Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation

Table 1 Maturation rates and activation rates of mice oocytes cultured with different concentrations of rapamycin

Group	Total No. of oocytes	Maturation rate, %	Activation rate, %
Control	118	80.83 ± 1.24	53.43 ± 2.34
1 nM R	106	83.13 ± 1.76	46.57 ± 2.34
10 nM R	91	85.93 ± 0.67	62.37 ± 1.52^*
100 nM R	103	71.93 ± 3.15	46.43 ± 2.47
1 μM R	111	60.63 ± 1.84^*	34.33 ± 1.95^**
10 μM R	113	66.03 ± 3.82	27.90 ± 2.36^**

R: rapamycin. Asterisks indicated statistical differences compared with the control group. *P < 0.05. **P < 0.01

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