Skip to main content
Fig. 6 | Reproductive Biology and Endocrinology

Fig. 6

From: Inhibition of mitochondrial cyclophilin D, a downstream target of glycogen synthase kinase 3α, improves sperm motility

Fig. 6

Effects of proteasome inhibitors on the cellular amount of CypD protein in mouse spermatozoa. A Representative western blot images of the effect of proteasome inhibitor MG115 on the amount of CypD protein. Proteasome inhibitor MG115 in TCM increased the amount of CypD protein in spermatozoa. No change is cellular amount of ATP5A, mitochondria marker was observed regardless of proteasome inhibitor treatment. At least three independent experiments were subjected to western blot analysis. B Effect of MG115 on sperm motility. MG115 significantly decreased total and progressive motility of spermatozoa (n = 4). Data are presented as mean ± SD. Significant differences are indicated by different letters using one-way ANOVA (p < 0.05). AU, arbitrary units

Back to article page

Reproductive Biology and Endocrinology

ISSN: 1477-7827

Contact us