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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells

Fig. 2

Comprehensive transcriptome analysis of microRNA and gene ontology enrichment analysis of targeted genes. (A) Venn diagram of microRNAs detected in PICK KO mouse and WT mouse. (B) Volcano plot highlighting differentially expressed microRNAs in oligoasthenospermia patients. The orange dots illustrate the 3 upregulated DEGs, while the green dots illustrate the 3 downregulated DEGs (adjusted P < 0.005 and log2 FC > 0.5). (C) Comparisons of the expression of the 6 microRNAs in the experimental and control groups by qPCR. (D) Gene ontology enrichment analysis of target genes confirmed multiple significant terms associated with vesicle trafficking. (E) The regulatory network of differentially expressed circRNAs, microRNAs and genes according to the transcriptome sequencing data

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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