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Table 2 Oocyte and blastocyst outcomes of PGT-A cycles with three COS protocols

From: Correlation between controlled ovarian stimulation protocols and euploid blastocyst rate in pre-implantation genetic testing for aneuploidy cycles

 

PPOS protocol

GnRH-a protocol

GnRH-ant protocol

P value

Cycles (n)

152

126

179

 

No. of oocytes retrieved

7.16 ± 5.00 a

12.22 ± 6.25 b

12.04 ± 6.40 b

< 0.001

No. of MII

6.40 ± 4.48 a

10.96 ± 5.60 b

10.22 ± 5.57 b

< 0.001

MII rate (n/%)

973/1088 (89.43%) a

1381/1540 (89.67%) a

1830/2155 (84.92%) b

< 0.001

No. of fertilized oocytes (2PN)

4.63 ± 2.99 a

8.40 ± 4.68 b

7.88 ± 4.62 b

< 0.001

2PN Fertilization rate (%)

758/973 (77.90%) a

1125/1381 (81.46%) a

1482/1830 (80.98) a

0.073

No. of blastocysts formed

3.36 ± 2.14 a

6.71 ± 4.27 b

5.96 ± 3.74 b

< 0.001

No. of blastocyst biopsied

2.26 ± 1.48 a

3.79 ± 2.57 b

3.76 ± 4.47 b

< 0.001

No. of euploidy blastocyst

0.75 ± 0.92 a

1.79 ± 1.78 b

1.80 ± 1.67 b

< 0.001

Euploidy rate per biopsied blastocyst (n/%)

114/344 (33.14%) a

226/460 (49.13%) b

323/668 (48.35%) b

< 0.001

Euploidy rate per oocyte retrieved (n/%)

114/1088 (10.48%) a

226/1540 (14.68%) b

323/2155 (14.99%) b

< 0.001

Euploidy rate per injected MII oocytes (n/%)

114/973 (11.72%) a

226/1381 (16.36%) b

323/1830 (17.65%) b

< 0.001

  1. MII, mature oocytes; 2PN, two pronuclei
  2. a.b means significant differences between the two groups