The reproductive potential of vitrified-warmed euploid embryos declines following repeated uterine transfers

Table 2 Clinical outcomes of the first, second and third vitrified-warmed euploid embryo transfers

	1st FET cycle	2nd FET cycle	3rd FET cycle
Vitrified-warmed embryo transfer cycles (n)	288	63	13
Vitrified-warmed embryos transferred (n)	364	82	17
Proportion of good-quality embryos [n (%)]	345 (94.8)^a,b	75 (91.5)^a	13 (76.5)^b
Total pregnancies per embryo transfer cycle [n (%)]	149 (53.0)	29 (49.2)	5 (38.5)
Clinical pregnancies per embryo transfer cycle [n (%)]	139 (49.4)	29 (49.2)	5 (38.5)
Livebirth rate per embryo transfer cycle [n (%)]	115 (41.1)	25 (42.4)	4 (30.8)
Miscarriages [n (%)]	32 (21.8)	4 (13.8)	1 (20.0)
Sustained implantation rate per single embryo transferred [n (%)]	170 (46.7)^c,d	33 (40.7)^c	5 (30.0)^d
Livebirth rate per single embryo transferred [n (%)]	135 (37.1)^e,f	28 (33.9)^e	4 (25.0)^f

Using Fisher exact test –^a 1st FET cycle vs. 2nd FET cycle (P = NS), ^b 1st FET cycle vs. 3rd FET cycle (P = 0.01),
Using Wilcoxon signed rank test -^c 1st FET cycle vs. 2nd FET cycle (P = NS), ^d 1st FET cycle vs. 3rd FET cycle (P = 0.01), ^e 1st FET cycle vs. 2nd FET cycle (P = NS), ^f 1st FET cycle vs. 3rd FET cycle (P = 0.02)

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