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Table 3 Clinical pregnancy and neonatal outcomes between patients who underwent single good-quality cleavage-stage embryo transfer and those who underwent transfer of a second poor-quality embryo with a good-quality embryo before and after PS matching

From: Effect of frozen-thawed embryo transfer with a poor-quality embryo and a good-quality embryo on pregnancy and neonatal outcomes

Variable

Cleavage-stage embryo transfer

Before matching

After matching

SET- GQE (N = 201)

DET- GQE + PQE (N = 421)

P value

SET- GQE (N = 169)

DET- GQE + PQE (N = 169)

P value

Implantation n (%)

78 (38.8)

208 (24.7)

0.000

63 (37.3)

93 (27.5)

0.025

OR (95%CI)

Reference

0.616 (0.428—0.886)

0.009

Reference

0.718 (0.450—1.145)

0.164

Clinical Pregnancy n (%)

76 (37.8)

167 (39.7)

0.657

61 (36.1)

74 (43.8)

0.183

OR (95%CI)

Reference

1.302 (0.885—1.914)

0.180

Reference

1.365 (0.876—2.127)

0.169

Live birth n (%)

63 (31.3)

134 (31.8)

0.903

53 (31.4)

66 (39.1)

0.172

OR (95%CI)

Reference

1.220 (0.808—1.841)

0.344

Reference

1.421 (0.907—2.228)

0.125

Multiple birth n (%)

5 (7.9)

29 (21.6)

0.018

4 (7.5)

16 (24.2)

0.015

OR (95%CI)

Reference

3.927 (1.273—12.113)

0.017

Reference

3.917 (1.189—12.911)

0.025

Miscarriage n (%)

13 (17.1)

33 (19.8)

0.624

8 (13.1)

8 (10.8)

0.680

OR (95%CI)

Reference

1.008 (0.510—1.991)

0.982

Reference

0.416 (0.061—2.833)

0.370

Preterm birth n (%)

7 (11.1)

20 (14.9)

0.468

6 (11.3)

10 (15.2)

0.543

OR (95%CI)

Reference

1.418 (0.555—3.625)

0.466

Reference

1.407 (0.459- 4.317)

0.550

Gestational age (weeks)

38.6 ± 1.9

38.2 ± 2.1

0.236

38. 6 ± 2.0

38.2 ± 1.9

0.225

OR (95%CI)

Reference

0.684 (0.382—1.223)

0.200

Reference

0.673 (0.347—1.306)

0.242

Birth height (mm)

49.3 ± 2.0

49.0 ± 2.2

0.283

49.3 ± 2.1

48.8 ± 2.1

0.186

OR (95%CI)

Reference

0.731 (0.418—1.278)

0.271

Reference

0.660 (0.341—1.277)

0.217

Birth weight (g)

3092.7 ± 563.0

3008.2 ± 595.2

0.319

3100.2 ± 588.7

2912.9 ± 555.6

0.059

OR (95%CI)

Reference

0.976 (0.928—1.026)

0.336

Reference

0.947 (0.890—1.008)

0.089

Low birth weight n (%)

11 (16.2)

32(19.6)

0.539

10 (17.5)

20 (24.4)

0.335

OR (95%CI)

Reference

1.673 (0.635—4.410)

0.298

Reference

1.688 (0.590—4.832)

0.329

Congenital anomalies n (%)

1 (1.5)

2 (1.2)

1.000

1 (1.8)

2 (2.4)

1.000

OR (95%CI)

-

-

-

Reference

1.279 (0.106- 15.369)

0.846

  1. Values are expressed as n (%), percentage (%) or mean ± standard deviation (SD) unless otherwise stated. P-values in bold depict statistical significance (P < 0.05) in comparison between SET-GQE and DET-GQE + PQE. ORs were adjusted for variables presented in the part of statistical analysis using multivariate GEE model before matching. ORs after matching were adjusted for propensity score
  2. SET Single embryo transfer, DET Double embryo transfer, GQE Good quality embryo, PQE Poor quality embryo, OR Odds ratio
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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