Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data

Table 2 Laboratory indicators

	Control (n = 4750)	RIF (n = 462)	t/X²	P
FSH (IU/L)	7.62 ± 3.35	8.64 ± 3.28	-2.722	0.007
LH (IU/L)	4.84 ± 3.18	4.63 ± 2.18	0.769	0.442
E₂ (pg/m L)	48.48 ± 20.67	45.59 ± 19.88	1.209	0.228
P (ng/m L)	0.89 ± 2.28	0.81 ± 0.76	0.337	0.736
PRL (ng/m L)	20.89 ± 10.32	20.19 ± 14.61	1.602	0.109
T (ng/m L)	0.43 ± 0.23	0.42 ± 0.25	0.212	0.833
AMH (ng/m L)	4.84 ± 3.71	3.07 ± 2.48	2.585	0.011
FT3 (pmol/L)	4.95 ± 0.6	4.93 ± 0.94	0.138	0.891
FT4 (pmol/L)	17.77 ± 3.56	17.93 ± 3.17	0.166	0.869
TSH (u IU/m L)	2.45 ± 0.3	2.61 ± 0.51	-1.255	0.217
HOMA-IR	1.81 ± 0.519	2.21 ± 0.67	-6.951	0.000
Chromosome karyotype (female partner)			0.332	0.564
Normal abnormal	4570(96.21) 180(3.79)	442(95.67) 20(4.33)
Chromosome karyotype (male partner)			0.065	0.798
Normal abnormal	4345(91.47) 405(8.53)	421(91.13) 41(8.87)
Hysteroscopy			184.569	0.000
Normal	3670(77.26)	224(48.48)
abnormal	1080(22.74)	238(51.52)
Endometrial thickness on the day of HCG administration (mm)	11.52 ± 1.91	9.54 ± 1.89	5.080	0.000
Immune factor
ACA			0.362	0.548
Positive Negative	305(6.42) 4445(93.58)	33(7.14) 429(92.86)
ANA			74.34	0.000
Positive Negative	575(12.11) 4175(87.89)	122(26.41) 340(73.59)
A-β2-GPI Ab			104.994	0.000
Positive Negative	120(2.53) 4630(97.47)	53(11.47) 409(88.53)
TG-Ab			73.558	0.000
Positive Negative	495(10.42) 4255(89.58)	110(23.81) 352(76.19)
TPO-Ab			24.679	0.000
Positive Negative	485(10.21) 4265(89.79)	82(17.75) 380(82.25)

The data are presented as the mean ± SD or % (n). The data were analysed by ANOVA or the chi-square test and Fisher’s exact test. HOMA-IR was calculated as follows: fasting insulin (µU/mL)*fasting glucose (mmol/L)/22.5. FSH, follicle-stimulating hormone; LH, luteinizing hormone; E2, oestradiol; P, progesterone; PRL, prolactin; T, testosterone; AMH, anti-Müllerian hormone; FT3, free triiodothyronine; FT4, free thyroxin; TSH, thyroid stimulating hormone; HOMA-IR, Homeostatic Model Assessment for Insulin Resistance; ACA, anticardiolipin antibody; ANA, antinuclear antibody; A-β2-GPI, anti-β2-glycoprotein I antibody; TG-Ab, anti-thyroglobulin antibody; TPO-Ab, anti-thyroid peroxidase antibody.

ISSN: 1477-7827