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Fig. 6 | Reproductive Biology and Endocrinology

Fig. 6

From: TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-κB signaling pathway

Fig. 6

TOP2A deficiency leads to impaired fertility in mice. A Flow diagram of the experimental design. B Western blotting of TOP2A protein expression in the mouse uterus at GD8.5 (ad-Ctrl, n = 6; ad-TOP2A, n = 6). C RT-qPCR of TOP2A mRNA expression in the mouse uterus at GD8.5 (ad-Ctrl, n = 6; ad-TOP2A, n = 6). D Representative images of the mouse uterus at GD8.5 (ad-Ctrl, n = 6; ad-TOP2A, n = 6). E Mice were sacrificed on GD8.5, and the fetuses were dissected from the uterus and weighed. Litter size and fetal weight were recorded (ad-Ctrl, n = 52 pups from 6 dams; ad-TOP2A, n = 51 pups from 6 dams). Mann–Whitney U test. Data are the mean ± SEM of 3 biological replicates unless stated otherwise. *p < 0.05, **p < 0.01, ***p < 0.001. ns, nonsignificant

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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