Articles

An open-label clinical trial to investigate the efficacy and safety of corifollitropin alfa combined with hCG in adult men with hypogonadotropic hypogonadism

Hypogonadotropic hypogonadism (HH) in men results in insufficient testicular function and deficiencies in testosterone and spermatogenesis. Combinations of human chorionic gonadotropin (hCG) and recombinant fo...

Authors: Eberhard Nieschlag, Pierre-Marc G. Bouloux, Barbara J. Stegmann, R. Ravi Shankar, Yanfen Guan, Anjela Tzontcheva, Christine McCrary Sisk and Hermann M. Behre

Chronic endometritis modifies decidualization in human endometrial stromal cells

Chronic endometritis (CE) is a continuous inflammation of uterine endometrium, and it is usually symptomless. As CE has been thought not to affect the reproductive status and general health of affected women, ...

Authors: Di Wu, Fuminori Kimura, Luyi Zheng, Mitsuaki Ishida, Yoko Niwa, Kimiko Hirata, Akie Takebayashi, Akiko Takashima, Kentaro Takahashi, Ryoji Kushima, Guangmei Zhang and Takashi Murakami

The effect of fertility stress on endometrial and subendometrial blood flow among infertile women

To investigate the effect of fertility stress on endometrial and subendometrial blood flow among infertile women.

Authors: Yuezhi Dong, Yanna Cai, Yu Zhang, Yurong Xing and Yingpu Sun

Expression of SOX2, NANOG and OCT4 in a mouse model of lipopolysaccharide-induced acute uterine injury and intrauterine adhesions

Activation of inflammation-mediated endometrial injury is suggested to play a decisive role in pathogenesis of intrauterine adhesion (IUA). The stem cell theory of endometrial diseases has been given a hotspot...

Authors: Li Xiao, Yong Song, Wei Huang, Shiyuan Yang, Jing Fu, Xue Feng and Min Zhou

Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 9–18% of women in reproductive age that causes hyperandrogenism and infertility due to dysfunctional follicular maturation and anovula...

Authors: Larissa Paixão, Ramon B. Ramos, Anita Lavarda, Debora M. Morsh and Poli Mara Spritzer

The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome

The influence of estradiol (E₂) on granulosa cell (GC) function has not been tested clinically in women with polycystic ovary syndrome (PCOS). The objective of this study is to determine if E₂ influences GC respo...

Authors: Michael V. Homer, Marcus A. Rosencrantz, Rana F. Shayya and R. Jeffrey Chang

REAC technology as optimizer of stallion spermatozoa liquid storage

REAC technology (acronym for Radio Electric Asymmetric Conveyor) is a technology platform for neuro and bio modulation. It has already proven to optimize the ions fluxes at the molecular level and the molecula...

Authors: Fiammetta Berlinguer, Valeria Pasciu, Sara Succu, Ignazio Cossu, Sabrina Caggiu, Daniela Addis, Alessandro Castagna, Vania Fontani, Salvatore Rinaldi and Eraldo Sanna Passino

The Human Oocyte Preservation Experience (HOPE) Registry: evaluation of cryopreservation techniques and oocyte source on outcomes

This prospective, Phase IV, multicenter, observational registry of assisted reproductive technology clinics in the USA studied outcomes of first cycles using thawed/warmed cryopreserved (by slow-freezing/vitri...

Authors: Zsolt Peter Nagy, Robert E. Anderson, Eve C. Feinberg, Brooke Hayward and Mary C. Mahony

An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients

Studies found that AGE-RAGE system is closely related to insulin resistance and hyperandrogenemia, which are two core pathophysiological processes in polycystic ovary syndrome (PCOS). This study is to investig...

Authors: Yu Liao, Rong Huang, Yun Sun, Jiang Yue, Jun Zheng, Lihua Wang, Tao Tao, Jing Ma, Shengxian Li and Wei Liu

The impact of endometriosis on the outcome of Assisted Reproductive Technology

Endometriosis has been described to impair fertility through various mechanisms. However, studies evaluating the reproductive outcomes of women undergoing assisted reproductive technologies show controversial ...

Authors: Mireia González-Comadran, Juan Enrique Schwarze, Fernando Zegers-Hochschild, Maria do Carmo B. Souza, Ramon Carreras and Miguel Ángel Checa

Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy

The lifesaving chemotherapy and radiation treatments that allow patients to survive cancer can also result in a lifetime of side-effects, including male infertility. Infertility in male cancer survivors is tho...

Authors: Travis Kotzur, Roberto Benavides-Garcia, Jennifer Mecklenburg, Jamila R. Sanchez, Matthew Reilly and Brian P. Hermann

Systematic review of worldwide trends in assisted reproductive technology 2004–2013

Assisted Reproductive Technology (ART) has undergone considerable changes over the last decade, with consequences on ART outcomes in different regions of the world being unknown.

Authors: Vitaly A. Kushnir, David H. Barad, David F. Albertini, Sarah K. Darmon and Norbert Gleicher

Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro

Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) are glycoprotein hormones regulating development and reproductive functions by acting on the same receptor (LHCGR). We compared the LH and hCG ac...

Authors: Laura Riccetti, Francesco De Pascali, Lisa Gilioli, Francesco Potì, Lavinia Beatrice Giva, Marco Marino, Simonetta Tagliavini, Tommaso Trenti, Flaminia Fanelli, Marco Mezzullo, Uberto Pagotto, Manuela Simoni and Livio Casarini

Induction of altered gene expression profiles in cultured bovine granulosa cells at high cell density

In previous studies it has been shown that bovine granulosa cells (GC) cultured at a high plating density dramatically change their physiological and molecular characteristics, thus resembling an early stage o...

Authors: Anja Baufeld, Dirk Koczan and Jens Vanselow

Hexokinase 2 drives glycogen accumulation in equine endometrium at day 12 of diestrus and pregnancy

Secretion of histotroph during the prolonged pre-implantation phase in mares is crucial to pregnancy maintenance, manifested as increased embryonic loss in mares with age-related endometrial degeneration. Glyc...

Authors: Sarah A. Bramer, Alysson Macedo and Claudia Klein

Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection

The study was designed to investigate the roles of endometrial thickness (EMT) at the day of human chorionic gonadotropin (hCG) administration on pregnancy outcomes in a large patient population.

Authors: Ning-Zhao Ma, Lei Chen, Wei Dai, Zhi-Qin Bu, Lin-Li Hu and Ying-Pu Sun

The abnormal expression of oxytocin receptors in the uterine junctional zone in women with endometriosis

The junctional zone (JZ), also called as the endometrial-myometrial junction, is related to peristaltic-like movements in the non-pregnant uterus. Hyperperistalsis and dysperistalsis of uterus constructions mi...

Authors: Miaomaio Huang, Xuqing Li, Peipei Guo, Zhaojuan Yu, Yuting Xu and Zhaolian Wei

Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters

There are reports showing that l-carnitine alone or in combination with other micronutrients improve sperm parameters. However, comparative studies are still lacking. This study was carried out to compare the ...

Authors: Markus Lipovac, Florian Bodner, Martin Imhof and Peter Chedraui

Variation in male spermiation response to exogenous hormones among divergent populations of Red-eyed Treefrogs

The non-lethal collection of sperm from live males is an important component for multiple captive-breeding techniques, including assisted reproductive technology (ART) protocols, sperm cryopreservation and in ...

Authors: Leah E. Jacobs, Jeanne M. Robertson and Kristine Kaiser

Arrest at the diplotene stage of meiotic prophase I is delayed by progesterone but is not required for primordial follicle formation in mice

In mammalian females, reproductive capacity is determined by the size of the primordial follicle pool. During embryogenesis, oogonia divide mitotically but cytokinesis is incomplete so oogonia remain connected...

Authors: Sudipta Dutta, Deion M. Burks and Melissa E. Pepling

Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients

Current evidence suggests that endometrial-derived stem cells, spilled in the peritoneal cavity via retrograde menstruation, are key players in the establishment of endometriotic lesions. The aim of this study...

Authors: Katharina Proestling, Peter Birner, Sukirthini Balendran, Nadine Nirtl, Erika Marton, Gülen Yerlikaya, Lorenz Kuessel, Theresa Reischer, Rene Wenzl, Berthold Streubel and Heinrich Husslein

ACTH-induced stress in weaned sows impairs LH receptor expression and steroidogenesis capacity in the ovary

Stress has been proved to impair the porcine reproduction soundly. Endocrine disruption, which is closely related to the persistent follicles, is possibly one of the results of stress, although the mechanism i...

Authors: H. S. Zhu, Z. Qian, H. L. Liu and E. D. Bao

Cryopreservation and xenografting of human ovarian fragments: medulla decreases the phosphatidylserine translocation rate

Phosphatidylserine is the phospholipid component which plays a key role in cell cycle signaling, specifically in regards to necrosis and apoptosis. When a cell affected by some negative factors, phosphatidylse...

Authors: Vladimir Isachenko, Plamen Todorov, Evgenia Isachenko, Gohar Rahimi, Bettina Hanstein, Mahmoud Salama, Peter Mallmann, Andrey Tchorbanov, Paul Hardiman, Natalie Getreu and Markus Merzenich

Characterization of exosomal release in bovine endometrial intercaruncular stromal cells

Cell-to-cell communication between the blastocyst and endometrium is critical for implantation. In recent years, evidence has emerged from studies in humans and several other animal species that exosomes are s...

Authors: Yong Qin Koh, Hassendrini N. Peiris, Kanchan Vaswani, Sarah Reed, Gregory E. Rice, Carlos Salomon and Murray D. Mitchell

Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer

α1,3-Galactosyltransferase (GGTA1) is essential for the biosynthesis of glycoproteins and therefore a simple and effective target for disrupting the expression of galactose α-1,3-galactose epitopes, which medi...

Authors: Wenmin Cheng, Heng Zhao, Honghao Yu, Jige Xin, Jia Wang, Luyao Zeng, Zaimei Yuan, Yubo Qing, Honghui Li, Baoyu Jia, Cejun Yang, Youfeng Shen, Lu Zhao, Weirong Pan, Hong-Ye Zhao, Wei Wang…

Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review

In the literature, there is growing evidence that subfertile patients who conceived after infertility treatments have an increased risk of pregnancy and perinatal complications and this is particularly true fo...

Authors: Stefano Palomba, Roy Homburg, Susanna Santagni, Giovanni Battista La Sala and Raoul Orvieto

The participation of the muscarinic receptors in the preoptic-anterior hypothalamic areas in the regulation of ovulation depends on the ovary

Muscarinic receptors (mAChRs) of the preoptic and anterior hypothalamus areas (POA-AHA) regulate ovulation in an asymmetric manner during the estrous cycle. The aims of the present study were to analyze the ef...

Authors: Adriana Espinosa-Valdez, Angélica Flores, Isabel Arrieta-Cruz, Mario Cárdenas, Roberto Chavira, Roberto Domínguez and María Esther Cruz

Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

Pigs with SCID can be a useful model in regenerative medicine, xenotransplantation, and cancer cell transplantation studies. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us to genera...

Authors: Jung-Taek Kang, Bumrae Cho, Junghyun Ryu, Caitlin Ray, Eun-Jin Lee, Yun-Jin Yun, SunMi Ahn, JinSeok Lee, Dal-Young Ji, Nathaniel Jue, Sherrie Clark-Deener, Kiho Lee and Kwang-Wook Park

Assisted reproductive technology pregnancy complications are significantly associated with endometriosis severity before conception: a retrospective cohort study

Endometriosis has been shown to be associated with second- to third-trimester pregnancy complications such as preterm birth and placenta previa, but the evidence is inconsistent. We hypothesized that endometri...

Authors: Tatsuya Fujii, Osamu Wada-Hiraike, Takeshi Nagamatsu, Miyuki Harada, Tetsuya Hirata, Kaori Koga, Tomoyuki Fujii and Yutaka Osuga

Involvement of mesosalpinx in endometrioma is a possible risk factor for decrease of ovarian reserve after cystectomy: a retrospective cohort study

Serum anti-Müllerian hormone (AMH) concentration has been used to assess ovarian reserve in patients with endometriosis, especially when endometrioma surgery is involved. Previously, we reported that decreased...

Authors: Ai Saito, Akira Iwase, Tomoko Nakamura, Satoko Osuka, Bayasula, Tomohiko Murase, Nao Kato, Chiharu Ishida, Sachiko Takikawa, Maki Goto and Fumitaka Kikkawa

Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS

Women with PCOS have elevated levels of the harmful Advanced Glycation End Products (AGEs), which are highly reactive molecules formed after glycation of lipids and proteins. Additionally, AGEs accumulate in t...

Authors: Deepika Garg and Zaher Merhi

Second Harmonic Generation microscopy reveals collagen fibres are more organised in the cervix of postmenopausal women

During labour, the cervix undergoes a series of changes to allow the passage of the fetoplacental unit. While this visible transformation is well-described, the underlying and causative microscopic changes, in...

Authors: Brenda F. Narice, Nicola H. Green, Sheila MacNeil and Dilly Anumba

Abdominal ectopic pregnancy after in vitro fertilization and single embryo transfer: a case report and systematic review

Ectopic pregnancy is the leading cause of maternal morbidity and mortality during the first trimester and the incidence increases dramatically with assisted-reproductive technology (ART), occurring in approxim...

Authors: Nicole Yoder, Reshef Tal and J. Ryan Martin

Effects of hyperandrogenism on metabolic abnormalities in patients with polycystic ovary syndrome: a meta-analysis

The study evaluated the effect of hyperandrogenism (HA) in polycystic ovary syndrome (PCOS) on metabolic parameters.

Authors: Rui Yang, Shuo Yang, Rong Li, Ping Liu, Jie Qiao and Yanwu Zhang

Local intra-uterine Ang-(1–7) infusion attenuates PGE₂ and 6-keto PGF_1α in decidualized uterus of pseudopregnant rats

Cyclooxygenase (COX)-derived prostanoids (PGE_2, PGI₂) are important contributors to the process of decidualization. Previous studies showed the presence of Ang-(1-7) in the primary and secondary decidualized zone...

Authors: K. Bridget Brosnihan, Victor M. Pulgar, Manish S. Bharadwaj, Liomar A. A. Neves and Liliya M. Yamaleyeva

Anti-platelet therapy holds promises in treating adenomyosis: experimental evidence

Recently emerging evidence indicates that endometriotic lesions are wounds undergoing repeated tissue injury and repair (ReTIAR), and platelets induce epithelial-mesenchymal transition (EMT), fibroblast-to-myo...

Authors: Bo Zhu, Yumei Chen, Xiaolu Shen, Xishi Liu and Sun-Wei Guo

Expression and regulation of ATF6α in the mouse uterus during embryo implantation

ATF6α, one of the sensor proteins in the stress signaling pathway of the endoplasmic reticulum, is located in the membrane of the endoplasmic reticulum. To date, the physiological function of ATF6α in the proc...

Authors: Yongjie Xiong, Wenzhe Li, Pengfei Lin, Lei Wang, Nan Wang, Fenglei Chen, Xiao Li, Aihua Wang and Yaping Jin

Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation

Iatrogenic parasitic myomas (PMs), caused by intra-corporeal power morcellation during laparoscopy is gradually increasing. However, the pathogenesis and medical treatment of PMs remain largely unelucidated.

Authors: Ben-Shian Huang, Muh-Hwa Yang, Peng-Hui Wang, Hsin-Yang Li, Teh-Ying Chou and Yi-Jen Chen

Comment on “Biosimilar FSH preparations- are they identical twins or just siblings?”

Authors: Thomas Strowitzki, Waldemar Kuczynski, Arnd Mueller and Peter Bias

Whether G-CSF administration has beneficial effect on the outcome after assisted reproductive technology? A systematic review and meta-analysis

Previous studies have explored the effect of granulocyte colony stimulating factor (G-CSF) administration on the outcome of assisted reproductive technology (ART), and came into controversial conclusions. The ...

Authors: J. Zhao, B. Xu, S. Xie, Q. Zhang and Y. P. Li

Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies

Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, and has important health implications for mother and child. Changes in the fetoplacental vessels may predict th...

Authors: Qian Meng, Li Shao, Xiucui Luo, Yingping Mu, Wen Xu, Li Gao, Haoqin Xu and Yugui Cui

Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease

Adenomyosis is linked to infertility, but the mechanisms behind this relationship are not clearly established. Similarly, the impact of adenomyosis on ART outcome is not fully understood. Our main objective wa...

Authors: J. M. Puente, A. Fabris, J. Patel, A. Patel, M. Cerrillo, A. Requena and J. A. Garcia-Velasco

Erratum: Biosimilar FSH preparations- are they identical twins or just siblings?

Authors: Raoul Orvieto and David B. Seifer

Effects of platelet-rich plasma in a model of bovine endometrial inflammation in vitro

Endometritis reduces fertility and is responsible for major economic losses in beef and dairy industries. The aim of this study was to evaluate an alternative therapy using platelet-rich plasma (PRP). PRP was ...

Authors: Maria Giovanna Marini, Claudia Perrini, Paola Esposti, Bruna Corradetti, Davide Bizzaro, Pietro Riccaboni, Eleonora Fantinato, Giuseppe Urbani, Giorgio Gelati, Fausto Cremonesi and Anna Lange-Consiglio

Chronic effects of an anti-angiogenic thrombospondin-1 mimetic peptide, ABT-898, on female mouse reproductive outcomes

Angiogenesis is an essential process in endometriosis disease progression. Earlier, we demonstrated that anti-angiogenic peptide, ABT-898 prevents neoangiogenesis of human endometriotic lesions in a xenograft ...

Authors: Andrew K. Edwards, Irina Olariu, Diane S. Nakamura, Soo Hyun Ahn and Chandrakant Tayade

Antioxidants reduce oxidative stress in follicular fluid of aged women undergoing IVF

The status characterized by the imbalance between pro-oxidants and antioxidants molecules, defined as oxidative stress, has been suggested to be involved in the pathogenesis of subfertility in females. This st...

Authors: Alice Luddi, Angela Capaldo, Riccardo Focarelli, Martina Gori, Giuseppe Morgante, Paola Piomboni and Vincenzo De Leo

45,X product of conception after preimplantation genetic diagnosis and euploid embryo transfer: evidence of a spontaneous conception confirmed by DNA fingerprinting

Preimplantation genetic screening (PGS) provides an opportunity to eliminate a potential implantation failure due to aneuploidy in infertile couples. Some studies clearly show that twins following single embry...

Authors: Daniela Bettio, Antonio Capalbo, Elena Albani, Laura Rienzi, Valentina Achille, Anna Venci, Filippo Maria Ubaldi and Paolo Emanuele Levi Setti

Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos

To preclude transfer of aneuploid embryos, current preimplantation genetic screening (PGS) usually involves one trophectoderm biopsy at blastocyst stage, assumed to represent embryo ploidy. Whether one such bi...

Authors: Norbert Gleicher, Andrea Vidali, Jeffrey Braverman, Vitaly A. Kushnir, David H. Barad, Cynthia Hudson, Yang-Guan Wu, Qi Wang, Lin Zhang and David F. Albertini

GnRH antagonist administration to postpone a weekend intrauterine insemination: a large cohort study from a public center

In Spanish public hospital Reproduction Units it is very problematic to perform programmed intrauterine insemination (IUI) on weekends, if indicated. Small previous pilot studies suggest that using a GnRH anta...

Authors: J. Gobernado, C. Alvarez-Colomo, L. Rodriguez-Tabernero, L. Barrero, J. M. F. Fernández-Gómez and J. Schneider

Modulation of gonadotrophin induced steroidogenic enzymes in granulosa cells by d-chiroinositol

d-chiroinositol (DCI) is a inositolphosphoglycan (IPG) involved in several cellular functions that control the glucose metabolism. DCI functions as second messenger in the insulin signaling pathway and it is c...

Authors: Sandro Sacchi, Federica Marinaro, Debora Tondelli, Jessica Lui, Susanna Xella, Tiziana Marsella, Daniela Tagliasacchi, Cindy Argento, Alessandra Tirelli, Simone Giulini and Antonio La Marca