Table 6 Clinical pregnancy and neonatal outcomes between patients who underwent single good-quality blastocyst transfer and those who underwent transfer of a second poor-quality blastocyst with a good-quality blastocyst before and after PS matching

Age < 35

Blastocyst transfer

Variable

Before matching

After matching

SET- GQE (N = 379)

DET- GQE + PQE (N = 197)

P value

SET- GQE (N = 181)

DET- GQE + PQE (N = 181)

P value

Implantation n (%)

218 (57.5)

159 (40.4)

0.000

97 (53.6)

146 (40.3)

0.003

OR (95%CI)

Reference

0.567 (0.416—0.772)

0.000

Reference

0.654 (0.454—0.941)

0.022

Clinical Pregnancy n (%)

213 (56.2)

123 (62.4)

0.150

94 (51.9)

113 (62.4)

0.044

OR (95%CI)

Reference

1.607 (1.085—2.380)

0.018

Reference

1.626 (1.017—2.599)

0.042

Live birth n (%)

167 (44.1)

99 (50.3)

0.157

70 (38.7)

90 (49.7)

0.034

OR (95%CI)

Reference

1.674 (1.147—2.445)

0.008

Reference

1.803 (1.165—2.789)

0.008

Multiple birth n (%)

2 (1.2)

24 (24.2)

0.000

1 (1.4)

23 (25.6)

0.000

OR (95%CI)

Reference

31.641 (6.827—146.651)

0.000

Reference

24.185 (3.285—178.062)

0.002

Miscarriage n (%)

46 (21.6)

24 (19.5)

0.650

24 (25.5)

23 (20.4)

0.376

OR (95%CI)

Reference

0.748 (0.404—1.383)

0.355

Reference

0.713 (0.370—1.373)

0.312

Preterm birth n (%)

8 (4.8)

15 (15.2)

0.004

3 (4.3)

14 (15.6)

0.022

OR (95%CI)

Reference

3.441 (1.330—8.906)

0.011

Reference

4.092 (1.153—14.518)

0.029

Gestational age (weeks)

39.0 ± 2.0

38.1 ± 2.3

0.000

38.9 ± 1.8

38.0 ± 2.3

0.005

OR (95%CI)

Reference

0.566 (0.324—0.989)

0.046

Reference

0.573 (0.304—1.080)

0.085

Birth height (mm)

49.7 ± 4.3

48.6 ± 3.3

0.016

49.3 ± 6.3

48.9 ± 2.5

0.605

OR (95%CI)

Reference

0.389 (0.198—0.764)

0.006

Reference

0.578 (0.248—1.345)

0.203

Birth weight (g)

3330.3 ± 548.8

3053.9 ± 610.6

0.000

3300.0 ± 637.7

3067.4 ± 606.0

0.014

OR (95%CI)

Reference

0.937 (0.898—0.979)

0.003

Reference

0.951 (0.899—1.006)

0.078

Low birth weight n (%)

12 (7.1)

18 (14.6)

0.036

8 (11.3)

16 (14.2)

0.571

OR (95%CI)

Reference

1.530 (0.561—4.172)

0.406

Reference

0.957 (0.340—2.699)

0.957

Congenital anomalies n (%)

0 (0)

1 (0.8)

0.421

0 (0)

1 (0.9)

1.000

OR (95%CI)

-

-

-

-

-

-

Age ≥ 35

Blastocyst transfer

Variable

Before matching

After matching

SET- GQE (N = 144)

DET- GQE + PQE (N = 119)

P value

SET- GQE (N = 102)

DET- GQE + PQE (N = 102)

P value

Implantation n (%)

56 (38.9)

68 (28.6)

0.037

40 (39.2)

61 (29.9)

0.102

OR (95%CI)

Reference

0.602 (0.380—0.954)

0.031

Reference

0.661 (0.396—1.103)

0.113

Clinical Pregnancy n (%)

56 (38.9)

57 (47.9)

0.142

40 (39.2)

50 (49.0)

0.159

OR (95%CI)

Reference

1.722 (1.046—2.835)

0.032

Reference

2.282 (1.458—3.571)

0.000

Live birth n (%)

46 (31.9)

41 (34.5)

0.667

34 (33.3)

36 (35.3)

0.768

OR (95%CI)

Reference

1.003 (0.582—1.729)

0.992

Reference

1.053 (0.589—1.884)

0.862

Multiple birth n (%)

0 (0)

3 (7.3)

0.101

0 (0)

3 (8.3)

0.240

OR (95%CI)

-

-

-

-

-

-

Miscarriage n (%)

10 (17.9)

16 (28.1)

0.197

6 (15.0)

14 (28.0)

0.140

OR (95%CI)

Reference

1.322 (0.455—3.839)

0.608

Reference

2.318 (0.794—6.771)

0.124

Preterm birth n (%)

4 (8.7)

4 (9.8)

1.000

2 (5.9)

4 (11.1)

0.674

OR (95%CI)

Reference

2.310 (0.295—18.101)

0.425

Reference

1.972 (0.352—11.040)

0.440

Gestational age (weeks)

38.9 ± 1.1

38.1 ± 2.8

0.105

38.9 ± 1.0

38.0 ± 3.0

0.063

OR (95%CI)

Reference

0.518 (0.281—0.955)

0.035

Reference

0.542 (0.224—1.311)

0.174

Birth height (mm)

49.9 ± 0.9

48.9 ± 4.4

0.128

50.0 ± 0.7

48.7 ± 4.7

0.103

OR (95%CI)

Reference

0.512 (0.185—1.422)

0.199

Reference

0.475 (0.132—1.709)

0.475

Birth weight (g)

3368.5 ± 383.2

3090.9 ± 636.5

0.014

3415.9 ± 351.0

3064.2 ± 658.9

0.005

OR (95%CI)

Reference

0.928 (0.869—0.992)

0.029

Reference

0.923 (0.862—0.987)

0.020

Low birth weight n (%)

1 (2.2)

5 (11.4)

0.107

0 (0)

5 (12.8)

0.057

OR (95%CI)

-

-

-

-

-

-

Congenital anomalies n (%)

0

0

-

0

0

-

OR (95%CI)

-

-

-

-

-

-