Figure 1
From: The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis
Proposed mechanisms of HGSOC pathogenesis. Incessant Ovulation Hypothesis: monthly physical damage from ovulation necessitates increased cell proliferation during repair, eventually leading to genomic instability. Gonadotropin hypothesis: Exposure to hormones released during ovulation inhibits natural apoptosis, uninterrupted hormonal fluctuations stimulate differentiation, proliferation, and ultimately malignant transformation.