Table 1 The summary of multi-omics biomarkers identified in this study
Categories | Potential biomarkers | Log (2) Foldchange | Major biological functions have been reported |
|---|---|---|---|
microRNA | miR-470-5p | up-regulation | inhibited mice depressive behavior through promoted hippocampal neurons growth |
miR-18a-5p | up-regulation | Modulates epithelial-mesenchymal transition in breast cancer; boost JAK2/STAT3 signaling activity to enhanced proliferation and migration of tumor | |
miR-300-3p | down-regulation | potential markers for transient ischemic attack in rats | |
miR-182-5p | down-regulation | possible biomarker for teratozoospermia patients in seminal plasma fluid | |
miR-337-5p | down-regulation | promotes the development of cardiac hypertrophy67; promote lymph node metastasis of human gastric cancer | |
let-7a-1-3p | down-regulation | the most abundant miRNAs family in testis; regulate the cell cycle and proliferation; associated with estrogen and androgen signaling | |
mRNA | C3/Rab3b/Apln | up-regulation | key regulators of membrane trafficking, regulates vesicle-mediated transport |
WNT4/Cyp21a1 | up-regulation | affects the concentration of testosterone in the blood | |
Atp1a1 | up-regulation | regulating sertoli tight junctions and gap junction | |
Ccdc39/ Cep131/ Nme5 | down-regulation | required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility | |
small Metabolite | Nicotinamide adenine dinucleotide/Menaquinone/Folic acid | up-regulation | Vitamin digestion and absorption |
Aldosterone/ 2-Methoxyestrone | up-regulation | Steroid hormone biosynthesi | |
Nicotinamide adenine dinucleotide | up-regulation | regulation of AMPK signal pathway which plays vital role in sperm motility, maintenance of the integrity of sperm membranes, and the mitochondrial membrane potential | |
Histamine | down-regulation | vesicle cycle in female reproduction system |