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  1. Endometriosis is an estrogen dependent, inflammatory disorder occurring in 5–10% of reproductive-aged women. Women with endometriosis have a lower body mass index (BMI) and decreased body fat compared to those...

    Authors: Masoumeh Majidi Zolbin, Ramanaiah Mamillapalli, Sepide E. Nematian, Laura Goetz and Hugh S. Taylor

    Citation: Reproductive Biology and Endocrinology 2019 17:36

    Content type: Research

    Published on:

  2. Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a pot...

    Authors: Eleftherios P. Samartzis, Daniel Fink, Manuel Stucki and Patrick Imesch

    Citation: Reproductive Biology and Endocrinology 2019 17:38

    Content type: Research

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  3. Ovarian hyperstimulation syndrome (OHSS) is a common and severe complication for patients undergoing IVF/ICSI-ET. Melatonin widely participates in the regulation of female reproductive endocrine activity. Howe...

    Authors: Yiran Li, Lanlan Fang, Yiping Yu, Hao Shi, Sijia Wang, Yanjie Guo and Yingpu Sun

    Citation: Reproductive Biology and Endocrinology 2019 17:37

    Content type: Research

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  4. Serum Antimüllerian hormone (AMH) has been shown to predict various in vitro fertilization (IVF) outcomes. AMH and progesterone (P) are products of granulosa cells of the ovary. Since overall granulosa cell nu...

    Authors: Shahryar K. Kavoussi, Shu-Hung Chen, Caitlin L. Hunn, Brady T. West, John David Wininger, Keikhosrow M. Kavoussi and Parviz K. Kavoussi

    Citation: Reproductive Biology and Endocrinology 2019 17:35

    Content type: Research

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  5. Women with Polycystic Ovary Syndrome (PCOS) present a heterogeneous reproductive and metabolic profile with an increased lifetime risk of Type 2 Diabetes (T2D). Early biomarkers of these metabolic disturbances...

    Authors: Pernille Bækgaard Udesen, Anja Elaine Sørensen, Mugdha V. Joglekar, Anandwardhan A. Hardikar, Marie Louise Muff Wissing, Anne-Lis Mikkelsen Englund and Louise Torp Dalgaard

    Citation: Reproductive Biology and Endocrinology 2019 17:34

    Content type: Research

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  6. The fibrinolytic system and its inhibitors play a number of roles, apart from their function in blood haemostasis and thrombosis, namely in ovarian folliculogenesis and in ovulation. Plasminogen is converted t...

    Authors: Genia F. Burchall, Dodie S. Pouniotis, Helena J. Teede, Sanjeeva Ranasinha, Kirsty A. Walters and Terrence J. Piva

    Citation: Reproductive Biology and Endocrinology 2019 17:33

    Content type: Research

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  7. A predominant difference between endometrial and normal cells is higher proliferation rate in the former cells which is benign. The genes of inhibitor of differentiation (ID) family play a major role in cell prol...

    Authors: Shirin Amirteimouri, Manan Ashini, Fariba Ramazanali, Reza Aflatoonian, Parvaneh Afsharian and Maryam Shahhoseini

    Citation: Reproductive Biology and Endocrinology 2019 17:32

    Content type: Research

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  8. .

    Authors: Alessandro Conforti, Sandro C. Esteves, Francesca Di Rella, Ida Strina, Pasquale De Rosa, Alessia Fiorenza, Fulvio Zullo, Giuseppe De Placido and Carlo Alviggi

    Citation: Reproductive Biology and Endocrinology 2019 17:31

    Content type: Correction

    Published on:

    The original article was published in Reproductive Biology and Endocrinology 2019 17:18

  9. In order to maximize In vitro fertilization (IVF) success rates in advanced- age patients, it has been suggested to favor the use of intracytoplasmic sperm injection (ICSI) over conventional insemination (CI),...

    Authors: Jacob Farhi, Kfir Cohen, Yossi Mizrachi, Ariel Weissman, Arieh Raziel and Raoul Orvieto

    Citation: Reproductive Biology and Endocrinology 2019 17:30

    Content type: Research

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  10. Proteomic studies of follicular fluid (FF) exist for several species, including the horse; however, the seasonal influence on FF proteome has not been explored in livestock. The application of high-throughput ...

    Authors: G. A. Dutra, G. M. Ishak, O. Pechanova, T. Pechan, D. G. Peterson, J. C. F. Jacob, S. T. Willard, P. L. Ryan, E. L. Gastal and J. M. Feugang

    Citation: Reproductive Biology and Endocrinology 2019 17:29

    Content type: Research

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  11. Syndecan-1 is a heparan sulfate proteoglycan acting as a co-receptor for cytokines and growth factors mediating developmental, immunological and angiogenic processes. In human, the uteroplacental localization ...

    Authors: Christina Gougoula, Alexandra P. Bielfeld, Sarah J. Pour, Jan-S. Krüssel, Martin Götte, W. Peter M. Benten and Dunja M. Baston-Büst

    Citation: Reproductive Biology and Endocrinology 2019 17:28

    Content type: Research

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  12. Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contr...

    Authors: Hiromitsu Hattori, Akane Kitamura, Fumiaki Takahashi, Norio Kobayashi, Akiko Sato, Naoko Miyauchi, Hidekazu Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Hirohito Metoki…

    Citation: Reproductive Biology and Endocrinology 2019 17:27

    Content type: Research

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  13. Hormonal contraceptives, particularly depot medroxyprogesterone acetate (DMPA), have been reported to be associated with substantially enhanced HIV acquisition; however, the biological mechanisms of this risk ...

    Authors: Liping Li, Jie Zhou, Weijia Wang, Lina Huang, Jiaoqin Tu, Lyndsey Baiamonte, Moselle Stark, Mistie Mills, Thomas J. Hope, Erma Z. Drobnis, Alison J. Quayle and Danny J. Schust

    Citation: Reproductive Biology and Endocrinology 2019 17:26

    Content type: Research

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  14. In dairy cows, the energy cost of milk yield results in a negative energy balance (EB) and body fat mobilization that impairs reproductive efficiency. Emerging evidence suggests that the novel adipokines, Reti...

    Authors: Namya Mellouk, Christelle Ramé, Mélodie Diot, Eric Briant, Jean-Luc Touzé, Daniel Guillaume, Pascal Froment and Joëlle Dupont

    Citation: Reproductive Biology and Endocrinology 2019 17:25

    Content type: Research

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  15. Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This st...

    Authors: Rahil Jannatifar, Kazem Parivar, Nasim Hayati Roodbari and Mohammad Hossein Nasr-Esfahani

    Citation: Reproductive Biology and Endocrinology 2019 17:24

    Content type: Research

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  16. Age-associated infertility is a problem worldwide, and management of oxidative stress is known to be essential. Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant...

    Authors: Nana Akino, Osamu Wada-Hiraike, Wataru Isono, Hiromi Terao, Harunori Honjo, Yuichiro Miyamoto, Michihiro Tanikawa, Kenbun Sone, Mana Hirano, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Kaori Koga, Katsutoshi Oda, Tomoyuki Fujii and Yutaka Osuga

    Citation: Reproductive Biology and Endocrinology 2019 17:23

    Content type: Research

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  17. Previous studies, which were primarily based on the fluorescent in-situ hybridisation (FISH) technique, revealed conflicting evidence regarding male foetal microchimerism in endometriosis. FISH is a relatively...

    Authors: Muzaffer A. Bhat, Jai B. Sharma, Kallol K. Roy, Jayasree Sengupta and Debabrata Ghosh

    Citation: Reproductive Biology and Endocrinology 2019 17:22

    Content type: Research

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  18. Endometriosis is thought to affect the effectiveness of ART by an increased risk of miscarriage. We aimed to investigate the impact of endometriosis in women achieving singleton pregnancies through IVF fresh c...

    Authors: Puyu Yang, Yang Wang, Zhangxin Wu, Ningning Pan, Liying Yan and Caihong Ma

    Citation: Reproductive Biology and Endocrinology 2019 17:21

    Content type: Research

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  19. Despite being born with a significant number of primordial cells which representing the ancestor cells of the germ-line, women experience a depletion of ovarian reserve and sub-fertility mid-way into their hea...

    Authors: Haroon Latif Khan, Shahzad Bhatti, Samina Suhail, Rohina Gul, Aisha Awais, Humaira Hamayun, Farah Enver, Sana Abbas, Zahira Hassan, Rameen Nisar, Saba Sardar and Warda Asif

    Citation: Reproductive Biology and Endocrinology 2019 17:20

    Content type: Research

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  20. Steroidogenesis is an indispensable process that is indirectly associated with spermatogenesis in the Leydig cell (LC) to utilize the lipid droplets (LDs) that are critical to maintaining normal testosterone s...

    Authors: Imran Tarique, Waseem Ali Vistro, Xuebing Bai, Ping Yang, Chen Hong, Yufei Huang, Abdul Haseeb, Enxue Liu, Noor Samad Gandahi, Mengdi Xu, Yifei Liu and Qiusheng Chen

    Citation: Reproductive Biology and Endocrinology 2019 17:19

    Content type: Research

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  21. To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation.

    Authors: Alessandro Conforti, Sandro C. Esteves, Francesca Di Rella, Ida Strina, Pasquale De Rosa, Alessia Fiorenza, Fulvio Zullo, Giuseppe De Placido and Carlo Alviggi

    Citation: Reproductive Biology and Endocrinology 2019 17:18

    Content type: Review

    Published on:

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2019 17:31

  22. The objective of this systematic review was to examine the literature and to compare the effectiveness of letrozole (LE) versus laparoscopic ovarian drilling (LOD) for the induction of ovulation in women with ...

    Authors: Qiong Yu, Shifu Hu, Yingying Wang, Guiping Cheng, Wei Xia and Changhong Zhu

    Citation: Reproductive Biology and Endocrinology 2019 17:17

    Content type: Review

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  23. Little is known about resident attitudes toward elective egg freezing (EF) or how educational exposure to EF affects residents’ views and ability to counsel patients. This study aimed to evaluate US OB/GYN res...

    Authors: Navid Esfandiari, Julia Litzky, Joshua Sayler, Pavel Zagadailov, Karen George and Leslie DeMars

    Citation: Reproductive Biology and Endocrinology 2019 17:16

    Content type: Research

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  24. To assess the predictive value of each individual morphological parameter: blastocoele expansion degree, inner cell mass (ICM), and trophectoderm (TE) grades on the clinical pregnancy outcome in frozen–warmed ...

    Authors: Jing Zhao, Yi Yan, Xi Huang, Lunquan Sun and Yanping Li

    Citation: Reproductive Biology and Endocrinology 2019 17:15

    Content type: Research

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  25. Intrauterine insemination (IUI) is the first-line treatment for non-tubal infertility. Injectable gonadotropins are often chosen as adjunctive stimulation to promote the growth of ovarian follicles in IUI cycl...

    Authors: Yiwen Liu, Xiang Y. Ye and Crystal Chan

    Citation: Reproductive Biology and Endocrinology 2019 17:14

    Content type: Research

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  26. Excessive gestational weight gain (GWG), which is associated with adverse long-term effects on the health of the offspring, has become a major clinical problem. Accumulating evidence indicates that the ovary k...

    Authors: Zhiyang Zhou, Qi Lin, Xinxin Xu, Gaby Sukma Illahi, Chenle Dong and Xueqing Wu

    Citation: Reproductive Biology and Endocrinology 2019 17:13

    Content type: Research

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  27. Among the factors causing male infertility, one of the most debated is the exposure to environmental contaminants. Recently, the chemical compound Bisphenol A (BPA) has drawn attention from the reproductive sc...

    Authors: Federica Cariati, Nadja D’Uonno, Francesca Borrillo, Stefania Iervolino, Giacomo Galdiero and Rossella Tomaiuolo

    Citation: Reproductive Biology and Endocrinology 2019 17:6

    Content type: Review

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  28. Detrimental exposures during pregnancy have been implicated in programming offspring to develop permanent changes in physiology and metabolism, increasing the risk for developing diseases in adulthood such as ...

    Authors: Amy K. Schutt, Chellakkan S. Blesson, Jean W. Hsu, Cecilia T. Valdes, William E. Gibbons, Farook Jahoor and Chandra Yallampalli

    Citation: Reproductive Biology and Endocrinology 2019 17:12

    Content type: Research

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  29. A mounting body of the literature suggests that environmental chemicals found in food and water could affect female reproduction. Many worldwide daily-used products have been shown to contain chemicals that co...

    Authors: Justin Rashtian, Diana E. Chavkin and Zaher Merhi

    Citation: Reproductive Biology and Endocrinology 2019 17:5

    Content type: Review

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  30. In assisted reproductive technology, prediction of treatment failure remains a great challenge. The development of more sensitive assays for measuring anti-Müllerian hormone (AMH) has allowed for the possibili...

    Authors: A. G. Grynnerup, K. Løssl, F. Pilsgaard, S. A. Lunding, M. Storgaard, J. W. Bogstad, L. Prætorius, A. Zedeler, L. Bungum, A. Nyboe Andersen and A. Pinborg

    Citation: Reproductive Biology and Endocrinology 2019 17:11

    Content type: Research

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  31. A low oxygen supply to the fetus causes intrauterine growth restriction and can affect gonadal development of the offspring, having a potential impact on fertility. We investigated histology and gene expressio...

    Authors: Valentina Pampanini, Kirsi Jahnukainen, Lena Sahlin, Daniela Germani, Antonella Puglianiello, Stefano Cianfarani and Olle Söder

    Citation: Reproductive Biology and Endocrinology 2019 17:10

    Content type: Research

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  32. MicroRNAs (miRNAs) are short, noncoding RNAs that posttranscriptionally regulate gene expression. In the past decade, studies on miRNAs in ovaries have revealed the key roles of miRNAs in ovarian development a...

    Authors: Jinbi Zhang, Yinxue Xu, Honglin Liu and Zengxiang Pan

    Citation: Reproductive Biology and Endocrinology 2019 17:9

    Content type: Review

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  33. Over the past two decades, public health has focused on the identification of environmental chemical factors that are able to adversely affect hormonal function, known as endocrine disruptors (EDs). EDs mimic ...

    Authors: Andrea Di Nisio and Carlo Foresta

    Citation: Reproductive Biology and Endocrinology 2019 17:4

    Content type: Review

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  34. A central dogma of mammalian reproductive biology is that the size of the primordial follicle pool represents reproductive capacity in females. The assembly of the primordial follicle starts after the primordi...

    Authors: Bo Pan and Julang Li

    Citation: Reproductive Biology and Endocrinology 2019 17:8

    Content type: Review

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  35. Diminished ovarian reserve (DOR) remains one of the greatest obstacles affecting the chance of a successful live birth after fertility treatment. The present study was set to investigate whether using a “dual ...

    Authors: Ming-Huei Lin, Frank Shao-Ying Wu, Yuh-Ming Hwu, Robert Kuo-Kuang Lee, Ryh-Sheng Li and Sheng-Hsiang Li

    Citation: Reproductive Biology and Endocrinology 2019 17:7

    Content type: Research

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  36. Fertility preservation (FP) protocols in case of breast cancer (BC) include mature oocyte cryopreservation following letrozole associated controlled ovarian hyperstimulation (Let-COH). To date, the impact of L...

    Authors: Oranite Goldrat, Geraldine Van Den Steen, Eric Gonzalez-Merino, Julie Dechène, Christine Gervy, Anne Delbaere, Fabienne Devreker, Viviane De Maertelaer and Isabelle Demeestere

    Citation: Reproductive Biology and Endocrinology 2019 17:3

    Content type: Research

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  37. Chronic endometritis (CE) is a condition which results in reduced receptivity of embryos by dysregulated lymphocyte subsets, abnormal expression of cytokines, chemokines and other regulatory molecules in the e...

    Authors: Wen-juan Wang, Hong Zhang, Zhong-quan Chen, Wei Zhang, Xue-mei Liu, Jiang-ye Fang, Fu-jun Liu and Joanne Kwak-Kim

    Citation: Reproductive Biology and Endocrinology 2019 17:2

    Content type: Research

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  38. Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melato...

    Authors: Longfei Xiao, Junjie Hu, Liangli Song, Yong Zhang, Weitao Dong, Yuting Jiang, Quanwei Zhang, Ligang Yuan and Xingxu Zhao

    Citation: Reproductive Biology and Endocrinology 2019 17:1

    Content type: Research

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  39. Air pollution is a cause of concern for human health. For instance, it is associated with an increased risk for cancer, cardiovascular and respiratory disorders. In vitro and in vivo studies suggested that air...

    Authors: Alessandro Conforti, Marika Mascia, Giuseppina Cioffi, Cristina De Angelis, Giuseppe Coppola, Pasquale De Rosa, Rosario Pivonello, Carlo Alviggi and Giuseppe De Placido

    Citation: Reproductive Biology and Endocrinology 2018 16:117

    Content type: Review

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  40. Recently, a novel approach with delaying the start of controlled ovarian stimulation along with gonadotropin-releasing hormone (GnRH) antagonist pretreatment for 7 days after estrogen priming for further suppr...

    Authors: Mahnaz Ashrafi, Arezoo Arabipoor, Azar Yahyaei, Zahra Zolfaghari and Firouzah Ghaffari

    Citation: Reproductive Biology and Endocrinology 2018 16:124

    Content type: Research

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  41. Exposure to air pollution has been clearly associated with a range of adverse health effects, including reproductive toxicity. However, a limited amount of research has been conducted to examine the associatio...

    Authors: Joanna Jurewicz, Emila Dziewirska, Michał Radwan and Wojciech Hanke

    Citation: Reproductive Biology and Endocrinology 2018 16:109

    Content type: Review

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  42. Hundreds of thousands of young women are diagnosed with cancer each year, and due to recent advances in screening programs, diagnostic methods and treatment options, survival rates have significantly improved....

    Authors: Roberto Marci, Maddalena Mallozzi, Luisa Di Benedetto, Mauro Schimberni, Stefano Mossa, Ilaria Soave, Stefano Palomba and Donatella Caserta

    Citation: Reproductive Biology and Endocrinology 2018 16:112

    Content type: Review

    Published on:

  43. During recent years, an increasing percentage of male infertility has to be attributed to an array of environmental, health and lifestyle factors. Male infertility is likely to be affected by the intense expos...

    Authors: Kavindra Kumar Kesari, Ashok Agarwal and Ralf Henkel

    Citation: Reproductive Biology and Endocrinology 2018 16:118

    Content type: Review

    Published on:

  44. The objective of this study was to carry out a systematic review and meta-analysis of embryologic and clinical outcomes following open versus closed vitrification of human oocytes and embryos.

    Authors: Hongcai Cai, Jean Damascene Niringiyumukiza, Yamin Li, Qiaohong Lai, Yinzhao Jia, Ping Su and Wenpei Xiang

    Citation: Reproductive Biology and Endocrinology 2018 16:123

    Content type: Review

    Published on:

  46. Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age ...

    Authors: Asher Bashiri, Katherine Ida Halper and Raoul Orvieto

    Citation: Reproductive Biology and Endocrinology 2018 16:121

    Content type: Review

    Published on:

  47. Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ p...

    Authors: Zhengling Liu, Zengyan Wang, Changhong Hao, Yonghui Tian and Jingjing Fu

    Citation: Reproductive Biology and Endocrinology 2018 16:120

    Content type: Research

    Published on:

  48. There is growing evidence that lifestyle choices account for the overall quality of health and life (QoL) reflecting many potential lifestyle risks widely associated with alterations of the reproductive functi...

    Authors: Stefano Palomba, Jessica Daolio, Sara Romeo, Francesco Antonino Battaglia, Roberto Marci and Giovanni Battista La Sala

    Citation: Reproductive Biology and Endocrinology 2018 16:113

    Content type: Review

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  49. Male infertility is a widespread condition among couples. In about 50% of cases, couple infertility is attributable to the male partner, mainly due to a failure in spermatogenesis. In recent times, the crucial...

    Authors: Alessandro Ilacqua, Giulia Izzo, Gian Pietro Emerenziani, Carlo Baldari and Antonio Aversa

    Citation: Reproductive Biology and Endocrinology 2018 16:115

    Content type: Review

    Published on:

  50. There is limited literature investigating the effects of body mass index (BMI) and androgen level on in vitro fertilization (IVF) outcomes with a gonadotropin-releasing hormone (GnRH)-antagonist protocol in po...

    Authors: Wan Yang, Rui Yang, Mingmei Lin, Yan Yang, Xueling Song, Jiajia Zhang, Shuo Yang, Ying Song, Jia Li, Tianshu Pang, Feng Deng, Hua Zhang, Ying Wang, Rong Li and Jie Jiao

    Citation: Reproductive Biology and Endocrinology 2018 16:119

    Content type: Research

    Published on:

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