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Fig. 7 | Reproductive Biology and Endocrinology

Fig. 7

From: Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression

Fig. 7

Schematic model depicting the repair mechanism of EnSCs against cisplatin-induced ferroptosis in granulosa cells. As shown in the figure, endometrial stem cells can upregulate Nrf2 expression in injured granulosa cells, while Nrf2 may further prompt the SLC7A11-GPX4 axis to inhibit ferroptosis thus taking a protective role in cisplatin-injured granulosa cells, which can be blocked by ML385. Meanwhile, EnSCs exert a similar repair effect as Fer-1 to inhibit the production of reactive oxygen ROS and lipid peroxidation. In conclusion, endometrial stem cells can inhibit cisplatin-induced ferroptosis of granulosa cells through upregulation of Nrf2 expression to achieve repair effects Additional file 1

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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