Figure 4

Semantic connectivity map (SCM) of the BMI response. Auto-CM, a fourth generation ANN developed at Semeion Research Centre (Italy), is able to outline the semantic connectivity maps transforming in physical distances the strength of the association among the variables. In order to transform the continuous into nominal variables the data have been dichotomized using the median as cut-off. The metformin responsiveness proved to be related, in order of priority, to oligo-amenorrhea (CYCL LOW: <4 menses/12 months), hyperandrogenemia (FAI HIGH: >9 %), hirsutism (FG HIGH: Ferriman-Gallwey score >12) and insulin-resistance (HOMA HIGH: HOMA-IR >4).