Table 3 Study characteristics of 6 studies about Vitamin supplementation impact on oxidative stress markers in women with endometriosis

Jennifer Mier-Cabrera et al;2007 [37]

Mexican

RCT

(16/18)

Intervention: 32.7 ± 2.36

Control:

32.8 ± 2.49

vitaminE84mg + vitaminC343mg for 6

Placebo pills for 6weeks

Intervention:pre-post:

( 28.05 ± 3.97–11.47 ± 4.47);

Control:pre-post: (27.69 ± 7.56–- 23.83 ± 8.10)

lipid hydroperoxides (LOHS) ↓,P < 0.05↑

Leila Amini et al, 2021 [32]

Iran

RCT

(30/30)

Intervention:

35.7 ± 5.71;

Control:

38.03 ± 6.47

vitaminE800IU + vitaminC1000mg for 8 weeks

placebo pills daily for 8 weeks

Intervention:pre-post:

(41 ± 2.37–17.74 ± 16.66);

Control:pre-post:

(32.09 ± 22.84–34.51 ± 28.66)

reactive oxygen spices (ROS)↓,P < 0.05, total antioxidant capacity unaffected

Abolfazl Mehdizadehkashi et al.;2021 [24]

Germany

RCT

(25/25)

Intervention:

34.8 ± 7.1; Control: 35.6 ± 7.0

50,000 IU vitamin D every 2 weeks for 12 weeks

placebo for 12 weeks

Intervention:pre-post:

( 6.1 ± 2.6–3.8 ± 2.3)

Control:pre-post: (7.3 ± 2.5– 5.2 ± 2.6)

total antioxidant capacity(TCA)↓,P < 0.05;high-sensitivity C-reactive protein (hs-CRP) P < 0.05

Nalini Santanam et al.,2013 [29]

Atlanta

RCT

(46/13)

19-41year

vitaminE1200IU + vitamin C1000mg for 8 weeks

peritoneal fluid inflammatory markers↓, RANTES (p ≤ 0.002)↓ interleukin-6↓(p ≤ 0.056) and monocyte chemotactic protein-1 ↓ (p ≤ 0.016)

Jennifer Mier-Cabrera et al.,2009 [15]

Mexican

RCT

(37/35)

Intervention: 32.70 ± 2.46 Control:33.8 ± 3.15

high antioxidant diet

(include f vitamin C 500 mg and vitamin E 20 mg) for 3mo

normal diet

Intervention:pre-post:

( 31.1 ± 4.7–23.0 ± 2.3)

Control group:pre-post:

(31.6 ± 5.4– 30.9 ± 3.2)

Lipid Hydroperoxides(LPH) ↓,p < 0.001

Xiang Lu et al.,2018 [38]

China

RCT

137/108

Intervention: 31.5 ± 3.5 Control:31.9 ± 3.00

Vitamin C 1000 mg/ day of 2mo

Non-treatment

oxidative stress markers were unaffected