Fig. 5

Proteomic analysis of EV cargo secreted by pHEECs. Physical interaction networks for proteins involved in GO biological processes, which could be clustered into A cell adhesion, B cell differentiation, C cell communication, D cell migration, E ECM organization, F vasculature development, and G reproduction processes. H Enrichment analysis of GO biological processes in EV protein cargo; intensity of the color represents the number of proteins from our data set associated with each process. I Representative image of Western blot for validation of the presence of proteins FN1, ITGAV, VTN, ANXA2, and PFN1. FDR, adjusted P value; count, number of proteins enriched in each biological process