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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells

Fig. 1

GDF-11 downregulates StAR expression in hGL cells. A and B, hGL cells were treated with 1, 10, and 30 ng/mL GDF-11 for 24 h. The mRNA (A) and protein (B) levels of StAR were determined by RT-qPCR and western blot, respectively. C, hGL cells were treated with 30 ng/mL GDF-11 (G11) or GDF-8 (G8) for 24 h. The protein levels of StAR were determined by western blot. D, hGL cells were treated with 1, 10, and 30 ng/mL GDF-11 for 24 h. The mRNA levels of P450scc and 3β-HSD were examined by RT-qPCR. The results are expressed as the mean ± SEM of at least three independent experiments. The values without a common letter are significantly different (p < 0.05)

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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