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  2. Patients found to be poor ovarian responders (POR) are a challenging patient population for any assisted reproduction technology. Despite attempts at various controlled ovarian stimulation schemes, reproductiv...

    Authors: Yanqun Luo, Li Sun, Mei Dong, Xiqian Zhang, Li Huang, Xiulan Zhu, Yingqi Nong and Fenghua Liu

    Citation: Reproductive Biology and Endocrinology 2020 18:102

    Content type: Research

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  3. Psychological stress can cause adverse health effects in animals and humans. Accumulating evidence suggests that psychological stress in female mice is associated with ovarian developmental abnormalities accom...

    Authors: Qiu-Yue Zhai, Jun-Jie Wang, Yu Tian, Xiaofang Liu and Zhenhua Song

    Citation: Reproductive Biology and Endocrinology 2020 18:101

    Content type: Review

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  4. Trophoblast cells are required for the establishment of pregnancy and fetal development. Apoptosis is an essential feature for trophoblast invasion. Uncontrolled trophoblast apoptosis is related to some compli...

    Authors: Bin He, Qi Yue Li, Yuan Yuan Wu, Jing Ling Ruan, Xiao Ming Teng, Da Jin Li and Chuan Ling Tang

    Citation: Reproductive Biology and Endocrinology 2020 18:100

    Content type: Research

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  5. The toxic effects of ionizing radiation on the gonads have been widely recognized. Sphingosine 1-phosphate (S1P) has a protective effect on ovarian injury, and although it is known that mitochondria are involv...

    Authors: Jiahui Zhao, Shuyun Zhang, Liesong Chen, Xiaolong Liu, Haihong Su, Lili Chen, Li Yang and Hong Zhang

    Citation: Reproductive Biology and Endocrinology 2020 18:99

    Content type: Research

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  6. Human embryogenesis frequently coinciding with cell division mistakes contributing to pervasive embryonic aneuploidy/mosaicism. While embryo self-correction was elegantly demonstrated in mouse models, human st...

    Authors: Raoul Orvieto, Chen Shimon, Shlomit Rienstein, Anat Jonish-Grossman, Hagit Shani and Adva Aizer

    Citation: Reproductive Biology and Endocrinology 2020 18:98

    Content type: Research

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  7. While single embryo transfer (SET) is widely advocated, double embryo transfer (DET) remains preferable in clinical practice to improve IVF success rate, especially in poor prognosis patients with only poor qu...

    Authors: Wenjie Wang, Jiali Cai, Lanlan Liu, Yingpei Xu, Zhenfang Liu, Jinghua Chen, Xiaoming Jiang, Xiaohua Sun and Jianzhi Ren

    Citation: Reproductive Biology and Endocrinology 2020 18:97

    Content type: Research

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  9. The current evidence on the association between obesity-associated markers and semen quality, serum reproductive hormones and lipids remains inconsistent. In this study, we tested the hypothesis that, in infer...

    Authors: Jian-Xiong Ma, Bin Wang, Hai-Song Li, Xue-Juan Jiang, Jia Yu, Cai-Fei Ding and Wang-Qiang Chen

    Citation: Reproductive Biology and Endocrinology 2020 18:95

    Content type: Research

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  10. This study investigated the expression of angiopoietin-like protein 2 (ANGPTL2) in the tissues of rat models of polycystic ovary syndrome (PCOS) and its correlation with PCOS.

    Authors: Dandan Wang, Yihong Guo, Shujuan Chai, Ke Shen, Yanchun Li and Ruiqin Zhao

    Citation: Reproductive Biology and Endocrinology 2020 18:94

    Content type: Research

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  11. One of the possible male sterility risk factors are polymorphisms of Methylenetetrahydrofolate reductase (MTHFR). However, the epidemiologic investigations described inconsistent results regarding MTHFR polymorph...

    Authors: Fereshteh Aliakbari, Farkhondeh Pouresmaeili, Nahal Eshghifar, Zahra Zolghadr and Faezeh Azizi

    Citation: Reproductive Biology and Endocrinology 2020 18:93

    Content type: Review

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  12. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhaojuan Hou, Qiong Zhang, Jing Zhao, Aizhuang Xu, Aihua He, Xi Huang, Shi Xie, Jing Fu, Lan Xiao and Yanping Li

    Citation: Reproductive Biology and Endocrinology 2020 18:92

    Content type: Correction

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    The original article was published in Reproductive Biology and Endocrinology 2019 17:74

  13. Oxidative stress (OS), defined as an imbalance between excessive reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) production and antioxidant insufficiency, has been suggested to be involved...

    Authors: Yan Gong, Kun Zhang, Dongsheng Xiong, Jiajing Wei, Hao Tan and Shengfang Qin

    Citation: Reproductive Biology and Endocrinology 2020 18:91

    Content type: Research

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  14. Microdissection testicular sperm extraction (microTESE) in men with non-obstructive azoospermia (NOA) is the procedure that results in the highest number of sperm cells retrieved for in vitro fertilization (IV...

    Authors: Parviz K. Kavoussi, Brady T. West, Shu-Hung Chen, Caitlin Hunn, Melissa S. Gilkey, G. Luke Machen, Keikhosrow M. Kavoussi, Amy Esqueda, J. David Wininger and Shahryar K. Kavoussi

    Citation: Reproductive Biology and Endocrinology 2020 18:90

    Content type: Research

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  15. Successful implantation and delivery require both the functional embryo and receptive endometrium in assisted reproductive technology (ART) cycles. However, little is known about embryo-endometrial interaction...

    Authors: Hong Lv, Xiuzhu Li, Jiangbo Du, Xiufeng Ling, Feiyang Diao, Qun Lu, Shiyao Tao, Lei Huang, Shiyao Chen, Xiumei Han, Kun Zhou, Bo Xu, Xiaoyu Liu, Hongxia Ma, Yankai Xia, Hongbing Shen…

    Citation: Reproductive Biology and Endocrinology 2020 18:89

    Content type: Research

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  16. Recently a novel method based on horizontal sperm migration in injection dishes has been introduced as an additional tool for preparation of semen sample in assisted reproductive technology (ART) procedures. I...

    Authors: Domenico Baldini, Annamaria Baldini, Erica Silvestris, Giovanni Vizziello, Daniele Ferri and Damiano Vizziello

    Citation: Reproductive Biology and Endocrinology 2020 18:88

    Content type: Research

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  17. Oocyte activation inefficiency is one of the reasons for female infertility and Ca2+ functions play a critical role in the regulation of oocyte activation. We used various inhibitors of Ca2+ channels located on t...

    Authors: Feng Wang, Ang Li, Tie-Gang Meng, Le-Yun Wang, Li-Juan Wang, Yi Hou, Heide Schatten, Qing-Yuan Sun and Xiang-Hong Ou

    Citation: Reproductive Biology and Endocrinology 2020 18:87

    Content type: Research

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  18. There is a need for a reference material to support the development and ensure the quality of immunoassays for human AMH. A batch of ampoules, coded 16/190, containing lyophilised recombinant AMH was evaluated...

    Authors: Jackie Ferguson, Jason Hockley, Peter Rigsby and Chris Burns

    Citation: Reproductive Biology and Endocrinology 2020 18:86

    Content type: Research

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  19. There is a growing body of evidence on low serum vitamin-D levels and the risk of uterine leiomyomas (UL). Therefore, this systematic review and meta-analysis was conducted to investigate the association betwe...

    Authors: Ramin Mohammadi, Reza Tabrizi, Kamran Hessami, Hoda Ashari, Peyman Nowrouzi-Sohrabi, Mahnaz Hosseini-Bensenjan and Nasrin Asadi

    Citation: Reproductive Biology and Endocrinology 2020 18:85

    Content type: Review

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  20. Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cyc...

    Authors: Palak Gujral, Vishakha Mahajan, Abbey C. Lissaman and Anna P. Ponnampalam

    Citation: Reproductive Biology and Endocrinology 2020 18:84

    Content type: Review

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  22. Previous studies have shown that there is an association between FMR1 CGG repeats and ovarian dysfunction. The aim of this study is to assess the association between the number of CGG repeats in FMR1 in Chinese p...

    Authors: Ruiyi Tang and Qi Yu

    Citation: Reproductive Biology and Endocrinology 2020 18:82

    Content type: Research

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  23. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-aged women. It is reported that intrauterine exposure to hyperandrogenism may induce the development of PCOS and a...

    Authors: Changling Duan, Tianjiao Pei, Yujing Li, Qi Cao, Hanxiao Chen and Jing Fu

    Citation: Reproductive Biology and Endocrinology 2020 18:81

    Content type: Review

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  25. Chromosomal inversion was considered to have adverse effects on pregnancy outcomes through abnormal gametogenesis. The purpose of this retrospective study was to investigate whether preimplantation genetic tes...

    Authors: Yuhan Shao, Jing Li, Juanjuan Lu, Hongchang Li, Yueting Zhu, Wenjie Jiang and Junhao Yan

    Citation: Reproductive Biology and Endocrinology 2020 18:79

    Content type: Research

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  26. Premature Ovarian Insufficiency (POI) is viewed as a type of infertility in which the menopausal status occurs before the physiological age. Several therapeutic strategies have been introduced in clinic for PO...

    Authors: Shahin Ahmadian, Sepideh Sheshpari, Mohammad Pazhang, Alberto Miranda Bedate, Rahim Beheshti, Mehran Mesgari Abbasi, Mohammad Nouri, Reza Rahbarghazi and Mahdi Mahdipour

    Citation: Reproductive Biology and Endocrinology 2020 18:78

    Content type: Research

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  27. Sheep are important livestock with variant ovulation rate and fertility. Dorset sheep is a typical breed with low prolificacy, whereas Small Tail Han sheep with FecB mutation (HanBB) have hyperprolificacy. Our...

    Authors: Xiangyang Miao, Qingmiao Luo, Lingli Xie, Huijing Zhao and Xiaoyu Qin

    Citation: Reproductive Biology and Endocrinology 2020 18:77

    Content type: Research

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  28. The aim of this meta-analysis was to evaluate the effect of growth hormone (GH) supplementation in poor responders undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

    Authors: Peiwen Yang, Ruxing Wu and Hanwang Zhang

    Citation: Reproductive Biology and Endocrinology 2020 18:76

    Content type: Review

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  29. Fertility preservation is particularly challenging in young women diagnosed with hematopoietic cancers, as transplantation of cryopreserved ovarian cortex in these women carries the risk for re-introducing can...

    Authors: Ahmed Baker Alshaikh, Arvind Manikantan Padma, Matilda Dehlin, Randa Akouri, Min Jong Song, Mats Brännström and Mats Hellström

    Citation: Reproductive Biology and Endocrinology 2020 18:75

    Content type: Research

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  31. With the rapid development of whole embryo freezing technology, more and more frozen-thawed embryo transfer (FET) was used in assisted reproductive technology. However, the best FET program for elderly women h...

    Authors: Mei Dong, Li Sun, Li Huang, Yanhong Yi, Xiqian Zhang, Ying Tan, Ge Song, Liling Liu, Fu Wei and Fenghua Liu

    Citation: Reproductive Biology and Endocrinology 2020 18:73

    Content type: Research

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  32. To investigate the associations between blastocyst development and the sex ratio (male:female) among singleton live births resulting from single-blastocyst frozen embryo transfer (FET) cycles.

    Authors: Hua Lou, Na Li, Xiaoke Zhang, Ling Sun, Xingling Wang, Dayong Hao and Shihong Cui

    Citation: Reproductive Biology and Endocrinology 2020 18:72

    Content type: Research

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  33. The in vitro maturation (IVM) technique has physical and financial benefits, but a lower efficiency and outcome that is still unclear whether it is related to polycystic ovary syndrome (PCOS) itself or the IVM...

    Authors: Nagwa Elshewy, Dongmei Ji, Zhiguo Zhang, Dawei Chen, Beili Chen, Rufeng Xue, Huan Wu, Jianye Wang, Ping Zhou and Yunxia Cao

    Citation: Reproductive Biology and Endocrinology 2020 18:71

    Content type: Research

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  34. Although varicocele is considered to be one of the leading causes of male infertility, the precise mechanism underlying how varicocele leads to male infertility is not completely understood. We found the lacta...

    Authors: Wen-bin Guo, Zhen-hui Huang, Cheng Yang, Xian-yuan Lv, Hui Xia, Hu Tian, Jian-kun Yang, Qi-zhao Zhou, Ming-kun Chen, Kang-yi Xue and Cun-dong Liu

    Citation: Reproductive Biology and Endocrinology 2020 18:70

    Content type: Research

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  35. Patients with polycystic ovarian syndrome (PCOS) are associated with known alterations in mitochondria DNA copy number (mtDNA-CN). The aim of this study is to study the change in mtDNA-CN in patients with PCOS...

    Authors: Po-Kai Yang, Chia-Hong Chou, Chin-Hao Chang, Shee-Uan Chen, Hong-Nerng Ho and Mei-Jou Chen

    Citation: Reproductive Biology and Endocrinology 2020 18:69

    Content type: Research

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  36. Multiple births and first pregnancy are associated with higher preeclampsia risk. It is unknown if the transfer of multiple embryos or first embryo transfer with assisted reproductive technology (ART) is also ...

    Authors: Cynthia K. Sites, Donna Wilson, Dana Bernson, Sheree Boulet and Yujia Zhang

    Citation: Reproductive Biology and Endocrinology 2020 18:68

    Content type: Research

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  37. Poor ovarian response remains one of the biggest challenges for reproductive endocrinologists. The introduction of corifollitropin alpha (CFA) offered an alternative option to other gonadotropins for its longe...

    Authors: F. M. Fusi, L. Zanga, M. Arnoldi, S. Melis, M. Cappato, I. Candeloro and A. Di Pasqua

    Citation: Reproductive Biology and Endocrinology 2020 18:67

    Content type: Research

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  38. The endometrial luminal epithelium is the first point of attachment of embryos during implantation. Failure of embryos to firmly adhere results in implantation failure and infertility. A receptive endometrial ...

    Authors: Wei Zhou, Leilani Santos and Evdokia Dimitriadis

    Citation: Reproductive Biology and Endocrinology 2020 18:66

    Content type: Research

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  39. Nicotine, a pharmacologically active component of tobacco adversely affects the male reproductive system and fertility whereas icariin (ICA), the main active ingredient in Epimedium herba has been used in the tre...

    Authors: Guochao Ni, Xuhui Zhang, Seth Yaw Afedo and Rong Rui

    Citation: Reproductive Biology and Endocrinology 2020 18:65

    Content type: Research

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  40. Recent developments in organoid technology are revolutionizing our knowledge about the biology, physiology, and function of various organs. Female reproductive biology and medicine also benefit from this techn...

    Authors: Heidar Heidari-Khoei, Fereshteh Esfandiari, Mohammad Amin Hajari, Zeynab Ghorbaninejad, Abbas Piryaei and Hossein Baharvand

    Citation: Reproductive Biology and Endocrinology 2020 18:64

    Content type: Review

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  42. Unexplained recurrent spontaneous abortion (URSA) is defined as two or more consecutive pregnancy losses, generally of unknown cause; it is related to a failure of fetal–maternal immunological tolerance. Regul...

    Authors: Li Luo, Xun Zeng, Zhongying Huang, Shan Luo, Lang Qin and Shangwei Li

    Citation: Reproductive Biology and Endocrinology 2020 18:62

    Content type: Research

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  43. Gestational diabetes mellitus (GDM) is the most common medical complication associated with pregnancy, which may impose risks on both mother and fetus. Micro RNAs (miRNAs) and long noncoding RNAs (lncRNAs) are...

    Authors: Yan Feng, Xin Qu, Yu Chen, Qi Feng, Yinghong Zhang, Jianwei Hu and Xiaoyan Li

    Citation: Reproductive Biology and Endocrinology 2020 18:61

    Content type: Research

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  44. A majority of common metabolic diseases can result in excessive lipolysis, leading to elevated levels of non-esterified fatty acids (NEFAs) in the body fluids. In females, increased NEFA levels in the follicul...

    Authors: Vijay Simha Baddela, Arpna Sharma and Jens Vanselow

    Citation: Reproductive Biology and Endocrinology 2020 18:60

    Content type: Review

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  46. Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disease with unknown pathogenesis. However, the treatment of Diane-35 combined with metformin can improve the endocrine and ovulation of PC...

    Authors: Shun Zhang, Haoyan Tu, Jun Yao, Jianghua Le, Zhengxu Jiang, Qianqian Tang, Rongrong Zhang, Peng Huo and Xiaocan Lei

    Citation: Reproductive Biology and Endocrinology 2020 18:58

    Content type: Research

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  47. A recently published Position Statement (PS) by the Preimplantation Genetics Diagnosis International Society (PGDIS) regarding utilization of preimplantation genetic testing for aneuploidy (PGT-A) in association ...

    Authors: N. Gleicher, D. F. Albertini, D. H. Barad, H. Homer, D. Modi, M. Murtinger, P. Patrizio, R. Orvieto, S. Takahashi, A. Weghofer, S. Ziebe and N. Noyes

    Citation: Reproductive Biology and Endocrinology 2020 18:57

    Content type: Debate

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  48. Bisphenol S (BPS) is increasingly used as a replacement for bisphenol A in the manufacture of products containing polycarbonates and epoxy resins. However, further studies of BPS exposure are needed for the as...

    Authors: Hedvika Řimnáčová, Miriam Štiavnická, Jiří Moravec, Marouane Chemek, Yaroslav Kolinko, Olga García-Álvarez, Peter R. Mouton, Azalia Mariel Carranza Trejo, Tereza Fenclová, Nikola Eretová, Petr Hošek, Pavel Klein, Milena Králíčková, Jaroslav Petr and Jan Nevoral

    Citation: Reproductive Biology and Endocrinology 2020 18:56

    Content type: Research

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  50. The use of recombinant human follicle-stimulating hormone (r-hFSH) in ovarian stimulation protocols for infertility treatment in assisted reproductive technology (ART) clinical practice is well established. Mo...

    Authors: Peter Sydow, Norbert Gmeinwieser, Katrin Pribbernow, Christoph Keck and Inka Wiegratz

    Citation: Reproductive Biology and Endocrinology 2020 18:54

    Content type: Research

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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