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  1. Over the past two decades, public health has focused on the identification of environmental chemical factors that are able to adversely affect hormonal function, known as endocrine disruptors (EDs). EDs mimic ...

    Authors: Andrea Di Nisio and Carlo Foresta

    Citation: Reproductive Biology and Endocrinology 2019 17:4

    Content type: Review

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  2. A central dogma of mammalian reproductive biology is that the size of the primordial follicle pool represents reproductive capacity in females. The assembly of the primordial follicle starts after the primordi...

    Authors: Bo Pan and Julang Li

    Citation: Reproductive Biology and Endocrinology 2019 17:8

    Content type: Review

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  3. Diminished ovarian reserve (DOR) remains one of the greatest obstacles affecting the chance of a successful live birth after fertility treatment. The present study was set to investigate whether using a “dual ...

    Authors: Ming-Huei Lin, Frank Shao-Ying Wu, Yuh-Ming Hwu, Robert Kuo-Kuang Lee, Ryh-Sheng Li and Sheng-Hsiang Li

    Citation: Reproductive Biology and Endocrinology 2019 17:7

    Content type: Research

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  4. Fertility preservation (FP) protocols in case of breast cancer (BC) include mature oocyte cryopreservation following letrozole associated controlled ovarian hyperstimulation (Let-COH). To date, the impact of L...

    Authors: Oranite Goldrat, Geraldine Van Den Steen, Eric Gonzalez-Merino, Julie Dechène, Christine Gervy, Anne Delbaere, Fabienne Devreker, Viviane De Maertelaer and Isabelle Demeestere

    Citation: Reproductive Biology and Endocrinology 2019 17:3

    Content type: Research

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  5. Chronic endometritis (CE) is a condition which results in reduced receptivity of embryos by dysregulated lymphocyte subsets, abnormal expression of cytokines, chemokines and other regulatory molecules in the e...

    Authors: Wen-juan Wang, Hong Zhang, Zhong-quan Chen, Wei Zhang, Xue-mei Liu, Jiang-ye Fang, Fu-jun Liu and Joanne Kwak-Kim

    Citation: Reproductive Biology and Endocrinology 2019 17:2

    Content type: Research

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  6. Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melato...

    Authors: Longfei Xiao, Junjie Hu, Liangli Song, Yong Zhang, Weitao Dong, Yuting Jiang, Quanwei Zhang, Ligang Yuan and Xingxu Zhao

    Citation: Reproductive Biology and Endocrinology 2019 17:1

    Content type: Research

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  7. Air pollution is a cause of concern for human health. For instance, it is associated with an increased risk for cancer, cardiovascular and respiratory disorders. In vitro and in vivo studies suggested that air...

    Authors: Alessandro Conforti, Marika Mascia, Giuseppina Cioffi, Cristina De Angelis, Giuseppe Coppola, Pasquale De Rosa, Rosario Pivonello, Carlo Alviggi and Giuseppe De Placido

    Citation: Reproductive Biology and Endocrinology 2018 16:117

    Content type: Review

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  8. Recently, a novel approach with delaying the start of controlled ovarian stimulation along with gonadotropin-releasing hormone (GnRH) antagonist pretreatment for 7 days after estrogen priming for further suppr...

    Authors: Mahnaz Ashrafi, Arezoo Arabipoor, Azar Yahyaei, Zahra Zolfaghari and Firouzah Ghaffari

    Citation: Reproductive Biology and Endocrinology 2018 16:124

    Content type: Research

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  9. Exposure to air pollution has been clearly associated with a range of adverse health effects, including reproductive toxicity. However, a limited amount of research has been conducted to examine the associatio...

    Authors: Joanna Jurewicz, Emila Dziewirska, Michał Radwan and Wojciech Hanke

    Citation: Reproductive Biology and Endocrinology 2018 16:109

    Content type: Review

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  10. Hundreds of thousands of young women are diagnosed with cancer each year, and due to recent advances in screening programs, diagnostic methods and treatment options, survival rates have significantly improved....

    Authors: Roberto Marci, Maddalena Mallozzi, Luisa Di Benedetto, Mauro Schimberni, Stefano Mossa, Ilaria Soave, Stefano Palomba and Donatella Caserta

    Citation: Reproductive Biology and Endocrinology 2018 16:112

    Content type: Review

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  11. During recent years, an increasing percentage of male infertility has to be attributed to an array of environmental, health and lifestyle factors. Male infertility is likely to be affected by the intense expos...

    Authors: Kavindra Kumar Kesari, Ashok Agarwal and Ralf Henkel

    Citation: Reproductive Biology and Endocrinology 2018 16:118

    Content type: Review

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  12. The objective of this study was to carry out a systematic review and meta-analysis of embryologic and clinical outcomes following open versus closed vitrification of human oocytes and embryos.

    Authors: Hongcai Cai, Jean Damascene Niringiyumukiza, Yamin Li, Qiaohong Lai, Yinzhao Jia, Ping Su and Wenpei Xiang

    Citation: Reproductive Biology and Endocrinology 2018 16:123

    Content type: Review

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  13. Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age ...

    Authors: Asher Bashiri, Katherine Ida Halper and Raoul Orvieto

    Citation: Reproductive Biology and Endocrinology 2018 16:121

    Content type: Review

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  14. Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ p...

    Authors: Zhengling Liu, Zengyan Wang, Changhong Hao, Yonghui Tian and Jingjing Fu

    Citation: Reproductive Biology and Endocrinology 2018 16:120

    Content type: Research

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  15. There is growing evidence that lifestyle choices account for the overall quality of health and life (QoL) reflecting many potential lifestyle risks widely associated with alterations of the reproductive functi...

    Authors: Stefano Palomba, Jessica Daolio, Sara Romeo, Francesco Antonino Battaglia, Roberto Marci and Giovanni Battista La Sala

    Citation: Reproductive Biology and Endocrinology 2018 16:113

    Content type: Review

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  16. Male infertility is a widespread condition among couples. In about 50% of cases, couple infertility is attributable to the male partner, mainly due to a failure in spermatogenesis. In recent times, the crucial...

    Authors: Alessandro Ilacqua, Giulia Izzo, Gian Pietro Emerenziani, Carlo Baldari and Antonio Aversa

    Citation: Reproductive Biology and Endocrinology 2018 16:115

    Content type: Review

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  17. There is limited literature investigating the effects of body mass index (BMI) and androgen level on in vitro fertilization (IVF) outcomes with a gonadotropin-releasing hormone (GnRH)-antagonist protocol in po...

    Authors: Wan Yang, Rui Yang, Mingmei Lin, Yan Yang, Xueling Song, Jiajia Zhang, Shuo Yang, Ying Song, Jia Li, Tianshu Pang, Feng Deng, Hua Zhang, Ying Wang, Rong Li and Jie Jiao

    Citation: Reproductive Biology and Endocrinology 2018 16:119

    Content type: Research

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  18. This article is a review that addresses the following topics, divided by paragraphs. The first paragraph investigates the effects of physical activity on ovarian function, analyzing in particular the changes c...

    Authors: Sandro La Vignera, Rosita A. Condorelli, Rossella Cannarella, Ylenia Duca and Aldo E. Calogero

    Citation: Reproductive Biology and Endocrinology 2018 16:108

    Content type: Review

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  19. Matrix metalloproteinases (Mmps) and their tissue inhibitors (Timps) are widely recognized as crucial factors for extracellular matrix remodeling in the ovary and are involved in follicular growth, ovulation, ...

    Authors: Gabriel Levin, Tatiane Maldonado Coelho, Nathali Guimarães Nóbrega, Marina Trombetta-Lima, Mari Cleide Sogayar and Ana Claudia Oliveira Carreira

    Citation: Reproductive Biology and Endocrinology 2018 16:116

    Content type: Research

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  20. It is universally accepted that lifestyle interventions are the first step towards a good overall, reproductive and sexual health. Cessation of unhealthy habits, such as tobacco, alcohol and drug use, poor nut...

    Authors: Andrea Sansone, Massimiliano Sansone, Diana Vaamonde, Paolo Sgrò, Ciro Salzano, Francesco Romanelli, Andrea Lenzi and Luigi Di Luigi

    Citation: Reproductive Biology and Endocrinology 2018 16:114

    Content type: Review

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  21. Diabetes induces many complications including reduced fertility and low oocyte quality, but whether it causes increased mtDNA mutations is unknown.

    Authors: Li Li, Chang-Sheng Wu, Guan-Mei Hou, Ming-Zhe Dong, Zhen-Bo Wang, Yi Hou, Heide Schatten, Gui-Rong Zhang and Qing-Yuan Sun

    Citation: Reproductive Biology and Endocrinology 2018 16:110

    Content type: Research

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  22. Maternal virilization during pregnancy is a rare phenomenon. Polycystic ovary syndrome (PCOS), luteoma and luteinic cysts are the most frequent and benign etiologies. This article presents two cases of recurre...

    Authors: M. Deknuydt, A. Dumont, A. Bruyneel, D. Dewailly and S. Catteau-Jonard

    Citation: Reproductive Biology and Endocrinology 2018 16:107

    Content type: Short communication

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  23. Given the seriousness of chemotherapy-induced ovarian injury in female cancer patients, the preservation of fertility, including through the use of cryopreservation technology and pharmaceuticals, requires inv...

    Authors: Ying Qin, Akira Iwase, Tomohiko Murase, Bayasula, Chiharu Ishida, Nao Kato, Tomoko Nakamura, Satoko Osuka, Sachiko Takikawa, Maki Goto, Tomomi Kotani and Fumitaka Kikkawa

    Citation: Reproductive Biology and Endocrinology 2018 16:106

    Content type: Research

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  24. Spermatogenesis is a complex process involving the self-renewal and differentiation of spermatogonia into mature spermatids in the seminiferous tubules. During spermatogenesis, germ cells migrate from the base...

    Authors: Yue Liu, Yanqin Hu, Li Wang and Chen Xu

    Citation: Reproductive Biology and Endocrinology 2018 16:105

    Content type: Research

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  25. The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones o...

    Authors: Liangshan Mu, Jiexue Pan, Lili Yang, Qianqian Chen, Ya Chen, Yili Teng, Peiyu Wang, Rong Tang, Xuefeng Huang, Xia Chen and Haiyan Yang

    Citation: Reproductive Biology and Endocrinology 2018 16:104

    Content type: Research

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  26. Since the first report of a decline in semen quality in 1974, there have been several reports of similar declines across populations. Despite some scattered reports of declining semen quality in the Indian sub...

    Authors: Priyanka Mishra, Mahendra Pal Singh Negi, Mukesh Srivastava, Kiran Singh and Singh Rajender

    Citation: Reproductive Biology and Endocrinology 2018 16:103

    Content type: Research

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  27. Traditional semen parameters have shown little to none predictive value for fertilization and blastocyst viability for a successful pregnancy. Therefore, the purpose of this study was to explore the usefulness...

    Authors: Pamela Tello-Mora, Leticia Hernández-Cadena, Jeimy Pedraza, Esther López-Bayghen and Betzabet Quintanilla-Vega

    Citation: Reproductive Biology and Endocrinology 2018 16:102

    Content type: Research

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  28. Early human placental development strongly resembles carcinogenesis in otherwise healthy tissues. The progenitor cells of the placenta, the cytotrophoblast, rapidly proliferate to produce a sufficient number o...

    Authors: Rachel C. West, Gerrit J. Bouma and Quinton A. Winger

    Citation: Reproductive Biology and Endocrinology 2018 16:101

    Content type: Review

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  29. FSHR SNPs may influence the ovarian sensitivity to endogenous and exogenous FSH stimulation. Given the paucity of data on the FSHR c.919A > G, c.2039A > G and − 29G > A SNPs in Hispanic population, we here analyz...

    Authors: Gabriela García-Jiménez, Teresa Zariñán, Rocío Rodríguez-Valentín, Nancy R. Mejía-Domínguez, Rubén Gutiérrez-Sagal, Georgina Hernández-Montes, Armando Tovar, Fabián Arechavaleta-Velasco, Patricia Canto, Julio Granados, Hortensia Moreno-Macias, Teresa Tusié-Luna, Antonio Pellicer and Alfredo Ulloa-Aguirre

    Citation: Reproductive Biology and Endocrinology 2018 16:100

    Content type: Research

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  30. Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility and hyperandrogenism. Evidence favors insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps pr...

    Authors: Lei Dou, Yahong Zheng, Lu Li, Xiaowei Gui, Yajuan Chen, Meng Yu and Yi Guo

    Citation: Reproductive Biology and Endocrinology 2018 16:99

    Content type: Research

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  31. The Sertoli cell is the only somatic cell within the seminiferous tubules, and is vital for testis development and spermatogenesis. Rosiglitazone (RSG) is a member of the thiazolidinedione family and is a pero...

    Authors: Xie Ge, Peng Pan, Jun Jing, Xuechun Hu, Li Chen, Xuhua Qiu, Rujun Ma, Kadiliya Jueraitetibaike, Xuan Huang and Bing Yao

    Citation: Reproductive Biology and Endocrinology 2018 16:98

    Content type: Research

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  32. Cryptorchidism as a common genitourinary malformation with the serious complication of male infertility draws widespread attention. With several reported miRNAs playing critical roles in spermatogonial stem ce...

    Authors: Zhenyu Huang, Dongdong Tang, Jingjing Gao, Xianming Dou, Peng Cheng, Dangwei Peng, Yao Zhang, Jun Mao, Li Zhang and Xiansheng Zhang

    Citation: Reproductive Biology and Endocrinology 2018 16:97

    Content type: Research

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  33. Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder in women of reproductive age and is commonly complicated by adverse endometrial outcomes. Long non-coding RNAs (lncRNAs) are a class of no...

    Authors: Xueying Zhang, Ying Xu, Lulu Fu, Dandan Li, Xiaowei Dai, Lianlian Liu, Jingshun Zhang, Lianwen Zheng and Manhua Cui

    Citation: Reproductive Biology and Endocrinology 2018 16:96

    Content type: Research

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  34. Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarkably decreases the chance of pregnancy, which might be related to its impact on metabolic abnormalities in these patients. It...

    Authors: Majid Dastorani, Esmat Aghadavod, Naghmeh Mirhosseini, Fatemeh Foroozanfard, Shahrzad Zadeh Modarres, Mehrnush Amiri Siavashani and Zatollah Asemi

    Citation: Reproductive Biology and Endocrinology 2018 16:94

    Content type: Research

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  35. Spontaneous abortion is one of the most common complications in early pregnancy. A preventive test to identify women who will experience a miscarriage, even before first symptoms occur, is not established. Act...

    Authors: Alexander Freis, Janina Schlegel, Volker Daniel, Julia Jauckus, Thomas Strowitzki and Ariane Germeyer

    Citation: Reproductive Biology and Endocrinology 2018 16:93

    Content type: Research

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  36. Evidence suggests that subclinical hypothyroidism (SCH) and thyroid autoimmunity (TAI) are associated with adverse pregnancy outcomes. This systematic review and meta-analysis was conducted to determine whethe...

    Authors: Meng Rao, Zhengyan Zeng, Shuhua Zhao and Li Tang

    Citation: Reproductive Biology and Endocrinology 2018 16:92

    Content type: Research

    Published on:

  37. Elevated plasma gonadotropins were associated with desensitization of Sertoli and Leydig cells in the male testis. Testis spermatogenesis ability would be improved via inhibiting high endogenous gonadotropin i...

    Authors: Xuechun Hu, Zheng Ding, Zhiwei Hong, Zhichuan Zou, Yuming Feng, Ruilou Zhu, Jinzhao Ma, Xie Ge, Chaojun Li and Bing Yao

    Citation: Reproductive Biology and Endocrinology 2018 16:91

    Content type: Research

    Published on:

  38. Dehydroepiandrosterone (DHEA) is now widely used as an adjuvant for in vitro fertilization (IVF) cycles in poor ovarian responders (PORs). Several studies showed that DHEA supplementation could improve IVF out...

    Authors: Chyi-Uei Chern, Kuan-Hao Tsui, Salvatore Giovanni Vitale, San-Nung Chen, Peng-Hui Wang, Antonio Cianci, Hsiao-Wen Tsai, Zhi-Hong Wen and Li-Te Lin

    Citation: Reproductive Biology and Endocrinology 2018 16:90

    Content type: Research

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  39. Letrozole is widely employed as ovulation induction agent in women with PCOS, but its use in mild stimulation (MS) protocols for IVF is limited. Aim of the present study was to evaluate the feasibility of a MS...

    Authors: Giuseppe D’Amato, Anna Maria Caringella, Antonio Stanziano, Clementina Cantatore, Simone Palini and Ettore Caroppo

    Citation: Reproductive Biology and Endocrinology 2018 16:89

    Content type: Research

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  40. Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. The...

    Authors: Mahsa Darbandi, Sara Darbandi, Ashok Agarwal, Pallav Sengupta, Damayanthi Durairajanayagam, Ralf Henkel and Mohammad Reza Sadeghi

    Citation: Reproductive Biology and Endocrinology 2018 16:87

    Content type: Review

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  41. The injection of estradiol valerate in female rats induces polycystic ovary syndrome, which is characterized by polycystic ovaries, anovulation, and hyperandrogenism. These characteristics have been associated...

    Authors: Julieta A. Espinoza, Wendy Alvarado, Berenice Venegas, Roberto Domínguez and Leticia Morales-Ledesma

    Citation: Reproductive Biology and Endocrinology 2018 16:86

    Content type: Research

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  42. Cisplatin (CDDP), a widely used chemotherapeutic agent, can induce excessive granulosa cell apoptosis, follicle loss and even premature ovarian insufficiency (POI). However, the mechanism remains elusive, alth...

    Authors: Yuping Wu, Congshun Ma, Huihui Zhao, Yuxia Zhou, Zhenguo Chen and Liping Wang

    Citation: Reproductive Biology and Endocrinology 2018 16:85

    Content type: Research

    Published on:

  43. Tyrosine kinase receptor erythropoietin-producing hepatocellular receptor A2 (EphA2) is abundant in the endometrium and plays a role in the establishment of eutopic implantation. A similar molecular mechanism ...

    Authors: Huan Jiang, Xiao-Yi Yang and Wei-Jie Zhu

    Citation: Reproductive Biology and Endocrinology 2018 16:84

    Content type: Research

    Published on:

  44. A molecule identical to nerve growth factor, with ovulation-inducing properties has been discovered in the seminal plasma of South American camelids (ovulation-inducing factor/nerve growth factor; OIF/NGF). We...

    Authors: Rodrigo A. Carrasco, Jaswant Singh and Gregg P. Adams

    Citation: Reproductive Biology and Endocrinology 2018 16:83

    Content type: Research

    Published on:

  45. Imprinted genes, which are expressed in a parent of origin-specific manner, are thought to mediate the genetic priorities of each parent in pregnancy. Recently we reported that some fetal imprinted gene varian...

    Authors: Clive J. Petry, Albert Koulman, Liangjian Lu, Benjamin Jenkins, Samuel Furse, Philippa Prentice, Lee Matthews, Ieuan A. Hughes, Carlo L. Acerini, Ken K. Ong and David B. Dunger

    Citation: Reproductive Biology and Endocrinology 2018 16:82

    Content type: Research

    Published on:

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