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Table 6 Embryo morphologic quality and ICSI outcomes, by PCOS phenotype

From: Polycystic ovary syndrome phenotype does not have impact on oocyte morphology

  PCOS A PCOS C PCOS D p value Adjusted p
Number of ICSI cycles 70 48 42
Fertilization rate, n/nMII ovo (%) 331/536
(61.8 [55.4 to 68.8])
233/394
(59.1 [52.0 to 67.2])
205/346
(59.2 [51.7 to 67.9])
0.93 0.93
Number of day 2-3 embryos 4.6 [4.1 to 5.1] 4.6 [4.1 to 5.3] 4.8 [4.2 to 5.5] 0.92 0.84
Grade 1 embryos (%)ǂ 159/319 (49.8 [42.7 to 58.2]) 113/222 (50.9 [42.3 to 61.2]) 104/201 (51.7 [42.7 to 62.7]) 0.93 0.86
Grade 3 embryos (%)ǂ 130/319
(40.8 [34.3 to 48.4])
89/222
(40.1 [32.6 to 46.8])
75/201
(37.3 [29.8 to 46.8])
0.76 0.58
Number of frozen embryos (n) ǂ 1.7 [1.4 to 2.0] 1.5 [1.2 to 1.9] 2.0 [1.6 to 2.5] 0.59 0.57
Fresh transferred embryos (n)ǂ 1.4 [1.1 to 1.7] 1.6 [1.3 to 2.0] 1.4 [1.1 to 1.8] 0.42 0.39
Implantation rate, n/nembryos transferred (%)* 28/89
(31.5 [21.7 to 45.6])
21/73
(28.8 [18.8 to 44.1])
18/56
(32.1 [20.3 to 51.0])
0.79 0.82
CPR, n/ntransfers with fresh embryos (%)* 26/53
(49.1 [36.0 to 62.3])
20/39
(51.3 [36.0 to 66.4])
15/33
(45.5 [29.6 to 62.3])
0.88 0.71ƒ
Live birth rate, n/ntransfers with fresh embryos (%)* 19/53
(35.8 [24.2 to 49.5])
16/39
(41.0 [26.9 to 56.8])
13/33
(39.4 [24.4 to 56.6])
0.92 0.44
Miscarriage rate, n/nclinical pregnancy (%)* 5/26
(19.2 [8.2 to 38.7])
3/20
(15.0 [4.9 to 37.6])
2/15
(13.3 [3.4 to 40.5])
0.89 NA
Cumulative CPR, n/ntotal transfers (%) 33/94
(35.1 [25.0 to 49.4])
26/65
(40.0 [27.2 to 58.8])
29/68
(42.6 [28.4 to 59.6])
0.51 0.43#
Cumulative CPR, n/ncycles (%) 33/70
(47.1 [33.5 to 66.3])
26/48
(54.2 [36.9 to 79.6])
29/42
(69.0 [48.0 to 99.4])
0.15 0.18#
  1. Values are quoted as the mean [95% CI] or no./total no. (rate [95%CI] in %). The p value was adjusted for the woman’s age, BMI and current smoking status, the type of COH protocol, and the total dose of rFSH
  2. ƒ additionally adjusted for the number of fresh embryos transferred
  3. # additionally adjusted for the total number of embryos transferred
  4. Abbreviations: CPR clinical pregnancy rate, NA not applicable, due to low frequencies
  5. ǂ cycles with no embryos obtained on day 2-3 were excluded
  6. * cycles with embryo transfer on day 5-6 and cycles with a “freeze-all” strategy were excluded