Characteristics of childhood-onset systemic lupus erythematosus in pregnancy and its association with pregnancy outcomes: a retrospective comparative cohort study

Table 3 Association between cSLE and disease activity during pregnancy

Disease activity	Univariable analysis		Multivariable analysis
Disease activity	OR (95%CI)	P value	OR (95%CI)	P value
Active SLE (N = 42)
cSLE	4.600 (1.814–11.664)	0.001	4.742 (1.678–13.405)	0.003
SLE in remission for < 6 months before pregnancy	7.500 (2.394–23.501)	0.001	9.700 (2.954–31.854)	< 0.001
Gestational age	0.906 (0.833–0.986)	0.022	0.950 (0.867–1.042)	0.276
Active LN (N = 37)
cSLE	4.577 (1.793–11.685)	0.001	4.652 (1.630–13.279)	0.004
SLE in remission for < 6 months before pregnancy	4.847 (1.626–14.447)	0.005	6.110 (1.952–19.123)	0.002
Gestational age	0.911 (0.835–0.994)	0.037	0.960 (0.875–1.053)	0.387

SLE systemic lupus erythematosus, LN lupus nephritis, cSLE childhood-onset systemic lupus erythematosus, OR odds ratio, CI confidence interval

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