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  2. Compaction is an important marker of embryonic genome activation and marks a critical step in the development to blastocyst. The objective of our study was to determine whether visualization of the embryonic c...

    Authors: Christine Hur, Vaani Nanavaty, Meng Yao and Nina Desai
    Citation: Reproductive Biology and Endocrinology 2023 21:12
    Content type: Research Published on:

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2023 21:63

  3. Erectile dysfunction is a common problem in males of couples experiencing pregnancy loss. Erectile dysfunction in males with couple infertile has been extensively investigated and found to be closely linked wi...

    Authors: Xiaowei Yu, Songling Zhang, Xiao Yuan Zhang and Qun Wang
    Citation: Reproductive Biology and Endocrinology 2023 21:11
    Content type: Research Published on:

  4. Metformin is the gold standard insulin sensitizer, which is widely used to treat insulin resistance in polycystic ovary syndrome (PCOS). However, metformin may induce gastrointestinal side effects.

    Authors: Dorina Greff, Anna E. Juhász, Szilárd Váncsa, Alex Váradi, Zoltán Sipos, Julia Szinte, Sunjune Park, Péter Hegyi, Péter Nyirády, Nándor Ács, Szabolcs Várbíró and Eszter M. Horváth
    Citation: Reproductive Biology and Endocrinology 2023 21:10
    Content type: Review Published on:

  5. Uterine leiomyomas (UL) are the most common benign tumor in women of reproductive age. Their pathology remains unclear, which hampers the development of safe and effective treatments. Raising evidence suggests...

    Authors: María Cristina Carbajo-García, Elena Juarez-Barber, Marina Segura-Benítez, Amparo Faus, Alexandra Trelis, Javier Monleón, Greta Carmona-Antoñanzas, Antonio Pellicer, James M. Flanagan and Hortensia Ferrero
    Citation: Reproductive Biology and Endocrinology 2023 21:9
    Content type: Research Published on:

  6. To construct prediction models based on the Bayesian network (BN) learning method for the probability of fertilization failure (including low fertilization rate [LRF] and total fertilization failure [TFF]) in ...

    Authors: Tian Tian, Fei Kong, Rui Yang, Xiaoyu Long, Lixue Chen, Ming Li, Qin Li, Yongxiu Hao, Yangbo He, Yunjun Zhang, Rong Li, Yuanyuan Wang and Jie Qiao
    Citation: Reproductive Biology and Endocrinology 2023 21:8
    Content type: Research Published on:

  7. Accumulating studies suggest that strict lockdown with enforcement including segregation to control the coronavirus disease 2019 (COVID-19) pandemic is associated with excess weight gain, but the such lockdown...

    Authors: Sho Tano, Tomomi Kotani, Takafumi Ushida, Yukako Iitani, Kenji Imai, Fumie Kinoshita and Hiroaki Kajiyama
    Citation: Reproductive Biology and Endocrinology 2023 21:7
    Content type: Research Published on:

  8. Human embryos express the prolactin (PRL) receptor at the morula and blastocyst stages. Treatment with PRL from cleavage to the blastocyst stage improves blastocyst outgrowth on fibronectin-coated dishes. Howe...

    Authors: Kenji Ezoe, Nanoha Fujiwara, Tetsuya Miki and Keiichi Kato
    Citation: Reproductive Biology and Endocrinology 2023 21:6
    Content type: Research Published on:

  9. Infertility affects one in every six couples in developed countries, and approximately 50% is of male origin. In 2021, sperm DNA fragmentation (SDF) testing became an evidence-based test for fertility evaluati...

    Authors: Anett Szabó, Szilárd Váncsa, Péter Hegyi, Alex Váradi, Attila Forintos, Teodóra Filipov, Júlia Ács, Nándor Ács, Tibor Szarvas, Péter Nyirády and Zsolt Kopa
    Citation: Reproductive Biology and Endocrinology 2023 21:5
    Content type: Review Published on:

  10. Emerging evidence of immunological dysfunction have been described in endometriosis. Dendritic cells (DCs), one of the main antigen-presenting cells, are specialized in the initiation and modulation of the ada...

    Authors: Zheng Qiaomei, Wu Ping, Zhao Yanjing, Wang Jinhua, Chen Shaozhan and Chen Lihong
    Citation: Reproductive Biology and Endocrinology 2023 21:4
    Content type: Research Published on:

  11. COVID-19 infection has been linked with erectile dysfunction, which has also raised apprehensions about the impact of COVID-19 vaccination on male sexual functions. The purpose of this study was to investigate...

    Authors: Poonam Mehta, Arijit Chakraborty, Syed Waseem Andrabi, Bhawani Sharma, Rakesh Kumar, L. V. K. S. Bhaskar and Singh Rajender
    Citation: Reproductive Biology and Endocrinology 2023 21:3
    Content type: Research Published on:

  12. Forty-six ,XY Differences/Disorders of Sex Development (DSD) are characterized by a broad phenotypic spectrum ranging from typical female to male with undervirilized external genitalia, or more rarely testicul...

    Authors: Khouloud Rjiba, Soumaya Mougou-Zerelli, Imen hadj Hamida, Ghada Saad, Bochra Khadija, Afef Jelloul, Wafa Slimani, Yosra Hasni, Sarra Dimassi, Hela Ben khelifa, Amira Sallem, Molka Kammoun, Hamza Hadj Abdallah, Moez Gribaa, Joelle Bignon-Topalovic, Sami Chelly…
    Citation: Reproductive Biology and Endocrinology 2023 21:2
    Content type: Research Published on:

  13. The exact role of sperm reactive oxygen species (ROS) in early embryo development has yet to be fully identified, and most of existing research did not differentiate female infertility factors, ignoring the im...

    Authors: Jin Liu, Keheng Zhu, Shiyan Xu, Wenjiao Tu, Xiaotan Lin, Youpeng Su, Rong Huang, Yuao Deng and Yu Liu
    Citation: Reproductive Biology and Endocrinology 2023 21:1
    Content type: Research Published on:

  14. There is a growing body of human, animal and in vitro studies on vitamin D (vit D) substitution in endometriosis. The aim of this systematic review is to critically appraise and qualitatively synthesize the resul...

    Authors: Dimitrios Rafail Kalaitzopoulos, Nicolas Samartzis, Angelos Daniilidis, Brigitte Leeners, Sofia Makieva, Konstantinos Nirgianakis, Ioannis Dedes, Julian Matthias Metzler, Patrick Imesch and Ioannis G. Lempesis
    Citation: Reproductive Biology and Endocrinology 2022 20:176
    Content type: Review Published on:

  15. The risk of hypertensive disorders of pregnancy (HDP) varies in women with gestational diabetes mellitus (GDM), depending on the degree of insulin resistance and is also influenced by obesity. The aim of this ...

    Authors: Almudena Lara-Barea, Begoña Sánchez-Lechuga, Manuel Aguilar-Diosdado and Cristina López-Tinoco
    Citation: Reproductive Biology and Endocrinology 2022 20:175
    Content type: Research Published on:

  16. Endometriosis is a chronic, inflammatory gynaecological disease that can have severe negative impacts on quality of life and fertility, placing burden on patients and the healthcare system. Due to the heterog...

    Authors: Simon Scheck, Emily S. J. Paterson and Claire E. Henry
    Citation: Reproductive Biology and Endocrinology 2022 20:174
    Content type: Review Published on:

  17. High-temperature requirement protease A2 (HtrA2/Omi) is a mitochondrial chaperone that is highly conserved from bacteria to humans. It plays an important role in mitochondrial homeostasis and apoptosis. In thi...

    Authors: Min Gao, Yanling Qiu, Tianqi Cao, Dungao Li, Jingwen Wang, Yiren Jiao, Zhiyun Chen and Junjiu Huang
    Citation: Reproductive Biology and Endocrinology 2022 20:173
    Content type: Research Published on:

  18. Authors: Liwei Yuan, Jia Cao, Mingyue Hu, Dabao Xu, Yan Li, Shiyun Zhao, Juanjuan Yuan, Huixing Zhang, Yani Huang, He Jin, Meixia Chen and Dan Liu
    Citation: Reproductive Biology and Endocrinology 2022 20:172
    Content type: Correction Published on:

    The original article was published in Reproductive Biology and Endocrinology 2022 20:121

  19. Nowadays, patients attempting social/elective egg freezing has spread globally. Ovarian stimulation (OS) with high daily gonatotropin doses, are commonly offered to this group of patients, aiming to achieve th...

    Authors: Raoul Orvieto, Adva Aizer, Bozhena Saar-Ryss, Lilach Marom-Haham, Meirav Noach-Hirsh, Jigal Haas and Ravit Nahum
    Citation: Reproductive Biology and Endocrinology 2022 20:171
    Content type: Research Published on:

  20. The precise pathogenesis of poor endometrial receptivity in recurrent implantation failure (RIF) remains unclear. This study was aimed at exploring the effects of different CD44 isoforms in the mid-secretory p...

    Authors: Xiaowei Zhou, Yi Cao, Mingjuan Zhou, Mi Han, Mengyu Liu, Yanqin Hu, Bufang Xu and Aijun Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:170
    Content type: Research Published on:

  21. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) is involved in inflammation and fertility in women with polycystic ovary syndrome (PCOS). This study aims to assess the role of ADAM...

    Authors: Yanbin Shi, Yang Shi, Guiyuan He, Guang Wang, Hongbo Liu and Xiaoguang Shao
    Citation: Reproductive Biology and Endocrinology 2022 20:169
    Content type: Research Published on:

  22. Preimplantation embryonic lethality is a driver of female infertility. Certain microRNAs (miRNAs) have previously been demonstrated to play important roles in the regulation of embryogenesis.

    Authors: Ou Jian, Ni MengXia, Xing Shiyu, Meng QingXia, Zou QinYan, Ding Jie, Wang Wei, Wan Jiaojiao, Li Hong and Huang Yining
    Citation: Reproductive Biology and Endocrinology 2022 20:168
    Content type: Research Published on:

  23. To investigate the effects of coenzyme Q10 (CoQ10) and transcutaneous electrical acupoint stimulation (TEAS) pretreatment on pregnancy in patients with poor ovarian response (POR).

    Authors: Shanqin Qi, Qi Liang, Lixia Yang, Xueyuan Zhou, Kun Chen and Ji Wen
    Citation: Reproductive Biology and Endocrinology 2022 20:167
    Content type: Research Published on:

  24. In mammals, normal fertilization depends on the structural and functional integrity of the zona pellucida (ZP), which is an extracellular matrix surrounding oocytes. Mutations in ZP may affect oogenesis, fertiliz...

    Authors: Juepu Zhou, Meng Wang, Qiyu Yang, Dan Li, Zhou Li, Juan Hu, Lei Jin and Lixia Zhu
    Citation: Reproductive Biology and Endocrinology 2022 20:166
    Content type: Review Published on:

  25. Polycystic ovary syndrome is associated with an increased rate of spontaneous abortion/early pregnancy loss and pups delivered to PCOS animals were abnormal. Currently, assisted reproductive technology has bee...

    Authors: Shivani Dhadhal and Laxmipriya Nampoothiri
    Citation: Reproductive Biology and Endocrinology 2022 20:165
    Content type: Research Published on:

  26. Sperm, during epididymal transit, acquires microRNAs(miRNAs), which are crucial for embryonic development. However, whether sperm miRNAs influenced by an obstructive epididymal environment affect embryonic dev...

    Authors: Xunwei Wu, Xiaomei He, Qian Liu and Honggang Li
    Citation: Reproductive Biology and Endocrinology 2022 20:164
    Content type: Research Published on:

  27. Obesity impacts fertility and is positively correlated with endometrial hyperplasia and endometrial cancer occurrence. Endometrial epithelia often harbor disease driver-mutations, while endometrial stroma are ...

    Authors: Mike R. Wilson, Hilary Skalski, Jake J. Reske, Marc Wegener, Marie Adams, Galen Hostetter, Hanne M. Hoffmann, Jamie J. Bernard, Victoria L. Bae-Jump, Jose M. Teixeira and Ronald L. Chandler
    Citation: Reproductive Biology and Endocrinology 2022 20:163
    Content type: Research Published on:

  28. Previous studies have demonstrated that the supraphysiological E2 level is negatively correlated with birthweight. However, the cut-off value of E2 level that significantly affects birthweight is unknown, and ...

    Authors: Jing Wu, Hengde Zhang and Xiaohong Wang
    Citation: Reproductive Biology and Endocrinology 2022 20:162
    Content type: Research Published on:

  29. Mammalian sperm maturation in the epididymis is mainly modulated by exosomes that are secreted into the epididymal lumen from epididymal epithelial cells (EECs). Exposure to oxidative stress (OS) resulting fro...

    Authors: Yangyang Li, Wenzhen Zhao, Rong Fu, Zhuoyao Ma, Yanqin Hu, Yue Liu and Zhide Ding
    Citation: Reproductive Biology and Endocrinology 2022 20:161
    Content type: Research Published on:

  30. MicroRNAs (miRNAs) are considered potential biomarkers for various diseases. This study investigated whether hsa-miR-320a-3p and hsa-miR-483-5p levels in human ovarian granulosa cells derived from follicular flui...

    Authors: Yu Liu, Qiaojuan Mei, Jiahao Yang, Qiuzi Shen, Min Zou, Jiao Li, Huaibiao Li, Ling Zhang and Wenpei Xiang
    Citation: Reproductive Biology and Endocrinology 2022 20:160
    Content type: Research Published on:

  31. The widely accepted explanation of preeclampsia (PE) pathogenesis is insufficient trophoblast invasion and impaired uterine spiral artery remodeling. However, the underlying molecular mechanism remains unclear.

    Authors: Lingyun Liao, Min Liu, Yijie Gao, Xiaohong Wei, Yangxue Yin, Linbo Gao and Rong Zhou
    Citation: Reproductive Biology and Endocrinology 2022 20:159
    Content type: Research Published on:

  32. Steroidogenesis is a complex process of sequential enzymatic reactions affected by climate change. Animals respond to altered day length, the so-called photoperiod, with changes in physiology. The study aimed ...

    Authors: Eman Hassan, Shahinaz Magdy, Amany Attaallah, Eman Gaber, Omnia Mansour, Rehab A. Gomaa, Hala Odessy, Maria Augustyniak, Lamia M. El-Samad and Abeer El Wakil
    Citation: Reproductive Biology and Endocrinology 2022 20:158
    Content type: Research Published on:

  33. Polycystic ovary syndrome (PCOS) is a complex reproductive disorder, that affects approximately 5–10% of women of reproductive age. The disease is complex because its evolution may be impacted by genetic, life...

    Authors: Faying Liu, Lifeng Tian, Jun Tan, Zengming Li, Haiyan Qin, Dingfei Xu, Zhihui Huang, Xingwu Wu, Ge Chen, Qiongfang Wu and Yang Zou
    Citation: Reproductive Biology and Endocrinology 2022 20:157
    Content type: Research Published on:

  34. Reproductive aging is characterized by a decline in oocyte quantity and quality, which is directly associated with a decline in reproductive potential, as well as poorer reproductive success and obstetrical ou...

    Authors: Ecem Esencan, Gabriela Beroukhim and David B. Seifer
    Citation: Reproductive Biology and Endocrinology 2022 20:156
    Content type: Review Published on:

  35. Altered sperm DNA methylation patterns of imprinted genes as well as certain spermatogenesis-related genes has been proposed as a possible mechanism of male subfertility. Some reports suggest that there is an ...

    Authors: Bing Song, Yujie Chen, Chao Wang, Guanjian Li, Zhaolian Wei, Xiaojin He and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:155
    Content type: Research Published on:

  36. The importance of actin and microtubule (MT) cytoskeletons in testis function in rodents is known to some extent, but its role in the etiology of azoospermia in humans remains unexplored. Here, we examined if ...

    Authors: Xiaolong Wu, Damin Yun, Mengmeng Sang, Jianpeng Liu, Liwei Zhou, Jie Shi, Lingling Wang, Tiao Bu, Linxi Li, YingYing Huang, Dengfeng Lin, Fei Sun and C. Yan Cheng
    Citation: Reproductive Biology and Endocrinology 2022 20:154
    Content type: Research Published on:

  37. Women with polycystic ovary syndrome (PCOS) have high circulating anti-Müllerian hormone (AMH) levels which is correlated with antral follicle count and polycystic ovarian morphology and negatively correlated ...

    Authors: Josefin Kataoka, Ingrid Larsson, Eva Lindgren, Li Oskarson Kindstrand, Johanna Schmidt and Elisabet Stener-Victorin
    Citation: Reproductive Biology and Endocrinology 2022 20:153
    Content type: Research Published on:

  38. Extracellular vesicles (EVs) could mediate embryo-maternal communication to affect embryo implantation by delivering biology information, including microRNA (miRNA), protein, lipid. Our previous research shows...

    Authors: Renwu Hua, Qiaorui Liu, Weisi Lian, Ting ting Kang, Dengying Gao, Cheng Huang, Yueying Wang and Minggang Lei
    Citation: Reproductive Biology and Endocrinology 2022 20:152
    Content type: Research Published on:

  39. This study aims to study whether the change of endometrial thickness between the day of human chorionic gonadotrophin (HCG) administration and the day of embryo transfer (ET) has any effect on ectopic pregnanc...

    Authors: Qiuyuan Li, Ahui Liu, Haofei Shen and Xuehong Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:151
    Content type: Research Published on:

  40. Peptidylarginine deiminase enzymes (PADs) convert arginine residues to citrulline in a process called citrullination or deimination. Recently, two PADs, PAD2 and PAD4, have been linked to hormone signaling in ...

    Authors: Kelly L. Sams, Chinatsu Mukai, Brooke A. Marks, Chitvan Mittal, Elena Alina Demeter, Sophie Nelissen, Jennifer K. Grenier, Ann E. Tate, Faraz Ahmed and Scott A. Coonrod
    Citation: Reproductive Biology and Endocrinology 2022 20:150
    Content type: Research Published on:

  41. Previous research has shown that the type and duration of erotic material that men have access to during masturbation can influence semen parameters. To our knowledge, the use of virtual reality (VR) headsets ...

    Authors: Daniel Rosenkjær, Allan Pacey, Robert Montgomerie and Anne-Bine Skytte
    Citation: Reproductive Biology and Endocrinology 2022 20:149
    Content type: Research Published on:

  42. Encapsulation of follicles within a biomatrix is one approach to maintaining 3-D follicle architecture during culture. Hyaluronan is one component of the natural extracellular matrix (ECM) that provides suppor...

    Authors: Nina Desai, Maribeth Spangler, Vaani Nanavaty, Arsela Gishto and Alyssa Brown
    Citation: Reproductive Biology and Endocrinology 2022 20:148
    Content type: Research Published on:

  43. To compare the efficacy and safety of follitropin delta in its individualized fixed-dose regimen with follitropin alfa in a conventional adjustable dosing regimen in Chinese women. 

    Authors: Rui Yang, Yunshan Zhang, Xiaoyan Liang, Xueru Song, Zhaolian Wei, Jianqiao Liu, Yezhou Yang, Jichun Tan, Qingxue Zhang, Yingpu Sun, Wei Wang, Weiping Qian, Lei Jin, Shuyu Wang, Yang Xu, Jing Yang…
    Citation: Reproductive Biology and Endocrinology 2022 20:147
    Content type: Research Published on:

  44. Tamoxifen (TAM) is a frequently-used treatment for breast cancer (BC). But the TAM resistance seriously affects the patient therapeutic effect. Previous research indicated that circular RNAs (circRNAs) might p...

    Authors: Shiyong Yang, Changwu Zou, Yuxin Li, Xianguo Yang, Wei Liu, Guannan Zhang and Nina Lu
    Citation: Reproductive Biology and Endocrinology 2022 20:146
    Content type: Research Published on:

  45. To assess the association between chromosomal polymorphisms (CPM) with congenital anomalies and perinatal complications in a cohort of newborns from couples undergoing intracytoplasmic sperm injection (ICSI), ...

    Authors: Freddy Rodriguez, Maria Cruz and Antonio Requena
    Citation: Reproductive Biology and Endocrinology 2022 20:145
    Content type: Research Published on:

  46. Nowadays, different modes and timing of GnRH-agonist combined with hCG trigger, for final follicular maturation, have been described. While LH + FSH are the naturally occurring final follicular maturation trig...

    Authors: Yuval Yung, Adva Aizer, Sarah Tieb, Sharon Avhar Maydan, Ettie Maman, Lilach Marom Haham, Jigal Haas and Raoul Orvieto
    Citation: Reproductive Biology and Endocrinology 2022 20:144
    Content type: Research Published on:

  47. In this case report, we highlight the practical dilemma, i.e. to perform ovarian tissue cryopreservation surgery in a 45, X Turner Syndrome patient or not, by reporting on the presence of follicles in a 13-yea...

    Authors: MJ Schleedoorn, K Fleischer, DDM Braat, AJM Oerlemans, AAEM van der Velden and R Peek
    Citation: Reproductive Biology and Endocrinology 2022 20:143
    Content type: Research Published on:

  48. Successful implantation is a complex process that is influenced by embryo quality, endometrial receptivity, immune factors, and the specific type of in vitro fertilization protocol used. DNA topoisomerase IIα ...

    Authors: Huijia Fu, Wang Tan, Zhi Chen, Zi Ye, Yuhan Duan, Jiayu Huang, Hongbo Qi and Xiru Liu
    Citation: Reproductive Biology and Endocrinology 2022 20:142
    Content type: Research Published on:

  49. Frozen-thawed embryo transfer (FET) is thought to be associated with obstetric and neonatal complications after in vitro fertilization/intracytoplasmic single sperm injection (IVF/ICSI) treatment. The study ai...

    Authors: Junting Xu, Hong Zhou, Tianfan Zhou, Yi Guo, Shanshan Liang, Yanping Jia, Kunming Li and Xiaoming Teng
    Citation: Reproductive Biology and Endocrinology 2022 20:141
    Content type: Research Published on:

  50. The gonadotropin-releasing hormone agonist (GnRH-a) has been used in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles for a long time. This paper evaluates the efficacy and safety of t...

    Authors: Ying Zhang, Wenxian Zhao, Yifan Han, Xin Chen, Shaoyuan Xu, Yueyue Hu, Honglu Diao and Changjun Zhang
    Citation: Reproductive Biology and Endocrinology 2022 20:140
    Content type: Research Published on:
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Reproductive Biology and Endocrinology

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