Skip to main content

Table 1 Protein cargo of EVs secreted by pHEECs related to implantation success

From: Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantation

UniProt accession Gene name Protein description References (PMID)
Endometrial receptivity
 P01023 A2M Alpha-2-macroglobulin 7,533,769, 1,380,439
 P60709 ACTB Actin, cytoplasmic 1 29,093,507, 23,638,092
 Q9UHI8 ADAMTS1 A disintegrin and metalloproteinase with thrombospondin motifs 1 23,751,571, 16,941,747
 O00468 AGRN Agrin 18,561,091, 16,885,540
 P07355 ANXA2 Annexin A2 31,738,896, 33,010,173
 P09525 ANXA4 Annexin A4 22,999,554
 P08758 ANXA5 Annexin A5 18,793,766
 P61769 B2M Beta-2-microglobulin 23,555,582, 16,251,498
 Q08722 CD47 Leukocyte surface antigen CD47 21,429,575, 26,839,151
 P08174 CD55 Complement decay-accelerating factor 23,427,180, 29,153,978
 P60953 CDC42 Cell division control protein 42 homolog 31,606,658, 20,357,266
 O15551 CLDN3 Claudin-3 26,340,953, 23,909,989
 P12109 COL6A1 Collagen alpha-1 (VI) chain 7,780,011
 P12110 COL6A2 Collagen alpha-2 (VI) chain 7,780,011
 P12111 COL6A3 Collagen alpha-3 (VI) chain 7,780,011
 P49747 COMP Cartilage oligomeric matrix protein 23,555,582
 P02511 CRYAB Alpha-crystallin B chain 9,237,261, 20,631,402
 P27487 DPP4 Dipeptidyl peptidase 4 28,523,980, 29,264,977
 P17813 ENG Endoglin 26,802,878
 P13726 F3 Tissue factor 23,555,582
 P21333 FLNA Filamin-A 25,557,137
 P05362 ICAM1 Intercellular adhesion molecule 1 21,448,983
 P56199 ITGA1 Integrin alpha-1 32,676,925, 9,130,881
 P17301 ITGA2 Integrin alpha-2 8,288,018, 9,130,881
 P23229 ITGA6 Integrin alpha-6 8,288,018, 9,130,881
 P05556 ITGB1 Integrin beta-1 32,676,925, 9,130,881
 P11047 LAMC1 Laminin subunit gamma-1 32,980,684, 32,676,925
 Q08380 LGALS3BP Galectin-3-binding protein 30,021,913
 P26038 MSN Moesin 14,613,898
 P15941 MUC1 Mucin-1 29,929,546, 25,747,132
 Q8WXI7 MUC16 Mucin-16 23,555,582
 Q99102 MUC4 Mucin-4 33,193,109
 O43490 PROM1 Prominin-1 27,166,505
 P21980 TGM2 Protein-glutamine gamma-glutamyltransferase 2 18,561,091
 Q9Y490 TLN1 Talin-1 33,711,384
Embryo implantation
 P15121 AKR1B1 Aldo–keto reductase family 1 member B1 17,640,989
 P04083 ANXA1 Annexin A1 32,403,233, 31,940,782
 P02647 APOA1 Apolipoprotein A-I 27,567,428, 21,676,393
 P35613 BSG Basigin 9,501,026, 12,214,805
 P01024 C3 Complement C3 28,283,674
 O00622 CCN1 CCN family member 1 17,171,641
 P16070 CD44 CD44 antigen 29,846,687
 P13987 CD59 CD59 glycoprotein 7,576,125, 32,973,817
 P06733 ENO1 Alpha-enolase 24,628,430
 Q14512 FGFBP1 Fibroblast growth factor-binding protein 1 26,764,347
 P02751 FN1 Fibronectin 16,621,928, 12,476,048
 P98160 HSPG2 Basement membrane-specific heparan sulfate proteoglycan core protein 17,442,708
 P26006 ITGA3 Integrin alpha-3 29,846,687
 P06756 ITGAV Integrin alpha-V 10,775,178, 30,929,718
 P05106 ITGB3 Integrin beta-3 10,775,178, 30,929,718
 Q16787 LAMA3 Laminin subunit alpha-3 33,715,134, 29,846,687
 Q13751 LAMB3 Laminin subunit beta-3 33,715,134
 Q13753 LAMC2 Laminin subunit gamma-2 33,715,134
 Q08431 MFGE8 Lactadherin 24,424,369
 P14543 NID1 Nidogen-1 16,607,619
 P07737 PFN1 Profilin-1 32,466,630
 P00749 PLAU Urokinase-type plasminogen activator 21,075,828
 P62937 PPIA Peptidyl-prolyl cis–trans isomerase A 32,580,158
 Q06830 PRDX1 Peroxiredoxin-1 33,860,638
 P20742 PZP Pregnancy zone protein 14,580,373
 P37802 TAGLN2 Transgelin-2 30,702,937
 P07996 THBS1 Thrombospondin-1 29,846,687
 P24821 TNC Tenascin 29,846,687
 P08670 VIM Vimentin 30,735,538
 P04004 VTN Vitronectin 18,026,832
 P62258 YWHAE 14–3-3 protein epsilon 33,634,576
 P63104 YWHAZ 14–3-3 protein zeta/delta 17,537,306
Early embryo development
 O14672 ADAM10 Disintegrin and metalloproteinase domain-containing protein 10 31,373,105, 12,354,787
 P15144 ANPEP Aminopeptidase N 28,859,152
 P05023 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 21,791,182, 31,405,390
 P05026 ATP1B1 Sodium/potassium-transporting ATPase subunit beta-1 17,317,668
 P48509 CD151 CD151 antigen 33,450,381
 Q00610 CLTC Clathrin heavy chain 1 33,718,352
 P14384 CPM Carboxypeptidase M 14,614,042
 P22352 GPX3 Glutathione peroxidase 3 33,322,741, 24,279,306
 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 33,856,486, 9,118,006
 P08238 HSP90AB1 Heat shock protein HSP 90-beta 33,856,486, 9,118,006
 O75367 MACROH2A1 Core histone macro-H2A.1 19,734,898
 Q13421 MSLN Mesothelin 33,216,405
 P63244 RACK1 Receptor of activated protein C kinase 1 25,143,135
 P08865 RPSA 40S ribosomal protein SA 25,800,042
 P62987 UBA52 Ubiquitin-60S ribosomal protein L40 30,135,083