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Table 6 Embryo morphologic quality and ICSI outcomes, by PCOS phenotype

From: Polycystic ovary syndrome phenotype does not have impact on oocyte morphology

 

PCOS A

PCOS C

PCOS D

p value

Adjusted p

Number of ICSI cycles

70

48

42

Fertilization rate, n/nMII ovo (%)

331/536

(61.8 [55.4 to 68.8])

233/394

(59.1 [52.0 to 67.2])

205/346

(59.2 [51.7 to 67.9])

0.93

0.93

Number of day 2-3 embryos

4.6 [4.1 to 5.1]

4.6 [4.1 to 5.3]

4.8 [4.2 to 5.5]

0.92

0.84

Grade 1 embryos (%)ǂ

159/319 (49.8 [42.7 to 58.2])

113/222 (50.9 [42.3 to 61.2])

104/201 (51.7 [42.7 to 62.7])

0.93

0.86

Grade 3 embryos (%)ǂ

130/319

(40.8 [34.3 to 48.4])

89/222

(40.1 [32.6 to 46.8])

75/201

(37.3 [29.8 to 46.8])

0.76

0.58

Number of frozen embryos (n) ǂ

1.7 [1.4 to 2.0]

1.5 [1.2 to 1.9]

2.0 [1.6 to 2.5]

0.59

0.57

Fresh transferred embryos (n)ǂ

1.4 [1.1 to 1.7]

1.6 [1.3 to 2.0]

1.4 [1.1 to 1.8]

0.42

0.39

Implantation rate, n/nembryos transferred (%)*

28/89

(31.5 [21.7 to 45.6])

21/73

(28.8 [18.8 to 44.1])

18/56

(32.1 [20.3 to 51.0])

0.79

0.82

CPR, n/ntransfers with fresh embryos (%)*

26/53

(49.1 [36.0 to 62.3])

20/39

(51.3 [36.0 to 66.4])

15/33

(45.5 [29.6 to 62.3])

0.88

0.71ƒ

Live birth rate, n/ntransfers with fresh embryos (%)*

19/53

(35.8 [24.2 to 49.5])

16/39

(41.0 [26.9 to 56.8])

13/33

(39.4 [24.4 to 56.6])

0.92

0.44

Miscarriage rate, n/nclinical pregnancy (%)*

5/26

(19.2 [8.2 to 38.7])

3/20

(15.0 [4.9 to 37.6])

2/15

(13.3 [3.4 to 40.5])

0.89

NA

Cumulative CPR, n/ntotal transfers (%)

33/94

(35.1 [25.0 to 49.4])

26/65

(40.0 [27.2 to 58.8])

29/68

(42.6 [28.4 to 59.6])

0.51

0.43#

Cumulative CPR, n/ncycles (%)

33/70

(47.1 [33.5 to 66.3])

26/48

(54.2 [36.9 to 79.6])

29/42

(69.0 [48.0 to 99.4])

0.15

0.18#

  1. Values are quoted as the mean [95% CI] or no./total no. (rate [95%CI] in %). The p value was adjusted for the woman’s age, BMI and current smoking status, the type of COH protocol, and the total dose of rFSH
  2. ƒ additionally adjusted for the number of fresh embryos transferred
  3. # additionally adjusted for the total number of embryos transferred
  4. Abbreviations: CPR clinical pregnancy rate, NA not applicable, due to low frequencies
  5. ǂ cycles with no embryos obtained on day 2-3 were excluded
  6. * cycles with embryo transfer on day 5-6 and cycles with a “freeze-all” strategy were excluded