Table 4 Mediation analysis of associations between three MTHFR/MTRR mutations and PCOS risk (mediated by homocysteine)
| Â | Â | Relative indirect effect (95% CI) | Relative direct effect (95% CI) | Total effect (95% CI) |
|---|---|---|---|---|
MTHFR C677T | CC | reference | reference | -0.003 [-0.004 - (-0.002)] |
CT | 0.062 (-0.240–0.354) | 0.167 (-0.337–0.670) | ||
TT | 0.069 (-0.492–0.706) | -0.431 (-1.260–0.399) | ||
MTHFR A1298C | AA | reference | reference | 0.102 (0.052–0.168) |
AC | 0.772 (0.464–1.132) | 0.155 (-0.353–0.663) | ||
CC | 1.861 (1.085–2.777) | -0.054 (-1.092–0.985) | ||
MTRR A66G | AA | reference | reference | 0.014 (-0.001–0.036) |
AG | -0.169 (-0.473–0.115) | -0.344 (-0.855–0.166) | ||
GG | 0.630 (0.149–1.211) | 0.135 (-0.693–0.963) |