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Table 2 Baseline clinical, ultrasonographic, biochemical parameters of the population who carried out 12 months of therapy vs the subpopulation who dropped out

From: Hyperandrogenism and menstrual imbalance are the best predictors of metformin response in PCOS patients

 

No drop-out (n°82)

Drop-out (n°21)

P value

Weight (Kg)

89.1 ± 17.2

84.1 ± 19.1

0.136

BMI (Kg/m2)

33.6 ± 5.6

31.6 ± 6.5

0.129

Glucose (mg/dL)

91 ± 9

93 ± 9

0.180

Insulin (μU/mL)

23 ± 12

19 ± 10

0.096

HOMA-IR

5.13 ± 2.89

4.32 ± 2.50

0.143

Total cholesterol (mg/dL)

193 ± 32

185 ± 30

0.214

LDL cholesterol (mg/dL)

125 ± 27

118 ± 25

0.205

HDL cholesterol (mg/dL)

42 ± 7

45 ± 10

0.238

Triglycerides (mg/dL)

130 ± 67

111 ± 50

0.188

WHR

0.91 ± 0.09

0.89 ± 0.11

0.393

T (ng/mL)

0.75 ± 0.35

0.58 ± 0.21

0.027

SHBG (nmol/L)

22.86 ± 10.28

26.11 ± 12.62

0.257

FAI %

13.86 ± 9.76

9.067 ± 5.071

0.001

Δ4A (ng/mL)

4.11 ± 0.645

3.859 ± 0.624

0.019

DHEAS (μg/dL)

289 ± 136

301 ± 119

0.321

F-G

14.23 ± 6.70

10.57 ± 6.70

0.007

LH/FSH

1.475 ± 0.725

1.479 ± 1.134

0.230

Menses/6 months

1.75 ± 1.63

2.28 ± 1.76

0.082

PCOM (US)

82%

65%

 

AFC (num - bothovaries)

44 ± 11

37 ± 7

0.0001

  1. BMI body mass index; HOMA-IR homeostatic model assessment of insulin resistance; WHR waist to hip ratio; T total testosterone; SHBG sex hormone binding globulin; FAI free-androgen-index; Δ4A Δ4-androstenedione; DHEAS dehydroepiandrosterone sulfate; F-G Ferriman–Gallwey score; LH luteinizing hormone; FSH follicle stimulating hormone; PCOM polycystic ovarian morphology; AFC antral follicle count