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  1. Anticentromere antibody (ACA) is a member of the antinuclear antibody spectrum (ANAs) which has been speculated to be associated with subfertility. Thus, the present study aimed to investigate the induction of...

    Authors: Hanyan Liu, Yufen Zhang, Haiying Liu, Qing Huang and Ying Ying

    Citation: Reproductive Biology and Endocrinology 2021 19:127

    Content type: Research

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  2. In late December 2019, the COVID-19 pandemic caused a great threat to people’s lives worldwide. As a special category of the population, pregnant women are vulnerable during emergencies. This study was designe...

    Authors: Jingyun Wang, Yun Wang, Mei-yao He, Yi-xiao Li, Xin Cheng, Xuesong Yang, Rui-man Li and Guang Wang

    Citation: Reproductive Biology and Endocrinology 2021 19:126

    Content type: Research

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  3. Among recurrent implantation failure (RIF) patients, the rate of successful implantation remains relatively low due to the complex etiology of the condition, including maternal, embryo and immune factors. Effe...

    Authors: Zhijin Hou, Fangjie Jiang, Jie Yang, Yang Liu, Hao Zha, Xiaoling Yang, Jia Bie and Yushi Meng

    Citation: Reproductive Biology and Endocrinology 2021 19:125

    Content type: Review

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  4. A consensus has been reached on the preferred primary outcome of all infertility treatment trials, which is the cumulative live birth rate (CLBR). Some recent randomized controlled trials (RCTs) and retrospect...

    Authors: Jingwei Yang, Xiaodong Zhang, Xiaoyan Ding, Yuting Wang, Guoning Huang and Hong Ye

    Citation: Reproductive Biology and Endocrinology 2021 19:124

    Content type: Research

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  5. Various circular RNAs (circRNAs) are dysregulated in the placenta of fetal growth restriction (FGR) fetuses, but their roles and regulatory mechanisms have not been fully elucidated. Herein, we aimed to elucid...

    Authors: Hui Wang, Caiqun Luo, Xiaoxia Wu, Jianming Zhang, Zhiyong Xu, Yang Liu, Bohong Li, Jing Li and Jiansheng Xie

    Citation: Reproductive Biology and Endocrinology 2021 19:123

    Content type: Research

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  6. Polycystic ovary syndrome (PCOS) is a neuroendocrine heterogeneous disease that frequently occurs in women of reproductive age, causing serious damage to the fertility, quality of life, and physical and mental...

    Authors: Xuechun Bai, Lianwen Zheng, Dandan Li and Ying Xu

    Citation: Reproductive Biology and Endocrinology 2021 19:122

    Content type: Review

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  7. Total fertilization failure represents a particularly frustrating condition for couples undergoing in vitro fertilization. With the aim of reducing the occurrence of total fertilization failure, intracytoplasm...

    Authors: Alessio Paffoni, Marco Reschini, Valerio Pisaturo, Cristina Guarneri, Simone Palini and Paola Viganò

    Citation: Reproductive Biology and Endocrinology 2021 19:121

    Content type: Review

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  8. This study aimed to detect the effect of angiotensin receptor 1 (AT1) knock out (KO) on spermatogenesis and hypothalamic-pituitary–gonadal (HPG) axis hormone expression.

    Authors: Fangfang Zhao, Yun Zou, Hui Li, Yaheng Zhang, Xuele Liu, Xuehao Zhao, Xinyi Wu, Wenyi Fei, Ziling Xu and Xuejun Yang

    Citation: Reproductive Biology and Endocrinology 2021 19:120

    Content type: Research

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  9. Exposure to endocrine-disrupting chemicals, such as Bisphenol A (BPA) and Bisphenol S (BPS), is widespread and has negative implications on embryonic development. Preliminary evidence revealed that in women un...

    Authors: Angela Christina Saleh, Reem Sabry, Gabriela Fabiana Mastromonaco and Laura Alessandra Favetta

    Citation: Reproductive Biology and Endocrinology 2021 19:119

    Content type: Research

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  10. Fertility-sparing therapy is an alternative conservative treatment for patients with early stage endometrioid cancer or atypical endometrial hyperplasia. In this study, we investigated pregnancy outcomes and p...

    Authors: Yuan Fan, Xingchen Li, Jiaqi Wang, Yiqin Wang, Li Tian and Jianliu Wang

    Citation: Reproductive Biology and Endocrinology 2021 19:118

    Content type: Research

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  11. Which fertilization method, between ICSI and IVF in split insemination treatments, has the highest clinical efficiency in producing clinically usable blastocyst?

    Authors: Sandrine Chamayou, Carmen Ragolia, Carmelita Alecci, Giorgia Storaci, Simona Romano, Roberta Sapienza, Elena Maglia, Annalisa Liprino, Clementina Cardea, Michele Fichera and Antonino Guglielmino

    Citation: Reproductive Biology and Endocrinology 2021 19:116

    Content type: Research

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  12. The period of time when the embryo and the endometrium undergo significant morphological alterations to facilitate a successful implantation—known as “window of implantation”—is a critical moment in human repr...

    Authors: Kasun Godakumara, James Ord, Freddy Lättekivi, Keerthie Dissanayake, Janeli Viil, Nageswara Rao Boggavarapu, Omid R Faridani, Kersti Jääger, Agne Velthut-Meikas, Ülle Jaakma, Andres Salumets and Alireza Fazeli

    Citation: Reproductive Biology and Endocrinology 2021 19:115

    Content type: Research

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  13. The immune mechanism was shown to be involved in the development of adenomyosis. The aim of the current study was to evaluate the expression of the immune checkpoints B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyos...

    Authors: Xiaoyan Qin, Wenjing Sun, Chong Wang, Mingjiang Li, Xingbo Zhao, Changzhong Li and Hui Zhang

    Citation: Reproductive Biology and Endocrinology 2021 19:114

    Content type: Research

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  14. Premature ovarian failure (POF) is a common disease in the field of Gynecology. Low intensity pulsed ultrasound (LIPUS) can promote tissue repair and improve function. This study was performed to determine the...

    Authors: Haopeng Xu, Yi Xia, Juan Qin, Jie Xu, Chongyan Li and Yan Wang

    Citation: Reproductive Biology and Endocrinology 2021 19:113

    Content type: Research

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  15. The tumor susceptibility gene 101 (Tsg101), a component of the endosomal sorting complex required for transport (ESCRT) complex I, is involved in multiple biological processes involving endomembranous structur...

    Authors: Hyunji Byun, Sojung Kwon, Kay-Uwe Wagner, Hyejin Shin and Hyunjung Jade Lim

    Citation: Reproductive Biology and Endocrinology 2021 19:112

    Content type: Research

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  16. Endometriosis is a benign gynecological disease that shares some characteristics with malignant tumors and affects approximately 10% of women of reproductive age. Endometrioma refers to endometriosis that appe...

    Authors: Yang Liu, Junyan Ma, Liqi Zhang, Jun Lin and Xiaohua Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:111

    Content type: Research

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  17. Until 2010, the National Assisted Reproductive Technology Surveillance System (NASS) report, published annually by the Center for Disease Control and Prevention (CDC), demonstrated almost constantly improving ...

    Authors: Norbert Gleicher, Lyka Mochizuki and David H. Barad

    Citation: Reproductive Biology and Endocrinology 2021 19:110

    Content type: Research

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  18. Morphological features are the most common criteria used to select human embryos for transfer to a receptive uterine cavity. However, such characteristics are not valid for embryos in cellular arrest. Even ane...

    Authors: Ricardo Josué Acuña-González, Mercedes Olvera-Valencia, Jorge Skiold López-Canales, Jair Lozano-Cuenca, Mauricio Osorio-Caballero and Héctor Flores-Herrera

    Citation: Reproductive Biology and Endocrinology 2021 19:109

    Content type: Research

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  19. The mechanism of recurrent implantation failure (RIF) is unclear at present and poor endometrial receptivity may be one of the leading reasons. This study aims to construct a competing endogenous RNA (ceRNA) n...

    Authors: Jialyu Huang, Ning Song, Leizhen Xia, Lifeng Tian, Jun Tan, Qianqian Chen, Jing Zhu and Qiongfang Wu

    Citation: Reproductive Biology and Endocrinology 2021 19:108

    Content type: Research

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  20. Heat stress (HS) occurs when body heat accumulation exceeds heat dissipation and is associated with swine seasonal infertility. HS contributes to compromised oocyte integrity and reduced embryo development. Au...

    Authors: Benjamin J. Hale, Yunsheng Li, Malavika K. Adur, Aileen F. Keating, Lance H. Baumgard and Jason W. Ross

    Citation: Reproductive Biology and Endocrinology 2021 19:107

    Content type: Research

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  21. Uterine leiomyoma is a benign tumor with unclear pathogenesis and inaccurate treatment. This tumor exhibits altered DNA methylation related to disease progression. DNMT inhibitors as 5-aza-2′-deoxycytidine (5-...

    Authors: María Cristina Carbajo-García, Ana Corachán, Marina Segura-Benitez, Javier Monleón, Julia Escrig, Amparo Faus, Antonio Pellicer, Irene Cervelló and Hortensia Ferrero

    Citation: Reproductive Biology and Endocrinology 2021 19:106

    Content type: Research

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  22. It has been previously demonstrated that cholesterol content and cholesterol/phospholipid ratio were significantly higher in asthenozoospermia and oligoasthenoteratozoospermia. The majority of published studie...

    Authors: Shuqiang Chen, Ming Wang, Li Li, Jun Wang, Xuhui Ma, Hengde Zhang, Yang Cai, Bin Kang, Jianlei Huang and Bo Li

    Citation: Reproductive Biology and Endocrinology 2021 19:105

    Content type: Research

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  23. Structural and physiological changes in sperm and semen parameters reduce fertility in diabetic patients. Securigera Securidaca (S. Securidaca) seed is a herbal medicine with hypoglycemic, antioxidant, and anti-h...

    Authors: Mohammad Babaei, Shahin Alizadeh-Fanalou, Alireza Nourian, Sahar Yarahmadi, Navid Farahmandian, Mohsen Nabi-Afjadi, Iraj Alipourfard and Elham Bahreini

    Citation: Reproductive Biology and Endocrinology 2021 19:104

    Content type: Research

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  24. Various luteal phase supports (LPSs) have been proven to increase the pregnancy rate in fresh cycles of in vitro fertilization or intracytoplasmic sperm injection; however, there is still significant debate re...

    Authors: Hanglin Wu, Songying Zhang, Xiaona Lin, Shasha Wang and Ping Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:103

    Content type: Review

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  25. Evaluate the effects of vitamin D3 (VD3) on sperm parameters and endocrine markers in infertile men with asthenozoospermia.

    Authors: Leila Maghsoumi-Norouzabad, Ahmad Zare Javid, Anahita Mansoori, Mohammadreza Dadfar and Amirarsalan Serajian

    Citation: Reproductive Biology and Endocrinology 2021 19:102

    Content type: Research

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  26. Human Ectopic Pregnancy (hEP) is the second most common cause of pregnancy-related deaths in the first trimester. Without timely detection, EPs can lead to an increased rate of infertility and an elevated risk...

    Authors: Wen Cai, Liu Yang, Ruiqing Zhang, Yixia Yang, Shuangdi Li and Jiarong Zhang

    Citation: Reproductive Biology and Endocrinology 2021 19:101

    Content type: Research

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  27. Preeclampsia (PE) is an idiopathic disease that occurs during pregnancy. It comprises multiple organ and system damage, and can seriously threaten the safety of the mother and infant throughout the perinatal p...

    Authors: Ningxia Sun, Shiting Qin, Lu Zhang and Shiguo Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:100

    Content type: Review

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  28. The gonadotropin-releasing hormone (GnRH) antagonist protocol for in vitro fertilization (IVF) often leads to lower pregnancy rates compared to the GnRH agonist protocol. Decreased endometrial receptivity is o...

    Authors: Dan Zhang, Mi Han, Mingjuan Zhou, Mengyu Liu, Yan Li, Bufang Xu and Aijun Zhang

    Citation: Reproductive Biology and Endocrinology 2021 19:99

    Content type: Research

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  29. The KIDScore™ Day 5 (KS-D5) model, version 3, is a general morphokinetic prediction model (Vitrolife, Sweden) for fetal heartbeat prediction after embryo transfer that was developed based on a large data set t...

    Authors: Keiichi Kato, Satoshi Ueno, Jørgen Berntsen, Motoki Ito, Kiyoe Shimazaki, Kazuo Uchiyama and Tadashi Okimura

    Citation: Reproductive Biology and Endocrinology 2021 19:98

    Content type: Research

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  30. Recent years have seen a rising incidence of male infertility, mostly caused by the decline of sperm quality. The ratio of infertile males to infertile females has escalated from 3:7 in 2013 to current 5:5, wh...

    Authors: Kang-Sheng Liu, Xiao-Dong Mao, Feng Pan and Rui Fang An

    Citation: Reproductive Biology and Endocrinology 2021 19:97

    Content type: Research

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  31. Successful human embryo implantation requires the differentiation of endometrial stromal cells (ESCs) into decidual cells during a process called decidualization. ESCs express specific markers of decidualizati...

    Authors: Esther Dos Santos, Hadia Moindjie, Valérie Sérazin, Lucie Arnould, Yoann Rodriguez, Khadija Fathallah, Eytan R. Barnea, François Vialard and Marie-Noëlle Dieudonné

    Citation: Reproductive Biology and Endocrinology 2021 19:96

    Content type: Research

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  32. Otogelin-like protein (encoded by Otogl) was highly structural similar to the gelforming mucin proteins. Although human OTOG mutations have been linked to deafness, the biological function of OTOGL in male germ c...

    Authors: Zhiming Li, Yan Zhang, Xinzong Zhang, Congcong Cao, Xiaomin Luo, Yaoting Gui, Yunge Tang and Shuiqiao Yuan

    Citation: Reproductive Biology and Endocrinology 2021 19:95

    Content type: Research

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    The Correction to this article has been published in Reproductive Biology and Endocrinology 2021 19:136

  33. The male and female prostates are controlled by steroid hormones, suffering important morphological and physiological changes after castration. Prolactin is involved in the regulation of the male prostate, hav...

    Authors: Marianna Zanatelli, Simone Jacovaci Colleta, Luiz Henrique Alves Guerra, Fernanda Cristina Alcântara Santos, Rejane Maira Góes, Patricia Simone Leite Vilamaior and Sebastião Roberto Taboga

    Citation: Reproductive Biology and Endocrinology 2021 19:94

    Content type: Research

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  34. Endometrial thickness (ET) has previously been shown to positively correlate with implantation and clinical pregnancy rates. Pregnancies achieved using in-vitro fertilization (IVF) technique are prone to highe...

    Authors: Gilad Karavani, Heli Alexandroni, Daniel Sheinin, Uri P. Dior, Alex Simon, Assaf Ben-Meir and Benjamin Reubinoff

    Citation: Reproductive Biology and Endocrinology 2021 19:93

    Content type: Research

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  35. The role of sexually transmitted infections (STIs) in semen parameters and male infertility is still a controversial area. Previous studies have found bacterial infection in a minority of infertile leukocytosp...

    Authors: Shun Bai, Yuan Li, Yangyang Wan, Tonghang Guo, Qi Jin, Ran Liu, Wenjuan Tang, Meiying Sang, Yuanyuan Tao, Baoguo Xie, Yun Zhao, Wei Li, Xiangdong Xu, Qiuling Yue, Xuechun Hu and Bo Xu

    Citation: Reproductive Biology and Endocrinology 2021 19:92

    Content type: Research

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  36. Several studies suggest that luteinizing hormone (LH) could improve IVF outcome in women of advanced reproductive age by optimizing androgen production. In this review, we assessed the role of recombinant-huma...

    Authors: Alessandro Conforti, Sandro C. Esteves, Peter Humaidan, Salvatore Longobardi, Thomas D’Hooghe, Raoul Orvieto, Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, Fulvio Zullo and Carlo Alviggi

    Citation: Reproductive Biology and Endocrinology 2021 19:91

    Content type: Review

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  37. This study compared the effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa; GONAL-f®) with urinary highly purified human menopausal gonadotropin (hMG HP; Menogon HP®), during assist...

    Authors: Klaus F. Bühler, Robert Fischer, Patrice Verpillat, Arthur Allignol, Sandra Guedes, Emmanuelle Boutmy, Wilma Bilger, Emilia Richter and Thomas D’Hooghe

    Citation: Reproductive Biology and Endocrinology 2021 19:90

    Content type: Research

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  38. After fertilization, the fusion of gametes results in the formation of totipotent zygote. During sperm-egg fusion, maternal factors participate in parental chromatin remodeling. H3.3 is a histone H3 variant th...

    Authors: Shi-meng Guo, Xing-ping Liu and Li-quan Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:87

    Content type: Short communication

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  39. Endometriosis is a chronic hormonal inflammatory disease characterized by the presence of endometrial tissue outside the uterus. Endometriosis often causes infertility, which brings physical and mental pain to...

    Authors: Yixin Wang, Jing Xiu, Tingting Yang, Chune Ren and Zhenhai Yu

    Citation: Reproductive Biology and Endocrinology 2021 19:86

    Content type: Research

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  40. The importance of spermatogonial stem cells (SSCs) in spermatogenesis is crucial and intrinsic factors and extrinsic signals mediate fate decisions of SSCs. Among endogenous regulators, microRNAs (miRNAs) play...

    Authors: Maryam Khanehzad, Seyed Mehdi Nourashrafeddin, Farid Abolhassani, Shokoofeh Kazemzadeh, Soheila Madadi, Elham Shiri, Parastoo Khanlari, Zahra Khosravizadeh and Azim Hedayatpour

    Citation: Reproductive Biology and Endocrinology 2021 19:85

    Content type: Research

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  41. Uterine adenomyosis is a benign disease, common among women in their 40 and 50 s, characterised by ectopic endometrial tissue in the uterine myometrial layer. Adenomyosis causes infertility and has a negative ...

    Authors: Takuya Iwasawa, Toshifumi Takahashi, Eri Maeda, Koichi Ishiyama, Satoshi Takahashi, Ryota Suganuma, Koki Matsuo, Masahito Tachibana, Rie Fukuhara, Hiromitsu Shirasawa, Wataru Sato, Yukiyo Kumazawa and Yukihiro Terada

    Citation: Reproductive Biology and Endocrinology 2021 19:84

    Content type: Research

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  42. Lysophosphatidic acid-supplemented culture medium significantly increases the oocyte maturation rate in vitro. However, potential targets and pathways involved remain unknown.

    Authors: Qigui Xie, Yaxin Xing, Jianhong Zhou, Ling Wang, Jie Wu and Ri-Cheng Chian

    Citation: Reproductive Biology and Endocrinology 2021 19:83

    Content type: Research

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  43. Recent studies have revealed that women with infertility have a higher risk of thyroid cancer (TC) than fertile women. However, studies on whether a history of thyroid cancer affects clinical outcomes in women...

    Authors: Ning Huang, Lin Zeng, Jie Yan, Hongbin Chi and Jie Qiao

    Citation: Reproductive Biology and Endocrinology 2021 19:82

    Content type: Research

    Published on:

  44. Let-7a is a small non-coding RNA that has been found to take part in cell proliferation and apoptosis. The hippo-YAP1 axis, known as a tumour suppressor pathway, also plays an important role in cell proliferat...

    Authors: Jun-Hua Huang, Hua Duan, Sha Wang, Yi-Yi Wang and Cheng-Xiao LV

    Citation: Reproductive Biology and Endocrinology 2021 19:81

    Content type: Research

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  45. Ovarian reserve reflects the quality and quantity of available oocytes and has become an indispensable measure for the better understanding of reproductive potential. Proteomic approaches are especially helpfu...

    Authors: Sanglin Li, Lina Hu and Chanyu Zhang

    Citation: Reproductive Biology and Endocrinology 2021 19:80

    Content type: Research

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  46. The aim of this study was to investigate characteristics associated with ectopic pregnancy (EP) that could be utilized for predicting morbidity or mortality.

    Authors: Ammar Al Naimi, Pablo Moore, Dörthe Brüggmann, Lisa Krysa, Frank Louwen and Franz Bahlmann

    Citation: Reproductive Biology and Endocrinology 2021 19:79

    Content type: Research

    Published on:

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