The impact of different endometrial preparation protocols on obstetric and neonatal complications in frozen-thawed embryo transfer: a retrospective cohort study of 3,458 singleton deliveries

Table 3 Univariate regression analysis of the different endometrial preparation protocols for obstetric and neonatal complications

	Programmed cycles vs Natural cycles		Minimal ovarian stimulation cycles vs Natural cycles		Programmed cycles vs Minimal ovarian stimulation cycles
	Crude OR (95%CI)	P value	Crude OR (95% CI)	P value	Crude OR (95% CI)	P value
Obstetric complications
HDP	2.074 (1.354–3.177)	0.001^a	1.939 (1.113–3.380)	0.020^a	1.069 (0.686–1.668)	0.767
GDM	1.206 (0.598–2.433)	0.601	1.682 (0.692–4.089)	0.251	0.717 (0.336–1.529)	0.389
ICP	1.081 (0.443–2.636)	0.864	0.290 (0.036–2.364)	0.248	3.728 (0.493–28.179)	0.202
Placenta previa	1.557 (0.869–2.791)	0.137	1.368 (0.610–3.069)	0.447	1.138 (0.572–2.264)	0.712
PROM	0.872 (0.570–1.333)	0.526	0.835 (0.444–1.572)	0.577	1.044 (0.580–1.879)	0.887
Preterm delivery	1.546 (1.114–2.145)	0.009^a	1.691 (1.099–2.603)	0.017^a	0.914 (0.636–1.313)	0.627
Postpartum haemorrhage	2.384 (0.989–5.746)	0.053	0.679 (0.136–3.376)	0.636	3.512 (0.836–14.746)	0.086
Neonatal complications
LGA	1.334 (1.082–1.644)	0.007^a	0.860 (0.624–1.185)	0.357	1.551 (1.161–2.071)	0.003^a
SGA	0.742 (0.523–1.019)	0.094	1.348 (0.868–2.094)	0.183	0.550 (0.366–0.826)	0.004^a
Macrosomia	1.427 (0.792–2.574)	0.237	1.090 (0.459–2.589)	0.846	1.310 (0.613–2.798)	0.486

Values are presented as n (%) or OR (95%CI)
OR odds ratio, CI confidence interval, HDP hypertensive disorders of pregnancy, GDM gestational diabetes mellitus, ICP intrahepatic cholestasis of pregnancy, PROM preterm rupture of membrane, LGA large for gestational age, SGA small for gestational age
^aP < 0.05

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