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Table 2 Characteristics and findings of hysteroscopy in included RCTs

From: Outpatient hysteroscopy impact on subsequent assisted reproductive technology: a systematic review and meta-analysis in patients with normal transvaginal sonography or hysterosalpingography images

Author, publication year

Abnormal

hysteroscopy

Etiology of unsuspected lesions1

Instrument

Anesthesia/

Sedation

Timing of procedure/subsequent ART

Demirol et al. (2004)

26.7%

EM polyps 15.7%

IUA 8.5%

Cervix stenosis 2.3%

5 mm diameter with 5 Fr working channel, 30° view (Bettocchi)

Midazolam 0.1 mg/kg IV when needed

Early follicular phase/NA

Raju et al. (2006)

38.0%

EM polyps 12.8%

Abn Cervix 12%

IUA 4.8%

EM hyperplasia 4.8%

Fibroids 0.4%

Anomalies2 3.2%

5 mm diameter with 5 Fr working channel, 30° view (Krishna)

Midazolam 0.1 mg/kg IV when needed

NA/NA

Shawki et al. (2012)

33.4%

EM polyps 10.8%

IUA 3.8%

Fibroids 3.8%

Endometritis 1.9%

Anomalies2 0.9%

EM hyperplasia 2.8%

3.5 mm diameter, 0° view (Versascope, Gynecare, Ethicon, Sommerville, NJ, USA)

None

NA/NA

Elsetohy et al. (2014)

43.3%

EM polyps 13.4%

Anomalies2 10.4%

Fibroids 7.2%

IUA 6.2%

4.3 mm diameter with 5 Fr working channel, 30° view

NA

Early to mid-follicular phase/Start ICSI cycle within 3 months

Alleyassin et al. (2015)

22.7%

Anomalies2 13.6%

EM polyps 5.4%

IUA 0.9%

EM hyperplasia 1.8%

4 mm diameter rigid hysteroscopy, 30°view

None

Mid-luteal phase/Start ICSI next cycle

Smit et al. (2016)

13.0%

EM polyps 9.5%

Anomalies2 2.3%

Fibroids 1.3%

IUA 1%

5 mm diameter with 5 Fr working channel, 30° view

Paracervical block when needed

Early to mid-follicular phase/Start ICSI cycle within 3 months

El-Toukhy et al. (2016)

26.0%

Anomalies2 8%

Cx stenosis 4%

EM polyps 3%3

IUA 0.9%

2.9 mm diameter rigid hysteroscopy, 30° view (TROPHYscope; Karl Storz, Tuttlingen)

None

Follicular phase/Started IVF in the following month

Abid et al. (2021)

31.0%

IUA 13%

EM polyps 8.3%

Endometritis 8.3%

Fibroids 1.2%

2.9 mm diameter (26,120 BA STORZ)

Analgesic treatment level 2 (Paracetamol/Codeine 500 mg/30 mg) 1 h before the procedure

Mid-follicular phase/Started IVF in the following month

Pounikar et al. (2022)

40.0%

NA

NA

NA

NA/Started IVF in the following month

Ghasemi et al. (2022)

NA

NA

5 Fr working channel, 30° view4

NA

Early to mid-follicular phase/NA

  1. ART, artificial reproductive treatment; EM, endometrial; IUA, intrauterine adhesion; Cx, cervix; IV, intravenous; NA, not available; ICSI, intracytoplasmic sperm injection
  2. 1 The percentage was calculated based on the number of patients who received hysteroscopy
  3. 2 The anomalies include septate, arcuate, or bicornuate uterus
  4. 3 The incidence included 1% micropolyps
  5. 4 The study did not report the diameter of the hysteroscopy