Trends in patient characteristics of our center's IVF population. Panel A demonstrates mean ages for IVF patients between 2005 and year-to-date 2009. Panel B demonstrates proportional shift from younger patients (<39 years) to older women (≥ 40 years). Panel C demonstrates that this age shift is also accompanied by a significant fall in AMH levels in younger women (ages 31-35 years) and, therefore, increasing DOR in these younger (POA) patients. Combined, these data explain why in 2009 close to 90% of the center's population was affected by either POA or DOR.