From: Small RNAs, spermatogenesis, and male infertility: a decade of retrospect
Study | Population type/size | Sample | Methodology | Inference |
---|---|---|---|---|
Chen et al. [145] | 8 non- obstructive azoospermic and 8 fertile controls | Extracellular vesicles piRNAs | Small RNA sequencing | piR-61,927 in seminal plasma EVs to predict the micro-TESE outcome in non- obstructive azoospermic patients. |
Hong et al. [146] | 118 asthenozoospermic, 93 azoospermic and 91 fertile controls | Seminal plasma | Small RNA sequencing and qRT-PCR | 61 piRNAs showed 10-fold difference between infertile and fertile group; piR-31,068, piR-43,771, piR-31,925, piR-43,773, piR-30,198, piR-55,272, piR-30,841 and piR-30,495 validated using qRT-PCR. |
Hong et al. [147] | 10 asthenozoospermic and 10 normozoospermic | Seminal exosomes and sperm | qRT-PCR and small RNA sequencing | piR-1207, piR-2107, piR-5937 and piR-5939 were significantly reduced in exosomes from asthenozoospermia patients. 22 piRNAs were downregulated (<-1.5) in sperm sample of asthenozoospermic men when compared to normozoospermic men. |
He et al. [148] | 3 asthenozoospermic and 3 fertile controls | Seminal plasma | Small RNA sequencing | Top 10 upregulated piRNAs: piR-26,591, piR-32,694, piR-18,725, piR-16,782, piR-25,491, piR-5952, piR-18,611, piR-18,586, piR-15,811, piR-17,725; top 10 downregulated piRNAs piR-15,551, piR-29,529, piR-25,106, piR-2645, piR-9170, piR-2912, piR-23,203, piR-6148, piR-32,713, piR-29,155. |
Cui et al. [149] | 186 infertile patients and 40 fertile controls | Sperm | qRT-PCR | piR-31,704 and piR-39,888Â were decreased in infertile group compared to control men. |