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Table 1 Modified QUIPS tool for assessment of study quality. The individual studies are defined as a high quality study (HQ), moderate quality study (MQ), or low quality study (LQ)

From: Active plasma renin concentration throughout healthy and complicated pregnancy: a systematic review and meta-analysis

Domain

Items for consideration

Al Kadi (2005) [20]

Baker (1992) [21]

Brown (1990) [24]

Brown (1992a) [25]

Brown (1992b) [27]

Brown (1993) [26]

Brown (1994) [22]

Brown (1995) [23]

Derkx (1987) [28]

Jarvis (2012) [29]

Langer (1998) [30]

Lewandowski (2023) [35]

Nicholson (1987) [5]

Pedersen (1982) [31]

Skinner (1972) [32]

Spaan (2013) [33]

Spaanderman (2001) [7]

Thomsen (1993) [34]

Study Participation

Adequate description of participant characteristics:

                  

Parity or gravidity

+

–

+

–

+

+

–

–

–

–

+

–

+

–

–

+

+

+

Health or comorbidities of participants

+

+

–

–

+

–

–

+

–

+

+

–

+

–

+

+

+

+

Clear reporting of weeks amenorrhea

+

+

+

+

+

+

–

+

+

+

+

+

–

–

+

+

+

+

Ethnicity

–

+

–

–

–

–

–

–

–

–

–

–

–

–

+

–

+

–

Height

–

–

+

–

+

+

–

+

–

+

–

–

–

–

–

–

+

–

Non-pregnant weight or BMI

+

–

–

–

–

–

–

–

–

+

–

–

–

–

–

–

+

–

Use of medication or supplements

+

+

+

+

+

+

+

+

+

+

–

–

+

+

+

+

+

+

Adequate description of participant recruitment

+

–

+

+

+

–

+

+

–

–

+

–

–

+

–

+

+

+

Adequate description of inclusion and exclusion criteria

+

–

–

–

–

–

–

+

–

+

+

+

–

+

–

+

+

–

Study Attrition

Reasons for loss to follow-up/drop-out are provided

?

?

?

?

?

?

?

?

–

?

?

?

?

?

?

–

+

–

Adequate description of participants lost to follow-up / differences between participants who completed and drop-outs

?

?

?

?

?

?

?

?

–

?

?

?

?

?

?

–

+

–

Variable Measurements

Method of APRC measurement is valid and reliable

+

+

+

+

+

+

+

+

+

?

+

+

+

+

+

?

+

+

The methods and setting are the same for all study participants and throughout follow up

+

+

+

+

+

+

+

–

+

+

+

+

?

+

+

+

+

+

Data Reporting

Time frame of measurements (gestational age) are reported as mean

–

–

+

+

+

+

–

+

–

+

+

+

–

–

–

+

–

–

Study Design

Study used a longitudinal study design

+

+

–

–

–

–

–

–

+

+

+

–

–

+

–

+

+

+

Multiple (≥2) longitudinal measurements during pregnancy of APRC

+

+

–

–

–

–

–

–

–

–

+

–

–

–

–

–

–

+

Baseline value was a prepregnant measurement of the variable

+

–

–

–

–

–

–

–

–

+

–

–

–

–

–

–

+

–

 

Score (%)

71

47

47

35

53

41

24

47

29

59

59

29

24

35

35

53

88

53

 

Quality

HQ

MQ

MQ

MQ

MQ

MQ

LQ

MQ

LQ

MQ

MQ

LQ

LQ

MQ

MQ

MQ

HQ

MQ