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  1. Content type: Short communication

    Retinoids (retinol and its derivatives) are required for the development and maintenance of normal physiological functions of the ovary. However, the mechanisms underlying the regulation of ovarian retinoid ho...

    Authors: Zhuo Liu, Yongfeng Sun, Yanwen Jiang, Yuqiang Qian, Shuxiong Chen, Shan Gao, Lu Chen, Chunjin Li and Xu Zhou

    Citation: Reproductive Biology and Endocrinology 2018 16:52

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  2. Content type: Research

    Puberty is the period during a female mammal’s life when it enters estrus and ovulates for the first time; this indicates that a mammal is capable of reproduction. The onset of puberty is a complex and tightly...

    Authors: Jing Ye, Zhiqiu Yao, Wenyu Si, Xiaoxiao Gao, Chen Yang, Ya Liu, Jianping Ding, Weiping Huang, Fugui Fang and Jie Zhou

    Citation: Reproductive Biology and Endocrinology 2018 16:51

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  3. Content type: Research

    Polycystic ovary syndrome (PCOS) is a complex genetic disease with multifarious phenotypes. Many researches use dehydroepiandrosterone (DHEA) to induce PCOS in pubertal mouse models. The aim of this study was ...

    Authors: Ya-Li Yang, Li-Feng Sun, Yan Yu, Tian-Xia Xiao, Bao-Bei Wang, Pei-Gen Ren, Hui-Ru Tang and Jian V. Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:50

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  4. Content type: Research

    Male factor infertility is quite common as 30–50% of infertility cases are due to sperm defects. The high sperm DNA fragmentation is one of the causes of male factor infertility. Many factors cause sperm DNA f...

    Authors: Basmah Al Omrani, Nadia Al Eisa, Murid Javed, Maher Al Ghedan, Hamoud Al Matrafi and Hamad Al Sufyan

    Citation: Reproductive Biology and Endocrinology 2018 16:49

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  5. Content type: Research

    Pelvic endometriosis (EM) and adenomyosis (AM) have different effects on the fallopian tube. This study aimed to assess the transport capability of the fallopian tube in women with pelvic EM or AM.

    Authors: Wei Xia, Duo Zhang, Jing Ouyang, Yan Liang, Huiyu Zhang, Zhen Huang, Guiling Liang, Qian Zhu, Xiaoming Guan and Jian Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:48

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  6. Content type: Research

    MicroRNAs (MiR) may promote fibroid development via altered expression of genes involved in cell proliferation and ECM formation, and evidence supports aberrant expression of MicroRNA (MiR) 21a-5p in fibroids....

    Authors: Eden R. Cardozo, Rosemary Foster, Anatte E. Karmon, Amy E. Lee, Leah W. Gatune, Bo R. Rueda and Aaron K. Styer

    Citation: Reproductive Biology and Endocrinology 2018 16:46

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  7. Content type: Research

    Stray dogs are the reservoirs and carriers of rabies and are definitive hosts of echinococcosis. To control the overpopulation of stray dogs, zona pellucida 3 (ZP3), a primary receptor for sperm, is a potentia...

    Authors: Ying Wang, Yijie Li, Beibei Zhang and Fuchun Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:47

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  8. Content type: Review

    Besides being a risk factor for multiple metabolic disorders, obesity could affect female reproduction. While increased adiposity is associated with hormonal changes that could disrupt the function of the hypo...

    Authors: Michelle Goldsammler, Zaher Merhi and Erkan Buyuk

    Citation: Reproductive Biology and Endocrinology 2018 16:45

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  9. Content type: Research

    LepR tyrosine site mutation mice (Y123F) exhibit decreased serum E2 levels, immature reproductive organs, infertility as well as metabolic abnormalities. Although the actions of leptin and lepR in the control ...

    Authors: Xiaoyu Tu, Miao Liu, Jianan Tang, Yu Zhang, Yan Shi, Lin Yu and Zhaogui Sun

    Citation: Reproductive Biology and Endocrinology 2018 16:44

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  10. Content type: Review

    Infertility in mammalian females has been a challenge in reproductive medicine. The causes of female infertility include anovulation, ovulated oocyte defects, abnormal fertilization, and insufficient luteal su...

    Authors: Jean Damascene Niringiyumukiza, Hongcai Cai and Wenpei Xiang

    Citation: Reproductive Biology and Endocrinology 2018 16:43

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  11. Content type: Research

    The sensitivity and specificity of non-invasive diagnostic methods for endometriosis, especially at early stages, are not optimal. The clinical diagnostic indicator cancer antigen 125 (CA125) performs poorly i...

    Authors: Jingjie Li, Lihuan Guan, Huizhen Zhang, Yue Gao, Jiahong Sun, Xiao Gong, Dongshun Li, Pan Chen, Xiaoyan Liang, Min Huang and Huichang Bi

    Citation: Reproductive Biology and Endocrinology 2018 16:42

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  12. Content type: Review

    The ‘omics’ approach for a noninvasive diagnosis of male reproductive system disorders has gained momentum during the last decade, particularly from a screening and prognosis point of view. Due to the rapid de...

    Authors: Luna Samanta, Rajeshwari Parida, Tania R. Dias and Ashok Agarwal

    Citation: Reproductive Biology and Endocrinology 2018 16:41

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  13. Content type: Research

    Docosahexaenoic acid (DHA) is a n-3 polyunsaturated fatty acid (PUFA) belonging to a family of biologically active fatty acids (FA), which are known to have numerous health benefits. N-3 PUFAs affect reproduct...

    Authors: Virginie Maillard, Alice Desmarchais, Maeva Durcin, Svetlana Uzbekova and Sebastien Elis

    Citation: Reproductive Biology and Endocrinology 2018 16:40

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  14. Content type: Research

    Hatching is crucial for mammalian embryo implantation, since difficulties during this process can lead to implantation failure, ectopic pregnancy and consequent infertility. Despite years of intensive research...

    Authors: Shaoquan Zhan, Shanbo Cao, Hongzi Du, Yuan Sun, Li Li, Chenhui Ding, Haiyan Zheng and Junjiu Huang

    Citation: Reproductive Biology and Endocrinology 2018 16:39

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  15. Content type: Research

    Polycystic ovary syndrome (PCOS) is a common endocrine disorder determined by polygenic traits as well as environmental factors. Lower vitamin D levels have been detected in PCOS women and related to hormone a...

    Authors: Betânia Rodrigues Santos, Sheila Bunecker Lecke and Poli Mara Spritzer

    Citation: Reproductive Biology and Endocrinology 2018 16:38

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  16. Content type: Research

    GnRH is the master molecule of reproduction that is influenced by several intrinsic and extrinsic factors such as neurotransmitters and neuropeptides. Any alteration in these regulatory loops may result in rep...

    Authors: Nirja Chaudhari, Mitali Dawalbhakta and Laxmipriya Nampoothiri

    Citation: Reproductive Biology and Endocrinology 2018 16:37

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  17. Content type: Research

    Women with polycystic ovary syndrome are more likely to suffer from obesity, insulin resistance, and chronic low-grade inflammation. In fact, the excessive activation of monocytes exacerbates oxidative stress ...

    Authors: Akin Usta, Eyup Avci, Cagla Bahar Bulbul, Hasan Kadi and Ertan Adali

    Citation: Reproductive Biology and Endocrinology 2018 16:34

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  18. Content type: Research

    Allopregnanolone is a neurosteroid synthesized in the central nervous system independently of steroidogenic glands; it influences sexual behavior and anxiety. The aim of this work is to evaluate the indirect e...

    Authors: Joana Antonela Asensio, Antonella Rosario Ramona Cáceres, Laura Tatiana Pelegrina, María de los Ángeles Sanhueza, Leopoldina Scotti, Fernanda Parborell and Myriam Raquel Laconi

    Citation: Reproductive Biology and Endocrinology 2018 16:35

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  19. Content type: Research

    Overweight/obese women with polycystic ovary syndrome (PCOS) are at increased risk of subfertility and complications of pregnancy, compared with normal-weight women. To implement controlled ovarian hyperstimul...

    Authors: Rui Chen, Shiping Chen, Manting Liu, Hua He, Haiyan Xu, Hanyan Liu, Hongzi Du, Weihua Wang, Xuefeng Xia and Jianqiao Liu

    Citation: Reproductive Biology and Endocrinology 2018 16:36

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  20. Content type: Short communication

    Some reports show that it is possible to isolate immature oocytes from human ovarian tissue retrieved by a cortex biopsy or ovariectomy of non-stimulated ovaries and mature them in vitro. The mature oocytes ca...

    Authors: Irma Virant-Klun and Andrej Vogler

    Citation: Reproductive Biology and Endocrinology 2018 16:33

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  21. Content type: Research

    Current medical treatments for endometriosis are very limited. Progestin and selective progesterone receptor modulators (SPRM) are developed but their efficacy, safety, mechanism and recurrence in endometriosi...

    Authors: Bo Liang, Ling Wu, Hui Xu, Chun Wai Cheung, Wen Ying Fung, Sze Wai Wong and Chi Chiu Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:32

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  22. Content type: Research

    Osteopontin (OPN) plays an important role in inflammatory processes and insulin resistance. Polycystic ovary syndrome (PCOS) is a reproductive metabolic disease associated with insulin resistance and metabolic...

    Authors: Yuying Wang, Wei Zhou, Chunhua Wu, Yi Zhang, Tzuchun Lin, Yun Sun, Wei Liu and Tao Tao

    Citation: Reproductive Biology and Endocrinology 2018 16:31

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  23. Content type: Research

    Excessive nerve growth factor (NGF) is commonly found in the follicular fluid of patients with polycystic ovary syndrome (PCOS). Furthermore, oocytes from PCOS patients exhibit lower developmental competence. ...

    Authors: Yiwen Zhai, Guidong Yao, Faiza Rao, Yong Wang, Xiaoyuan Song and Fei Sun

    Citation: Reproductive Biology and Endocrinology 2018 16:28

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  24. Content type: Research

    Management of women with reduced ovarian reserve or poor ovarian response (POR) to stimulation is one of the major challenges in reproductive medicine. The primary causes of POR remain elusive and oxidative st...

    Authors: Yangying Xu, Victoria Nisenblat, Cuiling Lu, Rong Li, Jie Qiao, Xiumei Zhen and Shuyu Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:29

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  25. Content type: Research

    In search of potential early biomarkers for timely prediction of gestational diabetes mellitus (GDM), we focused on afamin, a vitamin E–binding protein in human plasma.. Afamin plays a role in anti-apoptotic c...

    Authors: Angela Köninger, Annette Mathan, Pawel Mach, Mirjam Frank, Boerge Schmidt, Ekkehard Schleussner, Rainer Kimmig, Alexandra Gellhaus and Hans Dieplinger

    Citation: Reproductive Biology and Endocrinology 2018 16:30

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  26. Content type: Research

    Ovarian retinoid homeostasis plays an important role in the physiological function of the ovary. Retinol-binding protein 4 (RBP4) acts as the mediator for the systemic and intercellular transport of retinol an...

    Authors: Yanwen Jiang, Yun Zhao, Shuxiong Chen, Lu Chen, Chunjin Li and Xu Zhou

    Citation: Reproductive Biology and Endocrinology 2018 16:25

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  27. Content type: Research

    The initiation of primate embryo invasion into the endometrium and the formation of the placenta from trophoblasts, fetal mesenchyme, and vascular components are essential for the establishment of a successful...

    Authors: T. Arthur Chang, Gennadiy I. Bondarenko, Behzad Gerami-Naini, Jessica G. Drenzek, Maureen Durning, Mark A. Garthwaite, Jenna Kropp Schmidt and Thaddeus G. Golos

    Citation: Reproductive Biology and Endocrinology 2018 16:24

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  28. Content type: Research

    Many factors may lead to sperm DNA damage. However, it is little known that the correlations of sperm DNA damage with obesity-associated markers, and reproductive hormones and lipids levels in serum and semina...

    Authors: Jin-Chun Lu, Jun Jing, Li Chen, Yi-Feng Ge, Rui-Xiang Feng, Yuan-Jiao Liang and Bing Yao

    Citation: Reproductive Biology and Endocrinology 2018 16:23

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  29. Content type: Review

    Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the ‘...

    Authors: Erica Silvestris, Giovanni de Pergola, Raffaele Rosania and Giuseppe Loverro

    Citation: Reproductive Biology and Endocrinology 2018 16:22

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  30. Content type: Research

    A suitable culture system is important for follicle growth in adult bovine ovarian tissue. This study aimed to assess the avian chorioallantoic membrane (CAM) for short-term culture of adult bovine ovarian tis...

    Authors: Kylie Beck, Jaswant Singh, Mohammad Arshud Dar and Muhammad Anzar

    Citation: Reproductive Biology and Endocrinology 2018 16:21

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  31. Content type: Research

    Cerium oxide nanoparticles (CeO2 NPs) are able to store and release oxygen, conferring them scavenger activity against oxidative stress. However, their effects in reproductive systems are not yet well understood....

    Authors: Laura Falchi, Grazia Galleri, Gian Mario Dore, Maria Teresa Zedda, Salvatore Pau, Luisa Bogliolo, Federica Ariu, Alessandra Pinna, Stefano Nieddu, Plinio Innocenzi and Sergio Ledda

    Citation: Reproductive Biology and Endocrinology 2018 16:19

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  32. Content type: Research

    The use of oral progestin has been shown to effectively prevent luteining hormone (LH) surge during ovarian stimulation with daily human menopausal gonadotropin injections. This study was aimed to investigate ...

    Authors: Chen-Yu Huang, Guan-Yeu Chen, Miawh-Lirng Shieh and Hsin-Yang Li

    Citation: Reproductive Biology and Endocrinology 2018 16:18

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  33. Content type: Research

    Maternal-fetal crosstalk during embryo implantation is complex and regulated by local signaling molecules. Chemokines and their receptors are critical signaling components required for implantation and the pro...

    Authors: Jiayi Zheng, Haiping Wang and Wenhui Zhou

    Citation: Reproductive Biology and Endocrinology 2018 16:17

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  34. Content type: Review

    Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In...

    Authors: Xiaodan Cao, Yun Cui, Xiaoxia Zhang, Jiangtao Lou, Jun Zhou, Huafeng Bei and Renxiong Wei

    Citation: Reproductive Biology and Endocrinology 2018 16:16

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  35. Content type: Research

    The LH-induced folliculo-luteal transformation is connected with alterations of the gene expression profile in cells of the granulosa layer. It has been described that hypoxic conditions occur during luteiniza...

    Authors: Anja Baufeld and Jens Vanselow

    Citation: Reproductive Biology and Endocrinology 2018 16:15

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  36. Content type: Research

    There exist contradictive views on whether the vitamin D has association with clinical outcome of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). The present meta-analysis aim to e...

    Authors: Jing Zhao, Xi Huang, Bin Xu, Yi Yan, Qiong Zhang and Yanping Li

    Citation: Reproductive Biology and Endocrinology 2018 16:13

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  37. Content type: Research

    Forkhead Transcription Factor L2 (FOXL2) is a member of the forkhead family with important roles in reproduction. Recent studies showed that FOXL2 is expressed in human and bovine endometrium and that its leve...

    Authors: Michal Elbaz, Ron Hadas, Louise M. Bilezikjian and Eran Gershon

    Citation: Reproductive Biology and Endocrinology 2018 16:12

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  38. Content type: Short communication

    Primary ciliary dyskinesia (PCD) is a rare, autosomal recessive disease with abnormalities in the structure of cilia, causing impairment of muco-ciliary clearance with respiratory tract infections, heterotaxia...

    Authors: Sinan Ozkavukcu, Ciler Celik-Ozenci, Esma Konuk and Cem Atabekoglu

    Citation: Reproductive Biology and Endocrinology 2018 16:10

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  39. Content type: Research

    Endometriosis is a known cause of infertility. Differences in immune tolerance caused by regulatory T cells (Tregs) and transforming growth factor-β (TGF-β) are thought to be involved in the pathology of endom...

    Authors: Tetsuro Hanada, Shunichiro Tsuji, Misako Nakayama, Shiro Wakinoue, Kyoko Kasahara, Fuminori Kimura, Takahide Mori, Kazumasa Ogasawara and Takashi Murakami

    Citation: Reproductive Biology and Endocrinology 2018 16:9

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  40. Content type: Research

    Cystatin C (CST3), a cysteine protease inhibitor in seminal plasma, is expressed in animal uteri. However, its expression in the human female reproductive tract and its effect on human sperm capacitation are u...

    Authors: Robert Kuo-Kuang Lee, Huan-Chin Tseng, Yuh-Ming Hwu, Chi-Chen Fan, Ming-Huei Lin, Jhih-Jie Yu, Ling-Yu Yeh and Sheng-Hsiang Li

    Citation: Reproductive Biology and Endocrinology 2018 16:8

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  41. Content type: Hypothesis

    Embryos have evolved a remarkable capacity to find implantation site. The impressive navigation ability of natural blastocysts may rely on highly sensitive signals arising from embryos and specialized signal p...

    Authors: Onder Celik, Mustafa Acet, Haldun Arpaci, Levent Dikbas, Aytac Imren, Bulent Duran, Nilufer Celik, Sudenaz Celik, Cihat Unlu, Ibrahim Sahin and Suleyman Aydin

    Citation: Reproductive Biology and Endocrinology 2018 16:7

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  42. Content type: Review

    L-carnitine (LC), and its acetylated form, acetyl L-carnitine (ALC), have immense functional capabilities to regulate the oxidative and metabolic status of the female reproductive system. The vulnerability of ...

    Authors: Ashok Agarwal, Pallav Sengupta and Damayanthi Durairajanayagam

    Citation: Reproductive Biology and Endocrinology 2018 16:5

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  43. Content type: Research

    Preimplantation genetic screening (PGS) is increasingly utilized as an adjunct procedure to IVF. Recently healthy euploid live birth were reported following transfer of mosaic embryos. Several recent publicati...

    Authors: Vitaly A. Kushnir, Sarah K. Darmon, David H. Barad and Norbert Gleicher

    Citation: Reproductive Biology and Endocrinology 2018 16:6

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  44. Content type: Research

    The etiology and pathophysiology of endometriosis remain unclear. Accumulating evidence suggests that aberrant microRNA (miRNA) and transcription factor (TF) expression may be involved in the pathogenesis and ...

    Authors: Luyang Zhao, Chenglei Gu, Mingxia Ye, Zhe Zhang, Li’an Li, Wensheng Fan and Yuanguang Meng

    Citation: Reproductive Biology and Endocrinology 2018 16:4

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  45. Content type: Review

    In recent decades, the decline in human fertility has become increasingly more worrying: while therapeutic interventions might help, they are vexing for the couple and often burdened with high failure rates an...

    Authors: Andrea Sansone, Carla Di Dato, Cristina de Angelis, Davide Menafra, Carlotta Pozza, Rosario Pivonello, Andrea Isidori and Daniele Gianfrilli

    Citation: Reproductive Biology and Endocrinology 2018 16:3

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