Fig. 4
From: The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats
The effect of IGFBP-5 on puberty-relative gene expression and the time of vaginal opening in AVO experiments of female rats (n = 6/group). a The time of vaginal opening in female rats after IGFBP-5 ICV injection. b The expression level of puberty-related gene mRNA at VO in the rat hypothalamus (AVO). c The expression level of Igf-1, Igf-1r, Igfbp-5, Fshβ and Lhβ mRNA at VO in the rat pituitary (AVO). d The expression level of Igf-1,Igf-1r and Igfbp-5 mRNA at VO in the rat ovary (AVO). ** indicates a very significant difference (P < 0.01); * indicates a significant difference (P < 0.05)