Table 2 LPS following NC-FET: characteristics of the included studies
From: Preparation of the endometrium for frozen embryo transfer: an update on clinical practices
Study | Design | Sample size | Method of embryo freezing | HCG ovulation trigger | LPS regime | LPS time | Primary outcomes |
|---|---|---|---|---|---|---|---|
Lee et al. (2013) | Retrospective cohort | 408 | Not reported | No | IM 1500 IU uhCG | On FET day and 6 days after FET | n.s. in CPR |
Lee et al. (2017) | RCT | 450 | Not reported | No | IM 1500 IU uhCG | On FET day and 6 days after FET | n.s. in OPR |
Bjuresten et al. (2011) | RCT | 435 | Not reported | No | Vaginal micronized progesterone, 400 mg twice a day | Starting three days after the LH surge | LBR, P = 0.027 n.s. in CPR, MR |
Wanggren et al. (2022) | RCT | 488 | Slow freezing/ Vitrification | No | Vaginal progesterone tablets,100 mg twice daily | Starting on the day of FET and continued for six full weeks corresponding to 8 weeks of pregnancy | LBR, P = 0.017 |
Kyrou et al. (2010) | Retrospective cohort | 452 | Slow freezing | Yes | Vaginal micronized progesterone, 200Â mg three times daily | Starting one day following hCG trigger until 7 weeks of gestation | n.s. in OPR |
Kim et al. (2014) | Retrospective cohort | 228 | Vitrification | Yes | Vaginal progesterone gel once daily | Starting 2 days after hCG trigger until 11–12 weeks of gestation | LBR, P = 0.041 MR, P = 0.044 |
Eftekhar et al. (2013) | RCT | 103 | Vitrification | Yes | IM progesterone 50Â mg twice daily | Starting 36Â h following hCG trigger until 10 weeks of gestation | n.s. in CPR, IR |
Schwartz et al. (2019) | Retrospective cohort | 231 | Vitrification | Yes | Vaginal micronized progesterone, 200 mg twice daily | Starting two days following hCG trigger until 9 weeks of gestation | CPR, P = 0.020 |
Horowitz (2020) | RCT | 59 | Slow freezing/ Vitrification | Yes | Vaginal micronized progesterone, 100Â mg twice daily | Starting two days following hCG trigger until 8 weeks of gestation | n.s. in CPR |