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Fig. 7 | Reproductive Biology and Endocrinology

Fig. 7

From: Inhibition of mitochondrial cyclophilin D, a downstream target of glycogen synthase kinase 3α, improves sperm motility

Fig. 7

Roles of CypD in sperm motility regulation as a key regulator of GSK3α in spermatozoa. In fresh spermatozoa, GSK3α phosphorylates CypD, facilitating the formation of the CypD and ANT complex. This results in the opening of mPTP, decreasing MMP and ATP production and inhibits the activation of sperm motility. During sperm capacitation, inhibitory phosphorylation of GSK3α stimulates proteasomal degradation of CypD, inhibiting the mPTP opening, and which activates ATP production and sperm motility. ANT, adenine nucleotide translocator; mPTP, mitochondrial permeability transition pore; CypD, cyclophilin D; GSK3α, glycogen synthase kinase 3α; OMM, outer mitochondrial membrane; IMM, inner mitochondrial membrane; MMP, mitochondrial membrane potential; ATP, adenosine triphosphate

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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