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Table 1 Comparisons of pre- and post-DHEA cycles in 25 women with DOR*

From: Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR)

  Pre-DHEA Post-DHEA p-value
Cycle cancellations (%) 32.0 4.3 0.02
Number oocytes 3.4 ± 0.5 4.4 ± 0.5 <0.05
Fertilized oocytes (n) 1.4 ± 0.3 3.0 ± 0.5 <0.001
(%) 39 67 <0.001
Day 3 blastomeres 3.4 ± 0.4 4.7 ± 0.5 0.01
embryo grade 2.9 ± 0.1 3.4 ± 0.1 0.02
Cumulative embryoscore/oocytes 8.4 ± 1.5 16.1 ± 1.6 0.001
Number of transferred embryos 1.4 ± 0.2 2.4 ± 0.3 0.005
Normal day 3 embryos 1.2 ± 0.2 2.7 ± 0.4 0.001
  1. * 25 patients were evaluated in their respective IVF cycle outcomes pre- and post-DHEA. This study design potentially biases outcome against positive DHEA effects since patients who entered DHEA supplementation after a prior failed IVF cycle, quite obviously, reflected, in view of their prior IVF treatment failure, a negatively selected patient population. Pre- and post DHEA cycles occurred at ages 39 ± 0.8 and 40.4 ± 0.8 years, respectively, also mildly biasing the study against positive DHEA findings. Post-DHEA patients were on supplementation 17.6 ± 2.13 weeks by time of second IVF cycle. Data extracted from Barad and Gleicher [16].