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Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-κB signaling pathway

Fig. 3

TOP2A expression pattern in human endometrial tissue; the level of TOP2A in T-HESCs decreases upon decidualization. A Immunohistochemistry analysis of paraffin-embedded endometrial tissues in the proliferative and mid-secretory phases. Original magnification left panel: × 100, scale bar = 50 μm, right panel: × 200, scale bar = 20 μm. n = 3 in each group. B, C TOP2A and IGFBP1 protein levels and IGFBP1 and PRL mRNA expression in T-HESCs were measured by Western blotting and RT-qPCR every 48 h over a 4-day decidualization time course. Data are the mean ± SEM of 3 biological replicates unless stated otherwise. One-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001 compared to Day 0. ns, nonsignificant

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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