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  1. Total fertilization failure represents a particularly frustrating condition for couples undergoing in vitro fertilization. With the aim of reducing the occurrence of total fertilization failure, intracytoplasm...

    Authors: Alessio Paffoni, Marco Reschini, Valerio Pisaturo, Cristina Guarneri, Simone Palini and Paola Viganò
    Citation: Reproductive Biology and Endocrinology 2021 19:121
  2. This study aimed to detect the effect of angiotensin receptor 1 (AT1) knock out (KO) on spermatogenesis and hypothalamic-pituitary–gonadal (HPG) axis hormone expression.

    Authors: Fangfang Zhao, Yun Zou, Hui Li, Yaheng Zhang, Xuele Liu, Xuehao Zhao, Xinyi Wu, Wenyi Fei, Ziling Xu and Xuejun Yang
    Citation: Reproductive Biology and Endocrinology 2021 19:120
  3. Exposure to endocrine-disrupting chemicals, such as Bisphenol A (BPA) and Bisphenol S (BPS), is widespread and has negative implications on embryonic development. Preliminary evidence revealed that in women un...

    Authors: Angela Christina Saleh, Reem Sabry, Gabriela Fabiana Mastromonaco and Laura Alessandra Favetta
    Citation: Reproductive Biology and Endocrinology 2021 19:119
  4. Fertility-sparing therapy is an alternative conservative treatment for patients with early stage endometrioid cancer or atypical endometrial hyperplasia. In this study, we investigated pregnancy outcomes and p...

    Authors: Yuan Fan, Xingchen Li, Jiaqi Wang, Yiqin Wang, Li Tian and Jianliu Wang
    Citation: Reproductive Biology and Endocrinology 2021 19:118
  5. Which fertilization method, between ICSI and IVF in split insemination treatments, has the highest clinical efficiency in producing clinically usable blastocyst?

    Authors: Sandrine Chamayou, Carmen Ragolia, Carmelita Alecci, Giorgia Storaci, Simona Romano, Roberta Sapienza, Elena Maglia, Annalisa Liprino, Clementina Cardea, Michele Fichera and Antonino Guglielmino
    Citation: Reproductive Biology and Endocrinology 2021 19:116
  6. The period of time when the embryo and the endometrium undergo significant morphological alterations to facilitate a successful implantation—known as “window of implantation”—is a critical moment in human repr...

    Authors: Kasun Godakumara, James Ord, Freddy Lättekivi, Keerthie Dissanayake, Janeli Viil, Nageswara Rao Boggavarapu, Omid R Faridani, Kersti Jääger, Agne Velthut-Meikas, Ülle Jaakma, Andres Salumets and Alireza Fazeli
    Citation: Reproductive Biology and Endocrinology 2021 19:115
  7. The immune mechanism was shown to be involved in the development of adenomyosis. The aim of the current study was to evaluate the expression of the immune checkpoints B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyos...

    Authors: Xiaoyan Qin, Wenjing Sun, Chong Wang, Mingjiang Li, Xingbo Zhao, Changzhong Li and Hui Zhang
    Citation: Reproductive Biology and Endocrinology 2021 19:114
  8. Premature ovarian failure (POF) is a common disease in the field of Gynecology. Low intensity pulsed ultrasound (LIPUS) can promote tissue repair and improve function. This study was performed to determine the...

    Authors: Haopeng Xu, Yi Xia, Juan Qin, Jie Xu, Chongyan Li and Yan Wang
    Citation: Reproductive Biology and Endocrinology 2021 19:113
  9. The tumor susceptibility gene 101 (Tsg101), a component of the endosomal sorting complex required for transport (ESCRT) complex I, is involved in multiple biological processes involving endomembranous structur...

    Authors: Hyunji Byun, Sojung Kwon, Kay-Uwe Wagner, Hyejin Shin and Hyunjung Jade Lim
    Citation: Reproductive Biology and Endocrinology 2021 19:112
  10. Endometriosis is a benign gynecological disease that shares some characteristics with malignant tumors and affects approximately 10% of women of reproductive age. Endometrioma refers to endometriosis that appe...

    Authors: Yang Liu, Junyan Ma, Liqi Zhang, Jun Lin and Xiaohua Liu
    Citation: Reproductive Biology and Endocrinology 2021 19:111
  11. Until 2010, the National Assisted Reproductive Technology Surveillance System (NASS) report, published annually by the Center for Disease Control and Prevention (CDC), demonstrated almost constantly improving ...

    Authors: Norbert Gleicher, Lyka Mochizuki and David H. Barad
    Citation: Reproductive Biology and Endocrinology 2021 19:110
  12. Morphological features are the most common criteria used to select human embryos for transfer to a receptive uterine cavity. However, such characteristics are not valid for embryos in cellular arrest. Even ane...

    Authors: Ricardo Josué Acuña-González, Mercedes Olvera-Valencia, Jorge Skiold López-Canales, Jair Lozano-Cuenca, Mauricio Osorio-Caballero and Héctor Flores-Herrera
    Citation: Reproductive Biology and Endocrinology 2021 19:109
  13. The mechanism of recurrent implantation failure (RIF) is unclear at present and poor endometrial receptivity may be one of the leading reasons. This study aims to construct a competing endogenous RNA (ceRNA) n...

    Authors: Jialyu Huang, Ning Song, Leizhen Xia, Lifeng Tian, Jun Tan, Qianqian Chen, Jing Zhu and Qiongfang Wu
    Citation: Reproductive Biology and Endocrinology 2021 19:108
  14. Heat stress (HS) occurs when body heat accumulation exceeds heat dissipation and is associated with swine seasonal infertility. HS contributes to compromised oocyte integrity and reduced embryo development. Au...

    Authors: Benjamin J. Hale, Yunsheng Li, Malavika K. Adur, Aileen F. Keating, Lance H. Baumgard and Jason W. Ross
    Citation: Reproductive Biology and Endocrinology 2021 19:107
  15. Uterine leiomyoma is a benign tumor with unclear pathogenesis and inaccurate treatment. This tumor exhibits altered DNA methylation related to disease progression. DNMT inhibitors as 5-aza-2′-deoxycytidine (5-...

    Authors: María Cristina Carbajo-García, Ana Corachán, Marina Segura-Benitez, Javier Monleón, Julia Escrig, Amparo Faus, Antonio Pellicer, Irene Cervelló and Hortensia Ferrero
    Citation: Reproductive Biology and Endocrinology 2021 19:106
  16. It has been previously demonstrated that cholesterol content and cholesterol/phospholipid ratio were significantly higher in asthenozoospermia and oligoasthenoteratozoospermia. The majority of published studie...

    Authors: Shuqiang Chen, Ming Wang, Li Li, Jun Wang, Xuhui Ma, Hengde Zhang, Yang Cai, Bin Kang, Jianlei Huang and Bo Li
    Citation: Reproductive Biology and Endocrinology 2021 19:105
  17. Structural and physiological changes in sperm and semen parameters reduce fertility in diabetic patients. Securigera Securidaca (S. Securidaca) seed is a herbal medicine with hypoglycemic, antioxidant, and anti-h...

    Authors: Mohammad Babaei, Shahin Alizadeh-Fanalou, Alireza Nourian, Sahar Yarahmadi, Navid Farahmandian, Mohsen Nabi-Afjadi, Iraj Alipourfard and Elham Bahreini
    Citation: Reproductive Biology and Endocrinology 2021 19:104
  18. Various luteal phase supports (LPSs) have been proven to increase the pregnancy rate in fresh cycles of in vitro fertilization or intracytoplasmic sperm injection; however, there is still significant debate re...

    Authors: Hanglin Wu, Songying Zhang, Xiaona Lin, Shasha Wang and Ping Zhou
    Citation: Reproductive Biology and Endocrinology 2021 19:103
  19. Evaluate the effects of vitamin D3 (VD3) on sperm parameters and endocrine markers in infertile men with asthenozoospermia.

    Authors: Leila Maghsoumi-Norouzabad, Ahmad Zare Javid, Anahita Mansoori, Mohammadreza Dadfar and Amirarsalan Serajian
    Citation: Reproductive Biology and Endocrinology 2021 19:102
  20. Human Ectopic Pregnancy (hEP) is the second most common cause of pregnancy-related deaths in the first trimester. Without timely detection, EPs can lead to an increased rate of infertility and an elevated risk...

    Authors: Wen Cai, Liu Yang, Ruiqing Zhang, Yixia Yang, Shuangdi Li and Jiarong Zhang
    Citation: Reproductive Biology and Endocrinology 2021 19:101
  21. Preeclampsia (PE) is an idiopathic disease that occurs during pregnancy. It comprises multiple organ and system damage, and can seriously threaten the safety of the mother and infant throughout the perinatal p...

    Authors: Ningxia Sun, Shiting Qin, Lu Zhang and Shiguo Liu
    Citation: Reproductive Biology and Endocrinology 2021 19:100
  22. The gonadotropin-releasing hormone (GnRH) antagonist protocol for in vitro fertilization (IVF) often leads to lower pregnancy rates compared to the GnRH agonist protocol. Decreased endometrial receptivity is o...

    Authors: Dan Zhang, Mi Han, Mingjuan Zhou, Mengyu Liu, Yan Li, Bufang Xu and Aijun Zhang
    Citation: Reproductive Biology and Endocrinology 2021 19:99
  23. The KIDScore™ Day 5 (KS-D5) model, version 3, is a general morphokinetic prediction model (Vitrolife, Sweden) for fetal heartbeat prediction after embryo transfer that was developed based on a large data set t...

    Authors: Keiichi Kato, Satoshi Ueno, Jørgen Berntsen, Motoki Ito, Kiyoe Shimazaki, Kazuo Uchiyama and Tadashi Okimura
    Citation: Reproductive Biology and Endocrinology 2021 19:98
  24. Recent years have seen a rising incidence of male infertility, mostly caused by the decline of sperm quality. The ratio of infertile males to infertile females has escalated from 3:7 in 2013 to current 5:5, wh...

    Authors: Kang-Sheng Liu, Xiao-Dong Mao, Feng Pan and Rui Fang An
    Citation: Reproductive Biology and Endocrinology 2021 19:97
  25. Successful human embryo implantation requires the differentiation of endometrial stromal cells (ESCs) into decidual cells during a process called decidualization. ESCs express specific markers of decidualizati...

    Authors: Esther Dos Santos, Hadia Moindjie, Valérie Sérazin, Lucie Arnould, Yoann Rodriguez, Khadija Fathallah, Eytan R. Barnea, François Vialard and Marie-Noëlle Dieudonné
    Citation: Reproductive Biology and Endocrinology 2021 19:96
  26. Otogelin-like protein (encoded by Otogl) was highly structural similar to the gelforming mucin proteins. Although human OTOG mutations have been linked to deafness, the biological function of OTOGL in male germ c...

    Authors: Zhiming Li, Yan Zhang, Xinzong Zhang, Congcong Cao, Xiaomin Luo, Yaoting Gui, Yunge Tang and Shuiqiao Yuan
    Citation: Reproductive Biology and Endocrinology 2021 19:95

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2021 19:136

  27. The male and female prostates are controlled by steroid hormones, suffering important morphological and physiological changes after castration. Prolactin is involved in the regulation of the male prostate, hav...

    Authors: Marianna Zanatelli, Simone Jacovaci Colleta, Luiz Henrique Alves Guerra, Fernanda Cristina Alcântara Santos, Rejane Maira Góes, Patricia Simone Leite Vilamaior and Sebastião Roberto Taboga
    Citation: Reproductive Biology and Endocrinology 2021 19:94
  28. Endometrial thickness (ET) has previously been shown to positively correlate with implantation and clinical pregnancy rates. Pregnancies achieved using in-vitro fertilization (IVF) technique are prone to highe...

    Authors: Gilad Karavani, Heli Alexandroni, Daniel Sheinin, Uri P. Dior, Alex Simon, Assaf Ben-Meir and Benjamin Reubinoff
    Citation: Reproductive Biology and Endocrinology 2021 19:93
  29. The role of sexually transmitted infections (STIs) in semen parameters and male infertility is still a controversial area. Previous studies have found bacterial infection in a minority of infertile leukocytosp...

    Authors: Shun Bai, Yuan Li, Yangyang Wan, Tonghang Guo, Qi Jin, Ran Liu, Wenjuan Tang, Meiying Sang, Yuanyuan Tao, Baoguo Xie, Yun Zhao, Wei Li, Xiangdong Xu, Qiuling Yue, Xuechun Hu and Bo Xu
    Citation: Reproductive Biology and Endocrinology 2021 19:92

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2022 20:69

  30. Several studies suggest that luteinizing hormone (LH) could improve IVF outcome in women of advanced reproductive age by optimizing androgen production. In this review, we assessed the role of recombinant-huma...

    Authors: Alessandro Conforti, Sandro C. Esteves, Peter Humaidan, Salvatore Longobardi, Thomas D’Hooghe, Raoul Orvieto, Alberto Vaiarelli, Danilo Cimadomo, Laura Rienzi, Filippo Maria Ubaldi, Fulvio Zullo and Carlo Alviggi
    Citation: Reproductive Biology and Endocrinology 2021 19:91
  31. This study compared the effectiveness of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa; GONAL-f®) with urinary highly purified human menopausal gonadotropin (hMG HP; Menogon HP®), during assist...

    Authors: Klaus F. Bühler, Robert Fischer, Patrice Verpillat, Arthur Allignol, Sandra Guedes, Emmanuelle Boutmy, Wilma Bilger, Emilia Richter and Thomas D’Hooghe
    Citation: Reproductive Biology and Endocrinology 2021 19:90
  32. After fertilization, the fusion of gametes results in the formation of totipotent zygote. During sperm-egg fusion, maternal factors participate in parental chromatin remodeling. H3.3 is a histone H3 variant th...

    Authors: Shi-meng Guo, Xing-ping Liu and Li-quan Zhou
    Citation: Reproductive Biology and Endocrinology 2021 19:87
  33. Endometriosis is a chronic hormonal inflammatory disease characterized by the presence of endometrial tissue outside the uterus. Endometriosis often causes infertility, which brings physical and mental pain to...

    Authors: Yixin Wang, Jing Xiu, Tingting Yang, Chune Ren and Zhenhai Yu
    Citation: Reproductive Biology and Endocrinology 2021 19:86
  34. The importance of spermatogonial stem cells (SSCs) in spermatogenesis is crucial and intrinsic factors and extrinsic signals mediate fate decisions of SSCs. Among endogenous regulators, microRNAs (miRNAs) play...

    Authors: Maryam Khanehzad, Seyed Mehdi Nourashrafeddin, Farid Abolhassani, Shokoofeh Kazemzadeh, Soheila Madadi, Elham Shiri, Parastoo Khanlari, Zahra Khosravizadeh and Azim Hedayatpour
    Citation: Reproductive Biology and Endocrinology 2021 19:85
  35. Uterine adenomyosis is a benign disease, common among women in their 40 and 50 s, characterised by ectopic endometrial tissue in the uterine myometrial layer. Adenomyosis causes infertility and has a negative ...

    Authors: Takuya Iwasawa, Toshifumi Takahashi, Eri Maeda, Koichi Ishiyama, Satoshi Takahashi, Ryota Suganuma, Koki Matsuo, Masahito Tachibana, Rie Fukuhara, Hiromitsu Shirasawa, Wataru Sato, Yukiyo Kumazawa and Yukihiro Terada
    Citation: Reproductive Biology and Endocrinology 2021 19:84
  36. Lysophosphatidic acid-supplemented culture medium significantly increases the oocyte maturation rate in vitro. However, potential targets and pathways involved remain unknown.

    Authors: Qigui Xie, Yaxin Xing, Jianhong Zhou, Ling Wang, Jie Wu and Ri-Cheng Chian
    Citation: Reproductive Biology and Endocrinology 2021 19:83
  37. Recent studies have revealed that women with infertility have a higher risk of thyroid cancer (TC) than fertile women. However, studies on whether a history of thyroid cancer affects clinical outcomes in women...

    Authors: Ning Huang, Lin Zeng, Jie Yan, Hongbin Chi and Jie Qiao
    Citation: Reproductive Biology and Endocrinology 2021 19:82
  38. Let-7a is a small non-coding RNA that has been found to take part in cell proliferation and apoptosis. The hippo-YAP1 axis, known as a tumour suppressor pathway, also plays an important role in cell proliferat...

    Authors: Jun-Hua Huang, Hua Duan, Sha Wang, Yi-Yi Wang and Cheng-Xiao LV
    Citation: Reproductive Biology and Endocrinology 2021 19:81
  39. Ovarian reserve reflects the quality and quantity of available oocytes and has become an indispensable measure for the better understanding of reproductive potential. Proteomic approaches are especially helpfu...

    Authors: Sanglin Li, Lina Hu and Chanyu Zhang
    Citation: Reproductive Biology and Endocrinology 2021 19:80
  40. The aim of this study was to investigate characteristics associated with ectopic pregnancy (EP) that could be utilized for predicting morbidity or mortality.

    Authors: Ammar Al Naimi, Pablo Moore, Dörthe Brüggmann, Lisa Krysa, Frank Louwen and Franz Bahlmann
    Citation: Reproductive Biology and Endocrinology 2021 19:79
  41. Traditionally, final follicular maturation is triggered by a single bolus of human chorionic gonadotropin (hCG). This acts as a surrogate to the naturally occurring luteinizing hormone (LH) surge to induce lut...

    Authors: Kai-Lun Hu, Siwen Wang, Xiaohang Ye, Dan Zhang and Sarah Hunt
    Citation: Reproductive Biology and Endocrinology 2021 19:78
  42. Polycystic ovary syndrome (PCOS) causes anovulation and is associated with a reduced clinical pregnancy rate. Metformin, which is widely used for treating PCOS, can lead to successful pregnancy by restoring th...

    Authors: Miki Ohara, Hiromi Yoshida-Komiya, Miho Ono-Okutsu, Akiko Yamaguchi-Ito, Toshifumi Takahashi and Keiya Fujimori
    Citation: Reproductive Biology and Endocrinology 2021 19:77
  43. The majority of available studies on the AMH thresholds were not age-specific and performed the receiver operating characteristic curve (ROC) analysis, based on variations in sensitivity and specificity rather...

    Authors: Fahimeh Ramezani Tehrani, Maryam Rahmati, Fatemeh Mahboobifard, Faezeh Firouzi, Nazanin Hashemi and Fereidoun Azizi
    Citation: Reproductive Biology and Endocrinology 2021 19:76
  44. Increasing evidence supports a relationship between obesity and either infertility or subfertility in women. Most previous omics studies were focused on determining if the serum and follicular fluid expression...

    Authors: Chenchen Si, Nan Wang, Mingjie Wang, Yue Liu, Zhihong Niu and Zhide Ding
    Citation: Reproductive Biology and Endocrinology 2021 19:75
  45. Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder with various manifestations and complex etiology. Follicular fluid (FF) serves as the complex microenvironment for follicular development...

    Authors: Li Yu, Miao Liu, Zhenxin Wang, Te Liu, Suying Liu, Beili Wang, Baishen Pan, Xi Dong and Wei Guo
    Citation: Reproductive Biology and Endocrinology 2021 19:74
  46. Low endometrial receptivity is one of the major factors affecting successful implantation in assisted reproductive technologies (ART). Infertile patients with thin endometrium have a significantly lower cumula...

    Authors: Marina M. Ziganshina, Nataliya V. Dolgushina, Galina V. Kulikova, Nafisa M. Fayzullina, Ekaterina L. Yarotskaya, Nailia R. Khasbiullina, Nigora F. Abdurakhmanova, Aleksandra V. Asaturova, Alexander I. Shchegolev, Alina A. Dovgan and Gennady T. Sukhikh
    Citation: Reproductive Biology and Endocrinology 2021 19:73
  47. MicroRNAs (miRNAs) are small RNA molecules that modulate post-transcriptional gene regulation. They are often used as promising non-invasive biomarkers for the early diagnosis of cancer. However, their roles i...

    Authors: Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Celal Kaloglu, Ahmed M. Isa, Hooria Younas, Rachel Ziders, Yousaf Latif Khan, Zahira Hassan, Bilgün Oztürk Turhan, Aysegul Yildiz, Hikmet Hakan Aydin and Ender Yalcinkaya Kalyan
    Citation: Reproductive Biology and Endocrinology 2021 19:72

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