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  1. Ovarian carcinoma (OCa) continues to be the leading cause of death due to gynecologic malignancies and the vast majority of OCa is derived from the ovarian surface epithelium (OSE) and its cystic derivatives. ...

    Authors: Shuk-Mei Ho
    Citation: Reproductive Biology and Endocrinology 2003 1:73
  2. Mutations within the BRCA1 tumor suppressor gene occur frequently in familial epithelial ovarian carcinomas but they are a rare event in the much more prevalent sporadic form of the disease. However, decreased...

    Authors: Marcia L McCoy, Christopher R Mueller and Calvin D Roskelley
    Citation: Reproductive Biology and Endocrinology 2003 1:72
  3. Ovarian cancer represents the most lethal of the gynecological neoplasms. The molecular and genetic events associated with early ovarian oncogenesis are still largely unknown, thus contributing to the lack of ...

    Authors: Dusica Cvetkovic
    Citation: Reproductive Biology and Endocrinology 2003 1:68
  4. Ovarian cancer is the most lethal of all of the gynecological cancers and can arise from any cell type of the ovary, including germ cells, granulosa or stromal cells. However, the majority of ovarian cancers a...

    Authors: Barbara C Vanderhyden, Tanya J Shaw and Jean-François Ethier
    Citation: Reproductive Biology and Endocrinology 2003 1:67
  5. Ovarian cancer is among the most lethal of all malignancies in women. While chemotherapy is the preferred treatment modality, chemoresistance severely limits treatment success. Recent evidence suggests that de...

    Authors: Michael Fraser, Brendan Leung, Arezu Jahani-Asl, Xiaojuan Yan, Winston E Thompson and Benjamin K Tsang
    Citation: Reproductive Biology and Endocrinology 2003 1:66
  6. The expression of GnRH (GnRH-I, LHRH) and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the ov...

    Authors: Carsten Gründker and Günter Emons
    Citation: Reproductive Biology and Endocrinology 2003 1:65
  7. Sugar moieties of gonadotropins play no primary role in receptor binding but they strongly affect their circulatory half-life and consequently their in vivo biopotencies. In order to relate more precisely hepatic...

    Authors: Danièle Klett, Serge Bernard, François Lecompte, Hervé Leroux, Thierry Magallon, Alain Locatelli, Alain Lepape and Yves Combarnous
    Citation: Reproductive Biology and Endocrinology 2003 1:64
  8. These data compare the efficacy and safety of highly purified human-derived follicle-stimulating hormone (Bravelle(R)) and recombinant follitropin-β (Follistim(R)) in women undergoing in vitro fertilization.

    Authors: Richard P Dickey, John E Nichols, Michael P Steinkampf, Benjamin Gocial, Melvin Thornton, Bobby W Webster, Sandra M Bello, Jack Crain and Dennis C Marshall
    Citation: Reproductive Biology and Endocrinology 2003 1:63
  9. Gap junctions increase in size and abundance coincident with parturition, forming an intercellular communication network that permits the uterus to develop the forceful, coordinated contractions necessary for ...

    Authors: Rita K Loch-Caruso, Kay A Criswell, Carmen M Grindatti and Kelly A Brant
    Citation: Reproductive Biology and Endocrinology 2003 1:62
  10. The effects on spontaneous ovulation associated with the unilateral or bilateral sectioning of the superior ovarian nerves (SON) were analyzed in guinea pigs at different time intervals of the estrous cycle. D...

    Authors: F Luna, M Cortés, M Flores, B Hernández, A Trujillo and R Domínguez
    Citation: Reproductive Biology and Endocrinology 2003 1:61
  11. We recently showed that interleukin-1 (IL-1) is secreted by the placenta of a species of squamate reptile, the three-toed skink, Chalcides chalcides. In this study, we used immunohistochemical techniques to inves...

    Authors: Roberta Romagnoli, Chiara Cateni, Fabio M Guarino, Elisa Bigliardi and Luana Ricci Paulesu
    Citation: Reproductive Biology and Endocrinology 2003 1:60
  12. During rat estrous cycle, the endometrium proliferates in response to sex steroids and specific endometrial epithelial cells undergo apoptosis in absence of embryonic factors. The central executioner of apopto...

    Authors: Valerie Leblanc, Marie-Claude Dery, Carl Shooner and Eric Asselin
    Citation: Reproductive Biology and Endocrinology 2003 1:59
  13. In sheep, the uterus produces luteolytic pulses of prostaglandin F (PGF) on Days 15 to 16 of estrous cycle to regress the corpus luteum (CL). These PGF pulses are produced by the endometrial lumenal epithelium ...

    Authors: Seokwoon Kim, Youngsok Choi, Thomas E Spencer and Fuller W Bazer
    Citation: Reproductive Biology and Endocrinology 2003 1:58
  14. Estrogen receptors (ER) have important physiological roles in both the female and male reproductive systems. Previous studies using the estrogen receptor-α knockout mouse (αERKO) or antiestrogen treatment in a...

    Authors: Hyun Wook Cho, Rong Nie, Kay Carnes, Qing Zhou, Noaman AQ Sharief and Rex A Hess
    Citation: Reproductive Biology and Endocrinology 2003 1:57
  15. Oocyte control of granulosa and theca cell function may be mediated by several growth factors via a local feedback loop(s) between these cell types. This study examined both the role of oocyte-secreted factors...

    Authors: Victoria Brankin, Marcus RP Mitchell, Bob Webb and Morag G Hunter
    Citation: Reproductive Biology and Endocrinology 2003 1:55
  16. The Sperm Adhesion Molecule 1 (SPAM1) is an important sperm surface hyaluronidase with at least three functions in mammalian fertilization. Previously our laboratory reported that in the mouse, in addition to ...

    Authors: Eric A Evans, Hong Zhang and Patricia A Martin-DeLeon
    Citation: Reproductive Biology and Endocrinology 2003 1:54
  17. CatSper1 and CatSper2 are two recently identified channel-like proteins, which show sperm specific expression patterns. Through targeted mutagenesis in the mouse, CatSper1 has been shown to be required for fer...

    Authors: Anna Lobley, Valerie Pierron, Lindsey Reynolds, Liz Allen and David Michalovich
    Citation: Reproductive Biology and Endocrinology 2003 1:53
  18. Testosterone and estrogen are no longer considered male only and female only hormones. Both hormones are important in both sexes. It was known as early as the 1930's that developmental exposure to a high dose ...

    Authors: Rex A Hess
    Citation: Reproductive Biology and Endocrinology 2003 1:52
  19. To investigate the possible role of nitric oxide (NO) produced locally or intramurally in the quiescence of the pregnant myometrium, nitric oxide synthase (NOS) activity was measured in samples from first trim...

    Authors: J Al-Hijji, Ellika Andolf, Ricardo Laurini and Satish Batra
    Citation: Reproductive Biology and Endocrinology 2003 1:51
  20. Follicle-stimulating hormone (FSH), a member of gonadotropin family, is critical for follicular maturation and ovarian steroidogenesis. Serum FSH levels are known to fluctuate during different phases of menstr...

    Authors: Alan A Arslan, Anne Zeleniuch-Jacquotte, Annekatrin Lukanova, Sabina Rinaldi, Rudolf Kaaks and Paolo Toniolo
    Citation: Reproductive Biology and Endocrinology 2003 1:49
  21. The number and type of testicular germ cells undergoing apoptosis in different age groups of mice (from 7 to 360 days of age) was determined and compared in age-matched wild type (WT) control and in a transgen...

    Authors: D Antony Jeyaraj, Gail Grossman and Peter Petrusz
    Citation: Reproductive Biology and Endocrinology 2003 1:48
  22. Molecular and intra-cellular mechanisms involved in the regulation of apoptosis processes in endometrial cells are poorly understood and documented. We have investigated the possibility that Akt survival pathw...

    Authors: Marie-Claude Dery, Valerie Leblanc, Carl Shooner and Eric Asselin
    Citation: Reproductive Biology and Endocrinology 2003 1:47
  23. Distinct luteinizing hormone receptor (LHR) protein variants exist due to the posttranslational modifications. Besides ovaries, LHR immunoreactivity (LHRI) was also found in other tissues, such as the brain, f...

    Authors: Antonin Bukovsky, Korakod Indrapichate, Hiroshi Fujiwara, Maria Cekanova, Maria E Ayala, Roberto Dominguez, Michael R Caudle, Jay Wimalsena, Robert F Elder, Pleas Copas, James S Foster, Romaine I Fernando, Donald C Henley and Nirmala B Upadhyaya
    Citation: Reproductive Biology and Endocrinology 2003 1:46
  24. The possibility to predict the ability of a germ cell to properly sustain embryo development in vitro or in vivo as early as possible is undoubtedly the main problem of reproductive technologies. To date, only...

    Authors: Pia Lucidi, Nicola Bernabò, Maura Turriani, Barbara Barboni and Mauro Mattioli
    Citation: Reproductive Biology and Endocrinology 2003 1:45
  25. During the initial steps of implantation, the mouse uterine epithelium of the implantation chamber undergoes apoptosis in response to the interacting blastocyst. With progressing implantation, regression of th...

    Authors: Anike Joswig, Heinz-Dieter Gabriel, Mark Kibschull and Elke Winterhager
    Citation: Reproductive Biology and Endocrinology 2003 1:44
  26. Ablation of the low-affinity receptor subunit for leukemia inhibitory factor (LIFR) causes multi-systemic defects in the late gestation fetus. Because corticosterone is known to have a broad range of effects a...

    Authors: Carol B Ware, Angelique M Nelson and Denny Liggitt
    Citation: Reproductive Biology and Endocrinology 2003 1:43
  27. A growing body of evidences suggests that the ovary is a site of inflammatory reactions, and thus, ovarian cells could represent sources and targets of the interleukin-1 (IL-1) system. The purpose of this stud...

    Authors: Alain Martoriati and Nadine Gérard
    Citation: Reproductive Biology and Endocrinology 2003 1:42
  28. Selective estrogen receptor modulators (SERMs) have been developed in order to create means to control estrogenic effects on different tissues. A major drawback in treatment of estrogen receptor (ER) positive ...

    Authors: Denis Stygar, Natalia Muravitskaya, Britt Eriksson, Håkan Eriksson and Lena Sahlin
    Citation: Reproductive Biology and Endocrinology 2003 1:40
  29. We have shown previously that downregulation of intercaruncular stromal integrin αvβ3 in bovine endometrium on day 16 of the estrous cycle coincided with the antibody recognition of estrogen receptors (ER) in the...

    Authors: Sarah Kimmins, Gerald L Russell, Hai Choo Lim, Brian K Hall and Leslie A MacLaren
    Citation: Reproductive Biology and Endocrinology 2003 1:38
  30. During human pregnancy, the production of 17-beta-estradiol (E2) rises steadily to eighty fold at term, and placenta has been found to specifically bind estrogens. We have recently demonstrated the expression ...

    Authors: Antonin Bukovsky, Michael R Caudle, Maria Cekanova, Romaine I Fernando, Jay Wimalasena, James S Foster, Donald C Henley and Robert F Elder
    Citation: Reproductive Biology and Endocrinology 2003 1:36
  31. The ability of the testis to convert irreversibly androgens into estrogens is related to the presence of a microsomal enzymatic complex named aromatase, which is composed of a specific glycoprotein, the cytoch...

    Authors: Serge Carreau, Sophie Lambard, Christelle Delalande, Isabelle Denis-Galeraud, Barbara Bilinska and Sonia Bourguiba
    Citation: Reproductive Biology and Endocrinology 2003 1:35
  32. Embryo implantation, endometrial stromal cell decidualization and formation of a functional placenta are critical processes in the establishment and maintenance of pregnancy. Interleukin (IL)-11 signalling is ...

    Authors: E Dimitriadis, L Robb, Y-X Liu, AC Enders, H Martin, C Stoikos, E Wallace and LA Salamonsen
    Citation: Reproductive Biology and Endocrinology 2003 1:34
  33. Previous studies on the effect of repeated electro-acupuncture (EA) treatments in rats with steriod-induced polycystic ovaries (PCO), EA has been shown to modulate nerve growth factor (NGF) concentration in th...

    Authors: Elisabet Stener-Victorin, Thomas Lundeberg, Stefan Cajander, Luigi Aloe, Luigi Manni, Urban Waldenström and Per Olof Janson
    Citation: Reproductive Biology and Endocrinology 2003 1:33
  34. Simultaneous determinations of DNA content in cell nuclei and condensed chromatin bodies formed by heterochromatized regions of sex chromosomes (gonosomal chromatin bodies, GCB) have been performed in two trop...

    Authors: Tatiana G Zybina, Eugenia V Zybina, Margarita S Bogdanova and Grigory I Stein
    Citation: Reproductive Biology and Endocrinology 2003 1:32
  35. Ion channels occur as large families of related genes with cell-specific expression patterns. Granulosa cells have been shown to express voltage-gated potassium channels from more than one family. The purpose ...

    Authors: Yan Li, Suhasini Ganta, Fred B von Stein, Diane E Mason, Brianna M Mitchell and Lisa C Freeman
    Citation: Reproductive Biology and Endocrinology 2003 1:31
  36. The aim of this study was to analyse the multigenerational effects of para-nonylphenol (NP) and resveratrol (RES) on the body weight, organ weight and reproductive fitness of outbred CD-1 mice. The data indica...

    Authors: Vendula Kyselova, Jana Peknicova, Daniela Buckiova and Michael Boubelik
    Citation: Reproductive Biology and Endocrinology 2003 1:30
  37. Activin is known to play an important regulatory role in reproduction, including pregnancy. To further examine the role and signaling mechanism of activin in regulating placental function, the steady-state lev...

    Authors: Victor TS Chen, Chun Peng and Peter CK Leung
    Citation: Reproductive Biology and Endocrinology 2003 1:29
  38. The mature mouse egg contains the full complement of maternal proteins required for fertilization, the transition to zygotic transcription, and the beginning stages of embryogenesis. Many of these proteins rem...

    Authors: Meredith E Calvert, Laura C Digilio, John C Herr and Scott A Coonrod
    Citation: Reproductive Biology and Endocrinology 2003 1:27
  39. We have investigated the effects of indomethacin (IM), a non-steroidal anti-inflammatory drug, and the role of prostaglandins on the accumulation of leukocytes in the rat ovary during the periovulatory period....

    Authors: Francisco Gaytán, Concepción Morales, Carmen Bellido, Esteban Tarradas and José Eugenio Sánchez-Criado
    Citation: Reproductive Biology and Endocrinology 2003 1:26
  40. Cartilaginous fish are the oldest extant jawed vertebrates and the oldest line to have placentae. Their pivotal evolutionary position makes them attractive models to investigate the mechanisms involved in the ...

    Authors: Chiara Cateni, Luana Paulesu, Elisa Bigliardi and William C Hamlett
    Citation: Reproductive Biology and Endocrinology 2003 1:25
  41. Gonadal hormones have been shown to exert modulatory effects on nociception and analgesia. To investigate the role of gonadal hormones in the response by female rats to both phasic and persistent nociceptive s...

    Authors: Ilaria Ceccarelli, Paolo Fiorenzani, Cosimo Massafra and Anna Maria Aloisi
    Citation: Reproductive Biology and Endocrinology 2003 1:24
  42. Testis tumors occur frequently in dogs. The main types of tumors are Sertoli cell tumors, seminomas, and Leydig cell tumors. Mixed tumors and bilateral occurrence of tumors may be encountered frequently. To el...

    Authors: Monique AJ Peters, Jan A Mol, Monique E van Wolferen, Marja A Oosterlaken-Dijksterhuis, Katja J Teerds and Frederik J van Sluijs
    Citation: Reproductive Biology and Endocrinology 2003 1:22

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