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Table 1 Summary of stem cell therapy for POI

From: Therapeutic options for premature ovarian insufficiency: an updated review

Types Species and POI model Mechanisms Method of administration Outcome Reference
iPSCs ICR mice differentiation function cultured and induced in vitro differentiate into oogonia/gonocyte-like cells [69]
BMSCs cyclophosphamide-induced ovarian failure in rabbits increased the secretion of VEGF injected intravenously in the ear veins reduced FSH level increased serum estrogen level and follicle number [70]
BMSCs cisplatin-induced apoptosis of GCs/ aging rats downregulated P21 and Bax, upregulated the c-myc proto-oncogene mRNA co-culture in vitro/injected via vena caudalis inhibited GCs apoptosis [71]
ADSCs cisplatin-induced ovarian failure in mice induced angiogenesis intraovarian injected restored the number of ovarian follicles and corpus luteum [72]
MenSCs epirubicin-induced GCs injury/ cisplatin-induced ovarian failure in mice protected GCs from apoptosis and increased secretion of fibroblast growth factor 2 co-culture in vitro/injected via vena caudalis improved POI [73, 74]
PMSCs the pZP3-induced POI mice model reduced follicular atresia and GCs apoptosis injected via vena caudalis increased serum AMH and estrogen levels [75]
PMSCs the pZP3-induced POI mice model regulated Th17/Tc17 and Th17/Treg cell ratios by PI3K/Akt signal pathway intraovarian injected restored ovarian function [76]
PMSCs ovariectomized rat model upregulated antioxidant factors injected through the tail vein restored ovarian function [77]
PMSCs the pZP3-induced POI mice model inhibited endoplasmic reticulum stress inositol-demanding enzyme 1 signaling pathway injected through the tail vein reduced GCs apoptosis [78]
UC-MSCs cisplatin-induced ovarian failure in rat transform growth factor-β/Smad3 signaling pathway injected through the tail vein regulated the differentiation of ovarian stromal cells [79]
AFSCs gilt differentiatived potential co-culture in vitro differentiated into primordial follicle oocytes in vitro [80]
AMSCs cyclophosphamide-induced ovarian failure in rat reduced the expression of inflammatory cytokines injected through the tail vein inhibited ovarian inflammation [81]
exosomal miR-644-5p derived from BMSCs cisplatin-induced ovarian failure in mice targeted the regulation of p53 injected through the tail vein suppressed GCs apoptosis [82]
exosomal miR-144-5p derived from BMSCs cyclophosphamide-induced ovarian failure in rat target PTEN injected intraperitoneally inhibited GCs apoptosis [83]
miR-21 derived from BMSCs phosphamide mustard- induced apoptosis of GCs/ cyclophosphamide-induced ovarian failure in rat downregulated PTEN and PDCD4 co-culture in vitro/ injected into the bilateral ovaries repaired ovarian structure and function [84]
ADSC-derived exosomes cyclophosphamide-induced ovarian failure in mice regulated the SMAD pathway injected into the ovaries oogenesis and the proliferation of granular cells [85]
exosomal miRNA-17-5p derived from hUC-MSCs cyclophosphamide-induced ovarian failure in mice regulated SIRT7 signaling pathway injected into the ovaries improved ovarian function [86]
exosomal miR-10a/ and miR-146a derived from AFSCs cyclophosphamide-induced ovarian failure in mice inhibited follicular atresia transplanted into the ovaries increased GCs survival [87]
exosomal miR-320areleased from human AMSCs cyclophosphamide-induced ovarian failure in mice regulated Sirtuin4 injected into the ovaries delay ROS generation in POI [88]
collagen caffold+ ADSCs tripterygium glycosides induced ovarian failure in rat enhance the retention of ADSCs in target organs injected into the ovaries increase follicle counts [89]
collagen caffold+ UC-MSCs POI patients phosphorylation of FOXO3a and FOXO1 intraovarian injected/ activate follicles in dormant ovaries [90]
alginate+ ADSCs mice secrete cytokines co-culture in vitro support follicle genesis, survival, and maturation in vitro [91]