Table 1 Protein cargo of EVs secreted by pHEECs related to implantation success

Endometrial receptivity

 P01023

A2M

Alpha-2-macroglobulin

7,533,769, 1,380,439

 P60709

ACTB

Actin, cytoplasmic 1

29,093,507, 23,638,092

 Q9UHI8

ADAMTS1

A disintegrin and metalloproteinase with thrombospondin motifs 1

23,751,571, 16,941,747

 O00468

AGRN

Agrin

18,561,091, 16,885,540

 P07355

ANXA2

Annexin A2

31,738,896, 33,010,173

 P09525

ANXA4

Annexin A4

22,999,554

 P08758

ANXA5

Annexin A5

18,793,766

 P61769

B2M

Beta-2-microglobulin

23,555,582, 16,251,498

 Q08722

CD47

Leukocyte surface antigen CD47

21,429,575, 26,839,151

 P08174

CD55

Complement decay-accelerating factor

23,427,180, 29,153,978

 P60953

CDC42

Cell division control protein 42 homolog

31,606,658, 20,357,266

 O15551

CLDN3

Claudin-3

26,340,953, 23,909,989

 P12109

COL6A1

Collagen alpha-1 (VI) chain

7,780,011

 P12110

COL6A2

Collagen alpha-2 (VI) chain

7,780,011

 P12111

COL6A3

Collagen alpha-3 (VI) chain

7,780,011

 P49747

COMP

Cartilage oligomeric matrix protein

23,555,582

 P02511

CRYAB

Alpha-crystallin B chain

9,237,261, 20,631,402

 P27487

DPP4

Dipeptidyl peptidase 4

28,523,980, 29,264,977

 P17813

ENG

Endoglin

26,802,878

 P13726

F3

Tissue factor

23,555,582

 P21333

FLNA

Filamin-A

25,557,137

 P05362

ICAM1

Intercellular adhesion molecule 1

21,448,983

 P56199

ITGA1

Integrin alpha-1

32,676,925, 9,130,881

 P17301

ITGA2

Integrin alpha-2

8,288,018, 9,130,881

 P23229

ITGA6

Integrin alpha-6

8,288,018, 9,130,881

 P05556

ITGB1

Integrin beta-1

32,676,925, 9,130,881

 P11047

LAMC1

Laminin subunit gamma-1

32,980,684, 32,676,925

 Q08380

LGALS3BP

Galectin-3-binding protein

30,021,913

 P26038

MSN

Moesin

14,613,898

 P15941

MUC1

Mucin-1

29,929,546, 25,747,132

 Q8WXI7

MUC16

Mucin-16

23,555,582

 Q99102

MUC4

Mucin-4

33,193,109

 O43490

PROM1

Prominin-1

27,166,505

 P21980

TGM2

Protein-glutamine gamma-glutamyltransferase 2

18,561,091

 Q9Y490

TLN1

Talin-1

33,711,384

Embryo implantation

 P15121

AKR1B1

Aldo–keto reductase family 1 member B1

17,640,989

 P04083

ANXA1

Annexin A1

32,403,233, 31,940,782

 P02647

APOA1

Apolipoprotein A-I

27,567,428, 21,676,393

 P35613

BSG

Basigin

9,501,026, 12,214,805

 P01024

C3

Complement C3

28,283,674

 O00622

CCN1

CCN family member 1

17,171,641

 P16070

CD44

CD44 antigen

29,846,687

 P13987

CD59

CD59 glycoprotein

7,576,125, 32,973,817

 P06733

ENO1

Alpha-enolase

24,628,430

 Q14512

FGFBP1

Fibroblast growth factor-binding protein 1

26,764,347

 P02751

FN1

Fibronectin

16,621,928, 12,476,048

 P98160

HSPG2

Basement membrane-specific heparan sulfate proteoglycan core protein

17,442,708

 P26006

ITGA3

Integrin alpha-3

29,846,687

 P06756

ITGAV

Integrin alpha-V

10,775,178, 30,929,718

 P05106

ITGB3

Integrin beta-3

10,775,178, 30,929,718

 Q16787

LAMA3

Laminin subunit alpha-3

33,715,134, 29,846,687

 Q13751

LAMB3

Laminin subunit beta-3

33,715,134

 Q13753

LAMC2

Laminin subunit gamma-2

33,715,134

 Q08431

MFGE8

Lactadherin

24,424,369

 P14543

NID1

Nidogen-1

16,607,619

 P07737

PFN1

Profilin-1

32,466,630

 P00749

PLAU

Urokinase-type plasminogen activator

21,075,828

 P62937

PPIA

Peptidyl-prolyl cis–trans isomerase A

32,580,158

 Q06830

PRDX1

Peroxiredoxin-1

33,860,638

 P20742

PZP

Pregnancy zone protein

14,580,373

 P37802

TAGLN2

Transgelin-2

30,702,937

 P07996

THBS1

Thrombospondin-1

29,846,687

 P24821

TNC

Tenascin

29,846,687

 P08670

VIM

Vimentin

30,735,538

 P04004

VTN

Vitronectin

18,026,832

 P62258

YWHAE

14–3-3 protein epsilon

33,634,576

 P63104

YWHAZ

14–3-3 protein zeta/delta

17,537,306

Early embryo development

 O14672

ADAM10

Disintegrin and metalloproteinase domain-containing protein 10

31,373,105, 12,354,787

 P15144

ANPEP

Aminopeptidase N

28,859,152

 P05023

ATP1A1

Sodium/potassium-transporting ATPase subunit alpha-1

21,791,182, 31,405,390

 P05026

ATP1B1

Sodium/potassium-transporting ATPase subunit beta-1

17,317,668

 P48509

CD151

CD151 antigen

33,450,381

 Q00610

CLTC

Clathrin heavy chain 1

33,718,352

 P14384

CPM

Carboxypeptidase M

14,614,042

 P22352

GPX3

Glutathione peroxidase 3

33,322,741, 24,279,306

 P07900

HSP90AA1

Heat shock protein HSP 90-alpha

33,856,486, 9,118,006

 P08238

HSP90AB1

Heat shock protein HSP 90-beta

33,856,486, 9,118,006

 O75367

MACROH2A1

Core histone macro-H2A.1

19,734,898

 Q13421

MSLN

Mesothelin

33,216,405

 P63244

RACK1

Receptor of activated protein C kinase 1

25,143,135

 P08865

RPSA

40S ribosomal protein SA

25,800,042

 P62987

UBA52

Ubiquitin-60S ribosomal protein L40

30,135,083