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Fig. 7 | Reproductive Biology and Endocrinology

Fig. 7

From: Comparative analyses in transcriptome of human granulosa cells and follicular fluid micro-environment between poor ovarian responders with conventional controlled ovarian or mild ovarian stimulations

Fig. 7

Schematic diagram of the results in the background of cross-talkings within the follicle. The red and blue arrows represent the COS group and the mild group, respectively. The up and down arrows represent up-regulation and down-regulation, respectively. a Histologic and functional architecture of a mature follicle. Panels b, c, and d summarize the main findings of this study. b The KEGG analysis of DEGs between the two groups. After sequencing and analyzing the DEGs of granulosa cells from the two groups, the KEGG analysis showed four signaling pathways associated with the oocyte development. c Comparative analyses of the rate of good-quality embryos as well as the hormones and cytokines in the FF. Significantly higher rates of good-quality embryos were observed in the mild group. Compared with the COS group, the FSH and P levels in the FF were significantly lower in the mild group while the LH and T levels significantly higher. As for the cytokine concentrations, a significantly higher TGF-β2 concentration and a significantly lower GDF-9 level were detected in the mild group. d Comparative analyses of TGF-β2, TGF-βR2 and Smad3 in granulosa cells as well as TGF-β2 in the FF. The expressions of TGF-β2, TGF-βR2 and Smad3 in the mild group were significantly upregulated compared with the COS group

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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