Serum erythropoietin level is increased during stimulation for IVF but not in OHSS

Table 2 Serum erythropoietin and related laboratory measures in patients with ovarian hyperstimulation syndrome

	Early n = 25 Late n = 12	Admission n = 27	Worst day n = 28	Discharge n = 32	Follow-up n = 32	p
S-Epo (IU/L)^a	Early n = 13	8.8 (6.8–14.0)	12.0 (8.8–17.2)	13.0 (8.8–19.4)*	10.4 (9.1–12.6)**	0.53
S-Epo (IU/L)^a	Late n = 5	5.2 (3.8–8.5)	7.2 (5.1-9.0)	7.2 (3.6–10.0)*	6.5 (4.8–8.9)**	0.13
S-Prog (nmol/L)^a	Early n = 12	728.2 (646.1–1071.0)*	534.6 (411.0-923.7)*	153.0 (52.5–442.0)***	37.2 (1.8–48.6)***	< 0.001
S-Prog (nmol/L)^a	Late n = 3	1399.5 (707.1–1877.0)*	909.0 (885.2–1557.0)*	811.2 (753.4–1083.0)***	1022.5 (841.3–1142.0)***	N.D
B-Hb (g/L)^a	Early n = 21	143 (133–150)	127 (121–133)	118 (113–124)	123 (119–129)	< 0.001
B-Hb (g/L)^a	Late n = 10	143 (122–165)	134 (113–145)	121 (118–137)	112 (108–131)	< 0.001
SCr (µmol/L)^b	Early n = 17	64±12	60±10	56±6	57±10	< 0.01
SCr (µmol/L)^b	Late n = 9	65±13	56±9	55.5±7	54±7	< 0.01

S = serum, Epo = erythropoietin, Prog = progesterone, B-Hb = blood haemoglobin, SCr = serum creatinine, N.D = Not done (n < 5). The data are expressed as ^a median (95% confidence interval) for non-parametric variables and ^b mean ± standard deviation for parametric variables. Repeated measure analyses (minimum five samples available) were conducted with Friedman’s test for non-parametric variables and repeated measure ANOVA for parametric tests. P-value is for trend. Group differences between early and late OHSS were analysed with independent samples T-test test for parametric variables and Mann-Whitney U test for non-parametric variables. Differences between the groups are presented in the index: p *≤0.05, p **≤0.01, p ***≤0.001

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