Maresch CC, Stute DC, Alves MG, Oliveira PF, de Kretser DM, Linn T. Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review. Hum Reprod Update. 2018;24:86–105.
Xu Y, Wang L, He J, Bi Y, Li M, Wang T, et al. Prevalence and control of diabetes in Chinese adults. JAMA. 2013;310:948–59.
Akbarian F, Rahmani M, Tavalaee M, Abedpoor N, Taki M, Ghaedi K, et al. Effect of different high-fat and advanced glycation end-products diets in obesity and diabetes-prone C57BL/6 mice on sperm function. Int J Fertil Steril. 2021;15:226–33.
Ettinger S. Diabetic nephropathy, chronic kidney disease. In: Nutritional pathophysiology of obesity & its comorbidities; 2017. p. 161–89.
Thomas GN, Jiang CQ, Taheri S, Xiao ZH, Tomlinson B, Cheung BM, et al. A systematic review of lifestyle modification and glucose intolerance in the prevention of type 2 diabetes. Curr Diabetes Rev. 2010;6:378–87.
Baccetti B, La Marca A, Piomboni P, Capitani S, Bruni E, Petraglia F, et al. Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality. Hum Reprod. 2002;17:2673–7.
Carvalho MG, Silva KM, Aristizabal VHV, Ortiz PEO, Paranzini CS, Melchert A, et al. Effects of obesity and diabetes on sperm cell proteomics in rats. J Proteome Res. 2021;20:2628–42.
Condorelli RA, La Vignera S, Mongioi LM, Alamo A, Calogero AE. Diabetes mellitus and infertility: different pathophysiological effects in type 1 and type 2 on sperm function. Front Endocrinol (Lausanne). 2018;9:268.
Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and disease. Science. 2018;359(6374).
Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G. Spermidine: a novel autophagy inducer and longevity elixir. Autophagy. 2010;6:160–2.
Shahin NN, El-Nabarawy NA, Gouda AS, Megarbane B. The protective role of spermine against male reproductive aberrations induced by exposure to electromagnetic field - an experimental investigation in the rat. Toxicol Appl Pharmacol. 2019;370:117–30.
Hu J, Lu X, Zhang X, Shao X, Wang Y, Chen J, et al. Exogenous spermine attenuates myocardial fibrosis in diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress and the canonical Wnt signaling pathway. Cell Biol Int. 2020;44:1660–70.
Mendez JD, Balderas FL. Inhibition by L-arginine and spermidine of hemoglobin glycation and lipid peroxidation in rats with induced diabetes. Biomed Pharmacother. 2006;60:26–31.
Sadasivan SK, Vasamsetti B, Singh J, Marikunte VV, Oommen AM, Jagannath MR, et al. Exogenous administration of spermine improves glucose utilization and decreases bodyweight in mice. Eur J Pharmacol. 2014;729:94–9.
Ma J, Meng X, Liu Y, Yin C, Zhang T, Wang P, et al. Effects of a rhizome aqueous extract of Dioscorea batatas and its bioactive compound, allantoin in high fat diet and streptozotocin-induced diabetic mice and the regulation of liver, pancreas and skeletal muscle dysfunction. J Ethnopharmacol. 2020;259:112926.
Demirci T, Sahin E. The effect of chronic stress and obesity on sperm quality and testis histology in male rats; a morphometric and immunohistochemical study. Histol Histopathol. 2019;34:287–302.
Lei X, Huo P, Wang Y, Xie Y, Shi Q, Tu H, et al. Lycium barbarum polysaccharides improve testicular spermatogenic function in Streptozotocin-induced diabetic rats. Front Endocrinol (Lausanne). 2020;11:164.
Le J, Lei X, Ren Y, Li Z, Tu H, Ding F, et al. Exogenous oestradiol benzoate induces male mice azoospermia through modulation of oxidative stress and testicular metabolic cooperation. Mol Med Rep. 2019;19:4955–63.
Agarwal A, Baskaran S, Parekh N, Cho C-L, Henkel R, Vij S, et al. Male infertility. Lancet. 2021;397:319–33.
Singh R, Singh K. Male infertility: understanding, causes and treatment; 2017.
Costanzo PR, Suarez SM, Scaglia HE, Zylbersztein C, Litwak LE, Knoblovits P. Evaluation of the hypothalamic-pituitary-gonadal axis in eugonadal men with type 2 diabetes mellitus. Andrology. 2014;2:117–24.
La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero AE. Diabetes mellitus and sperm parameters. J Androl. 2012;33:145–53.
Liu C, Zhang C, Du H, Geng X, Zhao H. Remote ischemic preconditioning protects against ischemic stroke in streptozotocin-induced diabetic mice via anti-inflammatory response and anti-apoptosis. Brain Res. 2019;1724:146429.
Xu X, Liang T, Wen Q, Lin X, Tang J, Zuo Q, et al. Protective effects of total extracts of Averrhoa carambola L. (Oxalidaceae) roots on streptozotocin-induced diabetic mice. Cell Physiol Biochem. 2014;33:1272–82.
Dadras S, Abdollahifar MA, Nazarian H, Ghoreishi SK, Fallahnezhad S, Naserzadeh P, et al. Photobiomodulation improved stereological parameters and sperm analysis factors in streptozotocin-induced type 1 diabetes mellitus. J Photochem Photobiol B. 2018;186:81–7.
Mangoli E, Talebi AR, Anvari M, Pourentezari M. Effects of experimentally-induced diabetes on sperm parameters and chromatin quality in mice. Iran J Reprod Med. 2013;11:53–60.
Pegg AE. The function of spermine. IUBMB Life. 2014;66:8–18.
Gugliucci A, Menini T. The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules? Life Sci. 2003;72:2603–16.
Rubinstein S, Breitbart H. Role of spermine in mammalian sperm capacitation and acrosome reaction. Biochem J. 1991;278(Pt 1):25–8.
Singh BP, Saha I, Nandi I, Swamy MJ. Spermine and spermidine act as chemical chaperones and enhance chaperone-like and membranolytic activities of major bovine seminal plasma protein, PDC-109. Biochem Biophys Res Commun. 2017;493:1418–24.
Lefevre PL, Palin MF, Murphy BD. Polyamines on the reproductive landscape. Endocr Rev. 2011;32:694–712.
Zhao Q, Huang JF, Cheng Y, Dai MY, Zhu WF, Yang XW, et al. Polyamine metabolism links gut microbiota and testicular dysfunction. Microbiome. 2021;9:224.
Morales ME, Rico G, Bravo C, Tapia R, Alvarez C, Mendez JD. Progressive motility increase caused by L-arginine and polyamines in sperm from patients with idiopathic and diabetic asthenozoospermia. Ginecol Obstet Mex. 2003;71:297–303.
Liu Y, Yang Z, Kong D, Zhang Y, Yu W, Zha W. Metformin ameliorates testicular damage in male mice with Streptozotocin-induced type 1 diabetes through the PK2/PKR pathway. Oxidative Med Cell Longev. 2019;2019:5681701.
Koh PO. Streptozotocin-induced diabetes increases apoptosis through JNK phosphorylation and Bax activation in rat testes. J Vet Med Sci. 2007;69:969–71.
Yao D, GangYi Y, QiNan W. Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword. Genes Dis. 2021;8:438–47.
Fan J, Yang X, Li J, Shu Z, Dai J, Liu X, et al. Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway. Oncotarget. 2017;8:17475–90.
Ravel C, Jaillard S. The Sertoli cell. Morphologie. 2011;95:151–8.
Zhu Q, Li X, Ge RS. Toxicological effects of cadmium on mammalian testis. Front Genet. 2020;11:527.
Arikawe AP, Oyerinde A, Olatunji B II, Obika LF. Streptozotocin diabetes and insulin resistance impairment of spermatogenesis in adult rat testis: central vs. local mechanism. Niger J Physiol Sci. 2012;27:171–9.
Tavares RS, Portela JMD, Sousa MI, Mota PC, Ramalho-Santos J, Amaral S. High glucose levels affect spermatogenesis: an in vitro approach. Reprod Fertil Dev. 2017;29:1369–78.
Kopecky M, Semecky V, Nachtigal P. Vimentin expression during altered spermatogenesis in rats. Acta Histochem. 2005;107:279–89.
He D, Zhang D, Wei G, Lin T, Li X. Cytoskeleton vimentin disruption of mouse sertoli cells injured by nitrogen mustard in vitro. J Androl. 2007;28:389–96.
Xu Y, Lei H, Guan R, Gao Z, Li H, Wang L, et al. Prophylactic protective effects and its potential mechanisms of IcarisideII on streptozotocin induced spermatogenic dysfunction. Int J Mol Sci. 2014;15:16100–13.
Liang J, Wang N, He J, Du J, Guo Y, Li L, et al. Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4. eLife. 2019;8:e48767.
Yi XD, Zhanf YN, Xiao S, Lei XC. Role and regulatory mechanism of glycometabolism of Sertoli cells in spermatogenesis. Zhonghua Nan Ke Xue. 2019;25:923–7.
Boussouar F, Benahmed M. Lactate and energy metabolism in male germ cells. Trends Endocrinol Metab. 2004;15:345–50.
Alves MG, Martins AD, Jarak I, Barros A, Silva J, Sousa M, et al. Testicular lactate content is compromised in men with Klinefelter syndrome. Mol Reprod Dev. 2016;83:208–16.
Alves MG, Martins AD, Moreira PI, Carvalho RA, Sousa M, Barros A, et al. Metabolic fingerprints in testicular biopsies from type 1 diabetic patients. Cell Tissue Res. 2015;362:431–40.
Alves MG, Martins AD, Cavaco JE, Socorro S, Oliveira PF. Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function. Tissue Barriers. 2013;1:e23992.
Alves MG. Energetics of the male reproduction. Encyclopedia Reprod. 2018;1:451–7.
Meneses MJ, Bernardino RL, Sa R, Silva J, Barros A, Sousa M, et al. Pioglitazone increases the glycolytic efficiency of human Sertoli cells with possible implications for spermatogenesis. Int J Biochem Cell Biol. 2016;79:52–60.
Dias TR, Bernardino RL, Alves MG, Silva J, Barros A, Sousa M, et al. L-Theanine promotes cultured human Sertoli cells proliferation and modulates glucose metabolism. Eur J Nutr. 2019;58:2961–70.
Ruiz-Perez MV, Medina MA, Urdiales JL, Keinanen TA, Sanchez-Jimenez F. Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. J Biol Chem. 2015;290:6106–19.
Monticelli LA, Buck MD, Flamar AL, Saenz SA, Tait Wojno ED, Yudanin NA, et al. Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat Immunol. 2016;17:656–65.
Rocha CS, Martins AD, Rato L, Silva BM, Oliveira PF, Alves MG. Melatonin alters the glycolytic profile of Sertoli cells: implications for male fertility. Mol Hum Reprod. 2014;20:1067–76.