Table 2 Genotype distribution of MTHFR, MTRR mutations in the cases and controls according to additive, dominant, and recessive models
Gene & SNP | Model | Genotype | PCOS Group | Control Group | OR (95% CI) | P value | Adjusted ORa (95% CI) | P value |
|---|---|---|---|---|---|---|---|---|
N (%) | N (%) | |||||||
MTHFR C677T | Additive | CC | 67 (44.7%) | 157 (52.3%) | 1 | 0.184 | 1 | 0.352 |
CT | 68 (45.3%) | 109 (36.3%) | 1.462 (0.964–2.217) | 1.225 (0.790–1.899) | ||||
TT | 15 (10.0%) | 34 (11.3%) | 1.034 (0.528–2.023) | 0.753 (0.372–1.524) | ||||
Dominant | CT + TT | 83 (55.3%) | 143 (47.7%) | 1 | 0.126 | 1 | 0.628 | |
CC | 67 (44.7%) | 157 (52.3%) | 0.735 (0.496–1.090) | 0.902 (0.595–1.368) | ||||
Recessive | TT | 15 (10.0%) | 34 (11.3%) | 1 | 0.669 | 1 | 0.263 | |
CC + CT | 135 (90%) | 266 (88.7%) | 1.150 (0.605–2.186) | 1.467 (0.750–2.870) | ||||
MTHFRA1298C | Additive | AA | 65 (43.3%) | 195 (65.0%) | 1 | < 0.001 | 1 | < 0.001 |
AC | 63 (42.0%) | 91 (30.3%) | 2.077 (1.356–3.182) | 2.142 (1.376–3.336) | ||||
CC | 22 (14.7%) | 14 (4.7%) | 4.714 (2.280–9.748) | 3.755 (1.741–8.096) | ||||
Dominant | AC + CC | 85 (56.7%) | 105 (35.0%) | 1 | < 0.001 | 1 | < 0.001 | |
AA | 65 (43.3%) | 195 (65.0%) | 0.412 (0.276–0.615) | 0.422 (0.277–0.641) | ||||
Recessive | CC | 22 (14.7%) | 14 (4.7%) | 1 | < 0.001 | 1 | 0.008 | |
AA + AC | 128 (85.3%) | 286 (95.3%) | 0.285 (0.141–0.575) | 0.368 (0.176–0.771) | ||||
MTRR A66G | Additive | AA | 82 (54.7%) | 162 (54.0%) | 1 | 0.014 | 1 | 0.028 |
AG | 46 (30.7%) | 118 (39.3%) | 0.770 (0.500–1.186) | 0.694 (0.442–1.088) | ||||
GG | 22 (14.7%) | 20 (6.7%) | 2.173 (1.122–4.210) | 1.796 (0.902–3.572) | ||||
Dominant | AG + GG | 68 (45.3%) | 138 (46.0%) | 1 | 0.894 | 1 | 0.475 | |
AA | 82 (54.7%) | 162 (54.0%) | 1.027 (0.693–1.523) | 1.162 (0.770–1.753) | ||||
Recessive | GG | 22 (14.7%) | 20 (6.7%) | 1 | 0.007 | 1 | 0.031 | |
AA + AG | 128 (85.3%) | 280 (93.3%) | 0.416 (0.219–0.789) | 0.481 (0.247–0.935) |