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Table 3 Pregnancy and neonatal outcomes of Logistic and Propensity score matching

From: Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis, GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study

Outcomes

OHSS group (n = 385)

Binary logistic regression analysis Propensity score matching

Unmatched (n = 6356)

P value

Matched 1:4 (n = 1540)

P value

Live birth delivery rate, no. (%)

338/385 (87.8)

5380/6356 (84.6)

0.164

1331/1540 (86.4)

0.481

 Singleton, no. (%)

174/338 (51.5)

3913/5380 (72.7)

 < 0.001

721/1331 (54.2)

0.376

 Multiple, no. (%)

164/338 (48.5)

1467/5380 (27.3)

 < 0.001

610/1331 (45.8)

0.376

Preterm delivery, no. (%)

67/338 (19.8)

1456/5380 (27.1)

 < 0.001

262/1331 (19.7)

0.955

Miscarriages, no. (%)

47/385 (12.2)

976/6356 (15.4)

0.164

209/1540 (13.6)

0.481

Early miscarriages, no. (%)

23/385 (6.0)

607/6356 (9.6)

0.160

137/1540 (8.9)

0.063

Obstetric complications, no. (%)

27/385 (7.0)

414/6356 (6.5)

0.700

49/1540 (3.2)

0.001

 PP, no. (%)

3/385 (0.8)

35/6356 (0.6)

0.404

5/1540 (0.3)

0.215

 GDM, no. (%)

7/385 (1.8)

82/6356 (1.3)

0.178

9/1540 (0.6)

0.017

 HDP, no. (%)

12/385 (3.1)

137/6356 (2.2)

0.117

34/1540 (2.2)

0.184

 ICP, no. (%)

2/385 (0.5)

7/6356 (0.1)

0.056

1/1540 (0.1)

0.104

 VT, no. (%)

2/385 (0.5)

0

 < 0.001

0

0.040

Duration of gestation (weeks) (mean + SD)

38.0 ± 2.2

38.7 ± 2.0

0.020

38.7 ± 2.1

 < 0.001

Neonatal births

503

6855

 

1946

 

Neonatal complications, no. (%)

18/503 (3.6)

193/6855 (2.8)

0.322

40/1946 (2.1)

0.045

 NICU, no. (%)

16/503 (3.2)

143/6855 (2.1)

0.103

33/1946 (1.7)

0.034

Congenital diseases, no. (%)

2/503 (0.4)

15/6855 (0.2)

0.420

1/1946 (0.1)

0.048

Average neonatal weight (g) (mean + SD)

2800.7 ± 588.6

3040.0 ± 655.3

 < 0.001

2853.6 ± 659.6

0.081

LBW, no. (%)

128/503 (25.5)

1228/6855 (17.9)

 < 0.001

528/1946 (27.1)

0.441

  1. Note: Data are n (%) unless otherwise indicated. Plus-minus values are the mean±SD; SD Standard deviation. Statistically significant (P<0.05). OR, Odds ratio
  2. Live birth delivery rate; the number of deliveries that resulted in at least one live birth, expressed per 100 cycle attempts. the denominator in our study is the number of pregnancies who were diagnosed with clinical pregnancy after IVF/ICSI- fresh ET
  3. Premature delivery was defined as birth before 37 completed weeks and after 28 completed weeks of pregnancy
  4. Miscarriage included early- and late-term miscarriages. Early miscarriages occurred before 12 gestational weeks, and late-term miscarriages occurred between 13 and 28 gestational weeks
  5. Obstetric complications; PP Placenta previa, GDM Gestational diabetes mellitus, PROM Premature rupture of the fetal membranes, HDP hypertensive disorder of pregnancy, including gestational hypertension, preeclampsia, and eclampsia, ICP Intrahepatic cholestasis of pregnancy, VT Venous thrombosis
  6. Neonatal complications included prematurity, extremely low birth weight, perinatal asphyxia, major birth defects, sepsis, neonatal jaundice, and infant respiratory distress syndrome due to immaturity of the lungs
  7. NICU, neonatal intensive care unit, which concentrates on the care of premature babies and sick newborns, due to extreme low birth weight (LBW), perinatal asphyxia, major birth defects, sepsis, neonatal jaundice, and infant respiratory distress syndrome due to immaturity of the lungs and other complications
  8. Other neonatal complications: One neonatal death occurred in the NICU, and two congenital diseases occurred in the OHSS group. In the matched non-OHSS group, one death occurred within one year after birth, and one congenital disease, one chromosomal abnormality and five congenital diseases were present
  9. LBW Low birth weight (birth weight <2500 g)
  10. Threatened abortion refers to a small amount of vaginal bleeding, often dark red or bloody leukorrhea and accompanying paroxysmal abdominal pain or lower back pain in the absence of pregnancy discharge at <28 weeks of pregnancy
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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