Fig. 1
Impairment of insulin signaling pathway in granulosa cells from PCOS patients with IR. A, B Aktser473 phosphorylation after insulin stimulation (100 nM for 15 min) in granulosa cells from non-PCOS and PCOS patients with or without IR (n = 6 per group). C Glucose uptake after insulin stimulation (100 nM for 30 min) in granulosa cells from non-PCOS and PCOS patients with or without IR (n = 6 per group). All values are the mean ± SEM. IR, insulin resistance. * P < 0.05, ** P < 0.01 compared with without insulin stimulation in each group. # P < 0.05, ## P < 0.01 compared with non-PCOS without IR with insulin stimulation. & P < 0.05 compared with non-PCOS with IR with insulin stimulation. $ P < 0.05 compared with PCOS without IR with insulin stimulation