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  1. Content type: Research

    The sensitivity and specificity of non-invasive diagnostic methods for endometriosis, especially at early stages, are not optimal. The clinical diagnostic indicator cancer antigen 125 (CA125) performs poorly i...

    Authors: Jingjie Li, Lihuan Guan, Huizhen Zhang, Yue Gao, Jiahong Sun, Xiao Gong, Dongshun Li, Pan Chen, Xiaoyan Liang, Min Huang and Huichang Bi

    Citation: Reproductive Biology and Endocrinology 2018 16:42

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  2. Content type: Review

    The ‘omics’ approach for a noninvasive diagnosis of male reproductive system disorders has gained momentum during the last decade, particularly from a screening and prognosis point of view. Due to the rapid de...

    Authors: Luna Samanta, Rajeshwari Parida, Tania R. Dias and Ashok Agarwal

    Citation: Reproductive Biology and Endocrinology 2018 16:41

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  3. Content type: Research

    Docosahexaenoic acid (DHA) is a n-3 polyunsaturated fatty acid (PUFA) belonging to a family of biologically active fatty acids (FA), which are known to have numerous health benefits. N-3 PUFAs affect reproduct...

    Authors: Virginie Maillard, Alice Desmarchais, Maeva Durcin, Svetlana Uzbekova and Sebastien Elis

    Citation: Reproductive Biology and Endocrinology 2018 16:40

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  4. Content type: Research

    Hatching is crucial for mammalian embryo implantation, since difficulties during this process can lead to implantation failure, ectopic pregnancy and consequent infertility. Despite years of intensive research...

    Authors: Shaoquan Zhan, Shanbo Cao, Hongzi Du, Yuan Sun, Li Li, Chenhui Ding, Haiyan Zheng and Junjiu Huang

    Citation: Reproductive Biology and Endocrinology 2018 16:39

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  5. Content type: Research

    Polycystic ovary syndrome (PCOS) is a common endocrine disorder determined by polygenic traits as well as environmental factors. Lower vitamin D levels have been detected in PCOS women and related to hormone a...

    Authors: Betânia Rodrigues Santos, Sheila Bunecker Lecke and Poli Mara Spritzer

    Citation: Reproductive Biology and Endocrinology 2018 16:38

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  6. Content type: Research

    GnRH is the master molecule of reproduction that is influenced by several intrinsic and extrinsic factors such as neurotransmitters and neuropeptides. Any alteration in these regulatory loops may result in rep...

    Authors: Nirja Chaudhari, Mitali Dawalbhakta and Laxmipriya Nampoothiri

    Citation: Reproductive Biology and Endocrinology 2018 16:37

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  7. Content type: Research

    Overweight/obese women with polycystic ovary syndrome (PCOS) are at increased risk of subfertility and complications of pregnancy, compared with normal-weight women. To implement controlled ovarian hyperstimul...

    Authors: Rui Chen, Shiping Chen, Manting Liu, Hua He, Haiyan Xu, Hanyan Liu, Hongzi Du, Weihua Wang, Xuefeng Xia and Jianqiao Liu

    Citation: Reproductive Biology and Endocrinology 2018 16:36

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  8. Content type: Research

    Allopregnanolone is a neurosteroid synthesized in the central nervous system independently of steroidogenic glands; it influences sexual behavior and anxiety. The aim of this work is to evaluate the indirect e...

    Authors: Joana Antonela Asensio, Antonella Rosario Ramona Cáceres, Laura Tatiana Pelegrina, María de los Ángeles Sanhueza, Leopoldina Scotti, Fernanda Parborell and Myriam Raquel Laconi

    Citation: Reproductive Biology and Endocrinology 2018 16:35

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  9. Content type: Research

    Women with polycystic ovary syndrome are more likely to suffer from obesity, insulin resistance, and chronic low-grade inflammation. In fact, the excessive activation of monocytes exacerbates oxidative stress ...

    Authors: Akin Usta, Eyup Avci, Cagla Bahar Bulbul, Hasan Kadi and Ertan Adali

    Citation: Reproductive Biology and Endocrinology 2018 16:34

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  10. Content type: Short communication

    Some reports show that it is possible to isolate immature oocytes from human ovarian tissue retrieved by a cortex biopsy or ovariectomy of non-stimulated ovaries and mature them in vitro. The mature oocytes ca...

    Authors: Irma Virant-Klun and Andrej Vogler

    Citation: Reproductive Biology and Endocrinology 2018 16:33

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  11. Content type: Research

    Current medical treatments for endometriosis are very limited. Progestin and selective progesterone receptor modulators (SPRM) are developed but their efficacy, safety, mechanism and recurrence in endometriosi...

    Authors: Bo Liang, Ling Wu, Hui Xu, Chun Wai Cheung, Wen Ying Fung, Sze Wai Wong and Chi Chiu Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:32

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  12. Content type: Research

    Osteopontin (OPN) plays an important role in inflammatory processes and insulin resistance. Polycystic ovary syndrome (PCOS) is a reproductive metabolic disease associated with insulin resistance and metabolic...

    Authors: Yuying Wang, Wei Zhou, Chunhua Wu, Yi Zhang, Tzuchun Lin, Yun Sun, Wei Liu and Tao Tao

    Citation: Reproductive Biology and Endocrinology 2018 16:31

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  13. Content type: Research

    In search of potential early biomarkers for timely prediction of gestational diabetes mellitus (GDM), we focused on afamin, a vitamin E–binding protein in human plasma.. Afamin plays a role in anti-apoptotic c...

    Authors: Angela Köninger, Annette Mathan, Pawel Mach, Mirjam Frank, Boerge Schmidt, Ekkehard Schleussner, Rainer Kimmig, Alexandra Gellhaus and Hans Dieplinger

    Citation: Reproductive Biology and Endocrinology 2018 16:30

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  14. Content type: Research

    Management of women with reduced ovarian reserve or poor ovarian response (POR) to stimulation is one of the major challenges in reproductive medicine. The primary causes of POR remain elusive and oxidative st...

    Authors: Yangying Xu, Victoria Nisenblat, Cuiling Lu, Rong Li, Jie Qiao, Xiumei Zhen and Shuyu Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:29

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  15. Content type: Research

    Excessive nerve growth factor (NGF) is commonly found in the follicular fluid of patients with polycystic ovary syndrome (PCOS). Furthermore, oocytes from PCOS patients exhibit lower developmental competence. ...

    Authors: Yiwen Zhai, Guidong Yao, Faiza Rao, Yong Wang, Xiaoyuan Song and Fei Sun

    Citation: Reproductive Biology and Endocrinology 2018 16:28

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  16. Content type: Research

    Ovarian retinoid homeostasis plays an important role in the physiological function of the ovary. Retinol-binding protein 4 (RBP4) acts as the mediator for the systemic and intercellular transport of retinol an...

    Authors: Yanwen Jiang, Yun Zhao, Shuxiong Chen, Lu Chen, Chunjin Li and Xu Zhou

    Citation: Reproductive Biology and Endocrinology 2018 16:25

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  17. Content type: Research

    The initiation of primate embryo invasion into the endometrium and the formation of the placenta from trophoblasts, fetal mesenchyme, and vascular components are essential for the establishment of a successful...

    Authors: T. Arthur Chang, Gennadiy I. Bondarenko, Behzad Gerami-Naini, Jessica G. Drenzek, Maureen Durning, Mark A. Garthwaite, Jenna Kropp Schmidt and Thaddeus G. Golos

    Citation: Reproductive Biology and Endocrinology 2018 16:24

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  18. Content type: Research

    Many factors may lead to sperm DNA damage. However, it is little known that the correlations of sperm DNA damage with obesity-associated markers, and reproductive hormones and lipids levels in serum and semina...

    Authors: Jin-Chun Lu, Jun Jing, Li Chen, Yi-Feng Ge, Rui-Xiang Feng, Yuan-Jiao Liang and Bing Yao

    Citation: Reproductive Biology and Endocrinology 2018 16:23

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  19. Content type: Review

    Both obesity and overweight are increasing worldwide and have detrimental influences on several human body functions including the reproductive health. In particular, obese women undergo perturbations of the ‘...

    Authors: Erica Silvestris, Giovanni de Pergola, Raffaele Rosania and Giuseppe Loverro

    Citation: Reproductive Biology and Endocrinology 2018 16:22

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  20. Content type: Research

    A suitable culture system is important for follicle growth in adult bovine ovarian tissue. This study aimed to assess the avian chorioallantoic membrane (CAM) for short-term culture of adult bovine ovarian tis...

    Authors: Kylie Beck, Jaswant Singh, Mohammad Arshud Dar and Muhammad Anzar

    Citation: Reproductive Biology and Endocrinology 2018 16:21

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  21. Content type: Research

    Cerium oxide nanoparticles (CeO2 NPs) are able to store and release oxygen, conferring them scavenger activity against oxidative stress. However, their effects in reproductive systems are not yet well understood....

    Authors: Laura Falchi, Grazia Galleri, Gian Mario Dore, Maria Teresa Zedda, Salvatore Pau, Luisa Bogliolo, Federica Ariu, Alessandra Pinna, Stefano Nieddu, Plinio Innocenzi and Sergio Ledda

    Citation: Reproductive Biology and Endocrinology 2018 16:19

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  22. Content type: Research

    The use of oral progestin has been shown to effectively prevent luteining hormone (LH) surge during ovarian stimulation with daily human menopausal gonadotropin injections. This study was aimed to investigate ...

    Authors: Chen-Yu Huang, Guan-Yeu Chen, Miawh-Lirng Shieh and Hsin-Yang Li

    Citation: Reproductive Biology and Endocrinology 2018 16:18

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  23. Content type: Research

    Maternal-fetal crosstalk during embryo implantation is complex and regulated by local signaling molecules. Chemokines and their receptors are critical signaling components required for implantation and the pro...

    Authors: Jiayi Zheng, Haiping Wang and Wenhui Zhou

    Citation: Reproductive Biology and Endocrinology 2018 16:17

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  24. Content type: Review

    Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In...

    Authors: Xiaodan Cao, Yun Cui, Xiaoxia Zhang, Jiangtao Lou, Jun Zhou, Huafeng Bei and Renxiong Wei

    Citation: Reproductive Biology and Endocrinology 2018 16:16

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  25. Content type: Research

    The LH-induced folliculo-luteal transformation is connected with alterations of the gene expression profile in cells of the granulosa layer. It has been described that hypoxic conditions occur during luteiniza...

    Authors: Anja Baufeld and Jens Vanselow

    Citation: Reproductive Biology and Endocrinology 2018 16:15

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  26. Content type: Research

    There exist contradictive views on whether the vitamin D has association with clinical outcome of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). The present meta-analysis aim to e...

    Authors: Jing Zhao, Xi Huang, Bin Xu, Yi Yan, Qiong Zhang and Yanping Li

    Citation: Reproductive Biology and Endocrinology 2018 16:13

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  27. Content type: Research

    Forkhead Transcription Factor L2 (FOXL2) is a member of the forkhead family with important roles in reproduction. Recent studies showed that FOXL2 is expressed in human and bovine endometrium and that its leve...

    Authors: Michal Elbaz, Ron Hadas, Louise M. Bilezikjian and Eran Gershon

    Citation: Reproductive Biology and Endocrinology 2018 16:12

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  28. Content type: Short communication

    Primary ciliary dyskinesia (PCD) is a rare, autosomal recessive disease with abnormalities in the structure of cilia, causing impairment of muco-ciliary clearance with respiratory tract infections, heterotaxia...

    Authors: Sinan Ozkavukcu, Ciler Celik-Ozenci, Esma Konuk and Cem Atabekoglu

    Citation: Reproductive Biology and Endocrinology 2018 16:10

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  29. Content type: Research

    Endometriosis is a known cause of infertility. Differences in immune tolerance caused by regulatory T cells (Tregs) and transforming growth factor-β (TGF-β) are thought to be involved in the pathology of endom...

    Authors: Tetsuro Hanada, Shunichiro Tsuji, Misako Nakayama, Shiro Wakinoue, Kyoko Kasahara, Fuminori Kimura, Takahide Mori, Kazumasa Ogasawara and Takashi Murakami

    Citation: Reproductive Biology and Endocrinology 2018 16:9

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  30. Content type: Research

    Cystatin C (CST3), a cysteine protease inhibitor in seminal plasma, is expressed in animal uteri. However, its expression in the human female reproductive tract and its effect on human sperm capacitation are u...

    Authors: Robert Kuo-Kuang Lee, Huan-Chin Tseng, Yuh-Ming Hwu, Chi-Chen Fan, Ming-Huei Lin, Jhih-Jie Yu, Ling-Yu Yeh and Sheng-Hsiang Li

    Citation: Reproductive Biology and Endocrinology 2018 16:8

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  31. Content type: Hypothesis

    Embryos have evolved a remarkable capacity to find implantation site. The impressive navigation ability of natural blastocysts may rely on highly sensitive signals arising from embryos and specialized signal p...

    Authors: Onder Celik, Mustafa Acet, Haldun Arpaci, Levent Dikbas, Aytac Imren, Bulent Duran, Nilufer Celik, Sudenaz Celik, Cihat Unlu, Ibrahim Sahin and Suleyman Aydin

    Citation: Reproductive Biology and Endocrinology 2018 16:7

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  32. Content type: Research

    Preimplantation genetic screening (PGS) is increasingly utilized as an adjunct procedure to IVF. Recently healthy euploid live birth were reported following transfer of mosaic embryos. Several recent publicati...

    Authors: Vitaly A. Kushnir, Sarah K. Darmon, David H. Barad and Norbert Gleicher

    Citation: Reproductive Biology and Endocrinology 2018 16:6

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  33. Content type: Review

    L-carnitine (LC), and its acetylated form, acetyl L-carnitine (ALC), have immense functional capabilities to regulate the oxidative and metabolic status of the female reproductive system. The vulnerability of ...

    Authors: Ashok Agarwal, Pallav Sengupta and Damayanthi Durairajanayagam

    Citation: Reproductive Biology and Endocrinology 2018 16:5

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  34. Content type: Research

    The etiology and pathophysiology of endometriosis remain unclear. Accumulating evidence suggests that aberrant microRNA (miRNA) and transcription factor (TF) expression may be involved in the pathogenesis and ...

    Authors: Luyang Zhao, Chenglei Gu, Mingxia Ye, Zhe Zhang, Li’an Li, Wensheng Fan and Yuanguang Meng

    Citation: Reproductive Biology and Endocrinology 2018 16:4

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  35. Content type: Review

    In recent decades, the decline in human fertility has become increasingly more worrying: while therapeutic interventions might help, they are vexing for the couple and often burdened with high failure rates an...

    Authors: Andrea Sansone, Carla Di Dato, Cristina de Angelis, Davide Menafra, Carlotta Pozza, Rosario Pivonello, Andrea Isidori and Daniele Gianfrilli

    Citation: Reproductive Biology and Endocrinology 2018 16:3

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  36. Content type: Research

    Human epidemiological data show that breastfeeding reduces the mother’s probability of developing several disease conditions, including obesity and type II diabetes compared to mothers that give birth but do n...

    Authors: Hayden W. Hyatt, Yufeng Zhang, Wendy R. Hood and Andreas N. Kavazis

    Citation: Reproductive Biology and Endocrinology 2018 16:2

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  37. Content type: Research

    TGF-β signaling pathways regulate several crucial processes in female reproduction. AKT is a non-SMAD signaling pathway regulated by TGF-β ligands essential for oocyte maturation and early embryonic developmen...

    Authors: Mohamed Ashry, Sandeep K. Rajput, Joseph K. Folger, Jason G. Knott, Nabil A. Hemeida, Omaima M. Kandil, Refaat S. Ragab and George W. Smith

    Citation: Reproductive Biology and Endocrinology 2018 16:1

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  38. Content type: Research

    Plasma and urine levels of the potent vasodilator Ang-(1–7) are elevated in mid and late pregnancy and are correlated with elevated placental angiogenesis, fetal blood flow, and rapid fetal growth. We hypothes...

    Authors: Elham Ghadhanfar, Aseel Alsalem, Shaimaa Al-Kandari, Jumana Naser, Fawzi Babiker and Maie Al-Bader

    Citation: Reproductive Biology and Endocrinology 2017 15:97

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  39. Content type: Research

    Several studies have reported a correlation between antral follicle count by conventional 2D transvaginal sonography and serum anti-Müllerian hormone levels. However, few studies have investigated the effectiv...

    Authors: P. A. Peres Fagundes, R. Chapon, P. R. Olsen, A. K. Schuster, M. M. C. Mattia and J. S. Cunha-Filho

    Citation: Reproductive Biology and Endocrinology 2017 15:96

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  40. Content type: Research

    The published results regarding lymphocytes immunotherapy for unexplained recurrent miscarriage (uRM) patients are conflicting due to different screening criteria and therapeutic protocols. The objective of th...

    Authors: Mengyuan Liu, Xin Zhen, Hongyan Song, Junhao Chen, Xiaoling Sun, Xiaoqin Li, Jianjun Zhou, Guijun Yan, Lijun Ding and Haixiang Sun

    Citation: Reproductive Biology and Endocrinology 2017 15:95

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  41. Content type: Research

    Transforming growth factor beta (TGFB) superfamily signaling is implicated in the development of sex cord-stromal tumors, a category of poorly defined gonadal tumors. The aim of this study was to determine pot...

    Authors: Yang Gao, Xin Fang, David F. Vincent, David W. Threadgill, Laurent Bartholin and Qinglei Li

    Citation: Reproductive Biology and Endocrinology 2017 15:94

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  42. Content type: Review

    Polycystic ovary syndrome (PCOS) is a complex condition with high risk for dyslipidemia, dysglycemia, venous thromboembolism, cardiovascular disease and metabolic syndrome. Because the combined oral contracept...

    Authors: Sebastião Freitas de Medeiros

    Citation: Reproductive Biology and Endocrinology 2017 15:93

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  43. Content type: Short communication

    Recurrent pregnancy loss (RPL) is a frequently occurring disease, which is classified as idiopathic in more than 50% of cases. THBD, the endothelial cell receptor for thrombin, has been associated with distinc...

    Authors: Paula Quintero-Ronderos, Eric Mercier, Jean-Christophe Gris, Clara Esteban-Perez, Harold Moreno-Ortiz, Dora Janeth Fonseca, Elkin Lucena, Daniel Vaiman and Paul Laissue

    Citation: Reproductive Biology and Endocrinology 2017 15:92

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  44. Content type: Short communication

    We recently developed an air-liquid interface long-term culture of differentiated bovine oviductal epithelial cells (ALI-BOEC). This ex vivo oviduct epithelium is capable of supporting embryo development in co...

    Authors: Vera A. van der Weijden, Shuai Chen, Stefan Bauersachs, Susanne E. Ulbrich and Jennifer Schoen

    Citation: Reproductive Biology and Endocrinology 2017 15:91

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  45. Content type: Review

    Failure of embryo implantation is a major limiting factor in early pregnancy and assisted reproduction. Determinants of implantation include the embryo viability, the endometrial receptivity, and embryo-matern...

    Authors: Jingjie Liang, Shaoyu Wang and Zhengguang Wang

    Citation: Reproductive Biology and Endocrinology 2017 15:90

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