Fig. 2

RNA-seq analyses of orchidectomized and lumicrine signaling-deficient IS-caput epididymis. A–C, RNA-seq of sham-operated control vs. bilateral OD (A), contralateral side control vs. ipsilateral side in unilateral OD (B), sham-operated control vs. contralateral side control in unilateral OD (C). D-F, RNA-seq of WT vs. EDL (D), WT vs. W/Wv (E), and WT vs. Nell2^−/− (F). FPKM values are plotted. Statistically significantly downregulated (fold change < 0.1, and t-test P < 0.05) and upregulated (fold change > 10, and t-test P < 0.05) genes are represented in green and yellow, respectively