Table 3 Efficacy and safety in the Chinese population by AMH group

Gonadotropin use

 Duration of stimulation (days)

8.8 ± 1.4

8.6 ± 1.6

0.309^a

9.2 ± 1.9

8.9 ± 1.5

0.047^a

 Total dose (μg)

105.8 ± 16.7

110.2 ± 33.5

0.568^a

69.2 ± 19.2

110.4 ± 30.6

 < 0.001^a

 Average daily dose (μg/day)

12.0 ± 0.0

12.6 ± 1.7

0.279^a

7.5 ± 1.7

12.3 ± 1.6

 < 0.001^a

Number of follicles at end of stimulation

 Total number of follicles

10.3 ± 4.3

9.6 ± 4.4

0.302^a

13.4 ± 5.8

15.6 ± 6.4

 < 0.001^a

 Follicles ≥ 12 mm

8.8 ± 4.0

8.1 ± 4.1

0.238^a

11.2 ± 5.2

13.1 ± 5.6

 < 0.001^a

 Follicles ≥ 17 mm

4.0 ± 1.4

3.8 ± 1.3

0.309^a

4.3 ± 1.9

4.7 ± 2.1

0.119^a

Endocrine profile at end of stimulation

 FSH (IU/l)

17.0

13.3

 < 0.001^b

10.4

12.1

 < 0.001^b

 LH (IU/l)

2.0

2.3

0.124^b

1.6

1.8

0.036^b

 Estradiol (pmol/l)

6898

6239

0.179^b

7029

10,204

 < 0.001^b

 Progesterone (nmol/l)

3.1

2.7

0.215^b

2.2

3.2

 < 0.001^b

 Progesterone > 3.18 nmol/L

42 (54.5%)

39 (45.9%)

0.345^c

79 (26.6%)

151 (52.1%)

 < 0.001^c

 Inhibin A (ng/l)

341.3

310.2

0.159^b

366.6

500.8

 < 0.001^b

 Inhibin B (ng/l)

654.3

658.0

0.788^b

1153.0

1320.2

 < 0.001^b

Cancellations

 Cycle cancellation

0 (0.0%)

1 (1.2%)

1.000^c

12 (4.0%)

4 (1.4%)

0.073^c

 Cycle or transfer cancellation

6 (7.8%)

5 (5.8%)

0.757^c

50 (16.6%)

66 (22.4%)

0.079^c

Oocytes and embryos

 Women with at least one oocyte retrieved

76 (98.7%)

85 (98.8%)

1.000^c

288 (95.7%)

290 (98.3%)

0.092^c

 Oocytes retrieved (n)

9.2 ± 4.9

7.7 ± 3.6

0.068^a

10.5 ± 6.4

13.9 ± 7.8

 < 0.001^b

 Fertilized oocytes (n)

6.0 ± 3.3

5.0 ± 2.9

0.057^a

6.4 ± 4.5

8.5 ± 5.2

 < 0.001^a

 Fertilization rate^d (%)

66.0 ± 21.6

66.3 ± 22.9

0.914^a

62.5 ± 23.2

61.8 ± 21.1

0.280^a

 Day 3 embryos (n)

6.9 ± 3.8

5.7 ± 3.0

0.070^a

7.4 ± 4.9

9.7 ± 5.7

 < 0.001^a

 Day 3 good-quality embryos (n)

3.6 ± 2.9

3.4 ± 2.3

0.800^a

4.6 ± 3.9

5.9 ± 4.5

 < 0.001^a

OHSS

 Any OHSS

4 (5.2%)

1 (1.2%)

0.190^c

30 (10.0%)

35 (11.9%)

0.512^c

 Early OHSS (any grade)^e

3 (3.9%)

0 (0.0%)

0.103^c

15 (5.0%)

28 (9.5%)

0.039^c

 Late OHSS (any grade)^f

1 (1.3%)

1 (1.2%)

1.000^c

15 (5.0%)

7 (2.4%)

0.127^c

 Preventive interventions^g for early OHSS

0 (0.0%)

1 (1.2%)

1.000^c

6 (2.0%)

15 (5.1%)

0.047^c

 Early OHSS and/or preventive interventions

3 (3.9%)

1 (1.2%)

0.345^c

20 (6.6%)

41 (13.9%)

0.004^c