis), carotid artery diameter (Cdia),...

    Authors: Jonna Leppänen, Kaisa Randell, Ursula Schwab, Jussi Pihlajamäki, Leea Keski-Nisula, Tomi Laitinen and Seppo Heinonen

    Citation: Reproductive Biology and Endocrinology 2020 18:44

    Content type: Research

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  21. The blastocyst morphology provided valuable roles for predicting pregnancy and live birth, but was still not fully understood for evaluating miscarriage. The aim of this study was to explore the association be...

    Authors: Dayuan Shi, Jiawei Xu, Meixiang Zhang, Wenbin Niu, Hao Shi, Guidong Yao, Ying Li, Nan Zhang and Yingpu Sun

    Citation: Reproductive Biology and Endocrinology 2020 18:43

    Content type: Research

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  22. Follicular fluid is an important external environment for the growth and development of oocytes. A thorough identification of specific components in follicular fluid can better the existing understand of intra...

    Authors: Xingxing Zhang, Tianqi Wang, Jingyan Song, Jifeng Deng and Zhengao Sun

    Citation: Reproductive Biology and Endocrinology 2020 18:42

    Content type: Research

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  23. Patients with severe oligospermia and nonobstructive azoospermia have very limited numbers of viable sperm in their epididymal and testicular samples. Thus, cryopreservation of their sperm is performed to avoi...

    Authors: Shasha Liu and Fuping Li

    Citation: Reproductive Biology and Endocrinology 2020 18:41

    Content type: Review

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  24. The role of prostaglandin E2 (PGE2) in the successful resumption of oocyte meiosis and cumulus expansion has been well-documented. However, there remains very little information available on the influence of PGE2

    Authors: Dorota Boruszewska, Ilona Kowalczyk-Zieba, Katarzyna Suwik, Joanna Staszkiewicz-Chodor, Joanna Jaworska, Krzysztof Lukaszuk and Izabela Woclawek-Potocka

    Citation: Reproductive Biology and Endocrinology 2020 18:40

    Content type: Research

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  25. Germinal vesicle breakdown (GVBD) occurs during oocyte meiotic maturation, a period when transcriptional processes are virtually inactive. Thus, the maturing oocyte is reliant on processes such as post-transcr...

    Authors: Benjamin J. Hale, Yunsheng Li, Malavika K. Adur and Jason W. Ross

    Citation: Reproductive Biology and Endocrinology 2020 18:39

    Content type: Research

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  26. Human papillomavirus (HPV) has been considered as one of the most common sexually transmitted viruses that may be linked to unexplained infertility in men. The possible mechanisms underlying correlation betwee...

    Authors: Xiaodan Cao, Renxiong Wei, Xiaoxia Zhang, Jun Zhou, Jiangtao Lou and Yun Cui

    Citation: Reproductive Biology and Endocrinology 2020 18:38

    Content type: Review

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  27. We had previously demonstrated that vitrification reduces the levels of certain phospholipid classes, and that oocytes from aged mice show a similar lipidome alteration, even without vitrification. In the curr...

    Authors: Da-Eun Um, Hyejin Shin, Dayoung Park, Jeong Min Ahn, Jayeon Kim, Haengseok Song and Hyunjung Jade Lim

    Citation: Reproductive Biology and Endocrinology 2020 18:37

    Content type: Research

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  28. The endometrial preparation during frozen embryo transfer (FET) can be performed by natural cycle (NC), hormone replacement therapy (HRT) cycle and cycle with ovulation induction (OI). Whether different FET pr...

    Authors: Liping Zong, Peihao Liu, Liguang Zhou, Daimin Wei, Lingling Ding and Yingying Qin

    Citation: Reproductive Biology and Endocrinology 2020 18:36

    Content type: Research

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  29. The purpose of this study was to assess whether increased body mass index (BMI) negatively affects assisted reproductive technology (ART) outcomes among gestational carriers.

    Authors: Noga Fuchs Weizman, Miranda K. Defer, Janice Montbriand, Julia M. Pasquale, Adina Silver and Clifford L. Librach

    Citation: Reproductive Biology and Endocrinology 2020 18:35

    Content type: Research

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  30. Assisted reproductive technology (ART) insurance mandates resulted in improved access to infertility treatments like intracytoplasmic sperm injection (ICSI). Our objective was to examine whether ART insurance ...

    Authors: Pavel Zagadailov, David B. Seifer, He Shan, Shvetha M. Zarek and Albert L. Hsu

    Citation: Reproductive Biology and Endocrinology 2020 18:33

    Content type: Research

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  31. The interface between environmental risk factors and genetic factors could contribute to the pathogenesis of hyperandrogenism and insulin resistance in polycystic ovary syndrome (PCOS); however, the underlying...

    Authors: Junyu Zhai, Shang Li, Min Hu, Fangfang Di, Jiansheng Liu and Yanzhi Du

    Citation: Reproductive Biology and Endocrinology 2020 18:32

    Content type: Research

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  32. A number of microRNAs are aberrantly expressed in endometriosis and are involved in its pathogenesis. Our previous study demonstrated that has-miR-100-5p expression is enhanced in human endometriotic cyst stro...

    Authors: Kanetoshi Takebayashi, Kaei Nasu, Mamiko Okamoto, Yoko Aoyagi, Tomoko Hirakawa and Hisashi Narahara

    Citation: Reproductive Biology and Endocrinology 2020 18:31

    Content type: Research

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  33. Onset of spermatogenesis at puberty is critically dependent on the activity of hypothalamic-pituitary-gonadal axis and testosterone production by Leydig cells. The aim of this study was to examine whether acti...

    Authors: Alicja Kamińska, Sylwia Marek, Laura Pardyak, Małgorzata Brzoskwinia, Piotr Pawlicki, Barbara Bilińska and Anna Hejmej

    Citation: Reproductive Biology and Endocrinology 2020 18:30

    Content type: Research

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  34. Cold, an environmental factor, induces many reproductive diseases. It is known that endothelin (ET) is a potent vasoconstrictor, and cold stress can increase the expression of ET and its receptors. The cold st...

    Authors: Di Wang, Xiumei Cheng, Huimin Fang, Yanqing Ren, Xinhua Li, Weiwei Ren, Bing Xue and Cairui Yang

    Citation: Reproductive Biology and Endocrinology 2020 18:29

    Content type: Research

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  35. Chronic cyclic pelvic pain (CCPP) affects women’s quality of life and pituitary downregulation is often used for symptomatic relief. However, prolonged suppression of ovarian function is associated with menopa...

    Authors: Sallwa M. Alshehre, Sheila Duffy, Georgina Jones, William L. Ledger and Mostafa Metwally

    Citation: Reproductive Biology and Endocrinology 2020 18:28

    Content type: Research

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  36. The study aimed to investigate whether and how general and partial time intervals between processes, from human chorionic gonadotrophin (HCG) trigger to intracytoplasmic sperm injection (ICSI), affected the la...

    Authors: Yini Zhang, Yongzhuang Ma, Zishui Fang, Shiqiao Hu, Zhou Li, Lixia Zhu and Lei Jin

    Citation: Reproductive Biology and Endocrinology 2020 18:27

    Content type: Research

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  37. We have previously shown that hsa-miR-423-5p expression in ovarian granulosa cells is decreased in high ovarian response populations. The objective of the present study was to find the target gene and mechanis...

    Authors: Shi Xie, Qiong Zhang, Jing Zhao, Jie Hao, Jing Fu and Yanping Li

    Citation: Reproductive Biology and Endocrinology 2020 18:26

    Content type: Research

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  38. Type 2 diabetes touches young subjects of reproductive age in epidemic proportion. This study assesses glucose, total InsulinT, Insulin2 and insulin receptor subunits α and β in testis during mouse development...

    Authors: R.-Marc Pelletier, Hamed Layeghkhavidaki and María L. Vitale

    Citation: Reproductive Biology and Endocrinology 2020 18:25

    Content type: Research

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  39. Molecular analyses of vitamin D in a typical cycling endometrium has received minimal research attention in the reproductive field. This study was designed to assess how expression of the endometrial vitamin D...

    Authors: Jing Guo, Shan Liu, Peng Wang, Haiying Ren and Yuan Li

    Citation: Reproductive Biology and Endocrinology 2020 18:24

    Content type: Research

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  40. A limited number of publications have assessed the prevalence of hypertension (HTN) in polycystic ovary syndrome (PCOS) patients with inconclusive results. Since in general populations the occurrence of hypert...

    Authors: Mina Amiri, Fahimeh Ramezani Tehrani, Samira Behboudi-Gandevani, Razieh Bidhendi-Yarandi and Enrico Carmina

    Citation: Reproductive Biology and Endocrinology 2020 18:23

    Content type: Review

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  41. Bisphenol-A (BPA) has been reported to be associated to female infertility. Indeed, BPA has been found to be more frequently detected in infertile women thus leading to hypothesize a possible effect of BPA on ...

    Authors: Claudia Pivonello, Giovanna Muscogiuri, Antonio Nardone, Francesco Garifalos, Donatella Paola Provvisiero, Nunzia Verde, Cristina de Angelis, Alessandro Conforti, Mariangela Piscopo, Renata Simona Auriemma, Annamaria Colao and Rosario Pivonello

    Citation: Reproductive Biology and Endocrinology 2020 18:22

    Content type: Review

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  42. Considerable interest has been gathered on the relevant impact of preventable factors, including incorrect lifestyle and unhealthy habits, on female fertility. Smoking, alcohol and addictive drugs consumption ...

    Authors: Cristina de Angelis, Antonio Nardone, Francesco Garifalos, Claudia Pivonello, Andrea Sansone, Alessandro Conforti, Carla Di Dato, Felice Sirico, Carlo Alviggi, Andrea Isidori, Annamaria Colao and Rosario Pivonello

    Citation: Reproductive Biology and Endocrinology 2020 18:21

    Content type: Review

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  43. Antimullerian hormone (AMH) strongly correlates with ovarian reserve and response to controlled ovarian stimulation. Emerging data suggests that serum AMH level may also predict ART outcomes. However, AMH is c...

    Authors: Reshef Tal, Charles M. Seifer, Moisey Khanimov, David B. Seifer and Oded Tal

    Citation: Reproductive Biology and Endocrinology 2020 18:20

    Content type: Research

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  44. Several studies from the US and Europe have shown a population-level decline in serum testosterone in men from 1970’s to early 2000’s. However, to the best of our knowledge, no study examining population-level...

    Authors: Gabriel Chodick, Shdema Epstein and Varda Shalev

    Citation: Reproductive Biology and Endocrinology 2020 18:19

    Content type: Short communication

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  45. Polycystic ovarian syndrome (PCOS) is a multi-gene hereditary disorder caused by the interaction of certain gene variation with environmental factors. Previous studies have shown that vascular endothelial grow...

    Authors: Jiahui Zhao, Da Li, Huaiyun Tang and Lisha Tang

    Citation: Reproductive Biology and Endocrinology 2020 18:18

    Content type: Review

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  46. Sperm cryopreservation has been widely used in assisted reproductive technology (ART) and has resulted in millions of live births. Two principal approaches have been adopted: conventional (slow) freezing and v...

    Authors: Yong Tao, Erika Sanger, Arpornrad Saewu and Marie-Claude Leveille

    Citation: Reproductive Biology and Endocrinology 2020 18:17

    Content type: Review

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